Nicola Allen

Associate Professor

Molecular Neurobiology Laboratory

Hearst Foundation Development Chair

Salk Institute for Biological Studies - Publications

all Publications


Allen, N.J. Star Power: Astrocytes Regulate Behavior. (2019) Cell. 177(5):1091-1093. DOI: 10.1016/j.cell.2019.04.042

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Amor, D.J., Stephenson, S.E.M., Mustapha, M., Mensah, M.A., Ockeloen, C.W., Lee, W.S., Tankard, R.M., Phelan, D.G., Shinawi, M., de Brouwer, A.P.M., Pfundt, R., Dowling, C., Toler, T.L., Sutton, V.R., Agolini, E., Rinelli, M., Capolino, R., Martinelli, D., Zampino, G., Dumić, M., Reardon, W., Shaw-Smith, C., Leventer, R.J., Delatycki, M.B., Kleefstra, T., Mundlos, S., Mortier, G., Bahlo, M., Allen, N.J., Lockhart, P.J. Pathogenic Variants in GPC4 Cause Keipert Syndrome. (2019) American Journal of Human Genetics. DOI: 10.1016/j.ajhg.2019.02.026

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Dowling, C., Allen, N.J. Mice Lacking Glypican 4 Display Juvenile Hyperactivity and Adult Social Interaction Deficits. (2018) Brain Plasticity. 4(2):197-209. DOI: 10.3233/BPL-180079

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Allen, N.J., Lyons, D.A. Glia as architects of central nervous system formation and function. (2018) Science. 362(6411):181-185. DOI: 10.1126/science.aat0473

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Blanco-Suarez, E., Liu, T.F., Kopelevich, A., Allen, N.J. Astrocyte-Secreted Chordin-like 1 Drives Synapse Maturation and Limits Plasticity by Increasing Synaptic GluA2 AMPA Receptors. (2018) Neuron. DOI: 10.1016/j.neuron.2018.09.043

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Farhy-Tselnicker, I., Allen, N.J. Astrocytes, neurons, synapses: a tripartite view on cortical circuit development. (2018) Neural Dev. 13(1):7. DOI: 10.1186/s13064-018-0104-y

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Boisvert, M.M., Erikson, G.A., Shokhirev, M.N., Allen, N.J. The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain. (2018) Cell Reports. 22(1):269-285. DOI: 10.1016/j.celrep.2017.12.039

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Allen, N.J., Daneman, R. In Memoriam: Ben Barres. (2018) Journal of Cell Biology. DOI: 10.1083/jcb.201801019

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Zuidema, J.M., Kumeria, T., Kim, D., Kang, J., Wang, J., Hollett, G., Zhang, X., Roberts, D.S., Chan, N., Dowling, C., Blanco-Suarez, E., Allen, N.J., Tuszynski, M.H., Sailor, M.J. Oriented Nanofibrous Polymer Scaffolds Containing Protein-Loaded Porous Silicon Generated by Spray Nebulization. (2018) Adv. Mater. Weinheim. DOI: 10.1002/adma.201706785

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Allen, N.J., Eroglu, C. Cell Biology of Astrocyte-Synapse Interactions. (2017) Neuron. 96(3):697-708. DOI: 10.1016/j.neuron.2017.09.056

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Farhy-Tselnicker, I., van Casteren, A.C.M., Lee, A., Chang, V.T., Aricescu, A.R., Allen, N.J. Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation. (2017) Neuron. 96(2):428-445.e13. DOI: 10.1016/j.neuron.2017.09.053

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Bosworth, A.P., Allen, N.J. The diverse actions of astrocytes during synaptic development. (2017) Current Opinion in Neurobiology. 47:38-43. DOI: 10.1016/j.conb.2017.08.017

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Allen, N.J. Making Human Stars: A New Method to Generate Human Astrocytes. (2017) Neuron. 95(4):725-727. DOI: 10.1016/j.neuron.2017.08.006

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Dwyer, C.A., Scudder, S.L., Lin, Y., Dozier, L.E., Phan, D., Allen, N.J., Patrick, G.N., Esko, J.D. Neurodevelopmental Changes in Excitatory Synaptic Structure and Function in the Cerebral Cortex of Sanfilippo Syndrome IIIA Mice. (2017) Scientific Reports. 7:46576. DOI: 10.1038/srep46576

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Blanco-Suárez, E., Caldwell, A.L., Allen, N.J. Role of astrocyte-synapse interactions in CNS disorders. (2017) Journal of Physiology. 595(6):1903-1916. DOI: 10.1113/JP270988

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Chung, W.S., Allen, N.J., Eroglu, C. Astrocytes Control Synapse Formation, Function, and Elimination. (2015) Cold Spring Harbor Perspectives in Biology. 7(9):a020370. DOI: 10.1101/cshperspect.a020370

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Farhy Tselnicker, I., Boisvert, M.M., Allen, N.J. The role of neuronal versus astrocyte-derived heparan sulfate proteoglycans in brain development and injury. (2014) Biochem. Soc. Trans. 42(5):1263-9. DOI: 10.1042/BST20140166

