Clodagh O’Shea, PhD

教授

分子与细胞生物学实验室

Howard Hughes Medical Institute Faculty Scholar

Wicklow Chair

索尔克生物研究所 出版物

所有出版物


Dekker, J., Belmont, A.S., Guttman, M., Leshyk, V.O., Lis, J.T., Lomvardas, S., Mirny, L.A., O'Shea, C.C., Park, P.J., Ren, B., Politz, J.C.R., Shendure, J., Zhong, S. Corrigendum: The 4D nucleome project. (2017) 自然. DOI: 10.1038/nature24667

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Dekker, J., Belmont, A.S., Guttman, M., Leshyk, V.O., Lis, J.T., Lomvardas, S., Mirny, L.A., O'Shea, C.C., Park, P.J., Ren, B., Politz, J.C.R., Shendure, J., Zhong, S., 4D Nucleome Network The 4D nucleome project. (2017) 自然. 549(7671):219-226. DOI: 10.1038/nature23884

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Ou, H.D., Phan, S., Deerinck, T.J., Thor, A., Ellisman, M.H., O'Shea, C.C. ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells. (2017) 科学. 357(6349). DOI: 10.1126/science.aag0025

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Tufail, Y., Cook, D., Fourgeaud, L., Powers, C.J., Merten, K., Clark, C.L., Hoffman, E., Ngo, A., Sekiguchi, K.J., O'Shea, C.C., Lemke, G., Nimmerjahn, A. Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia. (2017) 神经元. 93(3):574-586.e8. DOI: 10.1016/j.neuron.2016.12.021

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Ou, H.D., Deerinck, T.J., Bushong, E., Ellisman, M.H., O'Shea, C.C. Visualizing viral protein structures in cells using genetic probes for correlated light and electron microscopy. (2015) Methods. 90:39-48. DOI: 10.1016/j.ymeth.2015.06.002

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Higginbotham, J.M., O'Shea, C.C. Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains. (2015) 病毒学杂志. 89(20):10260-72. DOI: 10.1128/JVI.01091-15

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Shah, G.A., O'Shea, C.C. Viral and Cellular Genomes Activate Distinct DNA Damage Responses. (2015) 牢房. 162(5):987-1002. DOI: 10.1016/j.cell.2015.07.058

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Heimbucher, T., Liu, Z., Bossard, C., McCloskey, R., Carrano, A.C., Riedel, C.G., Tanasa, B., Klammt, C., Fonslow, B.R., Riera, C.E., Lillemeier, B.F., Kemphues, K., Yates, J.R., O'Shea, C.C., Hunter, T., Dillin, A. The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity. (2015) Cell Metabolism. 22(1):151-63. DOI: 10.1016/j.cmet.2015.06.002

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Miyake-Stoner, S.J., O'Shea, C.C. Metabolism goes viral. (2014) Cell Metabolism. 19(4):549-50. DOI: 10.1016/j.cmet.2014.03.022

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Ou, H.D., Kwiatkowski, W., Deerinck, T.J., Noske, A., Blain, K.Y., Land, H.S., Soria, C., Powers, C.J., May, A.P., Shu, X., Tsien, R.Y., Fitzpatrick, J.A., Long, J.A., Ellisman, M.H., Choe, S., O'Shea, C.C. A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors. (2012) 牢房. 151(2):304-19. DOI: 10.1016/j.cell.2012.08.035

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Ou, H.D., May, A.P., O'Shea, C.C. The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication. (2011) Wiley Interdisciplinary Reviews. Systems biology and Medicine. 3(1):48-73. DOI: 10.1002/wsbm.88

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Espantman, K.C., O'Shea, C.C. aMAGEing new players enter the RING to promote ubiquitylation. (2010) 分子细胞. 39(6):835-7. DOI: 10.1016/j.molcel.2010.09.006

