Cancer

Videos

Salk Institute for Biological Studies - Cancer - Videos

Videos


Mysterious microproteins have major implications for human disease

LA JOLLA—As the tools to study biology improve, researchers are beginning to uncover details into microproteins, small components that appear to be key to some cellular processes, including those involved with cancer. Proteins are made up of chains of linked amino acids and the average human protein contains around 300 amino acids. Meanwhile, microproteins have fewer than 100 amino acids. Read more »


Two therapeutic targets identified for deadly lung cancer

The vast majority of deadly lung cancer cases (85 percent) are termed non-small-cell lung carcinomas (NSCLCs), which often contain a mutated gene called LKB1. Salk Institute researchers have now discovered precisely why inactive LKB1 results in cancer development. The surprising results, published in the online version of Cancer Discovery on July 26, 2019, highlight how LBK1 communicates with two enzymes that suppress inflammation in addition to cell growth, to block tumor growth. The findings could lead to new therapies for NSCLC. Read more »


Tackling Pancreatic Cancer

From the beginning of the Salk Institute, with the open architecture, the emphasis on people working with and collaborating with one another has been a secret to many of the big discoveries that have been made here. With the Concurring Cancer Initiative at Salk, we have five groups each of whom represents a different discipline all of whom have a common goal and each of us are highly motivated to work with one another to cure this very devastating disease.


Sugars that coat proteins are a possible drug target for pancreatitis

LA JOLLA—Pancreatitis is an inflammation of the pancreas that accounts for 275,000 hospitalizations in the United States annually. Patients who suffer from hereditary pancreatitis have a 40 to 50 percent lifetime risk of developing pancreatic cancer. Read more »


New study targets Achilles’ heel of pancreatic cancer, with promising results

LA JOLLA—Advanced pancreatic cancer is often symptomless, leading to late diagnosis only after metastases have spread throughout the body. Additionally, tumor cells are encased in a “protective shield,” a microenvironment conferring resistance to many cancer treatment drugs. Now, Salk Institute researchers, along with an international team of collaborators, have uncovered the role of a signaling protein that may be the Achilles’ heel of pancreatic cancer. Read more »