圣地亚哥—萨尔克生物研究所已晋升 沃尔夫冈·布施 晋升为教授，以表彰他对植物生物学领域的开创性贡献。此次晋升基于索尔克学院教授和客座研究员的推荐，并经校长批准 鲁斯蒂·盖奇 以及学院董事会。.
LA JOLLA—Fruit flies, like many animals, engage in a variety of courtship and fighting behaviors. Now, Salk scientists have uncovered the molecular mechanisms by which two sex-determining genes affect fruit fly behavior. The male flies’ courtship and aggression behaviors, they showed, are mediated by two distinct genetic programs. The findings, both published in eLife on April 21, 2020, demonstrate the complexity of the link between sex and behavior.
LA JOLLA—Persistent inflammation of the pancreas (chronic pancreatitis) is a known risk factor for developing pancreatic cancer, the third-deadliest cancer in the United States. Tuft cells—cells sensitive to chemical (chemosensory) changes typically found in the intestines and respiratory tract—had previously been discovered in the pancreas, but their function has largely remained a mystery. Now, a team of Salk scientists led by Professor 杰弗里·沃尔 and Staff Scientist Kathleen DelGiorno has uncovered the formation of tuft cells during pancreatitis and the surprising role of tuft cells in immunity, using mouse models of pancreatitis. The findings, published in Frontiers in Physiology on February 14, 2020, could lead to the development of new biomarkers to test for pancreatitis and pancreatic cancer.
拉霍亚—索尔克教授 罗纳德·埃文斯, Howard Hughes Medical investigator and director of Salk’s Gene Expression Laboratory, has been awarded a 2020 NOMIS Distinguished Scientist and Scholar Award by the NOMIS Foundation, a Swiss foundation that supports high-risk basic research. The award, which totals $2.5M, recognizes scientists for their “outstanding contributions to the advancement of science and human progress through their pioneering, innovative and collaborative research,” according to NOMIS. The award will enable Evans to decode how different parts of the body, including the brain, endocrine glands, gut, liver, immune cells and the microbiome, cooperate to maintain health.
拉霍亚托德·迈克尔 will return to Salk as a research professor in the Plant Molecular and Cellular Biology Laboratory, where he will oversee his own research group as well as provide key expertise in genomics to the Harnessing Plants Initiative (HPI). Michael completed his postdoctoral research at Salk in 2007 under the direction of Professor Joanne Chory, director of Salk’s Plant Molecular and Cellular Biology Laboratory and executive director of the Initiative. The non-tenured research professor track was created by Salk in 2018 to attract and retain top talent to the faculty.
LA JOLLA—The Salk Institute announced the hiring of Leona Flores, PhD, as executive director of the 索尔克癌症中心, to help oversee administrative and scientific management functions as a member of its leadership team and to provide decision strategy support to the Cancer Center’s director.
LA JOLLA—Due to the continuing spread of the novel coronavirus disease (COVID-19) and California Governor Gavin Newsom’s public health order last night for people to stay at home, the Institute is taking additional steps to minimize opportunities for viral transmission through the community.
LA JOLLA—Just like humans and other animals, plants have hormones. One role of plant hormones is to perceive trouble—whether an insect attack, drought or intense heat or cold—and then signal to the rest of the plant to respond.
March 6, 2020—The Salk Institute announced today that due to the unfolding novel coronavirus (COVID-19) spread, all public events scheduled to be held on the Salk campus through the end of March have been canceled. On Wednesday, the Institute closed its campus to the public and canceled all public tours of the iconic architectural landmark.
拉霍亚Salk’s Harnessing Plants Initiative (HPI) will receive a $12.5 million gift from Hess Corporation (NYSE: HES) to advance two projects to enhance plants’ natural ability to store carbon and mitigate the effects of climate change: the CRoPS (CO2 Removal on a Planetary Scale) program and the Coastal Plant Restoration (CPR) program. These projects build on the Salk discovery of a crucial gene that will help the team develop plants with larger root systems capable of absorbing and storing potentially billions of tons of carbon per year from the atmosphere.
LA JOLLA—People with bipolar disorder experience dramatic shifts in mood, oscillating between often debilitating periods of mania and depression. While a third of people with bipolar disorder can be successfully treated with the drug lithium, the majority of patients struggle to find treatment options that work.
LA JOLLA—Salk scientists have discovered how a powerful class of HIV drugs binds to a key piece of HIV machinery. By solving, for the first time, three-dimensional structures of this complex while different drugs were attached, the researchers showed what makes the therapy so potent. The work, which appeared in 科学 on January 30, 2020, provides insights that could help design or improve new treatments for HIV.
LA JOLLA—Researchers at the Salk Institute have discovered a unique pattern of DNA damage that arises in brain cells derived from individuals with a macrocephalic form of autism spectrum disorder (ASD). The observation, published in the journal Cell Stem Cell, helps explain what might go awry in the brain during cell division and development to cause the disorder.
LA JOLLA—Due to the modern tendency to postpone childbirth until later in life, a growing number of women are experiencing issues with infertility. Infertility likely stems from age-related decline of the ovaries, but the molecular mechanisms that lead to this decline have been unclear. Now, scientists from the U.S. and China have discovered, in unprecedented detail, how ovaries age in non-human primates. The findings, published in 细胞 on January 30, 2020, reveal several genes that could be used as biomarkers and point to therapeutic targets for diagnosing and treating female infertility and age-associated ovarian diseases, such as ovarian cancer, in humans.
拉霍亚—索尔克研究所董事会欢迎新成员拉里·詹宁斯（Larry Jennings, Jr.）和蒂莫西·肖恩（Timothy Schoen）。在丹尼尔·刘易斯（Daniel Lewis）的主持下，索尔克董事会有助于推动由脊髓灰质炎疫苗先驱乔纳斯·索尔克（Jonas Salk）于1960年创立的世界著名生物研究机构的发展方向。.
LA JOLLA—People with osteoarthritis, or “wear and tear” arthritis, have limited treatment options: pain relievers or joint replacement surgery. Now, Salk researchers have discovered that a powerful combination of two experimental drugs reverses the cellular and molecular signs of osteoarthritis in rats as well as in isolated human cartilage cells. Their results were published in the journal Protein & Cell on January 16, 2020.
LA JOLLA—Mitochondria, tiny structures present in most cells, are known for their energy-generating machinery. Now, Salk researchers have discovered a new function of mitochondria: they set off molecular alarms when cells are exposed to stress or chemicals that can damage DNA, such as chemotherapy. The results, published online in Nature Metabolism on December 9, 2019, could lead to new cancer treatments that prevent tumors from becoming resistant to chemotherapy.
拉霍亚——在阿尔茨海默病的小鼠模型中，被称为 CMS121 和 J147 的在研候选药物可以改善记忆力并减缓脑细胞的退化。现在，索尔克研究所的研究人员已经证明了这些化合物如何也能减缓健康老年小鼠的衰老，阻止大脑在衰老过程中发生的细胞损伤，并将特定分子的水平恢复到年轻大脑的水平。.
LA JOLLA—While scientists know of about 25,000 genes that code for biologically important proteins, additional, smaller genes hiding in our DNA may be just as important. But these tiny lines of genetic code have proven tough to track down.
