Salk Institute for Biological Studies - Human Cell Models of Aging

Human Cell Models of Aging


Human Cell Models of Aging

The overarching goal of the SD-NSC Human Cell Models of Aging Core is to create and make available powerful, new human cell-based models to enable studies into the molecular and cellular heterogeneity of human aging. Major activities and resources offered include:

  • Generate a bank of fibroblasts and corresponding induced pluripotent stem cells (iPSCs) that represent the breadth of healthy adult chronological age from a human cohort extensively phenotyped for key physical and functional measures of biological age.
  • Create induced cell models that maintain age-related phenotypes. Unlike iPSC-based reprogramming processes that can erase epigenetic and transcriptional signatures of aging, direct-conversion approaches can better maintain molecular signatures of aging in resultant cell types. This makes direct-induction protocols particularly well-suited for creating cellular models of human aging.
  • Drive technology development to create novel organoid and hybrid-cell models to investigate the role of cellular heterogeneity in human tissue and organ aging. This will be iPSC-derived organoids initially, but over time will involve integration of directly converted cells that maintain aging signatures.
  • Distribute protocols and key reagents relevant for creating induced cell types and organoid models.

Services and prices

  • Offerings for the Human Cell Models of Aging Core will be announced later in 2021.

Human Cell Models of Aging