Home > Faculty & Research > Faculty > Greg E. Lemke

Faculty

Greg E. Lemke

Professor
Molecular Neurobiology Laboratory

Our laboratory is interested in the signal transduction molecules that mediate cellular interactions during development of the mammalian nervous and immune system. We employ several experimental models, most of them in the mouse, which exploit both cell culture and molecular genetics.

Over the last several years, we have focused in particular on three receptor protein-tyrosine kinase signaling systems: the ErbB receptors and their ligands of the neuregulin family, the Eph receptors and their ephrin ligands, and the Tyro 3 family receptors and their ligands Gas6 and protein S. We have investigated the roles that these proteins play in neural and immune development by engineering and then analyzing knock-out and knock-in mutations in their corresponding genes in the chick and mouse.

Education

B.S., Life Sciences, Massachusetts Institute of Technology
Ph.D., Biology, California Institute of Technology
Postdoctoral fellowship, Columbia University

Awards and Honors

AAAS Fellow, 2008
Javits Neuroscience Investigator Award, 1994-2001
Rita Allen Scholars award, 1990-1995
Pew Scholar Award, 1986-1990
Basil O'Connor Starter Scholar Award, March of Dimes, 1987-1989

Selected Publications

Rothlin, C.V., Ghosh, S., Zuniga, E., Oldstone, M.B.A., and Lemke, G. (2007) TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131: 1124-1136.
Kim, J. W. and Lemke, G. (2006) Hedgehog-regulated localization of Vax2 control eye development. Genes and Development 20: 2833-2847.
Caraux, A., Lu, Q., Fernandez, N., Di Santo, J.P., Raulet, D.H., Lemke, G., and Roth, C. (2006) Receptor tyrosine kinases of the Tyro 3 Family play a critical role in Natural Killer cell differentiation. Nature Immunology 7: 747-754.
Reber, M., Burrola, P. and Lemke, G. (2004) A relative signaling model for the formation of a topographic neural map. Nature 431:847-853.
Lu, Q. and Lemke, G. (2001) Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 293: 306-311.
Brown, A., Yates, P.A., Burrola, P., Ortuno, D., Vaidya, A., Jessell, T.M., Pfaff, S.L., O'Leary, D.D. and Lemke G. (2000) Topographic mapping from the retina to the midbrain is controlled by relative but not absolute levels of EphA receptor signaling. Cell 102:77-88.
Lu, Q., Gore, M., Zhang, Q., Camenisch, T., Boast, S., Casagrande, F., Lai, C. Skinner, M., Klein, R., Matsushima, G.K., Earp, H.S., Goff, S. P. and Lemke, G. (1999) Receptor tyrosine kinases of the Tyro 3 family are essential regulators of mammalian spermatogenesis. Nature 398:723-728.

Salk News Releases

Bone marrow cells hand natural killer cells their license to attack dangerous invaders, June 5, 2006
Molecular "trip switch" shuts down inflammatory response, December 13, 2007
Three Salk scientists named 2007 AAAS Fellows, November 5, 2007
Vax and Pax: taking turns to build an eye, October 16, 2006
Bone marrow cells hand natural killer cells their license to attack dangerous invaders, June 5, 2006
Unrestrained retina too much of a good thing, May 15, 2005
Salk Scientists Provide New Mouse Model For Autoimmunity, July 12, 2001