Ye Zheng

Associate Professor

NOMIS Center for Immunobiology and Microbial Pathogenesis

Salk Institute for Biological Studies - Publications


Bapat SP, Suh JM, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RE and Zheng Y. (2015) Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature 528, 137–141.

Li X and Zheng Y. (2015) Regulatory T cell identity: formation and maintenance. Trends in Immunology 36(6):344-353.

Hernandez JB, Chang C, LeBlanc M, Grimm D, Le Lay J, Kaestner KH, Zheng Y, and Montminy M. (2015) The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation. Nat Commun. 6:7216.

Li X and Zheng Y. (2014) Treg identity protection by an epigenetic switch. Cell Cycle. 13(20):3159-60.

Li X, Liang Y, LeBlanc M, Benner C, and Zheng Y. (2014) Function of a Foxp3 cis-Element in Protecting Regulatory T Cell Identity. Cell 158(4):734–748.

Josefowicz SZ, Niec RE, Kim HY, Treuting P, Chinen T, Zheng Y, Umetsu DT, and Rudensky AY. (2012) Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature 482(7385):395–399.

Zheng Y. ChIP-on-chip for FoxP3. (2011) Methods Mol Biol.; 707:71-82.

Zheng Y, Josefowicz SZ, Chadhry A, Peng XP, Forbush K, Rudensky AY. (2010). Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature, 463:808-12

Zheng Y, Chaudhry A, Kas A, deRoos P, Kim JM, Chu TT, Corcoran L, Treuting P, Klein U, Rudensky AY. 2009. Regulatory T cell suppressor program co-opts transcription factor IRF4 to control Th2 responses. Nature 458: 351-6

Zheng Y, Rudensky AY. 2007. Foxp3 in control of the regulatory T cell lineage. Nat Immunol. 8: 457-62

Zheng Y, Josefowicz SZ, Kas A, Chu TT, Gavin MA, Rudensky AY. 2007. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 445: 936-40

Hsieh CS, Zheng Y, Liang Y, Fontenot JD, Rudensky AY. 2006. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat Immunol. 7: 401-10


BS, Peking University, Beijing, China
PhD, Columbia University, New York, NY
Postdoctoral Fellow, University of Washington, Seattle, WA
Research Scholar, Memorial Sloan-Kettering Cancer Center, New York, NY

Awards & Honors

  • 2010-2015 Rita Allen Scholar Award
  • 2005-2008 Cancer Research Institute postdoctoral fellowship