Geoffrey Wahl

Professor

Gene Expression Laboratory

Daniel and Martina Lewis Chair

Geoffrey Wahl
Salk Institute for Biological Studies - Publications

all Publications


Chung, C., Ma, Z., Dravis, C., Preissl, S., Poirion, O., Luna, G., Hou, X., Giraddi, R., Ren, B., Wahl, G.M. Single-Cell Chromatin Analysis of Mammary Gland Development Reveals Cell-State Transcriptional Regulators and Lineage Relationships (2019) Cell Reports. 29(2):495-510. DOI: 10.1016/j.celrep.2019.08.089

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Shi, Y., Gao, W., Lytle, N.K., Huang, P., Yuan, X., Dann, A.M., Ridinger-Saison, M., DelGiorno, K.E., Antal, C.E., Liang, G., Atkins, A.R., Erikson, G., Sun, H., Meisenhelder, J., Terenziani, E., Woo, G., Fang, L., Santisakultarm, T.P., Manor, U., Xu, R., Becerra, C.R., Borazanci, E., Von Hoff, D.D., Grandgenett, P.M., Hollingsworth, M.A., Leblanc, M., Umetsu, S.E., Collisson, E.A., Scadeng, M., Lowy, A.M., Donahue, T.R., Reya, T., Downes, M., Evans, R.M., Wahl, G.M., Pawson, T., Tian, R., Hunter, T. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. (2019) Nature. 569(7754):131-135. DOI: 10.1038/s41586-019-1130-6

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Giraddi, R.R., Chung, C.Y., Heinz, R.E., Balcioglu, O., Novotny, M., Trejo, C.L., Dravis, C., Hagos, B.M., Mehrabad, E.M., Rodewald, L.W., Hwang, J.Y., Fan, C., Lasken, R., Varley, K.E., Perou, C.M., Wahl, G.M., Spike, B.T. Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development. (2018) Cell Reports. 24(6):1653-1666.e7. DOI: 10.1016/j.celrep.2018.07.025

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Dravis, C., Chung, C.Y., Lytle, N.K., Herrera-Valdez, J., Luna, G., Trejo, C.L., Reya, T., Wahl, G.M. Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity. (2018) Cancer Cell. 34(3):466-482. DOI: 10.1016/j.ccell.2018.08.001

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Saison-Ridinger, M., DelGiorno, K.E., Zhang, T., Kraus, A., French, R., Jaquish, D., Tsui, C., Erikson, G., Spike, B.T., Shokhirev, M.N., Liddle, C., Yu, R.T., Downes, M., Evans, R.M., Saghatelian, A., Lowy, A.M., Wahl, G.M. Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. (2017) PLOS One. 12(12):e0189051. DOI: 10.1371/journal.pone.0189051

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Trejo, C.L., Luna, G., Dravis, C., Spike, B.T., Wahl, G.M. Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis. (2017) NPJ Breast Cancer. 3:16. DOI: 10.1038/s41523-017-0018-6

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Wahl, G.M., Spike, B.T. Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity. (2017) NPJ Breast Cancer. 3:14. DOI: 10.1038/s41523-017-0012-z

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Turner, K.M., Deshpande, V., Beyter, D., Koga, T., Rusert, J., Lee, C., Li, B., Arden, K., Ren, B., Nathanson, D.A., Kornblum, H.I., Taylor, M.D., Kaushal, S., Cavenee, W.K., Wechsler-Reya, R., Furnari, F.B., Vandenberg, S.R., Rao, P.N., Wahl, G.M., Bafna, V., Mischel, P.S. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. (2017) Nature. 543(7643):122-125. DOI: 10.1038/nature21356

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Adams, C.J., Yu, J.S., Mao, J.H., Jen, K.Y., Costes, S.V., Wade, M., Shoemake, J., Aina, O.H., Del Rosario, R., Menchavez, P.T., Cardiff, R.D., Wahl, G.M., Balmain, A. The Trp53 delta proline (Trp53ΔP) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development. (2016) Molecular Carcinogenesis. 55(9):1387-96. DOI: 10.1002/mc.22377

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Sancho-Martinez, I., Nivet, E., Xia, Y., Hishida, T., Aguirre, A., Ocampo, A., Ma, L., Morey, R., Krause, M.N., Zembrzycki, A., Ansorge, O., Vazquez-Ferrer, E., Dubova, I., Reddy, P., Lam, D., Hishida, Y., Wu, M.Z., Esteban, C.R., O'Leary, D., Wahl, G.M., Verma, I.M., Laurent, L.C., Izpisua Belmonte, J.C. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. (2016) Nature Communications. 7:10743. DOI: 10.1038/ncomms10743

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Dravis, C., Spike, B.T., Harrell, J.C., Johns, C., Trejo, C.L., Southard-Smith, E.M., Perou, C.M., Wahl, G.M. Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells. (2015) Cell Reports. 12(12):2035-48. DOI: 10.1016/j.celrep.2015.08.040

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Rozhok, A.I., Wahl, G.M., DeGregori, J. A Critical Examination of the "Bad Luck" Explanation of Cancer Risk. (2015) Cancer Prevention Research. 8(9):762-4. DOI: 10.1158/1940-6207.CAPR-15-0229

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Pfefferle, A.D., Spike, B.T., Wahl, G.M., Perou, C.M. Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy. (2015) Breast Cancer Research and Treatment. 149(2):425-37. DOI: 10.1007/s10549-014-3262-6

