LA JOLLA, CA—The National Institutes of Health (NIH) has selected 阿克塞尔·尼默雅恩 for a highly competitive EUREKA (Exceptional Unconventional Research Enabling Knowledge Acceleration) grant. Nimmerjahn is an Assistant Professor in the 韦特先进生物光子学中心 and holds the Richard Allan Barry Developmental Chair. The award, in the amount of $1.38M over four years, will support Nimmerjahn’s goal of better understanding the relationship between spinal cord physiology and brain activity and behavior. Data from this research should foster development of new treatment and rehabilitation strategies for spinal cord injury, tumors, infections, and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular dystrophy.
LA JOLLA, CA—The Board of Trustees of the Salk Institute is pleased to announce the election of Elizabeth Keadle as its newest member.
LA JOLLA, CA—The Salk Institute for Biological Studies announced the hiring of Anna-Marie Rooney as its Chief Communications Officer, to oversee all aspects of the world-renowned Institute’s communications efforts including strategy, print publications, media relations, electronic/web communications, social media outreach, and multimedia resources.
LA JOLLA, CA—The Juvenile Diabetes Research Foundation (JDRF) has given Salk scientist Mark Huising a five-year, $750,000 Career Development Award for his proposed study on how a novel network of receptors in human islets receives and integrates molecular signals. In pre-clinical models, activation of these receptors has proven to actually prevent diabetes. Career Development Awards are highly competitive and bestowed upon only a handful of people each year.
LA JOLLA,CA—In the past few years, as imaging tools and techniques have improved, scientists have been working tirelessly to build a detailed map of neural connections in the human brain—with the ultimate hope of understanding how the mind works.
LA JOLLA, CA—Salk scientist 塔季扬娜·沙尔佩 has received a CAREER award from the National Science Foundation (NSF) to fund upcoming research in her lab. The CAREER award supports faculty who exemplify the role of teacher-scholars through outstanding research, excellent education and the integration of education and research within the context of the mission of their organizations.
拉霍亚，加利福尼亚州—Alzheimer’s disease affects more than 26 million people worldwide. It is predicted to skyrocket as boomers age—nearly 106 million people are projected to have the disease by 2050. Fortunately, scientists are making progress towards therapies. A collaboration among several research entities, including the Salk Institute and the Sanford-Burnham Medical Research Institute, has defined a key mechanism behind the disease’s progress, giving hope that a newly modified Alzheimer’s drug will be effective.
LA JOLLA, CA—Proteins are the chief actors in cells, carrying out the duties specified by information encoded in our genes. Most proteins live only two days or less, ensuring that those damaged by inevitable chemical modifications are replaced with new functional copies.
LA JOLLA, CA—Schizophrenia is one of the most devastating neurological conditions, with only 30 percent of sufferers ever experiencing full recovery. While current medications can control most psychotic symptoms, their side effects can leave individuals so severely impaired that the disease ranks among the top ten causes of disability in developed countries.
LA JOLLA, CA—For many migraine sufferers, bright lights are a surefire way to exacerbate their headaches. And for some night-shift workers, just a stroll through a brightly lit parking lot during the morning commute home can be enough to throw off their body’s daily rhythms and make daytime sleep nearly impossible. But a new molecule that selectively blocks specialized light-sensitive receptors in the eyes could help both these groups of people, without affecting normal vision according to a study published August 25, 2013 in Nature Chemical Biology.
LA JOLLA, CA—Researchers at the Salk Institute for Biological Studies have discovered a powerful mechanism by which viruses such as influenza, West Nile and Dengue evade the body’s immune response and infect humans with these potentially deadly diseases. The findings may provide scientists with an attractive target for novel antiviral therapies.
LA JOLLA, CA—Proteins are the workhorses of cells, adopting conformations that allow them to set off chemical reactions, send signals and transport materials. But when a scientist is designing a new drug, trying to visualize the processes inside cells, or probe how molecules interact with each other, they can’t always find a protein that will do the job they want. Instead, they often engineer their own novel proteins to use in experiments, either from scratch or by altering existing molecules.
拉霍亚，加利福尼亚州——每年有超过 11,000 名美国人遭受脊髓损伤，其中超过四分之一的损伤是由于跌倒造成的，随着人口老龄化，这一数字可能会上升。脊髓损伤之所以如此多且永久致残，是因为人体缺乏再生神经纤维的能力。我们身体所能做的最好的就是将幸存的组织绕过损伤部位。.
LA JOLLA,CA—丹尼斯·奥利里 of the Salk Institute was the first scientist to show that the basic functional architecture of the cortex, the largest part of the human brain, was genetically determined during development. But as it so often does in science, answering one question opened up many others. O’Leary wondered what if the layout of the cortex wasn’t fixed? What would happen if it were changed?
LA JOLLA,CA—The Salk Institute received a record-setting $93 million from individuals, foundations and corporate donors during fiscal year 2012 to support the Campaign for Salk, the Institute’s first major fundraising campaign.
LA JOLLA, CA—Stem cells are key to the promise of regenerative medicine: the repair or replacement of injured tissues with custom grown substitutes. Essential to this process are induced pluripotent stem cells (iPSCs), which can be created from a patient’s own tissues, thus eliminating the risk of immune rejection. However, Shinya Yamanaka’s formula for iPSCs, for which he was awarded last year’s Nobel Prize, uses a strict recipe that allows for limited variations in human cells, restricting their full potential for clinical application.
LA JOLLA,CA—A team of scientists at the Salk Institute for Biological Studies has identified why disruption of a vital pathway in cell cycle control leads to the proliferation of cancer cells. Their findings on telomeres, the stretches of DNA at the ends of chromosomes that protect our genetic code and make it possible for cells to divide, suggest a potential target for preventive measures against cancer, aging and other diseases. The findings were published July 11, 2013 in Molecular Cell.
LA JOLLA,CA—Scientists studying cancer development have known about micronuclei
for some time. These erratic, small extra nuclei, which contain fragments, or whole
chromosomes that were not incorporated into daughter cells after cell division,
are associated with specific forms of cancer and are predictive of poorer prognosis.
LA JOLLA,CA—Tickets are now available online for the 18th annual “Symphony at Salk-a concert under the stars” featuring multi-talented
singer Katharine McPhee who will perform at the Institute on August 24 with the
San Diego Symphony 和
acclaimed guest conductor Maestro Thomas Wilkins.
加拉霍亚，加利福尼亚州——表观基因组的变化，包括 DNA 的化学修饰，可以作为基因组中的额外信息层，并被认为在学习和记忆以及与年龄相关的认知能力下降中起作用。美国索尔克生物学研究所科学家的一项新研究结果表明，DNA 甲基化（一种特殊的表观基因组修饰）的景观在从出生到成年的过渡过程中，在大脑细胞中具有高度动态性，有助于理解大脑细胞基因组中的信息是如何从胎儿发育到成年的。大脑比身体所有其他器官都要复杂得多，这一发现为更深入地了解大脑中复杂的连接模式是如何形成的打开了大门。.
