Salk Institute for Biological Studies - Cancer - Videos


Mysterious microproteins have major implications for human disease

LA JOLLA—As the tools to study biology improve, researchers are beginning to uncover details into microproteins, small components that appear to be key to some cellular processes, including those involved with cancer. Proteins are made up of chains of linked amino acids and the average human protein contains around 300 amino acids. Meanwhile, microproteins have fewer than 100 amino acids. Read more »

Two therapeutic targets identified for deadly lung cancer

The vast majority of deadly lung cancer cases (85 percent) are termed non-small-cell lung carcinomas (NSCLCs), which often contain a mutated gene called LKB1. Salk Institute researchers have now discovered precisely why inactive LKB1 results in cancer development. The surprising results, published in the online version of Cancer Discovery on July 26, 2019, highlight how LBK1 communicates with two enzymes that suppress inflammation in addition to cell growth, to block tumor growth. The findings could lead to new therapies for NSCLC. Read more »

Tackling Pancreatic Cancer

From the beginning of the Salk Institute, with the open architecture, the emphasis on people working with and collaborating with one another has been a secret to many of the big discoveries that have been made here. With the Concurring Cancer Initiative at Salk, we have five groups each of whom represents a different discipline all of whom have a common goal and each of us are highly motivated to work with one another to cure this very devastating disease.

Salk scientists uncover how high-fat diet drives colorectal cancer growth

A new study led by Salk Institute scientists and published in Cell suggests that high-fat diets fuel colorectal cancer growth by triggering a hormonal signal that lets potentially cancerous cells thrive. The findings could explain why colorectal cancer is being seen in younger people growing up at a time when higher-fat diets are common. Read more »

Maintaining the unlimited potential of stem cells

Scientists from the Salk Institute discovered a new protein complex that keeps the brakes on stem cells, allowing them to maintain their indefinite potential. The new complex, called GBAF and detailed in Nature Communications on December 3, 2018, could provide a future target for regenerative medicine. Read more »