Aging

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Salk Institute for Biological Studies - Aging - Videos

Videos


Chimeric tool advanced for wide range of regenerative medicine, biomedical research applications

LA JOLLA—The ability to grow the cells of one species within an organism of a different species offers scientists a powerful tool for research and medicine. It’s an approach that could advance our understanding of early human development, disease onset and progression and aging; provide innovative platforms for drug evaluation; and address the critical need for transplantable organs. Yet developing such capabilities has been a formidable challenge. Read more »


The science of aging


First immune-evading cells created to treat type 1 diabetes

LA JOLLA—Salk Institute scientists have made a major advance in the pursuit of a safe and effective treatment for type 1 diabetes, an illness that impacts an estimated 1.6 million Americans with a cost of $14.4 billion annually.

Using stem cell technology, Salk researchers generated the first human insulin-producing pancreatic cell clusters able to evade the immune system, as detailed in the journal Nature on August 19, 2020. These “immune shielded” cell clusters controlled blood glucose without immunosuppressive drugs in mice, once transplanted in the body. Read more »


Eat less, live longer

LA JOLLA—If you want to reduce levels of inflammation throughout your body, delay the onset of age-related diseases and live longer—eat less food. That’s the conclusion of a new study by scientists from the US and China that provides the most detailed report to date of the cellular effects of a calorie-restricted diet in rats. While the benefits of caloric restriction have long been known, the new results show how this restriction can protect against aging in cellular pathways, as detailed in Cell on February 27, 2020. Read more »


How old are your organs? To scientists’ surprise, organs are a mix of young and old cells

LA JOLLA—Scientists once thought that neurons, or possibly heart cells, were the oldest cells in the body. Now, Salk Institute researchers have discovered that the mouse brain, liver and pancreas contain populations of cells and proteins with extremely long lifespans—some as old as neurons. The findings, demonstrating “age mosaicism,” were published in Cell Metabolism on June 6, 2019. The team’s methods could be applied to nearly any tissue in the body to provide valuable information about lifelong function of non-dividing cells and how cells lose control over the quality and integrity of proteins and important cell structures during aging. Read more »