Metabolismo

La alimentación con restricción de tiempo mejora la salud de los bomberos

LA JOLLA—Firefighters are the heroes of our society, protecting us around the clock. But those 24-hour shifts are hard on the body and increase the risk of cardiometabolic diseases, such as heart disease and diabetes, as well as cancer. In collaboration with the San Diego Fire-Rescue Department, scientists from the Salk Institute and UC San Diego Health conducted a clinical trial and found that time-restricted eating improved measures of health and wellbeing in firefighters. The lifestyle intervention only required the firefighters to eat during a 10-hour window and did not involve skipping meals. Read more »

Benefits of time-restricted eating depend on age and sex

LA JOLLA—Time-restricted eating (TRE), a dietary regimen that restricts eating to specific hours, has garnered increased attention in weight-loss circles. A new study by Salk scientists further shows that TRE confers multiple health benefits besides weight loss. The study also shows that these benefits may depend on sex and age. Read more »

First immune-evading cells created to treat type 1 diabetes

LA JOLLA—Salk Institute scientists have made a major advance in the pursuit of a safe and effective treatment for type 1 diabetes, an illness that impacts an estimated 1.6 million Americans with a cost of $14.4 billion annually.

Using stem cell technology, Salk researchers generated the first human insulin-producing pancreatic cell clusters able to evade the immune system, as detailed in the journal Naturaleza on August 19, 2020. These “immune shielded” cell clusters controlled blood glucose without immunosuppressive drugs in mice, once transplanted in the body. Read more »

Come menos, vive más

LA JOLLA—Si desea reducir los niveles de inflamación en todo el cuerpo, retrasar la aparición de enfermedades relacionadas con la edad y vivir más tiempo, coma menos. Esa es la conclusión de un nuevo estudio realizado por científicos de Estados Unidos y China que proporciona el informe más detallado hasta la fecha de los efectos celulares de una dieta con restricción calórica en ratas. Si bien los beneficios de la restricción calórica se conocen desde hace mucho tiempo, los nuevos resultados muestran cómo esta restricción puede proteger contra el envejecimiento en las vías celulares, como se detalla en Célula el 27 de febrero de 2020. Read more »

Salk scientists modify CRISPR to epigenetically treat diabetes, kidney disease, muscular dystrophy

LA JOLLA—Salk scientists have created a new version of the CRISPR/Cas9 genome editing technology that allows them to activate genes without creating breaks in the DNA, potentially circumventing a major hurdle to using gene editing technologies to treat human diseases. Read more »