Rusty Gage


Laboratory of Genetics

Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease

Rusty Gage
Salk Institute for Biological Studies - Publications


Marchetto MC, Hrvoj-Mihic B, Kerman BE, Yu DX, Vadodaria KC, Linker SB, Narvaiza I, Santos R, Denli AM, Mendes APD, Oefner R, Cook J, McHenry L, Grasmick JM, Heard K, Fredlender C, Randolph-Moore L, Kshirsagar R, Xenitopoulos R, Chou G, Hah N, Muotri AR, Padmanabhan K, Semendeferi K, Gage FH. Species-specific maturation profiles of human, chimpanzee and bonobo neural cells. eLife, 2019 February 7; DOI: 10.7554/eLife.37527

Vadodaria KC, Ji Y, Skime M, Paquola A, Nelson T, Hall-Flavin D, Fredlender C, Heard KJ, Deng Y, Le AT, Dave S, Fung L, Li X, Marchetto MC, Weinshilboum R, Gage FH. Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons. Nature Neuroscience, 2019 January 30;

Schafer ST, Paquola ACM, Stern S, Gosselin D, Ku M, Pena M, Kuret TJM, Liyanage M, Mansour AAF, Jaeger BN, Marchetto MC, Glass CK, Mertens J, Gage FH. Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons. Nature Neuroscience, 2019 January 07;

Kim Y, Zheng X, Ansari Z, Bunnell MC, Herdy JR, Traxler L, Lee H, Paquola ACM, Blithikioti C, Ku M, Schlachetzki JCM, Winkler J, Edenhofer F, Glass CK, Paucar AA, Jaeger BN, Pham S, Boyer L, Campbell BC, Hunter T, Mertens J, Gage FH. Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile. Cell Reports, 2018 May 29; doi:10.1016/j.celrep.2018.04.105

Sarkar A, Mei A, Paquola ACM, Stern S, Bardy C, Klug JR, Kim S, Neshat N, Kim HJ, Ku M, Shokhirev MN, Adamowicz DH, Marchetto MC, Jappelli R, Erwin JA, Padmanabhan K, Shtrahman M, Jin X, Gage FH. Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro. Cell Stem Cell, 2018 May 3; doi:10.1016/j.stem.2018.04.009

Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage FH. An in vivo model of functional and vascularized human brain organoids. Nature Biotechnology, 2018 Apr 16; doi:10.1038/nbt.4127

Bedrosian TA, Quayle C, Novaresi N, Gage FH. Early life experience drives structural variation of neural genomes in mice. Science, 2018 Mar 23; doi:10.1126/science.aah3378

Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer MW, Gage FH. Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells. Cell Stem Cell, 2017 Nov 2; doi:10.1016/j.stem.2017.08.012

Santos R, Vadodaria KC, Jaeger BN, Mei A, Lefcochilos-Fogelquist S, Mendes APD, Erikson G, Shokhirev M, Randolph-Moore L, Fredlender C, Dave S, Oefner R, Fitzpatrick C, Pena M, Barron JJ, Ku M, Denli AM, Kerman BE, Charnay P, Kelsoe JR, Marchetto MC and Gage FH. Differentiation of Inflammation-responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells Stem Cell Reports, 2017 Jun 17; doi:10.1016/j.stemcr.2017.05.011

Gosselin G, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O’Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DG, Levy ML, Ransohoff RM, Gage FH, Glass CK. An environment-dependent transcriptional network specifies human microglia identity Science, 2017 May 25; doi: 10.1126/science.aal3222

S Stern, R Santos, M C Marchetto, A P D Mendes, G A Rouleau, S Biesmans, Q-W Wang, J Yao, P Charnay, A G Bang, M Alda and F H Gage. Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients’ responsiveness to lithium Molecular Psychiatry, (28 February 2017) | doi:10.1038/mp.2016.260.

Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR and Gage FH. L1-associated genomic regions are deleted in somatic cells of the healthy human brain Nature Neuroscience, 2016 Sep 12; doi:10.1038/nn.4388

Chailangkarn T, Trujillo CA, Freitas BC, Hrvoj-Mihic B, Herai RH, Yu DX, Brown TT, Marchetto MC, Bardy C, McHenry L, Stefanacci L, Järvinen A, Searcy YM, DeWitt M, Wong W, Lai P, Ard MC, Hanson KL, Romero S, Jacobs B, Dale AM, Dai L, Korenberg JR, Gage FH, Bellugi U, Halgren E, Semendeferi K & Muotri AR. A human neurodevelopmental model for Williams syndrome Nature, 2016 Aug 10; doi:10.1038/nature19067

Zheng X, Boyer L, Jin M, Mertens J, Kim Y, Ma L, Ma L, Hamm M, Gage F, Hunter T Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation eLife, 2016 Jun 10; doi: 10.7554/eLife.13374

Schafer ST, Han J, Pena M, von Bohlen Und Halbach O, Peters J, Gage FH. The Wnt Adaptor Protein Atp6ap2 Regulates Multiple Stages of Adult Hippocampal Neurogenesis. J Neurosci. 2015 Mar 25; 35(12):4983-98. doi: 10.1523/JNEUROSCI.4130-14.2015. PubMed PMID: 25810528.

Pei L, Mu Y, Leblanc M, Alaynick W, Barish GD, Pankratz M, Tseng TW, Kaufman S, Liddle C, Yu RT, Downes M, Pfaff SL, Auwerx J, Gage FH, Evans RM. Dependence of Hippocampal Function on Errgamma-Regulated Mitochondrial Metabolism. Cell Metab. 2015 Apr 7; 21(4):628-36. doi: 10.1016/j.cmet.2015.03.004. PubMed PMID: 25863252.

Deng W, Gage FH. The Effect of Immature Adult-Born Dentate Granule Cells on Hyponeophagial Behavior Is Related to Their Roles in Learning and Memory. Front Syst Neurosci. 2015 Mar 6; 9:34. doi: 10.3389/fnsys.2015.00034. eCollection 2015. PubMed PMID: 25798094.

Bardy C, van den Hurk M, Eames T, Marchand C, Hernandez RV, Kellogg M, Gorris M, Galet B, Palomares V, Brown J, Bang AG, Mertens J, Bohnke L, Boyer L, Simon S, Gage FH. Neuronal Medium That Supports Basic Synaptic Functions and Activity of Human Neurons in Vitro. Proc Natl Acad Sci U S A. 2015 Apr 13; pii: 201504393. [Epub ahead of print] PubMed PMID: 25870293.

Amador-Arjona A, Cimadamore F, Huang CT, Wright R, Lewis S, Gage FH, Terskikh AV. Sox2 Primes the Epigenetic Landscape in Neural Precursors Enabling Proper Gene Activation During Hippocampal Neurogenesis. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):E1936-45. doi: 10.1073/pnas.1421480112. Epub 2015 Mar 30. PubMed PMID: 25825708.

Adamowicz, DH, Mertens J, Gage FH. Alzheimer's Disease: Distinct Stages in Neurogenic Decline? Biol Psychiatry 2015 Apr 15;77(8):680-2. doi: 10.1016/j.biopsych.2015.02.021. PubMed PMID: 25835286.

Clemenson GD, Lee SW, Deng W, Barrera VR, Iwamoto KS, Fanselow MS, Gage FH. Enrichment Rescues Contextual Discrimination Deficit Associated with Immediate Shock. Hippocampus 2015 Mar;25(3):385-92. doi: 10.1002/hipo.22380. Epub 2014 Oct 31. PubMed PMID: 25330953.


BS, University of Florida
MS & PhD, The Johns Hopkins University

Awards & Honors

  • 2015 Paul G. Allen Family Foundation's Allen Distinguished Investigator Award
  • 2013 Fellow, National Academy of Inventors
  • 2013 George A. Miller Prize in Cognitive Neuroscience
  • 2011 Fyssen Foundation International Prize
  • 2011 Cáterda Santiago Grisolia Award
  • 2011-12 President of the International Society for Stem Cell Research
  • 2010 Member, American Philosophical Society
  • 2008 Keio Medical Science Prize Award, shared with Shimon Sakaguchi
  • 2005 Fellow of the American Academy of Arts and Sciences
  • 2003 Fellow of the National Academy of Sciences
  • 2003 Klaus Joachim Zulch-Preis through the Max Planck Society
  • 2002 MetLife Award for Medical Research
  • 2001 National Academy of Medicine
  • 2001 President, Society for Neuroscience
  • 1999 Max Planck Research Prize
  • 1997 Christopher Reeve Research Medal
  • 1993 Achievements in Health and Education
  • 1993 Charles A. Dana Award for Pioneering Achievements in Health and Education
  • 1990 IPSEN Prize in Neuronal Plasticity