美国癌症协会教授
分子与细胞生物学实验室
Renato Dulbecco Chair
Hunter, T. Poor man's ribo-seq: circa 1968. (2026) Open Biology. 16(1). DOI: 10.1098/rsob.250392
Reina, J., Vallmajo-Martin, Q., Ning, J., Michi, A.N., Yeung, K., Wahl, G.M., Hunter, T. LHPP expression in triple-negative breast cancer promotes tumor growth and metastasis by modulating the tumor microenvironment. (2025) 美国国家科学院院刊. 122(49):e2505653122. DOI: 10.1073/pnas.2505653122
Martyn, G.D., Kalagiri, R., Veggiani, G., Stanfield, R.L., Choudhuri, I., Sala, M., Meisenhelder, J., Chen, C., Biswas, A., Levy, R.M., Lyumkis, D., Wilson, I.A., Hunter, T., Sidhu, S.S. Using phage display for rational engineering of a higher-affinity humanized 3' phosphohistidine-specific antibody. (2025) Commun Chem. 8(1):381. DOI: 10.1038/s42004-025-01768-9
He, X., Chen, D., Liu, G., Wu, Q., Zhao, H., Guo, D., Jiang, X., Li, M., Meng, Y., Yin, Y., Ye, X., Luo, S., Xia, Y., Hunter, T., Lu, Z. PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth. (2025) 分子细胞. DOI: 10.1016/j.molcel.2025.02.024
Wang, X., Lee, D., Xu, H., Sui, Y., Meisenhelder, J., Hunter, T. PIN1 prolyl isomerase promotes initiation and progression of bladder cancer through the SREBP2-mediated cholesterol biosynthesis pathway. (2025) 癌症发现. DOI: 10.1158/2159-8290.CD-24-0866
He, F., Aebersold, R., Baker, M.S., Bian, X., Bo, X., Chan, D.W., Chang, C., Chen, L., Chen, X., Chen, Y.J., Cheng, H., Collins, B.C., Corrales, F., Cox, J., E, W., Van Eyk, J.E., Fan, J., Faridi, P., Figeys, D., Gao, G.F., Gao, W., Gao, Z.H., Goda, K., Goh, W.W.B., Gu, D., Guo, C., Guo, T., He, Y., Heck, A.J.R., Hermjakob, H., Hunter, T., Iyer, N.G., Jiang, Y., Jimenez, C.R., Joshi, L., Kelleher, N.L., Li, M., Li, Y., Lin, Q., Liu, C.H., Liu, F., Liu, G.H., Liu, Y., Liu, Z., Low, T.Y., Lu, B., Mann, M., Meng, A., Moritz, R.L., Nice, E., Ning, G., Omenn, G.S., Overall, C.M., Palmisano, G., Peng, Y., Pineau, C., Poon, T.C.W., Purcell, A.W., Qiao, J., Reddel, R.R., Robinson, P.J., Roncada, P., Sander, C., Sha, J., Song, E., Srivastava, S., Sun, A., Sze, S.K., Tang, C., Tang, L., Tian, R., Vizcaíno, J.A., Wang, C., Wang, C., Wang, X., Wang, X., Wang, Y., Weiss, T., Wilhelm, M., Winkler, R., Wollscheid, B., Wong, L., Xie, L., Xie, W., Xu, T., Xu, T., Yan, L., Yang, J., Yang, X., Yates, J., Yun, T., Zhai, Q., Zhang, B., Zhang, H., Zhang, L., Zhang, L., Zhang, P., Zhang, Y., Zheng, Y.Z., Zhong, Q., Zhu, Y. π-HuB: the proteomic navigator of the human body. (2024) 自然. 636(8042):322-331. DOI: 10.1038/s41586-024-08280-5
Huang, P., Gao, W., Fu, C., Wang, M., Li, Y., Chu, B., He, A., Li, Y., Deng, X., Zhang, Y., Kong, Q., Yuan, J., Wang, H., Shi, Y., Gao, D., Qin, R., Hunter, T., Tian, R. Clinical functional proteomics of intercellular signalling in pancreatic cancer. (2024) 自然. DOI: 10.1038/s41586-024-08225-y