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Allen, N.J. Synaptic plasticity: Astrocytes wrap it up. (2014) Current Biology. 24(15):R697-9. DOI: 10.1016/j.cub.2014.06.030

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Allen, N.J. Astrocyte regulation of synaptic behavior. (2014) Annual Review of Cell and Developmental Biology. 30:439-63. DOI: 10.1146/annurev-cellbio-100913-013053

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Allen, N.J. Role of glia in developmental synapse formation. (2013) Current Opinion in Neurobiology. 23(6):1027-33. DOI: 10.1016/j.conb.2013.06.004

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Allen, N.J., Bennett, M.L., Foo, L.C., Wang, G.X., Chakraborty, C., Smith, S.J., Barres, B.A. Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors. (2012) Nature. 486(7403):410-4. DOI: 10.1038/nature11059

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Foo, L.C., Allen, N.J., Bushong, E.A., Ventura, P.B., Chung, W.S., Zhou, L., Cahoy, J.D., Daneman, R., Zong, H., Ellisman, M.H., Barres, B.A. Development of a method for the purification and culture of rodent astrocytes. (2011) Neuron. 71(5):799-811. DOI: 10.1016/j.neuron.2011.07.022

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Kucukdereli, H., Allen, N.J., Lee, A.T., Feng, A., Ozlu, M.I., Conatser, L.M., Chakraborty, C., Workman, G., Weaver, M., Sage, E.H., Barres, B.A., Eroglu, C. Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. (2011) Proceedings of the National Academy of Sciences of the United States of America. 108(32):E440-9. DOI: 10.1073/pnas.1104977108

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Eroglu, C., Allen, N.J., Susman, M.W., O'Rourke, N.A., Park, C.Y., Ozkan, E., Chakraborty, C., Mulinyawe, S.B., Annis, D.S., Huberman, A.D., Green, E.M., Lawler, J., Dolmetsch, R., Garcia, K.C., Smith, S.J., Luo, Z.D., Rosenthal, A., Mosher, D.F., Barres, B.A. Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. (2009) Cell. 139(2):380-92. DOI: 10.1016/j.cell.2009.09.025

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Allen, N.J., Barres, B.A. Neuroscience: Glia - more than just brain glue. (2009) Nature. 457(7230):675-7. DOI: 10.1038/457675a


De Simoni, A., Allen, N.J., Attwell, D. Charge compensation for NADPH oxidase activity in microglia in rat brain slices does not involve a proton current. (2008) European Journal of Neuroscience. 28(6):1146-56. DOI: 10.1111/j.1460-9568.2008.06417.x

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Stevens, B., Allen, N.J., Vazquez, L.E., Howell, G.R., Christopherson, K.S., Nouri, N., Micheva, K.D., Mehalow, A.K., Huberman, A.D., Stafford, B., Sher, A., Litke, A.M., Lambris, J.D., Smith, S.J., John, S.W., Barres, B.A. The classical complement cascade mediates CNS synapse elimination. (2007) Cell. 131(6):1164-78. DOI: 10.1016/j.cell.2007.10.036

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Allen, N.J., Barres, B.A. Signaling between glia and neurons: focus on synaptic plasticity. (2005) Current Opinion in Neurobiology. 15(5):542-8. DOI: 10.1016/j.conb.2005.08.006

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Allen, N.J., Káradóttir, R., Attwell, D. A preferential role for glycolysis in preventing the anoxic depolarization of rat hippocampal area CA1 pyramidal cells. (2005) Journal of Neuroscience. 25(4):848-59. DOI: 10.1523/JNEUROSCI.4157-04.2005

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Allen, N.J., Attwell, D. The effect of simulated ischaemia on spontaneous GABA release in area CA1 of the juvenile rat hippocampus. (2004) Journal of Physiology. 561(Pt 2):485-98. DOI: 10.1113/jphysiol.2004.070490

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Allen, N.J., Káradóttir, R., Attwell, D. Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy. (2004) Pflugers Arch. 449(2):132-42. DOI: 10.1007/s00424-004-1318-x

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Allen, N.J., Rossi, D.J., Attwell, D. Sequential release of GABA by exocytosis and reversed uptake leads to neuronal swelling in simulated ischemia of hippocampal slices. (2004) Journal of Neuroscience. 24(15):3837-49. DOI: 10.1523/JNEUROSCI.5539-03.2004

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Allen, N.J., Attwell, D. Modulation of ASIC channels in rat cerebellar Purkinje neurons by ischaemia-related signals. (2002) Journal of Physiology. 543(Pt 2):521-9. DOI: 10.1113/jphysiol.2002.020297

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Education

BSc, Anatomical Sciences, University of Manchester, England
PhD, Neuroscience, University College London, England


Awards & Honors

  • 2018 Ben Barres Early Career Acceleration Award from the Chan Zuckerberg Initiative (CZI)
  • 2015 Pew Scholar
  • 2005-2008 Human Frontier Science Program (HFSP) Long Term Fellowship
  • 2004-2005 European Molecular Biology Organisation (EMBO) Long Term Fellowship
  • 1999-2003 Wellcome Trust PhD Fellowship