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Li, Y.C., Rodewald, L.W., Hoppmann, C., Wong, E.T., Lebreton, S., Safar, P., Patek, M., Wang, L., Wertman, K.F., Wahl, G.M. A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time. (2014) Cell Reports. 9(5):1946-58. DOI: 10.1016/j.celrep.2014.10.058

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Sherman, M.H., Yu, R.T., Engle, D.D., Ding, N., Atkins, A.R., Tiriac, H., Collisson, E.A., Connor, F., Van Dyke, T., Kozlov, S., Martin, P., Tseng, T.W., Dawson, D.W., Donahue, T.R., Masamune, A., Shimosegawa, T., Apte, M.V., Wilson, J.S., Ng, B., Lau, S.L., Gunton, J.E., Wahl, G.M., Hunter, T., Drebin, J.A., O'Dwyer, P.J., Liddle, C., Tuveson, D.A., Downes, M., Evans, R.M. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. (2014) Cell. 159(1):80-93. DOI: 10.1016/j.cell.2014.08.007

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Spike, B.T., Kelber, J.A., Booker, E., Kalathur, M., Rodewald, R., Lipianskaya, J., La, J., He, M., Wright, T., Klemke, R., Wahl, G.M., Gray, P.C. CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo. (2014) Stem Cell Reports. 2(4):427-39. DOI: 10.1016/j.stemcr.2014.02.010

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He, G., Zhang, Y.W., Lee, J.H., Zeng, S.X., Wang, Y.V., Luo, Z., Dong, X.C., Viollet, B., Wahl, G.M., Lu, H. AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity. (2014) Molecular and Cellular Biology. 34(2):148-57. DOI: 10.1128/MCB.00670-13

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Pfefferle, A.D., Herschkowitz, J.I., Usary, J., Harrell, J.C., Spike, B.T., Adams, J.R., Torres-Arzayus, M.I., Brown, M., Egan, S.E., Wahl, G.M., Rosen, J.M., Perou, C.M. Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. (2013) Genome Biology. 14(11):R125. DOI: 10.1186/gb-2013-14-11-r125

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Rasmussen, N.R., Wright, T.M., Brooks, S.A., Hacker, K.E., Debebe, Z., Sendor, A.B., Walker, M.P., Major, M.B., Green, J., Wahl, G.M., Rathmell, W.K. Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer. (2013) Journal of Biological Chemistry. 288(36):26301-10. DOI: 10.1074/jbc.M113.466086

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Makarem, M., Spike, B.T., Dravis, C., Kannan, N., Wahl, G.M., Eaves, C.J. Stem cells and the developing mammary gland. (2013) Journal of Mammary Gland Biology and Neoplasia. 18(2):209-19. DOI: 10.1007/s10911-013-9284-6

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Green, J.L., La, J., Yum, K.W., Desai, P., Rodewald, L.W., Zhang, X., Leblanc, M., Nusse, R., Lewis, M.T., Wahl, G.M. Paracrine Wnt signaling both promotes and inhibits human breast tumor growth. (2013) Proceedings of the National Academy of Sciences of the United States of America. 110(17):6991-6. DOI: 10.1073/pnas.1303671110

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Green, J.L., Bauer, M., Yum, K.W., Li, Y.C., Cox, M.L., Willert, K., Wahl, G.M. Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilities. (2013) PLOS One. 8(3):e58395. DOI: 10.1371/journal.pone.0058395

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Wade, M., Li, Y.C., Wahl, G.M. MDM2, MDMX and p53 in oncogenesis and cancer therapy. (2013) Nature Reviews. Cancer. 13(2):83-96. DOI: 10.1038/nrc3430

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Wade, M., Li, Y.C., Matani, A.S., Braun, S.M., Milanesi, F., Rodewald, L.W., Wahl, G.M. Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells. (2012) Oncogene. 31(45):4789-97. DOI: 10.1038/onc.2011.625

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Lee, J.H., Jin, Y., He, G., Zeng, S.X., Wang, Y.V., Wahl, G.M., Lu, H. Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein. (2012) Journal of Biological Chemistry. 287(25):20898-903. DOI: 10.1074/jbc.M111.336875

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Li, Y.C., Wahl, G.M. What a difference a phosphate makes: life or death decided by a single amino acid in MDM2. (2012) Cancer Cell. 21(5):595-6. DOI: 10.1016/j.ccr.2012.04.033

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Spike, B.T.*, Engle, D.D.*, Lin, J.C., Cheung, S.K., La, J., Wahl, G.M. A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. (2012) Cell Stem Cell. 10(2):183-97. DOI: 10.1016/j.stem.2011.12.018

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Wang, Y.V., Leblanc, M., Fox, N., Mao, J.H., Tinkum, K.L., Krummel, K., Engle, D., Piwnica-Worms, D., Piwnica-Worms, H., Balmain, A., Kaushansky, K., Wahl, G.M. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. (2011) Genes & Development. 25(13):1426-38. DOI: 10.1101/gad.2024411

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Spike, B.T., Wahl, G.M. p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome. (2011) Genes & Cancer. 2(4):404-19. DOI: 10.1177/1947601911410224

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Mizuno, H., Spike, B.T., Wahl, G.M., Levine, A.J. Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(52):22745-50. DOI: 10.1073/pnas.1017001108

