LA JOLLA, CA—A synthetic derivative of the curry spice turmeric, made by scientists at the Salk Institute for Biological Studies, dramatically improves the behavioral and molecular deficits seen in animal models of ischemic stroke and traumatic brain injury (TBI). Two new studies suggest that the novel compound may have clinical promise for these conditions, which currently lack good therapies.
LA JOLLA, CA—Better known as the light sensor that sets the body’s biological clock, melanopsin also plays an important role in vision: Via its messengers-so-called melanopsin-expressing retinal ganglion cells, or mRGCs-it forwards information about the brightness of incoming light directly to conventional visual centers in the brain, reports an international collaboration of scientists in this week’s issue of PLoS生物学.
LA JOLLA, CA—The Board of Trustees of the Salk Institute for Biological Studies unanimously voted to elect Dr. Benjamin H. Lewis and Ms. Faye H. Russell as new members during its November 19 meeting in La Jolla.
LA JOLLA, CA—The Salk Institute for Biological Studies today announced the establishment of the Renato Dulbecco Chair in Genomics and the Roger Guillemin Chair in Neuroscience based on an endowment of $6 million from Irwin Jacobs, chairman of the Salk’s Board of Trustees, and his wife Joan Klein Jacobs.
LA JOLLA, CA–With few exceptions, jumping genes-restless bits of DNA that can move freely about the genome-are forced to stay put. In patients with Rett syndrome, however, a mutation in the MeCP2 gene mobilizes so-called L1 retrotransposons in brain cells, reshuffling their genomes and possibly contributing to the symptoms of the disease when they find their way into active genes, report researchers at the Salk Institute for Biological Studies.
LA JOLLA, CA–Fisetin, a naturally occurring compound found in strawberries and other fruits and vegetables, slows the onset of motor problems and delays death in three models of Huntington’s disease, according to researchers at the Salk Institute for Biological Studies. The study, published in the online edition of Human Molecular Genetics, sets the stage for further investigations into fisetin’s neuroprotective properties in Huntington’s and other neurodegenerative conditions.
LA JOLLA, CA—A collaborative effort between researchers at the Salk Institute for Biological Studies and the University of California, San Diego, successfully used human induced pluripotent stem (iPS) cells derived from patients with Rett syndrome to replicate autism in the lab and study the molecular pathogenesis of the disease.
LA JOLLA, CA–A study by researchers at the Salk Institute for Biological Studies revealed that stem cells can sense a decrease in available nutrients and respond by retaining only a small pool of active stem cells for tissue maintenance. When, or if, favorable conditions return, stem cell numbers multiply to accommodate increased demands on the tissue.
LA JOLLA, CA–The Salk Institute for Biological Studies and Columbia University Medical Center have been awarded a $15 million grant by The Leona M. and Harry B. Helmsley Charitable Trust, establishing a collaborative program to fast-track the use of induced pluripotent stem (iPS) cells to gain new insight into disease mechanisms and screen for novel therapeutic drugs.
LA JOLLA, CA—Scientists are closer to solving one of the many mysteries of multiple sclerosis and other demyelinating diseases, thanks to a recent study conducted at the Salk Institute for Biological Studies. The research revealed a previously unknown connection between two ion channels, which, when misaligned, can cause the many bizarre symptoms that characterize the condition.
He was extremely smart and forward-thinking — a technology savant whose ideas were ahead of his time.
LA JOLLA, CA—For the second time in its 50-year history, the Salk Institute will award its Research Excellence and Public Service Medals. Gene expression pioneer Robert G. Roeder of The Rockefeller University will be awarded the Salk Institute Medal for Research Excellence. Irwin M. Jacobs, the renowned engineer, entrepreneur and philanthropist, will be awarded the Salk Institute Medal for Public Service.
LA JOLLA, CA—By comparing a clearly defined visual input with the electrical output of the retina, researchers at the Salk Institute for Biological Studies were able to trace for the first time the neuronal circuitry that connects individual photoreceptors with retinal ganglion cells, the neurons that carry visuals signals from the eye to the brain.
加利福尼亚州拉霍亚——就像猫一样，人类细胞也有有限的生命——一旦它们分裂一定的次数（幸运的是，超过九次），它们就会改变形状，减缓速度，最终停止分裂，这种现象被称为“细胞衰老”。.
LA JOLLA, CA—Biologists have found that a key protein that regulates the biological clocks of mammals also regulates glucose production in the liver and that altering the levels of this protein can improve the health of diabetic mice.
LA JOLLA, CA—A novel mechanism used by adenovirus to sidestep the cell’s suicide program, could go a long way to explain how tumor suppressor genes are silenced in tumor cells and pave the way for a new type of targeted cancer therapy, report researchers at the Salk Institute for Biological Studies in the Aug. 26, 2010 issue of 自然.
LA JOLLA, CA—People with Williams syndrome—known for their indiscriminate friendliness and ease with strangers—process spoken language differently from people with autism spectrum disorders—characterized by social withdrawal and isolation—found researchers at the Salk Institute for Biological Studies.
LA JOLLA, CA—A multi-institutional team headed by 约翰·扬, Ph.D., a professor at the Salk Institute for Biological Studies, and Sumit Chanda, Ph.D., an associate professor at Sanford-Burnham Medical Research Institute, has been awarded a $21 million Program Project Grant to dissect the early innate immune response to HIV infection using a systems biology approach.
Dr. Robert H. Wurtz, an NIH distinguished investigator and Salk Institute Non-Resident Fellow, will receive the 2010 Neuroscience Prize for his pioneering work in cognitive neuroscience.
