Clodagh O’Shea


Molecular and Cell Biology Laboratory

Howard Hughes Medical Institute Faculty Scholar

Salk Institute for Biological Studies - Publications


Ou, H.d., Phan, S., Deerinck, T.J., Thor, A., Ellisman, M.H., O'Shea, C.C. (2017) ChromEMT: Visualizing 3D chromatin structure and compaction of the human genome in interphase and mitotic cells. Science [Cover Article].

Shah, G. and O’Shea, C.C. (2015) Viral and Cellular Genomes Activate Distinct DNA Damage Responses. Cell, 162 (5), 987-1002.

Higginbotham, J.M. and O’Shea, C.C. (2015) Adenovirus E4-ORF3 targets PIAS3 and together with E1B-55K remodels SUMO interactions in the nucleus and at virus genome replication domain. Journal of Virology, 89 (20) 10260-72. [Cover Article].

Heimbucher, T., Liu, Z., Bossard, C., McCloskey, R., Carrano, A.C., Riedel, C.G., Tanasa, B., Klammt, C., Fonslow, B.R., Riera, C.E., Lillemeier, B., Kemphues, K., Yates, J.R., O'Shea, C., Hunter, T. and Dillin, A. (2015) The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity. Cell Metabolism, 22 (1), 151–163.

Ou H.D., Deerinck T.J., Bushong E., Ellisman M.H. and O’Shea, C.C. (2015) Visualizing viral protein structures in cells using genetic probes for correlated light and electron microscopy. Methods, (90) 39-48. [Cover Article].

Miyake-Stoner, S.J. and O'Shea, C.C. (2014) Metabolism goes viral. Cell Metab 19:549-550.

Ou, H.D., Kwiatkowski, W., Deerinck, T.J., Noske, A., Blain, K.Y., Land, H.S., Soria, C., Powers, C.J., May, A.P., Shu, X., Tsien, R.Y., Fitzpatrick, J.A.J., Long, J.A., Ellisman, M.H., Choe, S. and O'Shea, C.C. (2012) A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors. Cell 151:304-19.

Soria, C., Estermann, F., Espantman, K.E. and O'Shea, C.C. (2010). Heterochromatin silencing of p53 target genes by a small viral protein. Nature, 466, 1076-81.

Ou, H. May, A.P. and O'Shea, C. C. (2010). The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication. WIREs Systems Biology and Medicine (DOI: 10.1002/wsbm.88).

Espantman, K.C. and O'Shea, C.C. (2010) aMAGEing new players enter the RING to promote ubiquitylation. Mol Cell 39:835-837

Iacovides, D., O'Shea, C.C., Oses-Prieto, J., Burlingame, A. and McCormick, F. (2007) Critical role for arginine methylation in adenovirus-infected cells. J Virol 81:13209-13217.

Ringshausen, I., O'Shea, C.C., Finch, A.J., Brown Swigart, L., and Evan, G.I. (2006). Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell 10(6), 501-514.

O'Shea, C.C. (2005). Viruses: tools for tumor target discovery and agents for lytic cancer therapies - an introduction. Oncogene 24, 7636-7639.

O'Shea, C.C. (2005). Viruses- seeking and destroying the tumor program. Oncogene 24, 7640-7655.

O'Shea, C. C., Soria, C., Bagus, B., and McCormick, F. (2005). Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy. Cancer Cell 8 (1), 61-74. (Cover Article).

O'Shea, C. C., Choi, S., McCormick, F., and Stokoe, D. (2005). Adenovirus overrides cellular checkpoints for protein translation. Cell Cycle 4 (7), 883-888.

O'Shea, C. C., Klupsch, K., Choi, S., Bagus, B., Soria, C., Shen, J., McCormick, F., and Stokoe, D. (2005).Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. Embo Journal 24, 1211-1221.

O'Shea, C. C., and Fried, M. (2005). Modulation of the ARF-p53 pathway by the small DNA tumor viruses. Cell Cycle 4 (3), 449-452.

O'Shea, C. C. (2005). DNA tumor viruses - the spies who lyse us. Current Opinion in Genetics and Development 15, 18-26.

O'Shea, C. C., Johnson, L., Bagus, B., Choi, S., Nicholas, C., Shen, A., Boyle, L., Pandey, K., Soria, C., Kunich, J., Shen, Y., Habets, G., Ginzinger, D., McCormick, F. (2004). Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell 6, 611-623.


BS, Biochemistry and Microbiology, University College Cork, Ireland
PhD, Imperial College London/Imperial Cancer Research Fund, U.K.
Postdoctoral Fellow, UCSF Comprehensive Cancer Center, San Francisco, U.S.A

Awards & Honors

  • 2016 Howard Hughes Medical Institute Faculty Scholar
  • 2014 W. M. Keck Medical Research Program Award
  • 2014 Rose Hills Fellow
  • 2011Science/NSF International Science & Visualization Challenge, People's Choice
  • 2011 Anna Fuller Award for Cancer Research
  • 2010, 2011, 2012 Kavli Frontiers Fellow, National Academy of Sciences
  • 2009 Sontag Distinguished Scientist Award
  • 2009 American Cancer Society Research Scholar Award
  • 2008 ACGT Young Investigator Award for Cancer Gene Therapy
  • 2008 Arnold and Mabel Beckman Young Investigator Award
  • 2008 William Scandling Assistant Professor, Developmental Chair
  • 2007 Emerald Foundation Scholar