Martyn Goulding

Professor

Molecular Neurobiology Laboratory

Frederick W. and Joanna J. Mitchell Chair

Salk Institute for Biological Studies - Publications

all Publications


Paixão, S., Loschek, L., Gaitanos, L., Alcalà Morales, P., Goulding, M., Klein, R. Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements. (2019) Neuron. 104(4):749-764. DOI: 10.1016/j.neuron.2019.08.029

+ expand abstract


Acton, D., Ren, X., Di Costanzo, S., Dalet, A., Bourane, S., Bertocchi, I., Eva, C., Goulding, M. Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch. (2019) Cell Reports. 28(3):625-639.e6. DOI: 10.1016/j.celrep.2019.06.033

+ expand abstract


Gatto, G., Smith, K.M., Ross, S.E., Goulding, M. Neuronal diversity in the somatosensory system: bridging the gap between cell type and function. (2019) Current Opinion in Neurobiology. 56:167-174. DOI: 10.1016/j.conb.2019.03.002

+ expand abstract


Huang, T., Lin, S.H., Malewicz, N.M., Zhang, Y., Zhang, Y., Goulding, M., LaMotte, R.H., Ma, Q. Identifying the pathways required for coping behaviours associated with sustained pain. (2018) Nature. DOI: 10.1038/s41586-018-0793-8

+ expand abstract


Zhang, Y., Liu, S., Zhang, Y.Q., Goulding, M., Wang, Y.Q., Ma, Q. Timing Mechanisms Underlying Gate Control by Feedforward Inhibition. (2018) Neuron. DOI: 10.1016/j.neuron.2018.07.026

+ expand abstract


Ueno, M., Nakamura, Y., Li, J., Gu, Z., Niehaus, J., Maezawa, M., Crone, S.A., Goulding, M., Baccei, M.L., Yoshida, Y. Corticospinal Circuits from the Sensory and Motor Cortices Differentially Regulate Skilled Movements through Distinct Spinal Interneurons. (2018) Cell Reports. 23(5):1286-1300.e7. DOI: 10.1016/j.celrep.2018.03.137

+ expand abstract


Gatto, G., Goulding, M. Locomotion Control: Brainstem Circuits Satisfy the Need for Speed. (2018) Current Biology. 28(6):R256-R259. DOI: 10.1016/j.cub.2018.01.068

+ expand abstract


Koch, S.C., Del Barrio, M.G., Dalet, A., Gatto, G., Günther, T., Zhang, J., Seidler, B., Saur, D., Schüle, R., Goulding, M. RORβ Spinal Interneurons Gate Sensory Transmission during Locomotion to Secure a Fluid Walking Gait. (2017) Neuron. DOI: 10.1016/j.neuron.2017.11.011

+ expand abstract


Wu, J., Capelli, P., Bouvier, J., Goulding, M., Arber, S., Fortin, G. A V0 core neuronal circuit for inspiration. (2017) Nature Communications. 8(1):544. DOI: 10.1038/s41467-017-00589-2

+ expand abstract


Koch, S.C., Acton, D., Goulding, M. Spinal Circuits for Touch, Pain, and Itch. (2017) Annual Review of Physiology. DOI: 10.1146/annurev-physiol-022516-034303

+ expand abstract


Cheng, L., Duan, B., Huang, T., Zhang, Y., Chen, Y., Britz, O., Garcia-Campmany, L., Ren, X., Vong, L., Lowell, B.B., Goulding, M., Wang, Y., Ma, Q. Identification of spinal circuits involved in touch-evoked dynamic mechanical pain. (2017) Nature Neuroscience. 20(6):804-814. DOI: 10.1038/nn.4549

+ expand abstract


Flynn, J.R., Conn, V.L., Boyle, K.A., Hughes, D.I., Watanabe, M., Velasquez, T., Goulding, M.D., Callister, R.J., Graham, B.A. Anatomical and Molecular Properties of Long Descending Propriospinal Neurons in Mice. (2017) Frontiers in Neuroanatomy. 11:5. DOI: 10.3389/fnana.2017.00005

+ expand abstract


Sternfeld, M.J., Hinckley, C.A., Moore, N.J., Pankratz, M.T., Hilde, K.L., Driscoll, S.P., Hayashi, M., Amin, N.D., Bonanomi, D., Gifford, W.D., Sharma, K., Goulding, M., Pfaff, S.L. Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells. (2017) Elife. 6. DOI: 10.7554/eLife.21540

