Clodagh O’Shea, PhD

Profesor

Laboratorio de Biología Molecular y Celular

Howard Hughes Medical Institute Faculty Scholar

Silla Wicklow

Instituto Salk de Estudios Biológicos - Publicaciones

Todas las publicaciones


Dekker, J., Belmont, A.S., Guttman, M., Leshyk, V.O., Lis, J.T., Lomvardas, S., Mirny, L.A., O'Shea, C.C., Park, P.J., Ren, B., Politz, J.C.R., Shendure, J., Zhong, S. Corrigendum: The 4D nucleome project. (2017) Naturaleza. DOI: 10.1038/nature24667

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Dekker, J., Belmont, A.S., Guttman, M., Leshyk, V.O., Lis, J.T., Lomvardas, S., Mirny, L.A., O'Shea, C.C., Park, P.J., Ren, B., Politz, J.C.R., Shendure, J., Zhong, S., 4D Nucleome Network The 4D nucleome project. (2017) Naturaleza. 549(7671):219-226. DOI: 10.1038/nature23884

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Ou, H.D., Phan, S., Deerinck, T.J., Thor, A., Ellisman, M.H., O'Shea, C.C. ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells. (2017) Ciencia. 357(6349). DOI: 10.1126/science.aag0025

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Tufail, Y., Cook, D., Fourgeaud, L., Powers, C.J., Merten, K., Clark, C.L., Hoffman, E., Ngo, A., Sekiguchi, K.J., O'Shea, C.C., Lemke, G., Nimmerjahn, A. Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia. (2017) Neuron. 93(3):574-586.e8. DOI: 10.1016/j.neuron.2016.12.021

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Ou, H.D., Deerinck, T.J., Bushong, E., Ellisman, M.H., O'Shea, C.C. Visualizing viral protein structures in cells using genetic probes for correlated light and electron microscopy. (2015) Métodos. 90:39-48. DOI: 10.1016/j.ymeth.2015.06.002

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Higginbotham, J.M., O'Shea, C.C. Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains. (2015) Journal of Virology. 89(20):10260-72. DOI: 10.1128/JVI.01091-15

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Shah, G.A., O'Shea, C.C. Viral and Cellular Genomes Activate Distinct DNA Damage Responses. (2015) Móvil. 162(5):987-1002. DOI: 10.1016/j.cell.2015.07.058

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Heimbucher, T., Liu, Z., Bossard, C., McCloskey, R., Carrano, A.C., Riedel, C.G., Tanasa, B., Klammt, C., Fonslow, B.R., Riera, C.E., Lillemeier, B.F., Kemphues, K., Yates, J.R., O'Shea, C.C., Hunter, T., Dillin, A. The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity. (2015) Metabolismo Celular. 22(1):151-63. DOI: 10.1016/j.cmet.2015.06.002

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Miyake-Stoner, S.J., O'Shea, C.C. Metabolism goes viral. (2014) Metabolismo Celular. 19(4):549-50. DOI: 10.1016/j.cmet.2014.03.022

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Ou, H.D., Kwiatkowski, W., Deerinck, T.J., Noske, A., Blain, K.Y., Land, H.S., Soria, C., Powers, C.J., May, A.P., Shu, X., Tsien, R.Y., Fitzpatrick, J.A., Long, J.A., Ellisman, M.H., Choe, S., O'Shea, C.C. A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors. (2012) Móvil. 151(2):304-19. DOI: 10.1016/j.cell.2012.08.035

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Ou, H.D., May, A.P., O'Shea, C.C. The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication. (2011) Wiley Interdisciplinary Reviews. Systems biology and Medicine. 3(1):48-73. DOI: 10.1002/wsbm.88

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Espantman, K.C., O'Shea, C.C. aMAGEing new players enter the RING to promote ubiquitylation. (2010) Biología Celular Molecular. 39(6):835-7. DOI: 10.1016/j.molcel.2010.09.006