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Bernal, F., Wade, M., Godes, M., Davis, T.N., Whitehead, D.G., Kung, A.L., Wahl, G.M., Walensky, L.D. A stapled p53 helix overcomes HDMX-mediated suppression of p53. (2010) Cancer Cell. 18(5):411-22. DOI: 10.1016/j.ccr.2010.10.024

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Wade, M., Wang, Y.V., Wahl, G.M. The p53 orchestra: Mdm2 and Mdmx set the tone. (2010) Trends in Cell Biology. 20(5):299-309. DOI: 10.1016/j.tcb.2010.01.009

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Wang, Y.V., Wade, M., Wahl, G.M. Guarding the guardian: Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivo. (2009) Cell Cycle. 8(21):3443-4. DOI: 10.4161/cc.8.21.9744


Ponnamperuma, R.M., King, K.E., Elsir, T., Glick, A.B., Wahl, G.M., Nister, M., Weinberg, W.C. The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-beta-mediated growth regulation. (2009) Journal of Pathology. 219(2):263-74. DOI: 10.1002/path.2600

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Kawamura, T., Suzuki, J., Wang, Y.V., Menendez, S., Morera, L.B., Raya, A., Wahl, G.M., Izpisúa Belmonte, J.C. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. (2009) Nature. 460(7259):1140-4. DOI: 10.1038/nature08311

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Wang, Y.V., Leblanc, M., Wade, M., Jochemsen, A.G., Wahl, G.M. Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases. (2009) Cancer Cell. 16(1):33-43. DOI: 10.1016/j.ccr.2009.05.008

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Wade, M., Wahl, G.M. Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry? (2009) Molecular Cancer Research. 7(1):1-11. DOI: 10.1158/1541-7786.MCR-08-0423

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Wade, M., Rodewald, L.W., Espinosa, J.M., Wahl, G.M. BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death. (2008) Cell Cycle. 7(13):1973-82. DOI: 10.4161/cc.7.13.6072

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Wang, Y.V., Wade, M., Wong, E., Li, Y.C., Rodewald, L.W., Wahl, G.M. Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation. (2007) Proceedings of the National Academy of Sciences of the United States of America. 104(30):12365-70. DOI: 10.1073/pnas.0701497104

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Toledo, F., Wahl, G.M. MDM2 and MDM4: p53 regulators as targets in anticancer therapy. (2007) Int. J. Biochem. Cell Biol. 39(7-8):1476-82. DOI: 10.1016/j.biocel.2007.03.022

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Toledo, F., Lee, C.J., Krummel, K.A., Rodewald, L.W., Liu, C.W., Wahl, G.M. Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression. (2007) Molecular and Cellular Biology. 27(4):1425-32. DOI: 10.1128/MCB.00999-06

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Toledo, F., Wahl, G.M. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. (2006) Nature Reviews. Cancer. 6(12):909-23. DOI: 10.1038/nrc2012

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Wade, M., Wong, E.T., Tang, M., Stommel, J.M., Wahl, G.M. Hdmx modulates the outcome of p53 activation in human tumor cells. (2006) Journal of Biological Chemistry. 281(44):33036-44. DOI: 10.1074/jbc.M605405200

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Clarke, M.F., Dick, J.E., Dirks, P.B., Eaves, C.J., Jamieson, C.H., Jones, D.L., Visvader, J., Weissman, I.L., Wahl, G.M. Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. (2006) Cancer Research. 66(19):9339-44. DOI: 10.1158/0008-5472.CAN-06-3126


Toledo, F., Liu, C.W., Lee, C.J., Wahl, G.M. RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses. (2006) Nucleic Acids Research. 34(13):e92. DOI: 10.1093/nar/gkl518

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Wade, M., Wahl, G.M. c-Myc, genome instability, and tumorigenesis: the devil is in the details. (2006) Current Topics in Microbiology and Immunology. 302:169-203.

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Wahl, G.M. Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo. (2006) Cell Death and Differentiation. 13(6):973-83. DOI: 10.1038/sj.cdd.4401911

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Marine, J.C., Francoz, S., Maetens, M., Wahl, G., Toledo, F., Lozano, G. Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. (2006) Cell Death and Differentiation. 13(6):927-34. DOI: 10.1038/sj.cdd.4401912


Toledo, F., Krummel, K.A., Lee, C.J., Liu, C.W., Rodewald, L.W., Tang, M., Wahl, G.M. A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. (2006) Cancer Cell. 9(4):273-85. DOI: 10.1016/j.ccr.2006.03.014

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Tang, M., Wahl, G.M., Nistér, M. Explaining the biological activity of transactivation-deficient p53 variants. (2006) Nature Genetics. 38(4):395-6; author reply 396-7. DOI: 10.1038/ng0406-395


Wong, E.T., Kolman, J.L., Li, Y.C., Mesner, L.D., Hillen, W., Berens, C., Wahl, G.M. Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange. (2005) Nucleic Acids Research. 33(17):e147. DOI: 10.1093/nar/gni145

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Buzina, A., Aladjem, M.I., Kolman, J.L., Wahl, G.M., Ellis, J. Initiation of DNA replication at the human beta-globin 3' enhancer. (2005) Nucleic Acids Research. 33(14):4412-24. DOI: 10.1093/nar/gki747