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Soria, C., Estermann, F.E., Espantman, K.C., O'Shea, C.C. Heterochromatin silencing of p53 target genes by a small viral protein. (2010) 自然. 466(7310):1076-81. DOI: 10.1038/nature09307

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Iacovides, D.C., OShea, C.C., Oses-Prieto, J., Burlingame, A., McCormick, F. Critical role for arginine methylation in adenovirus-infected cells. (2007) 病毒学杂志. 81(23):13209-17. DOI: 10.1128/JVI.01415-06

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Ringshausen, I., O'Shea, C.C., Finch, A.J., Swigart, L.B., Evan, G.I. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. (2006) Cancer Cell. 10(6):501-14. DOI: 10.1016/j.ccr.2006.10.010

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O'Shea, C.C. Viruses - seeking and destroying the tumor program. (2005) 癌基因. 24(52):7640-55. DOI: 10.1038/sj.onc.1209047

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O'Shea, C.C. Viruses: tools for tumor target discovery, and agents for oncolytic therapies - an introduction. (2005) 癌基因. 24(52):7636-9. DOI: 10.1038/sj.onc.1209035


O'Shea, C.C., Soria, C., Bagus, B., McCormick, F. Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy. (2005) Cancer Cell. 8(1):61-74. DOI: 10.1016/j.ccr.2005.06.009

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O'Shea, C.C., Choi, S., McCormick, F., Stokoe, D. Adenovirus overrides cellular checkpoints for protein translation. (2005) Cell Cycle. 4(7):883-8. DOI: 10.4161/cc.4.7.1791

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O'Shea, C., Klupsch, K., Choi, S., Bagus, B., Soria, C., Shen, J., McCormick, F., Stokoe, D. Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. (2005) EMBO 期刊. 24(6):1211-21. DOI: 10.1038/sj.emboj.7600597

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O'Shea, C.C., Fried, M. Modulation of the ARF-p53 pathway by the small DNA tumor viruses. (2005) Cell Cycle. 4(3):449-52. DOI: 10.4161/cc.4.3.1555

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O'Shea, C.C. DNA tumor viruses -- the spies who lyse us. (2005) 遗传与发育意见。. 15(1):18-26. DOI: 10.1016/j.gde.2004.12.010

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O'Shea, C.C., Johnson, L., Bagus, B., Choi, S., Nicholas, C., Shen, A., Boyle, L., Pandey, K., Soria, C., Kunich, J., Shen, Y., Habets, G., Ginzinger, D., McCormick, F. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. (2004) Cancer Cell. 6(6):611-23. DOI: 10.1016/j.ccr.2004.11.012

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O'Shea, C.C., Crompton, T., Rosewell, I.R., Hayday, A.C., Owen, M.J. Raf regulates positive selection. (1996) European Journal of Immunology. 26(10):2350-5. DOI: 10.1002/eji.1830261012

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教育

BS, Biochemistry and Microbiology, University College Cork, Ireland
PhD, Imperial College London/Imperial Cancer Research Fund, U.K.
Postdoctoral Fellow, UCSF Comprehensive Cancer Center, San Francisco, U.S.A


奖项与荣誉

  • 2018 Allen Distinguished Investigator Award
  • 2016 Howard Hughes Medical Institute Faculty Scholar
  • 2014 W. M. Keck Medical Research Program Award
  • 2014 Rose Hills Fellow
  • 2011Science/NSF International Science & Visualization Challenge, People's Choice
  • 2011 Anna Fuller Award for Cancer Research
  • 2010, 2011, 2012 Kavli Frontiers Fellow, National Academy of Sciences
  • 2009 Sontag Distinguished Scientist Award
  • 2009 American Cancer Society Research Scholar Award
  • 2008 ACGT Young Investigator Award for Cancer Gene Therapy
  • 2008 Arnold and Mabel Beckman Young Investigator Award
  • 2008 William Scandling Assistant Professor, Developmental Chair
  • 2007 Emerald Foundation Scholar