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Gene Transfer, Targeting
and Therapeutics Core
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Viral Vector Core
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Recent Papers of Interest
Selective viral vector transduction of ErbB4 expressing cortical interneurons in vivo with a viral receptor–ligand bridge protein
., Choi et al., Proc Natl Acad Sci
Monosynaptic Rabies Virus Reveals Premotor Network Organization and Synaptic Specificity of Cholinergic Partition Cells
. Stepiene et al., Neuron
The next step in gene delivery: Molecular engineering of adeno-associated virus serotypes.
Faust et al., J Mol Cell Cardio
Proteasome Inhibitors Decrease AAV2 Capsid derived Peptide Epitope Presentation on MHC Class I Following Transduction
. Finn et al., Mol Ther
The neonatal blood-brain barrier is functionally effective, and immaturity does not explain differential targeting of AAV9
. Saunders et al., Nat Biotech
Intravenous administration of self-complementary AAV9 enables transgene delivery to adult motor neurons.
Duque et al., Mol Ther
High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors.
Petrs-Silva et al., Mol Ther
Comparative analysis of HIV-1-based lentiviral vectors bearing lyssavirus glycoproteins for neuronal gene transfer
. Federici et al., Genet Vaccines Ther
Production and purification of lentiviral vectors
– Verma Lab
Production and characterization of recombinant adeno-associated viral vectors
– Samulski lab
MTA for Samulski rAAV vectors
– UNC gene therapy core
Contact information for U. PENN vector core
– MTA for AAV serotypes 8,9 and rh10.
– information and discussion groups about lentiviral vectors
– distribution of useful plasmids including 2nd and 3rd generation lentiviral packaging systems.
– Human and mouse whole genome lentiviral shRNAmir vectors – pGIPZ and the tet-inducible pTRIPZ.