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Krummel, K.A., Lee, C.J., Toledo, F., Wahl, G.M. The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. (2005) Proceedings of the National Academy of Sciences of the United States of America. 102(29):10188-93. DOI: 10.1073/pnas.0503068102

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Nistér, M., Tang, M., Zhang, X.Q., Yin, C., Beeche, M., Hu, X., Enblad, G., van Dyke, T., Wahl, G.M. p53 must be competent for transcriptional regulation to suppress tumor formation. (2005) Oncogene. 24(22):3563-73. DOI: 10.1038/sj.onc.1208354

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Stommel, J.M., Wahl, G.M. A new twist in the feedback loop: stress-activated MDM2 destabilization is required for p53 activation. (2005) Cell Cycle. 4(3):411-7. DOI: 10.4161/cc.4.3.1522

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Thompson, T., Tovar, C., Yang, H., Carvajal, D., Vu, B.T., Xu, Q., Wahl, G.M., Heimbrook, D.C., Vassilev, L.T. Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis. (2004) Journal of Biological Chemistry. 279(51):53015-22. DOI: 10.1074/jbc.M410233200

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Yamamoto, N., Jiang, P., Yang, M., Xu, M., Yamauchi, K., Tsuchiya, H., Tomita, K., Wahl, G.M., Moossa, A.R., Hoffman, R.M. Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. (2004) Cancer Research. 64(12):4251-6. DOI: 10.1158/0008-5472.CAN-04-0643

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Stommel, J.M., Wahl, G.M. Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. (2004) EMBO Journal. 23(7):1547-56. DOI: 10.1038/sj.emboj.7600145

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Sears, J., Kolman, J., Wahl, G.M., Aiyar, A. Metaphase chromosome tethering is necessary for the DNA synthesis and maintenance of oriP plasmids but is insufficient for transcription activation by Epstein-Barr nuclear antigen 1. (2003) Journal of Virology. 77(21):11767-80.

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Tergaonkar, V., Pando, M., Vafa, O., Wahl, G., Verma, I. p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy. (2002) Cancer Cell. 1(5):493-503.

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Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T.K., Hampton, G.M., Wahl, G.M. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. (2002) Molecular Cell. 9(5):1031-44.

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Li, Q., Lee, J.Y., Castillo, R., Hixon, M.S., Pujol, C., Doppalapudi, V.R., Shepard, H.M., Wahl, G.M., Lobl, T.J., Chan, M.F. NB2001, a novel antibacterial agent with broad-spectrum activity and enhanced potency against beta-lactamase-producing strains. (2002) Antimicrobial Agents and Chemotherapy. 46(5):1262-8.

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Neuteboom, S.T., Karjian, P.L., Boyer, C.R., Beryt, M., Pegram, M., Wahl, G.M., Shepard, H.M. Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction. (2002) Molecular Cancer Therapeutics. 1(6):377-84.

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Boyer, C.R., Karjian, P.L., Wahl, G.M., Pegram, M., Neuteboom, S.T. Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011. (2002) Anticancer Drugs. 13(1):29-36.

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Aladjem, M.I., Rodewald, L.W., Lin, C.M., Bowman, S., Cimbora, D.M., Brody, L.L., Epner, E.M., Groudine, M., Wahl, G.M. Replication initiation patterns in the beta-globin loci of totipotent and differentiated murine cells: evidence for multiple initiation regions. (2002) Molecular and Cellular Biology. 22(2):442-52.

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Wahl, G.M., Carr, A.M. The evolution of diverse biological responses to DNA damage: insights from yeast and p53. (2001) Nature Cell Biology. 3(12):E277-86. DOI: 10.1038/ncb1201-e277

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Kanda, T., Otter, M., Wahl, G.M. Coupling of mitotic chromosome tethering and replication competence in epstein-barr virus-based plasmids. (2001) Molecular and Cellular Biology. 21(10):3576-88. DOI: 10.1128/MCB.21.10.3576-3588.2001

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Kanda, T., Otter, M., Wahl, G.M. Mitotic segregation of viral and cellular acentric extrachromosomal molecules by chromosome tethering. (2001) Journal of Cell Science. 114(Pt 1):49-58.

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Jimenez, G.S., Nister, M., Stommel, J.M., Beeche, M., Barcarse, E.A., Zhang, X.Q., O'Gorman, S., Wahl, G.M. A transactivation-deficient mouse model provides insights into Trp53 regulation and function. (2000) Nature Genetics. 26(1):37-43. DOI: 10.1038/79152

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Kanda, T., Wahl, G.M. The dynamics of acentric chromosomes in cancer cells revealed by GFP-based chromosome labeling strategies. (2000) J. Cell. Biochem. Suppl. Suppl 35:107-14.

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Wahl, G., Vafa, O. Genetic instability, oncogenes, and the p53 pathway. (2000) Cold Spring Harbor Symposia on Quantitative Biology. 65:511-20.


