Ye Zheng

Associate Professor

NOMIS Center for Immunobiology and Microbial Pathogenesis

Salk Institute for Biological Studies - Publications

all Publications


Owen, D.L., Mahmud, S.A., Sjaastad, L.E., Williams, J.B., Spanier, J.A., Simeonov, D.R., Ruscher, R., Huang, W., Proekt, I., Miller, C.N., Hekim, C., Jeschke, J.C., Aggarwal, P., Broeckel, U., LaRue, R.S., Henzler, C.M., Alegre, M.L., Anderson, M.S., August, A., Marson, A., Zheng, Y., Williams, C.B., Farrar, M.A. Thymic regulatory T cells arise via two distinct developmental programs. (2019) Nature Immunology. DOI: 10.1038/s41590-018-0289-6

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Klann, J.E., Kim, S.H., Remedios, K.A., He, Z., Metz, P.J., Lopez, J., Tysl, T., Olvera, J.G., Ablack, J.N., Cantor, J.M., Boland, B.S., Yeo, G., Zheng, Y., Lu, L.F., Bui, J.D., Ginsberg, M.H., Petrich, B.G., Chang, J.T. Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance. (2018) Journal of immunology. DOI: 10.4049/jimmunol.1800112

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Cao, Q., Zhao, X., Bai, J., Gery, S., Sun, H., Lin, D.C., Chen, Q., Chen, Z., Mack, L., Yang, H., Deng, R., Shi, X., Chong, L.W., Cho, H., Xie, J., Li, Q.Z., Müschen, M., Atkins, A.R., Liddle, C., Yu, R.T., Alkan, S., Said, J.W., Zheng, Y., Downes, M., Evans, R.M., Koeffler, H.P. Circadian clock cryptochrome proteins regulate autoimmunity. (2017) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1619119114

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He, N., Fan, W., Henriquez, B., Yu, R.T., Atkins, A.R., Liddle, C., Zheng, Y., Downes, M., Evans, R.M. Metabolic control of regulatory T cell (Treg) survival and function by Lkb1. (2017) Proceedings of the National Academy of Sciences of the United States of America. DOI: 10.1073/pnas.1715363114

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Wang, J., He, N., Zhang, N., Quan, D., Zhang, S., Zhang, C., Yu, R.T., Atkins, A.R., Zhu, R., Yang, C., Cui, Y., Liddle, C., Downes, M., Xiao, H., Zheng, Y., Auwerx, J., Evans, R.M., Leng, Q. NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection. (2017) Nature Communications. 8(1):959. DOI: 10.1038/s41467-017-00931-8

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Zheng, Y. A Rogue Foxp3 Mutant Undermines Treg Cell Function. (2017) Immunity. 47(2):211-214. DOI: 10.1016/j.immuni.2017.07.024

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Klann, J.E., Remedios, K.A., Kim, S.H., Metz, P.J., Lopez, J., Mack, L.A., Zheng, Y., Ginsberg, M.H., Petrich, B.G., Chang, J.T. Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. (2017) Journal of immunology. 198(12):4639-4651. DOI: 10.4049/jimmunol.1601165

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Chinen, T., Kannan, A.K., Levine, A.G., Fan, X., Klein, U., Zheng, Y., Gasteiger, G., Feng, Y., Fontenot, J.D., Rudensky, A.Y. An essential role for the IL-2 receptor in Treg cell function. (2016) Nature Immunology. 17(11):1322-1333. DOI: 10.1038/ni.3540

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Liu, W.H., Kang, S.G., Huang, Z., Wu, C.J., Jin, H.Y., Maine, C.J., Liu, Y., Shepherd, J., Sabouri-Ghomi, M., Gonzalez-Martin, A., Xu, S., Hoffmann, A., Zheng, Y., Lu, L.F., Xiao, N., Fu, G., Xiao, C. A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells. (2016) Journal of Experimental Medicine. 213(9):1901-19. DOI: 10.1084/jem.20160204

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Bapat, S.P., Myoung Suh, J., Fang, S., Liu, S., Zhang, Y., Cheng, A., Zhou, C., Liang, Y., LeBlanc, M., Liddle, C., Atkins, A.R., Yu, R.T., Downes, M., Evans, R.M., Zheng, Y. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. (2015) Nature. 528(7580):137-41. DOI: 10.1038/nature16151

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Hernandez, J.B., Chang, C., LeBlanc, M., Grimm, D., Le Lay, J., Kaestner, K.H., Zheng, Y., Montminy, M. The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation. (2015) Nature Communications. 6:7216. DOI: 10.1038/ncomms8216

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Li, X., Zheng, Y. Regulatory T cell identity: formation and maintenance. (2015) Trends in Immunology. 36(6):344-53. DOI: 10.1016/j.it.2015.04.006

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Li, X., Liang, Y., LeBlanc, M., Benner, C., Zheng, Y. Function of a Foxp3 cis-element in protecting regulatory T cell identity. (2014) Cell. 158(4):734-48. DOI: 10.1016/j.cell.2014.07.030

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Zheng, Y. ChIP-on-chip for FoxP3. (2011) Methods in Molecular Biology. 707:71-82. DOI: 10.1007/978-1-61737-979-6_6

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Li, M., Carpio, D.F., Zheng, Y., Bruzzo, P., Singh, V., Ouaaz, F., Medzhitov, R.M., Beg, A.A. An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells. (2001) Journal of immunology. 166(12):7128-35.

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Zheng, Y., Ouaaz, F., Bruzzo, P., Singh, V., Gerondakis, S., Beg, A.A. NF-kappa B RelA (p65) is essential for TNF-alpha-induced fas expression but dispensable for both TCR-induced expression and activation-induced cell death. (2001) J. Immunol. 166(8):4949-57.

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Education

BS, Peking University, Beijing, China
PhD, Columbia University, New York, NY
Postdoctoral Fellow, University of Washington, Seattle, WA
Research Scholar, Memorial Sloan-Kettering Cancer Center, New York, NY


Awards & Honors

  • 2010-2015 Rita Allen Scholar Award
  • 2005-2008 Cancer Research Institute postdoctoral fellowship