Clodagh O’Shea, PhD

Profesor

Laboratorio de Biología Molecular y Celular

Investigador Titular del Instituto Médico Howard Hughes

Silla Wicklow

Instituto Salk de Estudios Biológicos - Publicaciones

Todas las publicaciones


Dekker, J., Belmont, A.S., Guttman, M., Leshyk, V.O., Lis, J.T., Lomvardas, S., Mirny, L.A., O'Shea, C.C., Park, P.J., Ren, B., Politz, J.C.R., Shendure, J., Zhong, S. Corrigendum: The 4D nucleome project. (2017) Naturaleza. DOI: 10.1038/nature24667

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Dekker, J., Belmont, A.S., Guttman, M., Leshyk, V.O., Lis, J.T., Lomvardas, S., Mirny, L.A., O'Shea, C.C., Park, P.J., Ren, B., Politz, J.C.R., Shendure, J., Zhong, S., 4D Nucleome Network The 4D nucleome project. (2017) Naturaleza. 549(7671):219-226. DOI: 10.1038/nature23884

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Ou, H.D., Phan, S., Deerinck, T.J., Thor, A., Ellisman, M.H., O'Shea, C.C. ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells. (2017) Ciencia. 357(6349). DOI: 10.1126/science.aag0025

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Tufail, Y., Cook, D., Fourgeaud, L., Powers, C.J., Merten, K., Clark, C.L., Hoffman, E., Ngo, A., Sekiguchi, K.J., O'Shea, C.C., Lemke, G., Nimmerjahn, A. Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia. (2017) Neurona. 93(3):574-586.e8. DOI: 10.1016/j.neuron.2016.12.021

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Ou, H.D., Deerinck, T.J., Bushong, E., Ellisman, M.H., O'Shea, C.C. Visualizing viral protein structures in cells using genetic probes for correlated light and electron microscopy. (2015) Métodos. 90:39-48. DOI: 10.1016/j.ymeth.2015.06.002

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Higginbotham, J.M., O'Shea, C.C. Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains. (2015) Revista de Virología. 89(20):10260-72. DOI: 10.1128/JVI.01091-15

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Shah, G.A., O'Shea, C.C. Viral and Cellular Genomes Activate Distinct DNA Damage Responses. (2015) Móvil. 162(5):987-1002. DOI: 10.1016/j.cell.2015.07.058

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Heimbucher, T., Liu, Z., Bossard, C., McCloskey, R., Carrano, A.C., Riedel, C.G., Tanasa, B., Klammt, C., Fonslow, B.R., Riera, C.E., Lillemeier, B.F., Kemphues, K., Yates, J.R., O'Shea, C.C., Hunter, T., Dillin, A. The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity. (2015) Metabolismo Celular. 22(1):151-63. DOI: 10.1016/j.cmet.2015.06.002

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Miyake-Stoner, S.J., O'Shea, C.C. Metabolism goes viral. (2014) Metabolismo Celular. 19(4):549-50. DOI: 10.1016/j.cmet.2014.03.022

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Ou, H.D., Kwiatkowski, W., Deerinck, T.J., Noske, A., Blain, K.Y., Land, H.S., Soria, C., Powers, C.J., May, A.P., Shu, X., Tsien, R.Y., Fitzpatrick, J.A., Long, J.A., Ellisman, M.H., Choe, S., O'Shea, C.C. A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors. (2012) Móvil. 151(2):304-19. DOI: 10.1016/j.cell.2012.08.035

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Ou, H.D., May, A.P., O'Shea, C.C. The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication. (2011) Wiley Interdisciplinary Reviews. Systems biology and Medicine. 3(1):48-73. DOI: 10.1002/wsbm.88

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Espantman, K.C., O'Shea, C.C. aMAGEing new players enter the RING to promote ubiquitylation. (2010) Biología Celular Molecular. 39(6):835-7. DOI: 10.1016/j.molcel.2010.09.006