Khan, S.H., Moritsugu, J., Wahl, G.M. Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion. (2000) Proceedings of the National Academy of Sciences of the United States of America. 97(7):3266-71. DOI: 10.1073/pnas.050560997

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Jimenez, G.S., Khan, S.H., Stommel, J.M., Wahl, G.M. p53 regulation by post-translational modification and nuclear retention in response to diverse stresses. (1999) Oncogene. 18(53):7656-65. DOI: 10.1038/sj.onc.1203013

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Fox, R.I., Herrmann, M.L., Frangou, C.G., Wahl, G.M., Morris, R.E., Strand, V., Kirschbaum, B.J. Mechanism of action for leflunomide in rheumatoid arthritis. (1999) Clin. Immunol. 93(3):198-208. DOI: 10.1006/clim.1999.4777

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Fox, R.I., Herrmann, M.L., Frangou, C.G., Wahl, G.M., Morris, R.E., Kirschbaum, B.J. How does leflunomide modulate the immune response in rheumatoid arthritis? (1999) BioDrugs. 12(4):301-15.

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Jimenez, G.S., Bryntesson, F., Torres-Arzayus, M.I., Priestley, A., Beeche, M., Saito, S., Sakaguchi, K., Appella, E., Jeggo, P.A., Taccioli, G.E., Wahl, G.M., Hubank, M. DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage. (1999) Nature. 400(6739):81-3. DOI: 10.1038/21913

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Stommel, J.M., Marchenko, N.D., Jimenez, G.S., Moll, U.M., Hope, T.J., Wahl, G.M. A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. (1999) EMBO Journal. 18(6):1660-72. DOI: 10.1093/emboj/18.6.1660

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Jiang, X.R., Jimenez, G., Chang, E., Frolkis, M., Kusler, B., Sage, M., Beeche, M., Bodnar, A.G., Wahl, G.M., Tlsty, T.D., Chiu, C.P. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. (1999) Nature Genetics. 21(1):111-4. DOI: 10.1038/5056

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Jiang, W., Jimenez, G., Wells, N.J., Hope, T.J., Wahl, G.M., Hunter, T., Fukunaga, R. PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. (1998) Molecular Cell. 2(6):877-85.

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Aladjem, M.I., Rodewald, L.W., Kolman, J.L., Wahl, G.M. Genetic dissection of a mammalian replicator in the human beta-globin locus. (1998) Science. 281(5379):1005-9.

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Paulson, T.G., Almasan, A., Brody, L.L., Wahl, G.M. Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage. (1998) Molecular and Cellular Biology. 18(5):3089-100.

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Kanda, T., Sullivan, K.F., Wahl, G.M. Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. (1998) Current Biology. 8(7):377-85.

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Shimizu, N., Itoh, N., Utiyama, H., Wahl, G.M. Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. (1998) Journal of Cell Biology. 140(6):1307-20.

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Khan, S.H., Wahl, G.M. p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest. (1998) Cancer Research. 58(3):396-401.

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Aladjem, M.I., Spike, B.T., Rodewald, L.W., Hope, T.J., Klemm, M., Jaenisch, R., Wahl, G.M. ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. (1998) Current Biology. 8(3):145-55.

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Aladjem, M.I., Wahl, G.M. Mapping replication fork direction by leading strand analysis. (1997) Methods. 13(3):281-92. DOI: 10.1006/meth.1997.0527

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Linke, S.P., Harris, M.P., Neugebauer, S.E., Clarkin, K.C., Shepard, H.M., Maneval, D.C., Wahl, G.M. p53-mediated accumulation of hypophosphorylated pRb after the G1 restriction point fails to halt cell cycle progression. (1997) Oncogene. 15(3):337-45. DOI: 10.1038/sj.onc.1201200

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Wahl, G.M., Linke, S.P., Paulson, T.G., Huang, L.C. Maintaining genetic stability through TP53 mediated checkpoint control. (1997) Cancer Surveys. 29:183-219.

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Linke, S.P., Clarkin, K.C., Wahl, G.M. p53 mediates permanent arrest over multiple cell cycles in response to gamma-irradiation. (1997) Cancer Research. 57(6):1171-9.

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Di Leonardo, A., Khan, S.H., Linke, S.P., Greco, V., Seidita, G., Wahl, G.M. DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. (1997) Cancer Research. 57(6):1013-9.

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Aladjem, M.I., Brody, L.L., O'Gorman, S., Wahl, G.M. Positive selection of FLP-mediated unequal sister chromatid exchange products in mammalian cells. (1997) Molecular and Cellular Biology. 17(2):857-61.

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Jones, S.N., Sands, A.T., Hancock, A.R., Vogel, H., Donehower, L.A., Linke, S.P., Wahl, G.M., Bradley, A. The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. (1996) Proceedings of the National Academy of Sciences of the United States of America. 93(24):14106-11.

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Paulson, T.G., Wright, F.A., Parker, B.A., Russack, V., Wahl, G.M. Microsatellite instability correlates with reduced survival and poor disease prognosis in breast cancer. (1996) Cancer Research. 56(17):4021-6.

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Huang, L.C., Clarkin, K.C., Wahl, G.M. p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts. (1996) Cancer Research. 56(13):2940-4.

