Daniel Hollern

Assistant Professor

NOMIS Center for Immunobiology and Microbial Pathogenesis

Daniel Hollern
Salk Institute for Biological Studies - Publications


Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer.
Crosby EJ, Acharya CR, Haddad AF, Rabiola CA, Lei G, Wei JP, Yang XY, Wang T, Liu CX, Wagner KU, Muller WJ, Chodosh LA, Broadwater G, Hyslop T, Shepherd JH, Hollern DP, He X, Perou CM, Chai S, Ashby BK, Vincent BG, Snyder JC, Force J, Morse MA, Lyerly HK, Hartman ZC.
Clin Cancer Res. 2020 Jul 30. doi: 10.1158/1078-0432.CCR-20-0389. Online ahead of print.
PMID: 32732224

FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease.
Garcia-Recio S, Thennavan A, East MP, Parker JS, Cejalvo JM, Garay JP, Hollern DP, He X, Mott KR, Galván P, Fan C, Selitsky SR, Coffey AR, Marron D, Brasó-Maristany F, Burgues O, Albanell J, Rojo F, Lluch A, Martinez de Dueñas E, Rosen JM, Johnson GL, Carey LA, Prat A, Perou CM.
J Clin Invest. 2020 Jun 23:130323. doi: 10.1172/JCI130323. Online ahead of print.
PMID: 32573490

NCOA5 deficiency promotes a unique liver protumorigenic microenvironment through p21WAF1/CIP1 overexpression, which is reversed by metformin.
Williams M, Liu X, Zhang Y, Reske J, Bahal D, Gohl TG, Hollern D, Ensink E, Kiupel M, Luo R, Das R, Xiao H.
Oncogene. 2020 May;39(19):3821-3836. doi: 10.1038/s41388-020-1256-x. Epub 2020 Mar 20.
PMID: 32203160

Virus expression detection reveals RNA-sequencing contamination in TCGA.
Selitsky SR, Marron D, Hollern D, Mose LE, Hoadley KA, Jones C, Parker JS, Dittmer DP, Perou CM.
BMC Genomics. 2020 Jan 28;21(1):79. doi: 10.1186/s12864-020-6483-6.
PMID: 31992194

B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer.
Hollern DP, Xu N, Thennavan A, Glodowski C, Garcia-Recio S, Mott KR, He X, Garay JP, Carey-Ewend K, Marron D, Ford J, Liu S, Vick SC, Martin M, Parker JS, Vincent BG, Serody JS, Perou CM.
Cell. 2019 Nov 14;179(5):1191-1206.e21. doi: 10.1016/j.cell.2019.10.028.
PMID: 31730857

E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration.
Hollern DP, Swiatnicki MR, Rennhack JP, Misek SA, Matson BC, McAuliff A, Gallo KA, Caron KM, Andrechek ER.
Sci Rep. 2019 Jul 24;9(1):10718. doi: 10.1038/s41598-019-47218-0.
PMID: 31341204

Identification of Jun loss promotes resistance to histone deacetylase inhibitor entinostat through Myc signaling in luminal breast cancer.
Tanioka M, Mott KR, Hollern DP, Fan C, Darr DB, Perou CM.
Genome Med. 2018 Nov 30;10(1):86. doi: 10.1186/s13073-018-0597-3.
PMID: 30497520

A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer.
Hollern DP, Contreras CM, Dance-Barnes S, Silva GO, Pfefferle AD, Xiong J, Darr DB, Usary J, Mott KR, Perou CM.
Breast Cancer Res Treat. 2019 Feb;174(1):143-155. doi: 10.1007/s10549-018-5061-y. Epub 2018 Nov 27.
PMID: 30484104

Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast.
An Y, Adams JR, Hollern DP, Zhao A, Chang SG, Gams MS, Chung PED, He X, Jangra R, Shah JS, Yang J, Beck LA, Raghuram N, Kozma KJ, Loch AJ, Wang W, Fan C, Done SJ, Zacksenhaus E, Guidos CJ, Perou CM, Egan SE.
Cell Rep. 2018 Oct 16;25(3):702-714.e6. doi: 10.1016/j.celrep.2018.09.056.
PMID: 30332649

A Review of FOXI3 Regulation of Development and Possible Roles in Cancer Progression and Metastasis.
Mukherjee A, Hollern DP, Williams OG, Rayburn TS, Byrd WA, Yates C, Jones JD.
Front Cell Dev Biol. 2018 Jul 3;6:69. doi: 10.3389/fcell.2018.00069. eCollection 2018.
PMID: 30018953

