Janelle Ayres

Professor and Laboratory Head, Molecular and Systems Physiology Laboratory
Gene Expression Laboratory
NOMIS Center for Immunobiology and Microbial Pathogenesis
Helen McLoraine Developmental Chair

Salk Institute for Biological Studies - Publications

all Publications


McCarville, J.L., Ayres, J.S. Host-Pathogen Relationship Advice: Fat Protects against a Broken Heart. (2019) Cell Metabolism. 30(3):409-411. DOI: 10.1016/j.cmet.2019.08.007

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Wallace, M., Green, C.R., Roberts, L.S., Lee, Y.M., McCarville, J.L., Sanchez-Gurmaches, J., Meurs, N., Gengatharan, J.M., Hover, J.D., Phillips, S.A., Ciaraldi, T.P., Guertin, D.A., Cabrales, P., Ayres, J.S., Nomura, D.K., Loomba, R., Metallo, C.M. Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. (2018) Nature Chemical Biology. 14(11):1021-1031. DOI: 10.1038/s41589-018-0132-2

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Sanchez, K.K., Chen, G.Y., Schieber, A.M.P., Redford, S.E., Shokhirev, M.N., Leblanc, M., Lee, Y.M., Ayres, J.S. Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen. (2018) Cell. 175(1):146-158. DOI: 10.1016/j.cell.2018.07.016

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Chen, G.Y., Ayres, J.S. When the Gut Gets Tough, the Enterocytes Get Going. (2018) Immunity. 48(5):837-839. DOI: 10.1016/j.immuni.2018.04.036

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Lee, Y.M., Ayres, J.S. Decoding the intestinal epithelium cell by cell. (2018) Nature Immunology. 19(1):7-9. DOI: 10.1038/s41590-017-0011-0


Rao, S., Ayres, J.S. Resistance and tolerance defenses in cancer: Lessons from infectious diseases. (2017) Seminars in Immunology. 32:54-61. DOI: 10.1016/j.smim.2017.08.004

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Rauch, I., Deets, K.A., Ji, D.X., von Moltke, J., Tenthorey, J.L., Lee, A.Y., Philip, N.H., Ayres, J.S., Brodsky, I.E., Gronert, K., Vance, R.E. NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. (2017) Immunity. 46(4):649-659. DOI: 10.1016/j.immuni.2017.03.016

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Rao, S., Schieber, A.M., O'Connor, C.P., Leblanc, M., Michel, D., Ayres, J.S. Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and Transmission. (2017) Cell. 168(3):503-516.e12. DOI: 10.1016/j.cell.2017.01.006

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Ayres, J.S. Microbes Dress for Success: Tolerance or Resistance? (2017) Trends in Microbiology. 25(1):1-3. DOI: 10.1016/j.tim.2016.11.006

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Schieber, A.M., Ayres, J.S. Thermoregulation as a disease tolerance defense strategy. (2016) Pathog Dis. 74(9). DOI: 10.1093/femspd/ftw106

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Ayres, J.S. Disease Tolerance Trick or Treat: Give Your Brain Something Good to Eat. (2016) Cell. 166(6):1368-70. DOI: 10.1016/j.cell.2016.08.034

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Ayres, J.S. Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism. (2016) Cell. 165(6):1323-1331. DOI: 10.1016/j.cell.2016.05.049

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Shen, R., Wang, B., Giribaldi, M.G., Ayres, J., Thomas, J.B., Montminy, M. Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(23):E3307-14. DOI: 10.1073/pnas.1606106113

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Schieber, A.M., Lee, Y.M., Chang, M.W., Leblanc, M., Collins, B., Downes, M., Evans, R.M., Ayres, J.S. Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling. (2015) Science. 350(6260):558-63. DOI: 10.1126/science.aac6468

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Ayres, J.S. Inflammasome-microbiota interplay in host physiologies. (2013) Cell Host & Microbe. 14(5):491-7. DOI: 10.1016/j.chom.2013.10.013

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Manzanillo, P.S., Ayres, J.S., Watson, R.O., Collins, A.C., Souza, G., Rae, C.S., Schneider, D.S., Nakamura, K., Shiloh, M.U., Cox, J.S. The ubiquitin ligase parkin mediates resistance to intracellular pathogens. (2013) Nature. 501(7468):512-6. DOI: 10.1038/nature12566