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Huang, L.C., Clarkin, K.C., Wahl, G.M. Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest. (1996) Proceedings of the National Academy of Sciences of the United States of America. 93(10):4827-32. DOI: 10.1073/pnas.93.10.4827

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Linke, S.P., Clarkin, K.C., Di Leonardo, A., Tsou, A., Wahl, G.M. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. (1996) Genes & Development. 10(8):934-47. DOI: 10.1101/gad.10.8.934

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Shimizu, N., Kanda, T., Wahl, G.M. Selective capture of acentric fragments by micronuclei provides a rapid method for purifying extrachromosomally amplified DNA. (1996) Nature Genetics. 12(1):65-71. DOI: 10.1038/ng0196-65

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Aladjem, M.I., Groudine, M., Brody, L.L., Dieken, E.S., Fournier, R.E., Wahl, G.M., Epner, E.M. Participation of the human beta-globin locus control region in initiation of DNA replication. (1995) Science. 270(5237):815-9. DOI: 10.1126/science.270.5237.815

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Li, W., Fan, J., Hochhauser, D., Banerjee, D., Zielinski, Z., Almasan, A., Yin, Y., Kelly, R., Wahl, G.M., Bertino, J.R. Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines. (1995) Proceedings of the National Academy of Sciences of the United States of America. 92(22):10436-40.

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Kelly, R.E., DeRose, M.L., Draper, B.W., Wahl, G.M. Identification of an origin of bidirectional DNA replication in the ubiquitously expressed mammalian CAD gene. (1995) Molecular and Cellular Biology. 15(8):4136-48.

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Almasan, A., Yin, Y., Kelly, R.E., Lee, E.Y., Bradley, A., Li, W., Bertino, J.R., Wahl, G.M. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. (1995) Proceedings of the National Academy of Sciences of the United States of America. 92(12):5436-40.

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Almasan, A., Linke, S.P., Paulson, T.G., Huang, L.C., Wahl, G.M. Genetic instability as a consequence of inappropriate entry into and progression through S-phase. (1995) Cancer Metastasis Rev. 14(1):59-73.

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Di Leonardo, A., Linke, S.P., Clarkin, K., Wahl, G.M. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. (1994) Genes & Development. 8(21):2540-51.

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Van den Berg, C.L., McGill, J.R., Kuhn, J.G., Walsh, J.T., De La Cruz, P.S., Davidson, K.K., Wahl, G.M., Von Hoff, D.D. Pharmacokinetics of hydroxyurea in nude mice. (1994) Anticancer Drugs. 5(5):573-8.

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Eckhardt, S.G., Dai, A., Davidson, K.K., Forseth, B.J., Wahl, G.M., Von Hoff, D.D. Induction of differentiation in HL60 cells by the reduction of extrachromosomally amplified c-myc. (1994) Proceedings of the National Academy of Sciences of the United States of America. 91(14):6674-8.

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Almasan, A., Mangelsdorf, D.J., Ong, E.S., Wahl, G.M., Evans, R.M. Chromosomal localization of the human retinoid X receptors. (1994) Genomics. 20(3):397-403. DOI: 10.1006/geno.1994.1193

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Di Leonardo, A., Linke, S.P., Yin, Y., Wahl, G.M. Cell cycle regulation of gene amplification. (1993) Cold Spring Harbor Symposia on Quantitative Biology. 58:655-67.


Barclay, B.J., Ondrusek, N.K., Wildenhain, Y.D., Huang, T., Carlone, R.L., Clement, J.M., Wahl, G.M. Effect of genomic position on amplification of the DFR1 gene in Saccharomyces cerevisiae. (1993) Adv. Exp. Med. Biol. 338:545-50.


Carroll, S.M., DeRose, M.L., Kolman, J.L., Nonet, G.H., Kelly, R.E., Wahl, G.M. Localization of a bidirectional DNA replication origin in the native locus and in episomally amplified murine adenosine deaminase loci. (1993) Molecular and Cellular Biology. 13(5):2971-81.

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Nonet, G.H., Wahl, G.M. Introduction of YACs containing a putative mammalian replication origin into mammalian cells can generate structures that replicate autonomously. (1993) Somat. Cell Mol. Genet. 19(2):171-92.

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Nonet, G.H., Carroll, S.M., DeRose, M.L., Wahl, G.M. Molecular dissection of an extrachromosomal amplicon reveals a circular structure consisting of an imperfect inverted duplication. (1993) Genomics. 15(3):543-58. DOI: 10.1006/geno.1993.1107

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Yin, Y., Tainsky, M.A., Bischoff, F.Z., Strong, L.C., Wahl, G.M. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. (1992) Cell. 70(6):937-48.

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Von Hoff, D.D., McGill, J.R., Forseth, B.J., Davidson, K.K., Bradley, T.P., Van Devanter, D.R., Wahl, G.M. Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity. (1992) Proceedings of the National Academy of Sciences of the United States of America. 89(17):8165-9.

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Haughey, B.H., von Hoff, D.D., Windle, B.E., Wahl, G.M., Mock, P.M. c-myc oncogene copy number in squamous carcinoma of the head and neck. (1992) Am J Otolaryngol. 13(3):168-71.

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Kimmel, M., Axelrod, D.E., Wahl, G.M. A branching process model of gene amplification following chromosome breakage. (1992) Mutat. Res. 276(3):225-39.

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Windle, B.E., Wahl, G.M. Molecular dissection of mammalian gene amplification: new mechanistic insights revealed by analyses of very early events. (1992) Mutat. Res. 276(3):199-224.


Von Hoff, D.D., Waddelow, T., Forseth, B., Davidson, K., Scott, J., Wahl, G. Hydroxyurea accelerates loss of extrachromosomally amplified genes from tumor cells. (1991) Cancer Research. 51(23 Pt 1):6273-9.