+ expand abstract


Tuncdemir, S.N., Wamsley, B., Stam, F.J., Osakada, F., Goulding, M., Callaway, E.M., Rudy, B., Fishell, G. Early Somatostatin Interneuron Connectivity Mediates the Maturation of Deep Layer Cortical Circuits. (2016) Neuron. 89(3):521-35. DOI: 10.1016/j.neuron.2015.11.020

+ expand abstract


Bourane, S., Duan, B., Koch, S.C., Dalet, A., Britz, O., Garcia-Campmany, L., Kim, E., Cheng, L., Ghosh, A., Ma, Q., Goulding, M. Gate control of mechanical itch by a subpopulation of spinal cord interneurons. (2015) Science. 350(6260):550-4. DOI: 10.1126/science.aac8653

+ expand abstract


Britz, O., Zhang, J., Grossmann, K.S., Dyck, J., Kim, J.C., Dymecki, S., Gosgnach, S., Goulding, M. A genetically defined asymmetry underlies the inhibitory control of flexor-extensor locomotor movements. (2015) Elife. 4. DOI: 10.7554/eLife.04718

+ expand abstract


Bourane, S., Grossmann, K.S., Britz, O., Dalet, A., Del Barrio, M.G., Stam, F.J., Garcia-Campmany, L., Koch, S., Goulding, M. Identification of a spinal circuit for light touch and fine motor control. (2015) Cell. 160(3):503-15. DOI: 10.1016/j.cell.2015.01.011

+ expand abstract


Duan, B., Cheng, L., Bourane, S., Britz, O., Padilla, C., Garcia-Campmany, L., Krashes, M., Knowlton, W., Velasquez, T., Ren, X., Ross, S., Lowell, B.B., Wang, Y., Goulding, M., Ma, Q. Identification of spinal circuits transmitting and gating mechanical pain. (2014) Cell. 159(6):1417-1432. DOI: 10.1016/j.cell.2014.11.003

+ expand abstract


Carcagno, A.L., Di Bella, D.J., Goulding, M., Guillemot, F., Lanuza, G.M. Neurogenin3 restricts serotonergic neuron differentiation to the hindbrain. (2014) Journal of Neuroscience. 34(46):15223-33. DOI: 10.1523/JNEUROSCI.3403-14.2014

+ expand abstract


Hatori, M., Gill, S., Mure, L.S., Goulding, M., O'Leary, D.D., Panda, S. Lhx1 maintains synchrony among circadian oscillator neurons of the SCN. (2014) Elife. 3:e03357. DOI: 10.7554/eLife.03357

+ expand abstract


Goulding, M., Bourane, S., Garcia-Campmany, L., Dalet, A., Koch, S. Inhibition downunder: an update from the spinal cord. (2014) Current Opinion in Neurobiology. 26:161-6. DOI: 10.1016/j.conb.2014.03.006

+ expand abstract


Zhang, J., Lanuza, G.M., Britz, O., Wang, Z., Siembab, V.C., Zhang, Y., Velasquez, T., Alvarez, F.J., Frank, E., Goulding, M. V1 and v2b interneurons secure the alternating flexor-extensor motor activity mice require for limbed locomotion. (2014) Neuron. 82(1):138-50. DOI: 10.1016/j.neuron.2014.02.013

+ expand abstract


Borowska, J., Jones, C.T., Zhang, H., Blacklaws, J., Goulding, M., Zhang, Y. Functional subpopulations of V3 interneurons in the mature mouse spinal cord. (2013) Journal of Neuroscience. 33(47):18553-65. DOI: 10.1523/JNEUROSCI.2005-13.2013

+ expand abstract


Del Barrio, M.G., Bourane, S., Grossmann, K., Schüle, R., Britsch, S., O'Leary, D.D., Goulding, M. A transcription factor code defines nine sensory interneuron subtypes in the mechanosensory area of the spinal cord. (2013) PLOS One. 8(11):e77928. DOI: 10.1371/journal.pone.0077928

+ expand abstract


Francius, C., Harris, A., Rucchin, V., Hendricks, T.J., Stam, F.J., Barber, M., Kurek, D., Grosveld, F.G., Pierani, A., Goulding, M., Clotman, F. Identification of multiple subsets of ventral interneurons and differential distribution along the rostrocaudal axis of the developing spinal cord. (2013) PLOS One. 8(8):e70325. DOI: 10.1371/journal.pone.0070325

+ expand abstract


Li, Y., Stam, F.J., Aimone, J.B., Goulding, M., Callaway, E.M., Gage, F.H. Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus. (2013) Proceedings of the National Academy of Sciences of the United States of America. 110(22):9106-11. DOI: 10.1073/pnas.1306912110