Integrated Molecular Characterization of Testicular Germ Cell Tumors.
Shen H, Shih J, Hollern DP, Wang L, Bowlby R, Tickoo SK, Thorsson V, Mungall AJ, Newton Y, Hegde AM, Armenia J, Sánchez-Vega F, Pluta J, Pyle LC, Mehra R, Reuter VE, Godoy G, Jones J, Shelley CS, Feldman DR, Vidal DO, Lessel D, Kulis T, Cárcano FM, Leraas KM, Lichtenberg TM, Brooks D, Cherniack AD, Cho J, Heiman DI, Kasaian K, Liu M, Noble MS, Xi L, Zhang H, Zhou W, ZenKlusen JC, Hutter CM, Felau I, Zhang J, Schultz N, Getz G, Meyerson M, Stuart JM; Cancer Genome Atlas Research Network, Akbani R, Wheeler DA, Laird PW, Nathanson KL, Cortessis VK, Hoadley KA.
Cell Rep. 2018 Jun 12;23(11):3392-3406. doi: 10.1016/j.celrep.2018.05.039.
PMID: 29898407

Histological subtypes of mouse mammary tumors reveal conserved relationships to human cancers.
Hollern DP, Swiatnicki MR, Andrechek ER.
PLoS Genet. 2018 Jan 18;14(1):e1007135. doi: 10.1371/journal.pgen.1007135. eCollection 2018 Jan.
PMID: 29346386

LPA receptor activity is basal specific and coincident with early pregnancy and involution during mammary gland postnatal development.
Acosta D, Bagchi S, Broin PÓ, Hollern D, Racedo SE, Morrow B, Sellers RS, Greally JM, Golden A, Andrechek E, Wood T, Montagna C.
Sci Rep. 2016 Nov 3;6:35810. doi: 10.1038/srep35810.
PMID: 27808166

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.
Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PN, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, Dinh AT, Stephanopoulos G, Manalis SR, Yaffe MB, Andrechek ER, Fendt SM, Vander Heiden MG.
Mol Cell. 2015 Jan 8;57(1):95-107. doi: 10.1016/j.molcel.2014.10.027. Epub 2014 Dec 4.
PMID: 25482511

The E2F transcription factors regulate tumor development and metastasis in a mouse model of metastatic breast cancer.
Hollern DP, Honeysett J, Cardiff RD, Andrechek ER.
Mol Cell Biol. 2014 Sep;34(17):3229-43. doi: 10.1128/MCB.00737-14. Epub 2014 Jun 16.
PMID: 24934442

Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression.
Chen F, Li A, Gao S, Hollern D, Williams M, Liu F, VanSickle EA, Andrechek E, Zhang C, Yang C, Luo R, Xiao H.
Cell Death Dis. 2014 May 22;5(5):e1242. doi: 10.1038/cddis.2014.224.
PMID: 24853420

NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors.
Zhou X, Hollern D, Liao J, Andrechek E, Wang H.
Cell Death Dis. 2013 Mar 28;4(3):e560. doi: 10.1038/cddis.2013.82.
PMID: 23538441

A mouse model with T58A mutations in Myc reduces the dependence on KRas mutations and has similarities to claudin-low human breast cancer.
Hollern DP, Yuwanita I, Andrechek ER.
Oncogene. 2013 Mar 7;32(10):1296-304. doi: 10.1038/onc.2012.142. Epub 2012 Apr 23.
PMID: 22525269

Prediction and genetic demonstration of a role for activator E2Fs in Myc-induced tumors.
Fujiwara K, Yuwanita I, Hollern DP, Andrechek ER.
Cancer Res. 2011 Mar 1;71(5):1924-32. doi: 10.1158/0008-5472.CAN-10-2386. Epub 2011 Jan 18.
PMID: 21245101


PhD, Cell and Molecular Biology, Michigan State University
Postdoctoral Fellow, University of North Carolina
BS, Biology, Grand Valley State University

Awards & Honors

  • 2019 Joseph S. Pagano Award
  • 2015 NIH NCI F32 Award Ruth L. Kirschstein National Research Service Award
  • 2014 NIH NCI F31 Award Ruth L. Kirschstein National Research Service Award
  • 2014 Aitch Foundation Award