LA JOLLA, CA—The well-being of living cells requires specialized squads of proteins that maintain order. Degraders chew up worn-out proteins, recyclers wrap up damaged organelles, and-most importantly-DNA repair crews restitch anything that resembles a broken chromosome. If repair is impossible, the crew foreman calls in executioners to annihilate a cell. As unsavory as this last bunch sounds, failure to summon them is one aspect of what makes a cancer cell a cancer cell.
LA JOLLA, CA—A single injection of cocaine or methamphetamine in mice caused their brains to put the brakes on neurons that generate sensations of pleasure, and these cellular changes lasted for at least a week, according to research by scientists at the Salk Institute for Biological Studies.
LA JOLLA, CA—Renato Dulbecco, M.D., Nobel Prize winner and a global leader in cancer research passed away February 19 at his home in La Jolla. Born on February 22, 1914, he was just shy of his 98th birthday.
LA JOLLA,CA—Drugs targeting an enzyme involved in inflammation might offer a new avenue for treating certain lung cancers, according to a new study by scientists at the Salk Institute for Biological Studies.
LA JOLLA, CA—Researchers at the Salk Institute have discovered a startling feature of early brain development that helps to explain how complex neuron wiring patterns are programmed using just a handful of critical genes. The findings, published in Célula, may help scientists develop new therapies for neurological disorders, such as amyotrophic lateral sclerosis (ALS), and provide insight into certain cancers.
LA JOLLA, CA—Reviving a theory first proposed in the late 1800s that the development of organs in the normal embryo and the development of cancers are related, scientists at the Salk Institute for Biological Studies have studied organ development in mice to unravel how breast cancers, and perhaps other cancers, develop in people. Their findings provide new ways to predict and personalize the diagnosis and treatment of cancer.
LA JOLLA, CA—Uno de los grandes misterios de la biología es por qué las células envejecen. Ahora, científicos del Instituto Salk de Estudios Biológicos informan que han descubierto una debilidad en un componente de las células cerebrales que podría explicar cómo ocurre el proceso de envejecimiento en el cerebro.
LA JOLLA, CA—Lora B. Sweeney, a postdoctoral researcher at the Salk Institute for Biological Studies has been named a Damon Runyon Fellow.
LA JOLLA, CA—The Genetics Society of America(GSA) has honored Joanne Chory, Salk Institute professor and director of the Plant Molecular and Cellular Biology Laboratory and Howard H. and Maryam R. Newman Chair in Plant Biology, as the recipient of the prestigious 2012 Genetics Society of America Medal.
LA JOLLA, CA—Salk Institute scientist Ronald Evans has been selected as the recipient of the prestigious 2012 Wolf Prize in Medicine, Israel’s highest award for achievements benefiting mankind. According to the Wolf Prize jury, Evans was selected for his discovery of the gene super-family encoding nuclear receptors and elucidating the mechanism of action of this class of receptors.
LA JOLLA, CA—Scientists at the Salk Institute for Biological Studies have identified a gene that tells cells to develop multiple cilia, tiny hair-like structures that move fluids through the lungs and brain. The finding may help scientists generate new therapies that use stem cells to replace damaged tissues in the lung and other organs.
LA JOLLA, CA—Dr. Wylie Vale, a Salk Institute professor and world-renowned expert on brain hormones, died January 3 while on vacation in Hana, Hawaii. He was 70 years old.
LA JOLLA, CA—There’s a 3-D world in our brains. It’s a landscape that mimics the outside world, where the objects we see exist as collections of neural circuits and electrical impulses.
LA JOLLA, CA—Científicos descubrieron un eslabón perdido entre el reloj biológico del cuerpo y el sistema de metabolismo del azúcar, un hallazgo que podría ayudar a evitar los graves efectos secundarios de los medicamentos utilizados para tratar el asma, las alergias y la artritis.
LA JOLLA, CA—Un nuevo candidato a fármaco podría ser el primero capaz de detener el devastador deterioro mental de la enfermedad de Alzheimer, según los hallazgos de un estudio publicado en PLoS ONE.
LA JOLLA, CA—Investigadores del Instituto Salk de Estudios Biológicos han desarrollado una forma de utilizar las propias células de los pacientes para curar potencialmente la anemia falciforme y muchos otros trastornos causados por mutaciones en un gen que ayuda a producir hemoglobina en la sangre.
LA JOLLA, CA—Un equipo internacional de científicos ha creado ratones y gusanos superfuertes y de alta resistencia suprimiendo un inhibidor natural del crecimiento muscular, lo que sugiere que los tratamientos para la degeneración muscular relacionada con la edad o la genética están al alcance.
LA JOLLA, CA—El Instituto Salk se complace en anunciar el nombramiento de cinco miembros del profesorado que recibirán cátedras dotadas establecidas por líderes filantrópicos en apoyo de la investigación científica.
LA JOLLA, CA—Una de las pocas formas fiables de extender la vida de un organismo, ya sea una mosca de la fruta o un ratón, es restringir la ingesta de calorías. Ahora, un nuevo estudio en moscas de la fruta está ayudando a explicar por qué tales dietas mínimas están relacionadas con la longevidad y ofreciendo pistas sobre los efectos del envejecimiento en el comportamiento de las células madre.
LA JOLLA, CA—Una nueva clase de medicamentos antiinflamatorios puede servir algún día como alternativa a los esteroides de uso médico y, posiblemente, ayudar a evitar los graves efectos secundarios de los esteroides, basándose en los hallazgos de la investigación en el Instituto Salk de Estudios Biológicos.