+ expand abstract


Goulding, M. Motor neurons that multitask. (2012) Neuron. 76(4):669-70. DOI: 10.1016/j.neuron.2012.11.011

+ expand abstract


Stam, F.J., Hendricks, T.J., Zhang, J., Geiman, E.J., Francius, C., Labosky, P.A., Clotman, F., Goulding, M. Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program. (2012) Development. 139(1):179-90. DOI: 10.1242/dev.071134

+ expand abstract


Ikrar, T., Shi, Y., Velasquez, T., Goulding, M., Xu, X. Cell-type specific regulation of cortical excitability through the allatostatin receptor system. (2012) Front Neural Circuits. 6:2. DOI: 10.3389/fncir.2012.00002

+ expand abstract


Grossmann, K.S., Giraudin, A., Britz, O., Zhang, J., Goulding, M. Genetic dissection of rhythmic motor networks in mice. (2010) Progress in Brain Research. 187:19-37. DOI: 10.1016/B978-0-444-53613-6.00002-2

+ expand abstract


Garcia-Campmany, L., Stam, F.J., Goulding, M. From circuits to behaviour: motor networks in vertebrates. (2010) Current Opinion in Neurobiology. 20(1):116-25. DOI: 10.1016/j.conb.2010.01.002

+ expand abstract


Lin, W., Metzakopian, E., Mavromatakis, Y.E., Gao, N., Balaskas, N., Sasaki, H., Briscoe, J., Whitsett, J.A., Goulding, M., Kaestner, K.H., Ang, S.L. Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development. (2009) Developmental Biology. 333(2):386-96. DOI: 10.1016/j.ydbio.2009.07.006

+ expand abstract


Goulding, M. Circuits controlling vertebrate locomotion: moving in a new direction. (2009) Nature Reviews. Neuroscience. 10(7):507-18. DOI: 10.1038/nrn2608

+ expand abstract


Zhang, Y., Narayan, S., Geiman, E., Lanuza, G.M., Velasquez, T., Shanks, B., Akay, T., Dyck, J., Pearson, K., Gosgnach, S., Fan, C.M., Goulding, M. V3 spinal neurons establish a robust and balanced locomotor rhythm during walking. (2008) Neuron. 60(1):84-96. DOI: 10.1016/j.neuron.2008.09.027

+ expand abstract


Pagliardini, S., Ren, J., Gray, P.A., Vandunk, C., Gross, M., Goulding, M., Greer, J.J. Central respiratory rhythmogenesis is abnormal in lbx1- deficient mice. (2008) Journal of Neuroscience. 28(43):11030-41. DOI: 10.1523/JNEUROSCI.1648-08.2008

+ expand abstract


Wang, Z., Li, L., Goulding, M., Frank, E. Early postnatal development of reciprocal Ia inhibition in the murine spinal cord. (2008) Journal of Neurophysiology. 100(1):185-96. DOI: 10.1152/jn.90354.2008

+ expand abstract


Xu, Y., Lopes, C., Qian, Y., Liu, Y., Cheng, L., Goulding, M., Turner, E.E., Lima, D., Ma, Q. Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons. (2008) Journal of Neuroscience. 28(15):4037-46. DOI: 10.1523/JNEUROSCI.4126-07.2008

+ expand abstract


Pillai, A., Mansouri, A., Behringer, R., Westphal, H., Goulding, M. Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord. (2007) Development. 134(2):357-66. DOI: 10.1242/dev.02717

+ expand abstract


Tan, E.M., Yamaguchi, Y., Horwitz, G.D., Gosgnach, S., Lein, E.S., Goulding, M., Albright, T.D., Callaway, E.M. Selective and quickly reversible inactivation of mammalian neurons in vivo using the Drosophila allatostatin receptor. (2006) Neuron. 51(2):157-70. DOI: 10.1016/j.neuron.2006.06.018

+ expand abstract


Mizuguchi, R., Kriks, S., Cordes, R., Gossler, A., Ma, Q., Goulding, M. Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons. (2006) Nature Neuroscience. 9(6):770-8. DOI: 10.1038/nn1706

+ expand abstract


Gosgnach, S., Lanuza, G.M., Butt, S.J., Saueressig, H., Zhang, Y., Velasquez, T., Riethmacher, D., Callaway, E.M., Kiehn, O., Goulding, M. V1 spinal neurons regulate the speed of vertebrate locomotor outputs. (2006) Nature. 440(7081):215-9. DOI: 10.1038/nature04545

