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Owen Witte – Finding Targets for Cancer Therapy

Brian Druker – From 4G10 to Gleevec and Beyond

Jonathan Cooper – p130Cas Initiates Integrin Adhesion Assembly

Yongjian Huang – A Molecular Mechanism for the Generation of Ligand-dependent Differential Outputs by the Epidermal Growth Factor Receptor

Benjamin G. Neel – Cell-Autonomous and Non-Autonomous Resistance to SHP2 Inhibition

Thomas H. Mann – Protein Kinase C as a Molecular Clock that Controls CD8+ T Cell Function and Exhaustion

Art Weiss – Insights into TCR Ligand Discrimination via Kinetic Proofreading

Ruth Palmer – Exploiting ALK-driven Signaling in Neuroblastoma

Radha Mukherjee – Regulation of PTEN Translation by PI3K Signaling Maintains Pathway Homeostasis

Ann Marie Pendergast -Tyrosine Kinase-regulated Transcription and Translation Networks Promote Brain Metastasis and Reveal Therapeutic Vulnerabilities

Michael J. Eck – Structural Insights into RAF Activation

Mariano Barbacid – Mouse Models of Oncogenic KRAS-induced Cancer

Renee Read – YAP/TAZ Transcriptional Co-activators Drive Neuro-glial Stem/Progenitor Cell Identity in High Grade Gliomas

Greg Lemke – Microglial TAM Receptors and the Development of Alzheimer’s Disease

Duygu Ozmadenci – Tumor FAK Orchestrates Immunosuppression in Ovarian Cancer via the CD155/TIGIT Axis

Mark A. Lemmon – Ligand Discrimination and Signaling by the EGF Receptor

Anju Sreelatha – AMPylation: a New Signaling Paradigm in the Mitochondria

Y. Jessie Zhang -Spatiotemporal Recruitment of Transcription Regulators by the Post-translational Modifications on RNA Polymerase II

Natalie Luhtala – Illuminating Histidine Phosphorylation in the Pancreatic Tumor Microenvironment

Jared L. Johnson – A Global Atlas of Substrate Specificities for the Human Protein Kinome

Elena B. Pasquale – Illuminating the Biochemical Activity Architecture of the Cell

Margaret C. Frame – Interrogating Functional Links between the Adhesome and the Nucleus

Joan Brugge – From Src to HER2/EGFR and Breast Cancer

Cameron T. Flower – Resolving the Kinetics of Oncogenic Signaling Inhibition by Phosphoproteomics

Harold Varmus – New Perspectives on Oncogenic Transformation