Janelle Ayres

Associate Professor

NOMIS Center for Immunobiology and Microbial Pathogenesis

Helen McLoraine Developmental Chair

Salk Institute for Biological Studies - Publications

all Publications


Sanchez, K.K., Chen, G.Y., Schieber, A.M.P., Redford, S.E., Shokhirev, M.N., Leblanc, M., Lee, Y.M., Ayres, J.S. Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen. (2018) Cell. DOI: 10.1016/j.cell.2018.07.016

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Chen, G.Y., Ayres, J.S. When the Gut Gets Tough, the Enterocytes Get Going. (2018) Immunity. 48(5):837-839. DOI: 10.1016/j.immuni.2018.04.036

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Lee, Y.M., Ayres, J.S. Decoding the intestinal epithelium cell by cell. (2018) Nat. Immunol. 19(1):7-9. DOI: 10.1038/s41590-017-0011-0


Rao, S., Ayres, J.S. Resistance and tolerance defenses in cancer: Lessons from infectious diseases. (2017) Semin. Immunol. DOI: 10.1016/j.smim.2017.08.004

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Rauch, I., Deets, K.A., Ji, D.X., von Moltke, J., Tenthorey, J.L., Lee, A.Y., Philip, N.H., Ayres, J.S., Brodsky, I.E., Gronert, K., Vance, R.E. NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. (2017) Immunity. 46(4):649-659. DOI: 10.1016/j.immuni.2017.03.016

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Rao, S., Schieber, A.M., O'Connor, C.P., Leblanc, M., Michel, D., Ayres, J.S. Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and Transmission. (2017) Cell. 168(3):503-516.e12. DOI: 10.1016/j.cell.2017.01.006

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Ayres, J.S. Microbes Dress for Success: Tolerance or Resistance? (2017) Trends Microbiol. 25(1):1-3. DOI: 10.1016/j.tim.2016.11.006

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Schieber, A.M., Ayres, J.S. Thermoregulation as a disease tolerance defense strategy. (2016) Pathog Dis. 74(9). DOI: 10.1093/femspd/ftw106

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Ayres, J.S. Disease Tolerance Trick or Treat: Give Your Brain Something Good to Eat. (2016) Cell. 166(6):1368-70. DOI: 10.1016/j.cell.2016.08.034

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Ayres, J.S. Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism. (2016) Cell. 165(6):1323-1331. DOI: 10.1016/j.cell.2016.05.049

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Shen, R., Wang, B., Giribaldi, M.G., Ayres, J., Thomas, J.B., Montminy, M. Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance. (2016) Proc. Natl. Acad. Sci. U.S.A. 113(23):E3307-14. DOI: 10.1073/pnas.1606106113

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Schieber, A.M., Lee, Y.M., Chang, M.W., Leblanc, M., Collins, B., Downes, M., Evans, R.M., Ayres, J.S. Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling. (2015) Science. 350(6260):558-63. DOI: 10.1126/science.aac6468

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Ayres, J.S. Inflammasome-microbiota interplay in host physiologies. (2013) Cell Host Microbe. 14(5):491-7. DOI: 10.1016/j.chom.2013.10.013

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Manzanillo, P.S., Ayres, J.S., Watson, R.O., Collins, A.C., Souza, G., Rae, C.S., Schneider, D.S., Nakamura, K., Shiloh, M.U., Cox, J.S. The ubiquitin ligase parkin mediates resistance to intracellular pathogens. (2013) Nature. 501(7468):512-6. DOI: 10.1038/nature12566

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von Moltke, J., Ayres, J.S., Kofoed, E.M., Chavarría-Smith, J., Vance, R.E. Recognition of bacteria by inflammasomes. (2013) Annu. Rev. Immunol. 31:73-106. DOI: 10.1146/annurev-immunol-032712-095944

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Ayres, J.S., Trinidad, N.J., Vance, R.E. Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota. (2012) Nat. Med. 18(5):799-806. DOI: 10.1038/nm.2729

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Ayres, J.S., Vance, R.E. Cellular teamwork in antibacterial innate immunity. (2012) Nat. Immunol. 13(2):115-7. DOI: 10.1038/ni.2212


Stone, E.F., Fulton, B.O., Ayres, J.S., Pham, L.N., Ziauddin, J., Shirasu-Hiza, M.M. The circadian clock protein timeless regulates phagocytosis of bacteria in Drosophila. (2012) PLoS Pathog. 8(1):e1002445. DOI: 10.1371/journal.ppat.1002445

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Ayres, J.S., Schneider, D.S. Tolerance of infections. (2012) Annu. Rev. Immunol. 30:271-94. DOI: 10.1146/annurev-immunol-020711-075030

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Ayres, J.S., Schneider, D.S. The role of anorexia in resistance and tolerance to infections in Drosophila. (2009) PLoS Biol. 7(7):e1000150. DOI: 10.1371/journal.pbio.1000150

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Ayres, J.S., Schneider, D.S. A signaling protease required for melanization in Drosophila affects resistance and tolerance of infections. (2008) PLoS Biol. 6(12):2764-73. DOI: 10.1371/journal.pbio.0060305

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Schneider, D.S., Ayres, J.S. Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases. (2008) Nat. Rev. Immunol. 8(11):889-95. DOI: 10.1038/nri2432

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Gordon, M.D., Ayres, J.S., Schneider, D.S., Nusse, R. Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin. (2008) PLoS Pathog. 4(7):e1000111. DOI: 10.1371/journal.ppat.1000111

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Ayres, J.S., Freitag, N., Schneider, D.S. Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection. (2008) Genetics. 178(3):1807-15. DOI: 10.1534/genetics.107.083782

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Shirasu-Hiza, M.M., Dionne, M.S., Pham, L.N., Ayres, J.S., Schneider, D.S. Interactions between circadian rhythm and immunity in Drosophila melanogaster. (2007) Curr. Biol. 17(10):R353-5. DOI: 10.1016/j.cub.2007.03.049


Schneider, D.S., Ayres, J.S., Brandt, S.M., Costa, A., Dionne, M.S., Gordon, M.D., Mabery, E.M., Moule, M.G., Pham, L.N., Shirasu-Hiza, M.M. Drosophila eiger mutants are sensitive to extracellular pathogens. (2007) PLoS Pathog. 3(3):e41. DOI: 10.1371/journal.ppat.0030041

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Ayres, J.S., Schneider, D.S. Genomic dissection of microbial pathogenesis in cultured Drosophila cells. (2006) Trends Microbiol. 14(3):101-4. DOI: 10.1016/j.tim.2006.01.008

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Education

BA, Molecular & Cell Biology, University of California, Berkeley
PhD, Microbiology & Immunology, Stanford University School of Medicine
Postdoctoral Fellow, University of California, Berkeley


Awards & Honors

  • 2018 National Institutes of Health Pioneer Award
  • 2018 Blavatnik National Award for Young Scientists
  • 2015 Young Faculty Award from DARPA
  • 2014 Searle Scholar
  • 2010-2013 National Institutes of Health Ruth L. Kirschstein National Research Service Award
  • 2008 The Professor Sidney Raffel Award
  • 2004 - 2007 National Science Foundation Graduate Student Fellowship
  • 2002 I.L. Chaikoff Memorial Award