Janelle Ayres

Associate Professor

NOMIS Center for Immunobiology and Microbial Pathogenesis

Helen McLoraine Developmental Chair

Janelle S. Ayres
Salk Institute for Biological Studies - Publications


S. Rao, A. M. Palaferri Schieber, C. P. O’Connor, M. Leblanc, D. Michel, J. S. Ayres. Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and Transmission Cell (2017) Jan 26;168(3):503-516.e12.

J.S. Ayres, N.J. Trinidad and R.E. Vance. Lethal inflammasome activation by a multi-drug resistant pathobiont upon antibiotic disruption of the microbiota. Nat Med (2012) Apr:22(18) 799-806.

E. Stone*, B. Fulton*, J.S. Ayres, L. Pham, J. Ziauddin, and M. Shirasu-Hiza The circadian clock protein Timeless regulates phagocytosis of bacteria in Drosophila. PLoS Pathogens (2012) Jan:8(1):e1002445.

J.S. Ayres and D.S. Schneider. The role of anorexia in resistance and tolerance to infections in Drosophila. PLoS Biology (2009) Jul:7(7): e1000150.

J.S. Ayres and D.S. Schneider. A signaling protease required for melanization in Drosophila affects resistance and tolerance of infections. PLoS Biology (2008) Dec;6(12):e305.

J.S. Ayres, N. Freitag and D.S. Schneider. Identification of Drosophila mutants altering defense and endurance of Listeria monocytogenes infection. Genetics (2008) Mar;178(3):1807-15.

M.D. Gordon, J.S. Ayres, D.S. Schneider and R. Nusse. Pathogenesis of Listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin. PLoS Pathogens (2008) Jul;4(7):e1000111.

M.M. Shirasu-Hiza, M.S. Dionne*, L.N. Pham*, J.S. Ayres* and D.S. Schneider. Interactions between circadian rhythm and immunity in Drosophila melanogaster. Current Biology (2007) May;17(10): R353-55. *authors contributed equally.

D.S. Schneider, J.S. Ayres*, S.M. Brandt*, A. Costa*, M.S. Dionne*, M.M. Gordon*, E.M. Mabery*, M.G. Moule*, L.N. Pham* and M.M. Shirasu-Hiza*. Drosophila eiger mutants are sensitive to extracellular pathogens. PLoS Pathogens (2007) March;3(3):e41. *authors contributed equally.

Invited Reviews

J. von Moltke, J.S. Ayres, E.M. Kofoed, J. Chavarria-Smith, R.E. Vance. Recognition of bacteria by inflammasomes. Annu Rev Immunol, under review.

J.S. Ayres and R.E. Vance. Cellular teamwork in antibacterial innate immunity. Nat Immunol (2012) Jan:19(2) 115-7.

J.S. Ayres and D.S. Schneider. Tolerance of infections. Annu Rev Immunol (2012):(30) 271-94.

J.S. Ayres and D.S. Schneider. Genomic dissection of microbial pathogenesis in cultured Drosophila cells. Trends Microbiol (2006) Mar;14(3):101-4.


D.S. Schneider and J.S. Ayres. Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases. Nat Rev Immunol (2008) Nov;8(11):889-95.


BA, Molecular & Cell Biology, University of California, Berkeley
PhD, Microbiology & Immunology, Stanford University School of Medicine
Postdoctoral Fellow, University of California, Berkeley

Awards & Honors

  • 2015 Young Faculty Award from DARPA
  • 2014 Searle Scholar
  • 2010-2013 National Institute of Health Ruth L. Kirschstein National Research Service Award
  • 2008 The Professor Sidney Raffel Award
  • 2004 - 2007 National Science Foundation Graduate Student Fellowship
  • 2002 I.L. Chaikoff Memorial Award