Salk Institute promotes three top scientists

April 12, 2013

Salk Institute promotes three top scientists

April 12, 2013

LA JOLLA, CA—The Salk Institute is pleased to announce the promotions of faculty members, John Reynolds to the rank of full professor and Clodagh O’Shea and Tatyana Sharpee to associate professors based on recommendations by the Salk faculty and nonresident fellows, and approved by President William R. Brody and the Institute’s Board of Trustees.

“It is especially gratifying to be able to award these promotions to such an excellent group of scientists,” says Brody. “This is well deserved acknowledgment of all they have accomplished as scientific leaders and innovative researchers in their respective fields. On behalf of the Salk community, I extend to each of them our congratulations.”

约翰·雷诺兹 who conducts his research in the Systems Neurobiology Laboratories, explores the fundamental nature of the computations that are carried out by the neocortex, including those that enable us to attend to sensory stimuli. He seeks to understand how and why these computations fail in brain disease—research that is essential to developing treatments for disorders in which attention and vision are impaired, such as visual agnosia, Balint’s Syndrome, visual neglect, attentional aspects of autism, schizophrenia and Alzheimer’s Disease. The long-range goal of Reynolds’s laboratory is to understand the neural mechanisms of selective visual attention at the level of the individual neuron and the cortical circuit, and to relate these to perception and conscious awareness.

Clodagh O’Shea of the Molecular and Cell Biology Laboratory and holder of the William Scandling Developmental Chair, is an expert on oncolytic viruses – viruses that can only reproduce in cancer cells. Such viruses offer a novel and potentially self-perpetuating cancer therapy: Each time a virus infects a cancer cell and successfully multiplies, the virus ultimately kills the cancer cell by bursting it open to release thousands of viral progenies. The next generation seeks out remaining tumor cells and distant micro-metastases but leaves normal cells unharmed. O’Shea is at the forefront of this cutting edge technology and her lab has developed a new generation of the engineered adenovirus to more effectively seek out and rupture cancer cells, while leaving healthy cells intact. Her lab is also working in parallel on other multi-pronged strategies ranging from arming tumor-seeking viruses with toxic proteins to re-engineering their outer “coat” so they can home in on tissue-specific targets.

塔季扬娜·沙尔佩 of the Computational Neurobiology Laboratory studies how the brain operates in a natural sensory environment. She works on theoretical principles of how the brain processes information and examines how sensory processing is shaped by the need to create parsimonious representations of events in the outside world. Using methods from physics and information theory, Sharpee and her colleagues are developing statistical methods that can help identify how the brain can rapidly recognize objects despite variations in their position relative to us. This work may eventually lead to better prostheses for patients whose object recognition has been impaired as a result of a stroke or neurodegenerative diseases.

关于索尔克生物研究所：

索尔克生物研究所是世界顶尖的基础研究机构之一，其国际知名的教职人员在一个独特、协作和富有创造性的环境中，深入探究生命科学的基本问题。索尔克科学家们致力于发现和指导未来几代研究人员，通过研究神经科学、遗传学、细胞和植物生物学以及相关学科，在癌症、衰老、阿尔茨海默氏症、糖尿病和传染病的认识方面做出了开创性的贡献。.

学院取得了许多成就，获得了包括诺贝尔奖和美国国家科学院院士在内的无数荣誉。该研究所由脊髓灰质炎疫苗先驱 Jonas Salk 博士于 1960 年创立，是一家独立的非营利组织和建筑地标。.