Regulatory Biology Laboratory
Edwin K. Hunter Chair
Peña-Hernández et al., 2015. Genome wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I. Proc. Natl. Acad. Sci. USA, 112(7): E677-86.
Lee et al., 2014. Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing. Proc. Natl. Acad. Sci. USA 111(44): E4726-35.
Krawczyk, M. and Emerson, B.M. 2014. p50-Associated COX-2 Extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-kB complexes. eLife 10.7554/eLife.01776.
Lopez-Diaz, F.J., Gascard, P., Balakrishnan S., Zhao, J., del Rincon, S.V., Spruck, C., Tlsty, T.D., and Emerson, B.M. 2013. Coordinate transcriptional and translational repression of p53 by TGF-β1 impairs the stress response. Molecular Cell 50: 552-564.
Morachis J.M., Huang, R., and Emerson, B.M. 2011. Identification of kinase inhibitors that target transcription initiation by RNA polymerase II. Oncotarget 2:18-28.
Lambert, G., Estevez-Salmeron, L., Oh, S., Liao, D., Emerson, B.M., Tlsty, T.D., and Austin, R.H. 2011. An analogy between the evolution of drug resistance in bacterial communities and malignant tissues. Nature Reviews Cancer 11: 375-382.
Morachis, J.M., Murawsky, C.M., and Emerson, B.M. 2010. Regulation of the p53 transcriptional response by tructurally diverse core promoters Genes Dev 24(2): 135-47.
Witcher, M., and Emerson, B.M. 2009. Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary. Molecular Cell 34: 271-84.
Kaeser, M. D., Asianian, A., Dong, M. Q. Yates, J. R. 3rd, and Emerson, B.M. 2008. BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells. J.Biol. Chem. 283: 32254-63.
Kaeser, M.D. and Emerson, B.M. 2006. Remodeling plans for cellular specialization: unique styles for every room. In Current Opinion in Genetics and Development, V. Pirrotta and M. van Lohuizen, eds. 16: 508-512.
Gomes, N.P., Bjerke, G., Llorente, B., Szostek, S.A., Emerson, B.M., and Espinosa, J.M. 2006. Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes Dev. 20: 601-612.
Espinosa, J.M., Verdun, R.E., and Emerson, B.M. 2003. p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage. Molecular Cell 12: 1015-1027.
Kadam, S. and Emerson, B.M. 2003. Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes. Molecular Cell 11: 377-389.
Emerson, B.M. 2002. Specificity of gene regulation. Cell 109: 267-270.
Kadam, S. and Emerson, B.M. 2002. Mechanisms of chromatin assembly and transcription. In Current Opinion in Cell Biology, A. Lamond and S. Gasser, eds.14 (3): 262-268.
Espinosa, J.M. and Emerson, B.M. 2001. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed co-factor recruitment. Molecular Cell. 8: 57-69.
Xu, W., Chen, H., Tini, M., Montminy, M., Emerson, B.M., and Evans, R.M. 2001. A transcriptional switch mediated by co-factor methylation. Science 294: 2507-2511.
Kadam, S., McAlpine, G.S., Phelan, M.L., Kingston, R.E., Jones, K.A. and Emerson, B.M. 2000. Functional selectivity of mammalian SWI/SNF subunits. Genes Dev. 14: 2441-2451.
BA, Biology, University of California, San Diego
PhD, Molecular Biology, Washington University
Postdoctoral Fellow, National Institutes of Health