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Carroll, S.M., Trotter, J., Wahl, G.M. Replication timing control can be maintained in extrachromosomally amplified genes. (1991) Molecular and Cellular Biology. 11(9):4779-85.

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O'Gorman, S., Fox, D.T., Wahl, G.M. Recombinase-mediated gene activation and site-specific integration in mammalian cells. (1991) Science. 251(4999):1351-5.

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Windle, B., Draper, B.W., Yin, Y.X., O'Gorman, S., Wahl, G.M. A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration. (1991) Genes & Development. 5(2):160-74.

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Benner, S.E., Wahl, G.M., Von Hoff, D.D. Double minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines. (1991) Anticancer Drugs. 2(1):11-25.

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Ruiz, J.C., Wahl, G.M. Chromosomal destabilization during gene amplification. (1990) Molecular and Cellular Biology. 10(6):3056-66.

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Barringer, K.J., Orgel, L., Wahl, G., Gingeras, T.R. Blunt-end and single-strand ligations by Escherichia coli ligase: influence on an in vitro amplification scheme. (1990) Gene. 89(1):117-22.

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Stark, G.R., Debatisse, M., Giulotto, E., Wahl, G.M. Recent progress in understanding mechanisms of mammalian DNA amplification. (1989) Cell. 57(6):901-8.


Wahl, G.M. The importance of circular DNA in mammalian gene amplification. (1989) Cancer Research. 49(6):1333-40.


Ruiz, J.C., Choi, K.H., von Hoff, D.D., Roninson, I.B., Wahl, G.M. Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line. (1989) Molecular and Cellular Biology. 9(1):109-15.

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Ruiz, J.C., Wahl, G.M. Formation of an inverted duplication can be an initial step in gene amplification. (1988) Molecular and Cellular Biology. 8(10):4302-13.

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Von Hoff, D.D., Needham-VanDevanter, D.R., Yucel, J., Windle, B.E., Wahl, G.M. Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules. (1988) Proceedings of the National Academy of Sciences of the United States of America. 85(13):4804-8.

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Carroll, S.M., DeRose, M.L., Gaudray, P., Moore, C.M., Needham-Vandevanter, D.R., Von Hoff, D.D., Wahl, G.M. Double minute chromosomes can be produced from precursors derived from a chromosomal deletion. (1988) Molecular and Cellular Biology. 8(4):1525-33.

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Barclay, B.J., Huang, T., Nagel, M.G., Misener, V.L., Game, J.C., Wahl, G.M. Mapping and sequencing of the dihydrofolate reductase gene (DFR1) of Saccharomyces cerevisiae. (1988) Gene. 63(2):175-85.

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Wahl, G.M., Berger, S.L. Screening colonies or plaques with radioactive nucleic acid probes. (1987) Meth. Enzymol. 152:415-23.


Evans, G.A., Wahl, G.M. Cosmid vectors for genomic walking and rapid restriction mapping. (1987) Meth. Enzymol. 152:604-10.


Wahl, G.M., Berger, S.L., Kimmel, A.R. Molecular hybridization of immobilized nucleic acids: theoretical concepts and practical considerations. (1987) Meth. Enzymol. 152:399-407.


Carroll, S.M., Gaudray, P., De Rose, M.L., Emery, J.F., Meinkoth, J.L., Nakkim, E., Subler, M., Von Hoff, D.D., Wahl, G.M. Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional evidence for a mammalian replication origin. (1987) Molecular and Cellular Biology. 7(5):1740-50.

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Meinkoth, J., Killary, A.M., Fournier, R.E., Wahl, G.M. Unstable and stable CAD gene amplification: importance of flanking sequences and nuclear environment in gene amplification. (1987) Molecular and Cellular Biology. 7(4):1415-24.

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Wahl, G.M., Lewis, K.A., Ruiz, J.C., Rothenberg, B., Zhao, J., Evans, G.A. Cosmid vectors for rapid genomic walking, restriction mapping, and gene transfer. (1987) Proceedings of the National Academy of Sciences of the United States of America. 84(8):2160-4.

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Meinkoth, J., Wahl, G.M. Nick translation. (1987) Meth. Enzymol. 152:91-4.


Wahl, G.M., Meinkoth, J.L., Kimmel, A.R. Northern and Southern blots. (1987) Meth. Enzymol. 152:572-81.


Ruiz, J.C., Wahl, G.M. Escherichia coli aspartate transcarbamylase: a novel marker for studies of gene amplification and expression in mammalian cells. (1986) Molecular and Cellular Biology. 6(9):3050-8.

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Meinkoth, J.L., Legouy, E., Brison, O., Wahl, G.M. New RNA species is produced by alternate polyadenylation following rearrangement associated with CAD gene amplification. (1986) Somat. Cell Mol. Genet. 12(4):339-50.

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Gaudray, P., Trotter, J., Wahl, G.M. Fluorescent methotrexate labeling and flow cytometric analysis of cells containing low levels of dihydrofolate reductase. (1986) Journal of Biological Chemistry. 261(14):6285-92.

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Stark, G.R., Wahl, G.M. Gene amplification. (1984) Annual Review of Biochemistry. 53:447-91. DOI: 10.1146/annurev.bi.53.070184.002311


Meinkoth, J., Wahl, G. Hybridization of nucleic acids immobilized on solid supports. (1984) Analytical Biochemistry. 138(2):267-84.