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Soria, C., Estermann, F.E., Espantman, K.C., O'Shea, C.C. Heterochromatin silencing of p53 target genes by a small viral protein. (2010) Naturaleza. 466(7310):1076-81. DOI: 10.1038/nature09307

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Iacovides, D.C., OShea, C.C., Oses-Prieto, J., Burlingame, A., McCormick, F. Critical role for arginine methylation in adenovirus-infected cells. (2007) Revista de Virología. 81(23):13209-17. DOI: 10.1128/JVI.01415-06

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Ringshausen, I., O'Shea, C.C., Finch, A.J., Swigart, L.B., Evan, G.I. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. (2006) Célula cancerosa. 10(6):501-14. DOI: 10.1016/j.ccr.2006.10.010

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O'Shea, C.C. Viruses - seeking and destroying the tumor program. (2005) Oncogén. 24(52):7640-55. DOI: 10.1038/sj.onc.1209047

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O'Shea, C.C. Viruses: tools for tumor target discovery, and agents for oncolytic therapies - an introduction. (2005) Oncogén. 24(52):7636-9. DOI: 10.1038/sj.onc.1209035


O'Shea, C.C., Soria, C., Bagus, B., McCormick, F. Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy. (2005) Célula cancerosa. 8(1):61-74. DOI: 10.1016/j.ccr.2005.06.009

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O'Shea, C.C., Choi, S., McCormick, F., Stokoe, D. Adenovirus overrides cellular checkpoints for protein translation. (2005) Ciclo celular. 4(7):883-8. DOI: 10.4161/cc.4.7.1791

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O'Shea, C., Klupsch, K., Choi, S., Bagus, B., Soria, C., Shen, J., McCormick, F., Stokoe, D. Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. (2005) Revista EMBO. 24(6):1211-21. DOI: 10.1038/sj.emboj.7600597

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O'Shea, C.C., Fried, M. Modulation of the ARF-p53 pathway by the small DNA tumor viruses. (2005) Ciclo celular. 4(3):449-52. DOI: 10.4161/cc.4.3.1555

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O'Shea, C.C. DNA tumor viruses -- the spies who lyse us. (2005) Current Opinion in Genetics & Development. 15(1):18-26. DOI: 10.1016/j.gde.2004.12.010

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O'Shea, C.C., Johnson, L., Bagus, B., Choi, S., Nicholas, C., Shen, A., Boyle, L., Pandey, K., Soria, C., Kunich, J., Shen, Y., Habets, G., Ginzinger, D., McCormick, F. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. (2004) Célula cancerosa. 6(6):611-23. DOI: 10.1016/j.ccr.2004.11.012

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O'Shea, C.C., Crompton, T., Rosewell, I.R., Hayday, A.C., Owen, M.J. Raf regulates positive selection. (1996) European Journal of Immunology. 26(10):2350-5. DOI: 10.1002/eji.1830261012

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Educación

BS, Bioquímica y Microbiología, University College Cork, Irlanda
Doctorado, Imperial College London/Imperial Cancer Research Fund, Reino Unido.
Investigador posdoctoral, Centro Integral de Cáncer de la UCSF, San Francisco, EE. UU.


Premios y distinciones

  • Premio Allen Distinguished Investigator 2018
  • Investigador del Howard Hughes Medical Institute de 2016
  • Premio del Programa de Investigación Médica W. M. Keck 2014
  • Beca Rose Hills 2014
  • 2011Science/NSF International Science & Visualization Challenge, Voto del Público
  • Premio Anna Fuller de Investigación del Cáncer 2011
  • 2010, 2011, 2012 Becario Kavli Frontiers, Academia Nacional de Ciencias
  • Premio Sontag 2009 al Científico Distinguido
  • Premio de Investigación de la Sociedad Americana del Cáncer 2009
  • Premio Joven Investigador ACGT 2008 en Terapia Génica contra el Cáncer
  • Premio Arnold and Mabel Beckman Young Investigator 2008
  • 2008 William Scandling Profesor Asistente, Presidente de Desarrollo
  • Académico de la Emerald Foundation 2007