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"Aging is the single biggest risk factor for most human diseases, ranging from arthritis and cancer to diabetes and neurodegenerative disease. Our goal is to unravel the basic molecular mechanisms that drive the aging process, which will allow us to promote healthy aging for humankind." -
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Andrew Dillin (Director) Howard Hughes Medical Institute Investigator Associate Professor, Molecular and Cell Biology Laboratory 858-453-4100 x1002 Dillin@salk.edu |
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"Our lab is interested in understanding the molecular genetics of metabolic disease and inflammation, including atherosclerosis and diabetes as well as cancer, and using this information to devise cures for their treatment. By tinkering with a metabolic program in muscle, we stumbled upon ‘exercise in a pill.’ " | Ronald M. Evans Howard Hughes Medical Institute Investigator Professor, Gene Expression Laboratory March of Dimes Chair in Molecular and Developmental Biology 858-453-4100 x1302 evans@salk.edu |
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"How the adult central nervous system adapts to environmental stimulation may hold the key to new therapies that replace or enhance damaged brain and spinal cord tissues. That’s why our lab is so intent on pursuing the mechanisms behind this process." | Fred H. Gage Professor, Laboratory of Genetics Vi and John Adler Chair for Research on Age-Related Neurodegenerative Diseases 858-453-4100 x1012 gage@salk.edu |
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"I am interested in how the organization and architecture of the nucleus influences gene activity and how disruption of three-dimensional order can cause developmental defects, cancer, and premature aging." | Martin W. Hetzer Hearst Endowment Associate Professor Molecular and Cell Biology Laboratory 858-453-4100 x1419 hetzer@salk.edu |
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"Our ultimate goal is to try to understand the molecular and cellular basis of organ and tissue regeneration." | Juan Carlos Izpisúa Belmonte Professor, Gene Expression Laboratory 858-453-4100 x1130 belmonte@salk.edu |
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"The behavior of stem cells is regulated both by intrinsic factors within the stem cells and extrinsic factors from the surrounding environment, known as the stem cell niche. I am interested in how the relationship between stem cells and their environment changes during development, aging, and tumorigenesis." | Leanne Jones Assistant Professor, Laboratory of Genetics 858-453-4100 x1869 ljones@salk.edu |
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"Safeguarding the ends of linear chromosomes, known as telomeres, is essential for any animal’s survival. We are trying to understand how cells keep tabs on their telomeres and prevent catastrophic meltdowns to gain a better understanding of the interrelationship of aging and cancer." | Jan Karlseder Associate Professor, Molecular and Cell Biology Laboratory 858-453-4100 x1867 karlseder@salk.edu |
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"I am fascinated by the complex DNA transactions that chromosomes undergo—particularly the types of events that occur at telomeres, the very tips of chromosomes. When these telomere-associated DNA processes start to run out of steam, or conversely become overly active, this can lead to either premature aging or cancer predisposition." |
Vicki Lundblad |
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"Obesity is a major risk factor in the development of adult-onset diabetes, which is characterized by the inability of cells in the body to respond to insulin. By studying key genetic switches that control food intake and metabolism, we hope to identify molecules that will be amenable to drug therapy for insulin-resistant individuals." |
Marc R. Montminy Professor, Clayton Foundation Laboratories for Peptide Biology J. W. Kieckhefer Professor 858-453-4100 x1394 montminy@salk.edu |
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"When a normal cell runs low on energy, it won’t divide, but in some cases, cancer cells can override the built-in shutoff. The same cellular brake helps cells and organisms adapt their glucose metabolism. I am particularly interested in understanding the molecular link between cancer and metabolism since it embodies a critical intervention point for future therapeutics." |
Reuben J. Shaw Hearst Endowment Assistant Professor, Molecular and Cell Biology Laboratory 858-453-4100 x1258 shaw@salk.edu |