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Soria, C., Estermann, F.E., Espantman, K.C., O'Shea, C.C. Heterochromatin silencing of p53 target genes by a small viral protein. (2010) Naturaleza. 466(7310):1076-81. DOI: 10.1038/nature09307

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Iacovides, D.C., OShea, C.C., Oses-Prieto, J., Burlingame, A., McCormick, F. Critical role for arginine methylation in adenovirus-infected cells. (2007) Journal of Virology. 81(23):13209-17. DOI: 10.1128/JVI.01415-06

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Ringshausen, I., O'Shea, C.C., Finch, A.J., Swigart, L.B., Evan, G.I. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. (2006) Cancer Cell. 10(6):501-14. DOI: 10.1016/j.ccr.2006.10.010

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O'Shea, C.C. Viruses - seeking and destroying the tumor program. (2005) Oncogene. 24(52):7640-55. DOI: 10.1038/sj.onc.1209047

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O'Shea, C.C. Viruses: tools for tumor target discovery, and agents for oncolytic therapies - an introduction. (2005) Oncogene. 24(52):7636-9. DOI: 10.1038/sj.onc.1209035


O'Shea, C.C., Soria, C., Bagus, B., McCormick, F. Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy. (2005) Cancer Cell. 8(1):61-74. DOI: 10.1016/j.ccr.2005.06.009

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O'Shea, C.C., Choi, S., McCormick, F., Stokoe, D. Adenovirus overrides cellular checkpoints for protein translation. (2005) Ciclo celular. 4(7):883-8. DOI: 10.4161/cc.4.7.1791

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O'Shea, C., Klupsch, K., Choi, S., Bagus, B., Soria, C., Shen, J., McCormick, F., Stokoe, D. Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. (2005) EMBO Journal. 24(6):1211-21. DOI: 10.1038/sj.emboj.7600597

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O'Shea, C.C., Fried, M. Modulation of the ARF-p53 pathway by the small DNA tumor viruses. (2005) Ciclo celular. 4(3):449-52. DOI: 10.4161/cc.4.3.1555

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O'Shea, C.C. DNA tumor viruses -- the spies who lyse us. (2005) Current Opinion in Genetics & Development. 15(1):18-26. DOI: 10.1016/j.gde.2004.12.010

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O'Shea, C.C., Johnson, L., Bagus, B., Choi, S., Nicholas, C., Shen, A., Boyle, L., Pandey, K., Soria, C., Kunich, J., Shen, Y., Habets, G., Ginzinger, D., McCormick, F. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. (2004) Cancer Cell. 6(6):611-23. DOI: 10.1016/j.ccr.2004.11.012

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O'Shea, C.C., Crompton, T., Rosewell, I.R., Hayday, A.C., Owen, M.J. Raf regulates positive selection. (1996) European Journal of Immunology. 26(10):2350-5. DOI: 10.1002/eji.1830261012

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Educación

BS, Biochemistry and Microbiology, University College Cork, Ireland
PhD, Imperial College London/Imperial Cancer Research Fund, U.K.
Postdoctoral Fellow, UCSF Comprehensive Cancer Center, San Francisco, U.S.A


Premios y distinciones

  • 2018 Allen Distinguished Investigator Award
  • 2016 Howard Hughes Medical Institute Faculty Scholar
  • 2014 W. M. Keck Medical Research Program Award
  • 2014 Rose Hills Fellow
  • 2011Science/NSF International Science & Visualization Challenge, People's Choice
  • 2011 Anna Fuller Award for Cancer Research
  • 2010, 2011, 2012 Kavli Frontiers Fellow, National Academy of Sciences
  • 2009 Sontag Distinguished Scientist Award
  • 2009 American Cancer Society Research Scholar Award
  • 2008 ACGT Young Investigator Award for Cancer Gene Therapy
  • 2008 Arnold and Mabel Beckman Young Investigator Award
  • 2008 William Scandling Assistant Professor, Developmental Chair
  • 2007 Emerald Foundation Scholar