La Jolla, CA – Come summer, we will once again marvel at the amazing athletic skills of Olympic athletes while in fact, the simple act of walking is no less remarkable. Just to prevent us from toppling over, the neuromuscular circuitry that controls all bodily movements relies on constant sensory feedback from the periphery to fine-tune its commands to hundreds of muscles.
La Jolla, CA – The Salk Institute announced today that Irwin and Joan Jacobs have established a $10 million matching fund to support the creation of 10 Senior Scientist Endowed Chairs. By providing a match, this fund enables 10 donors to each make a gift of $2 million to create and name a highly prestigious and permanent chair. The Irwin and Joan Jacobs Leadership Challenge will add a $1 million match to each gift, thus providing each Chair with a $3 million endowment. Each named chair will provide key support to a Salk Institute Senior scientist.
La Jolla, CA – Those spindly plants that desperately try to reach for a break in the canopy formed by larger plants all suffer from the same affliction: Shade avoidance syndrome or SAS. Now, the molecular details of SAS have been brought to light by researchers at the Salk Institute for Biological Studies.
La Jolla, CA – Dr. Clodagh O’Shea, an assistant professor in the Molecular and Cellular Biology Laboratory at the Salk Institute for Biological Studies, has been selected for the 2007 Young Investigator’s Award in Gene Therapy for Cancer. She will receive $500,000 over a three-year period to develop the “next generation oncolytic adenoviruses for p53-selective tumor therapy.”
La Jolla, CA – The fifth annual Pearl Meister Greengard Prize, an international award to recognize outstanding women scientists, has been awarded to Salk professor 维姬·伦德布拉德, Ph.D., for her groundbreaking work in telomere biology.
La Jolla, CA – A team of scientists at the Salk Institute for Biological Studies has discovered that the roundworm C. elegans constructs the protective tips of its chromosomes – known as telomeres – with a little more panache than do mammals, a finding that could deepen our understanding of the interrelationship of aging and cancer.
La Jolla, CA – Continually revved up insulin production, the kind that results from overeating and obesity, slowly dulls the body’s response to insulin. As a result, blood sugar levels start to creep up, setting the stage for diabetes-associated complications such as blindness, stroke and renal failure. To make matters even worse, chronically elevated blood sugar concentrations exacerbate insulin resistance.
加拉谷，加利福尼亚州——根据索尔克生物研究所和哈佛大学公共卫生学院科学家的新研究，一种以控制细胞燃烧脂肪的能力而闻名的核受体蛋白，在动脉中也具有强大的抗炎作用，可抑制易患有害斑块的小鼠的动脉粥样硬化。.
拉霍亚，加利福尼亚州 – 相当长一段时间以来，科学家们一直怀疑所谓的己糖胺通路——细胞内主要糖代谢途径的一个小分支——与胰岛素抵抗的发展有关。但他们一直未能精确地找出其潜在机制。.
La Jolla, CA – The editors of the 美国国家科学院院刊 (PNAS) selected the article “Targeted delivery of proteins across the blood-brain barrier” by Brian J. Spencer, Ph.D. and Inder M. Verma, Ph.D., for the 2007 Cozzarelli Prize, which recognizes papers that reflect the highest standards of scientific excellence and originality.
拉霍亚，加利福尼亚州 塔季扬娜·沙尔佩, an assistant professor in the Laboratory for Computational Biology, has been named an Alfred P. Sloan Research Fellow. She will receive a grant of $50,000 for a two-year period.
La Jolla, CA – Controlled by a tightly regulated choreography that determines what should go up and what should go down, plants develop along a polar axis with a root on one end and a shoot on the other.
La Jolla, CA – The Vilcek Foundation has named Salk professor Dr. 英德·维尔马 as the recipient of its 2008 prize in biomedical science. The honor is awarded annually to foreign-born individuals for their extraordinary contributions to society in the United States.
加州拉霍亚——在体力与脑力锻炼的促进下，神经干细胞在一生中会持续产生新的神经元，但这些新生的神经元的确切功能一直是争论的焦点。通过移除一个维持神经干细胞增殖状态的基因主控开关，索尔克生物研究所的研究人员终于获得了一些确切的答案。.
La Jolla, CA – A gift of $11.5 million has been received on behalf of the Nomis Foundation, a European foundation being established by G.H. “Heini” Thyssen, a long-time friend and Trustee of the Salk Institute, to fund appointments for new investigators specialized in microbial pathogenesis and viral and cellular immunology. The gift, which will launch the Immunobiology and Microbial Pathogenesis program, fulfills a critical component of the Institute’s strategic scientific plan.
La Jolla, CA – Ipsen (Euronext:FR0010259150; IPN) and the Salk Institute for Biological Studies announced today that they will be signing a memorandum of understanding setting the framework for the creation of the Ipsen Life Sciences Program at the Salk Institute. The mission of the partnership is to advance knowledge in the field of proliferative and degenerative diseases through fundamental and applied biology research.
La Jolla, CA – Early stage breast cancer that has not yet invaded the surrounding tissues may already contain highly motile cells, which brings the tumor one step closer to metastasis, report researchers at the Salk Institute for Biological Studies.
La Jolla, CA – Cells keep a close watch over the transcriptome – the totality of all parts of the genome that are expressed in any given cell at any given time. Researchers at the Salk Institute for Biological Studies and the University of Missouri-Kansas City teamed up to peel back another layer of transcriptional regulation and gain new insight into how genomes work.