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von Moltke, J., Ayres, J.S., Kofoed, E.M., Chavarría-Smith, J., Vance, R.E. Recognition of bacteria by inflammasomes. (2013) Annual Review of Immunology. 31:73-106. DOI: 10.1146/annurev-immunol-032712-095944

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Ayres, J.S., Trinidad, N.J., Vance, R.E. Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota. (2012) Nature Medicine. 18(5):799-806. DOI: 10.1038/nm.2729

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Ayres, J.S., Vance, R.E. Cellular teamwork in antibacterial innate immunity. (2012) Nature Immunology. 13(2):115-7. DOI: 10.1038/ni.2212


Stone, E.F., Fulton, B.O., Ayres, J.S., Pham, L.N., Ziauddin, J., Shirasu-Hiza, M.M. The circadian clock protein timeless regulates phagocytosis of bacteria in Drosophila. (2012) PLOS pathogens. 8(1):e1002445. DOI: 10.1371/journal.ppat.1002445

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Ayres, J.S., Schneider, D.S. Tolerance of infections. (2012) Annual Review of Immunology. 30:271-94. DOI: 10.1146/annurev-immunol-020711-075030

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Ayres, J.S., Schneider, D.S. The role of anorexia in resistance and tolerance to infections in Drosophila. (2009) PLOS Biology. 7(7):e1000150. DOI: 10.1371/journal.pbio.1000150

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Ayres, J.S., Schneider, D.S. A signaling protease required for melanization in Drosophila affects resistance and tolerance of infections. (2008) PLOS Biology. 6(12):2764-73. DOI: 10.1371/journal.pbio.0060305

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Schneider, D.S., Ayres, J.S. Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases. (2008) Nature Reviews. Immunology. 8(11):889-95. DOI: 10.1038/nri2432

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Gordon, M.D., Ayres, J.S., Schneider, D.S., Nusse, R. Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin. (2008) PLOS pathogens. 4(7):e1000111. DOI: 10.1371/journal.ppat.1000111

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Ayres, J.S., Freitag, N., Schneider, D.S. Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection. (2008) Genetics. 178(3):1807-15. DOI: 10.1534/genetics.107.083782

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Shirasu-Hiza, M.M., Dionne, M.S., Pham, L.N., Ayres, J.S., Schneider, D.S. Interactions between circadian rhythm and immunity in Drosophila melanogaster. (2007) Current Biology. 17(10):R353-5. DOI: 10.1016/j.cub.2007.03.049


Schneider, D.S., Ayres, J.S., Brandt, S.M., Costa, A., Dionne, M.S., Gordon, M.D., Mabery, E.M., Moule, M.G., Pham, L.N., Shirasu-Hiza, M.M. Drosophila eiger mutants are sensitive to extracellular pathogens. (2007) PLOS pathogens. 3(3):e41. DOI: 10.1371/journal.ppat.0030041

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Ayres, J.S., Schneider, D.S. Genomic dissection of microbial pathogenesis in cultured Drosophila cells. (2006) Trends in Microbiology. 14(3):101-4. DOI: 10.1016/j.tim.2006.01.008

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McCarville, J.L., Ayres, J.S. Disease tolerance: concept and mechanisms. (2018) Current Opinion in Immunology. 50:88-93. DOI: 10.1016/j.coi.2017.12.003

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Education

BA, Molecular & Cell Biology, University of California, Berkeley
PhD, Microbiology & Immunology, Stanford University School of Medicine
Postdoctoral Fellow, University of California, Berkeley


Awards & Honors

  • 2018 National Institutes of Health Pioneer Award
  • 2018 Blavatnik National Award for Young Scientists
  • 2015 Young Faculty Award from DARPA
  • 2014 Searle Scholar
  • 2010-2013 National Institutes of Health Ruth L. Kirschstein National Research Service Award
  • 2008 The Professor Sidney Raffel Award
  • 2004 - 2007 National Science Foundation Graduate Student Fellowship
  • 2002 I.L. Chaikoff Memorial Award