+ expand abstract


Nakahira, E., Kagawa, T., Shimizu, T., Goulding, M.D., Ikenaka, K. Direct evidence that ventral forebrain cells migrate to the cortex and contribute to the generation of cortical myelinating oligodendrocytes. (2006) Developmental Biology. 291(1):123-31. DOI: 10.1016/j.ydbio.2005.12.010

+ expand abstract


Quina, L.A., Pak, W., Lanier, J., Banwait, P., Gratwick, K., Liu, Y., Velasquez, T., O'Leary, D.D., Goulding, M., Turner, E.E. Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways. (2005) Journal of Neuroscience. 25(50):11595-604. DOI: 10.1523/JNEUROSCI.2837-05.2005

+ expand abstract


Alvarez, F.J., Jonas, P.C., Sapir, T., Hartley, R., Berrocal, M.C., Geiman, E.J., Todd, A.J., Goulding, M. Postnatal phenotype and localization of spinal cord V1 derived interneurons. (2005) Journal of Comparative Neurology. 493(2):177-92. DOI: 10.1002/cne.20711

+ expand abstract


Cheng, L., Samad, O.A., Xu, Y., Mizuguchi, R., Luo, P., Shirasawa, S., Goulding, M., Ma, Q. Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. (2005) Nature Neuroscience. 8(11):1510-5. DOI: 10.1038/nn1569

+ expand abstract


Kriks, S., Lanuza, G.M., Mizuguchi, R., Nakafuku, M., Goulding, M. Gsh2 is required for the repression of Ngn1 and specification of dorsal interneuron fate in the spinal cord. (2005) Development. 132(13):2991-3002. DOI: 10.1242/dev.01878

+ expand abstract


Goulding, M., Pfaff, S.L. Development of circuits that generate simple rhythmic behaviors in vertebrates. (2005) Current Opinion in Neurobiology. 15(1):14-20. DOI: 10.1016/j.conb.2005.01.017

+ expand abstract


Goulding, M. How early is firing required for wiring? (2004) Neuron. 43(5):601-3. DOI: 10.1016/j.neuron.2004.08.027

+ expand abstract


Goulding, M. Neurobiology: a matter of balance. (2004) Nature. 429(6991):515-7. DOI: 10.1038/429515a


Lanuza, G.M., Gosgnach, S., Pierani, A., Jessell, T.M., Goulding, M. Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movements. (2004) Neuron. 42(3):375-86.

+ expand abstract


Cheng, L., Arata, A., Mizuguchi, R., Qian, Y., Karunaratne, A., Gray, P.A., Arata, S., Shirasawa, S., Bouchard, M., Luo, P., Chen, C.L., Busslinger, M., Goulding, M., Onimaru, H., Ma, Q. Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates. (2004) Nature Neuroscience. 7(5):510-7. DOI: 10.1038/nn1221

+ expand abstract


Sapir, T., Geiman, E.J., Wang, Z., Velasquez, T., Mitsui, S., Yoshihara, Y., Frank, E., Alvarez, F.J., Goulding, M. Pax6 and engrailed 1 regulate two distinct aspects of renshaw cell development. (2004) Journal of Neuroscience. 24(5):1255-64. DOI: 10.1523/JNEUROSCI.3187-03.2004

+ expand abstract


Goulding, M., Lanuza, G., Sapir, T., Narayan, S. The formation of sensorimotor circuits. (2002) Current Opinion in Neurobiology. 12(5):508-15.

+ expand abstract


Gross, M.K., Dottori, M., Goulding, M. Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord. (2002) Neuron. 34(4):535-49.

+ expand abstract


Dottori, M., Gross, M.K., Labosky, P., Goulding, M. The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate. (2001) Development. 128(21):4127-38.

+ expand abstract


Nicholson, L.F., Ma, L., Goulding, M. Cloning and expression of Munc 30: a member of the paired -like homeodomain gene family. (2001) Cell Biology International. 25(4):351-65. DOI: 10.1006/cbir.2000.0638

+ expand abstract


Lamar, E., Kintner, C., Goulding, M. Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation. (2001) Development. 128(8):1335-46.

+ expand abstract


Goulding, M., Lamar, E. Neuronal patterning: Making stripes in the spinal cord. (2000) Current Biology. 10(15):R565-8.


