Martin Hetzer

Vice President, Chief Science Officer

Professor

Molecular and Cell Biology Laboratory

Jesse and Caryl Philips Foundation Chair

Salk Institute for Biological Studies - Publications

List of Publications


Franks, T.M., Benner, C., Narvaiza, I., Marchetto, M.C., Young, J.M., Malik, H.S., Gage, F.H. and Hetzer, M.W. (2016) Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev. 30:1155-71

Ibarra, A., Benner, C., Tyagi, S., Cool, J. and Hetzer M.W. (2016) Nucleoporin-mediated regulation of cell identity genes. Genes Dev. 30:2253-2258

Hatch, E.M and Hetzer W.M. (2016) Nuclear envelope rupture is induced by actin-based nucleus confinement. J. Cell Biol. 215:27-36

Mertens, J., Paquola, A., Ku, M., Hatch, E.M., Bohnke, L., Ladjevardi, S., McGrath, S., Campbell, B., Lee, H., Herdy, J.R., Goncalves, J.T., Toda, T. Kim, Y., Winkler, J., Yao, J., Hetzer, M.W., Gage, F.H. (2015) Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell

Ori, H., Toyama, B., Harris, M., Bock, T., Iskar, M., Bork, P., Ingolia, N., Hetzer, M.W., and Beck, M. (2015) Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats. Cell Systems

Hatch, E.M. and Hetzer, M.W. (2015) Linking Micronuclei to Chromosome Fragmentation. Cell 161:1502-1504

Jacinto, F.V., Benner, C. and Hetzer, M.W. (2015) The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes Dev. 29:1224-1238

Hatch, E.M. and Hetzer, M.W. (2015) Chromothripsis. Curr. Biol. 25:R397-399

Gomez-Cavazos, J.S. and Hetzer, M.W. (2015) The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. J. Cell Biol. 208:671-681

Ibarra, A. and Hetzer, M.W. (2015) Nuclear pore proteins and the control of genome functions. Genes Dev. 29:337-349.

Buchwalter, A.L., Liang, Y. and Hetzer, M.W. (2014) Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. Mol. Biol. Cell 25:2472-84

Hatch, E. and Hetzer, M. (2014) Breaching the nuclear envelope in development and disease. J. Cell Biol. 205:133-41

Buchwalter, A. and Hetzer, M.W. (2014) Nuclear pores set the speed limit for mitosis. Cell 156:868-869

Toyama, B.H., Savas, J.N., Park, S.K., Harris, M.S., Ingolia, N.T., Yates, J.R. and Hetzer, M.W. (2013) Identification of long-lived proteins reveals exceptional stability of essential cellular structures. Cell 2013 Aug 29;154(5):971-82. doi: 10.1016/j.cell.2013.07.037.

Hatch, E.M., Fischer, A.H., Deerink, T.J. and Hetzer, M.W. (2013) Catastrophic nuclear envelope collapse in cancer cell micronuclei. Cell 154:47-60.

Regner, B.M, Vucinic, D., Domnisoru, C., Bartol, T.M., Hetzer, M.W., Tartakovsky, D.M. and Sejnowski, T.J. (2013) Characterizing intracellular transport mechanisms with random walks in a model system. Biophys J 104:1652-1660.

Liang, Y., Franks, T.M., Marchetto, M.C., Gage, F.H and Hetzer, M.W. (2013) Dynamic association of NUP98 with the human genome. Plos Genet 9:e1003308

Toyama, B.H. and Hetzer, M.W (2013) Protein homeostasis: live long won't prosper. Nature Rev Mol Cell Biol 14:55-61.

Franks, T.M. and Hetzer, M.W (2013) The role of Nup98 in transcription regulation in healthy and diseased cells. Trends in Cell Biol 23:112-117.

Savas, J.N., Toyama, B.H., Xu, T., Yates J.R. and Hetzer, M.W. (2012) Extremely long-lived nuclear pore proteins in the rat brain. Science 335: 942.

D'Angelo, M.A., Gomez-Cavazos, J.S., Mei, A., Lackner, D.H. and Hetzer, M.W. (2012) A change in nuclear pore complex composition regulates cell differentiation. Dev Cell 22, 1-13

Talamas, J. and Hetzer, M.W. (2011) POM121 and Sun1 play a role in ealry steps of interphase NPC assembly. J Cell Biol 194: 27-37

Doucet, C., Talamas, J. and Hetzer, M.W. (2010) Cell Cycle Dependent Differences in Nuclear Pore Complex Assembly in Metazoa. Cell 141: 1030-1041.

Capelson, M., Liang, Y., Schulte, R., Mair, W, Wagner, U. and Hetzer, M.W. (2010) Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Cell 140: 372-383.

D'Angelo, M.A., Raices, M., Panowski, S.H. and Hetzer, M.W. (2009) Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in post-mitotic cells. Cell 136: 284-295.

Education

Undergraduate degree, University of Vienna, Austria
PhD, Biochemistry and Genetics, Vienna Biocenter, Austria
Postdoctoral work at EMBL, Heidelberg, Germany


Awards & Honors

  • 2015 National Institutes of Health (NIH) Transformative Research Award
  • 2013 Glenn Award for Research in Biological Mechanisms of Aging
  • 2009 ASCINA Award (Austrian Scientists and Scholars in North America)
  • 2009 Early Career Life Science Award, American Society of Cell Biology
  • 2009-2013 Ellison Medical Foundation Senior Scholar in Aging
  • 2009-2013 American Cancer Society Research Scholar
  • 2005 Pew Scholar
  • 2000-2003 APART fellow
  • 1998-2003 EMBO long term fellowship
  • 1997 Austrian science award in Genetics
  • 1997 Erwin Schroedinger fellowship