Richman, D.D., Cleveland, P.H., Redfield, D.C., Oxman, M.N., Wahl, G.M. Rapid viral diagnosis. (1984) J. Infect. Dis. 149(3):298-310.

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Wahl, G.M., Robert de Saint Vincent, B., DeRose, M.L. Effect of chromosomal position on amplification of transfected genes in animal cells. (1984) Nature. 307(5951):516-20.

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Wahl, G.M., Vitto, L., Rubnitz, J. Co-amplification of rRNA genes with CAD genes in N-(phosphonacetyl)-L-aspartate-resistant Syrian hamster cells. (1983) Molecular and Cellular Biology. 3(11):2066-75.

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Chu, B.C., Wahl, G.M., Orgel, L.E. Derivatization of unprotected polynucleotides. (1983) Nucleic Acids Research. 11(18):6513-29.

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Redfield, D.C., Richman, D.D., Albanil, S., Oxman, M.N., Wahl, G.M. Detection of herpes simplex virus in clinical specimens by DNA hybridization. (1983) Diagn. Microbiol. Infect. Dis. 1(2):117-28.

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de Saint Vincent, B.R., Wahl, G.M. Homologous recombination in mammalian cells mediates formation of a functional gene from two overlapping gene fragments. (1983) Proceedings of the National Academy of Sciences of the United States of America. 80(7):2002-6.

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Folger, K.R., Wong, E.A., Wahl, G., Capecchi, M.R. Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. (1982) Molecular and Cellular Biology. 2(11):1372-87.

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Wahl, G.M., Vitto, L., Padgett, R.A., Stark, G.R. Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization. (1982) Molecular and Cellular Biology. 2(3):308-19.

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Padgett, R.A., Wahl, G.M., Stark, G.R. Properties of dispersed, highly repeated DNA within and near the hamster CAD gene. (1982) Molecular and Cellular Biology. 2(3):302-7.

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Padgett, R.A., Wahl, G.M., Stark, G.R. Structure of the gene for CAD, the multifunctional protein that initiates UMP synthesis in Syrian hamster cells. (1982) Molecular and Cellular Biology. 2(3):293-301.

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de Saint Vincent, B.R., Delbrück, S., Eckhart, W., Meinkoth, J., Vitto, L., Wahl, G. The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker. (1981) Cell. 27(2 Pt 1):267-77.

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Wahl, G.M., Padgett, R.A., Stark, G.R. Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells. (1979) Journal of Biological Chemistry. 254(17):8679-89.

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Wahl, G.M., Stern, M., Stark, G.R. Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. (1979) Proceedings of the National Academy of Sciences of the United States of America. 76(8):3683-7.

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Alwine, J.C., Kemp, D.J., Parker, B.A., Reiser, J., Renart, J., Stark, G.R., Wahl, G.M. Detection of specific RNAs or specific fragments of DNA by fractionation in gels and transfer to diazobenzyloxymethyl paper. (1979) Meth. Enzymol. 68:220-42.


Kohli, J., Kwong, T., Altruda, F., Söll, D., Wahl, G. Characterization of a UGA-suppressing serine tRNA from Schizosaccharomyces pombe with the help of a new in vitro assay system for eukaryotic suppressor tRNAs. (1979) Journal of Biological Chemistry. 254(5):1546-51.

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Padgett, R.A., Wahl, G.M., Coleman, P.F., Stark, G.R. N-(Phosphonacetyl)-L-aspartate-resistant hamster cells overaccumulate a single mRNA coding for the multifunctional protein that catalyzes the first steps of UMP synthesis. (1979) Journal of Biological Chemistry. 254(3):974-80.

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Capecchi, M.R., Hughes, S.H., Wahl, G.M. Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro. (1975) Cell. 6(3):269-77.

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Wahl, G.M., Hughes, S.H., Capecchi, M.R. Immunological characterization of hypoxanthine-guanine phosphoribosyl transferase mutants of mouse L cells: evidence for mutations at different loci in the HGPRT gene. (1975) Journal of Cellular Physiology. 85(2 Pt 1):307-20. DOI: 10.1002/jcp.1040850217

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Hughes, S.H., Wahl, G.M., Capecchi, M.R. Purification and characterization of mouse hypoxanthine-guanine phosphoribosyltransferase. (1975) Journal of Biological Chemistry. 250(1):120-6.

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Capecchi, M.R., Capecchi, N.E., Hughes, S.H., Wahl, G.M. Selective degradation of abnormal proteins in mammalian tissue culture cells. (1974) Proceedings of the National Academy of Sciences of the United States of America. 71(12):4732-6.

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Sigman, D.S., Wahl, G.M., Creighton, D.J. Models for metalloenzymes. Zinc ion catalyzed phosphorylation of 1,10-phenanthroline-2-carbinol by adenosine triphosphate. (1972) Biochemistry. 11(12):2236-42.


Education

BA, Bacteriology, UCLA
PhD, Biological Chemistry, Harvard University
Postdoctoral Fellow, Stanford University


Awards & Honors

  • 2014, Fellow, American Academy of Arts and Sciences (AAAS)
  • 2013, Fellow, American Association for Cancer Research
  • Scientific Advisory Board, Pancreatic Cancer Action Network
  • 2010, Susan G. Komen Scholar
  • 2008, American Association for the Advancement of Science (AAAS) Fellow
  • 2005-06, President, American Association for Cancer Research