Mah, S.P., Saueressig, H., Goulding, M., Kintner, C., Dressler, G.R. Kidney development in cadherin-6 mutants: delayed mesenchyme-to-epithelial conversion and loss of nephrons. (2000) Developmental Biology. 223(1):38-53. DOI: 10.1006/dbio.2000.9738

+ expand abstract


Gross, M.K., Moran-Rivard, L., Velasquez, T., Nakatsu, M.N., Jagla, K., Goulding, M. Lbx1 is required for muscle precursor migration along a lateral pathway into the limb. (2000) Development. 127(2):413-24.

+ expand abstract


Saueressig, H., Burrill, J., Goulding, M. Engrailed-1 and netrin-1 regulate axon pathfinding by association interneurons that project to motor neurons. (1999) Development. 126(19):4201-12.

+ expand abstract


Bang, A.G., Papalopulu, N., Goulding, M.D., Kintner, C. Expression of Pax-3 in the lateral neural plate is dependent on a Wnt-mediated signal from posterior nonaxial mesoderm. (1999) Developmental Biology. 212(2):366-80. DOI: 10.1006/dbio.1999.9319

+ expand abstract


Goulding, M. Specifying motor neurons and their connections. (1998) Neuron. 21(5):943-6.


Burrill, J.D., Moran, L., Goulding, M.D., Saueressig, H. PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development. (1997) Development. 124(22):4493-503.

+ expand abstract


Bang, A.G., Papalopulu, N., Kintner, C., Goulding, M.D. Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm. (1997) Development. 124(10):2075-85.

+ expand abstract


Maroto, M., Reshef, R., Münsterberg, A.E., Koester, S., Goulding, M., Lassar, A.B. Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissue. (1997) Cell. 89(1):139-48.

+ expand abstract


Daston, G., Lamar, E., Olivier, M., Goulding, M. Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse. (1996) Development. 122(3):1017-27.

+ expand abstract


Bang, A.G., Goulding, M.D. Regulation of vertebrate neural cell fate by transcription factors. (1996) Current Opinion in Neurobiology. 6(1):25-32.

+ expand abstract


Kilpatrick, T.J., Brown, A., Lai, C., Gassmann, M., Goulding, M., Lemke, G. Expression of the Tyro4/Mek4/Cek4 gene specifically marks a subset of embryonic motor neurons and their muscle targets. (1996) Molecular and Cellular Neurosciences. 7(1):62-74. DOI: 10.1006/mcne.1996.0005

+ expand abstract


Goulding, M., Lumsden, A., Paquette, A.J. Regulation of Pax-3 expression in the dermomyotome and its role in muscle development. (1994) Development. 120(4):957-71.

+ expand abstract


Goulding, M., Paquette, A. Pax genes and neural tube defects in the mouse. (1994) Ciba Found. Symp. 181:103-13; discussion 113-7.

+ expand abstract


Goulding, M., Sterrer, S., Fleming, J., Balling, R., Nadeau, J., Moore, K.J., Brown, S.D., Steel, K.P., Gruss, P. Analysis of the Pax-3 gene in the mouse mutant splotch. (1993) Genomics. 17(2):355-63. DOI: 10.1006/geno.1993.1332

+ expand abstract


Goulding, M.D., Lumsden, A., Gruss, P. Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord. (1993) Development. 117(3):1001-16.

+ expand abstract


Walther, C., Guenet, J.L., Simon, D., Deutsch, U., Jostes, B., Goulding, M.D., Plachov, D., Balling, R., Gruss, P. Pax: a murine multigene family of paired box-containing genes. (1991) Genomics. 11(2):424-34.

+ expand abstract


Goulding, M.D., Chalepakis, G., Deutsch, U., Erselius, J.R., Gruss, P. Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. (1991) EMBO Journal. 10(5):1135-47.

+ expand abstract


Erselius, J.R., Goulding, M.D., Gruss, P. Structure and expression pattern of the murine Hox-3.2 gene. (1990) Development. 110(2):629-42.

+ expand abstract


Goulding, M.D., Gruss, P. The homeobox in vertebrate development. (1989) Current Opinion in Cell Biology. 1(6):1088-93.


Goulding, M.D., Ralph, R.K. Cyclic-AMP-induced c-fos expression and its relevance to differentiation of a transformed mast cell line. (1989) Biochimica et Biophysica Acta. 1007(1):99-108.

+ expand abstract


Education

Cell biology, University of Auckland, New Zealand
PhD, Cellular and Molecular Biology, University of Auckland
Postdoctoral Fellow, Max Planck Institute for Biophysical Chemistry


Awards & Honors

  • 2006 Jacob Javits Neuroscience Investigator Award
  • 1994-1998 Pew Scholar
  • 1993-1995 Basil O'Connor Research Award