Martyn, G.D., Kalagiri, R., Veggiani, G., Stanfield, R.L., Choudhuri, I., Sala, M., Meisenhelder, J., Chen, C., Biswas, A., Levy, R.M., Lyumkis, D., Wilson, I.A., Hunter, T., Sidhu, S.S. Using phage display for rational engineering of a higher affinity humanized 3' phosphohistidine-specific antibody. (2024) bioRxiv. DOI: 10.1101/2024.11.04.621849
Ning, J., Sala, M., Reina, J., Kalagiri, R., Hunter, T., McCullough, B.S. Histidine Phosphorylation: Protein Kinases and Phosphatases. (2024) Int J Mol Sci. 25(14). DOI: 10.3390/ijms25147975
Rivier, C., Hunter, T., Evans, R.M. Roger Guillemin (1924 to 2024): Discoverer of brain hormones that control physiology. (2024) 美国国家科学院院刊. 121(20):e2407309121. DOI: 10.1073/pnas.2407309121
Reina, J., Vallmajo-Martin, Q., Ning, J., Michi, A.N., Yeung, K., Wahl, G.M., Hunter, T. LHPP expression in triple-negative breast cancer promotes tumor growth and metastasis by modulating the tumor microenvironment. (2024) bioRxiv. DOI: 10.1101/2024.04.19.590151
Chen, C.W., Su, C., Huang, C.Y., Huang, X.R., Cuili, X., Chao, T., Fan, C.H., Ting, C.W., Tsai, Y.W., Yang, K.C., Yeh, T.Y., Hsieh, S.T., Chen, Y.J., Feng, Y., Hunter, T., Chang, Z.F. NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia. (2024) 自然-通讯. 15(1):2264. DOI: 10.1038/s41467-024-46385-7
Liang, G., Oh, T.G., Hah, N., Tiriac, H., Shi, Y., Truitt, M.L., Antal, C.E., Atkins, A.R., Li, Y., Fraser, C., Ng, S., Pinto, A.F.M., Nelson, D.C., Estepa, G., Bashi, S., Banayo, E., Dai, Y., Liddle, C., Yu, R.T., Hunter, T., Engle, D.D., Han, H., Von Hoff, D.D., Downes, M., Evans, R.M. 抑制基质中I类HDAC会遏制胰腺癌的进展。. (2023) 自然-通讯. 14(1):7791. DOI: 10.1038/s41467-023-42178-6
Lewis, B.M., Cho, C.Y., Her, H.L., Mizrahi, O., Hunter, T., Yeo, G.W. LARP4 Is an RNA-Binding Protein That Binds Nuclear-Encoded Mitochondrial mRNAs To Promote Mitochondrial Function. (2023) 核糖核酸. DOI: 10.1261/rna.079799.123
Branch, M.R., Hsu, C.L., Ohnishi, K., Shen, W.C., Lee, E., Meisenhelder, J., Winborn, B., Sopher, B.L., Taylor, J.P., Hunter, T., La Spada, A.R. MAP4K3 inhibits Sirtuin-1 to repress the LKB1-AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex. (2023) Life Sci Alliance. 6(8). DOI: 10.26508/lsa.202201525
Chen, D., Varanasi, S.K., Hara, T., Traina, K., Sun, M., McDonald, B., Farsakoglu, Y., Clanton, J., Xu, S., Garcia-Rivera, L., Mann, T.H., Du, V., Chung, H.K., Xu, Z., Tripple, V., Casillas, E., Ma, S., O'Connor, C., Yang, Q., Zheng, Y., Hunter, T., Lemke, G., Kaech, S.M. CTLA-4 blockade induces CD4 T cell IFNγ-driven microglial phagocytosis and anti-tumor function in glioblastoma. (2023) Immunity. DOI: 10.1016/j.immuni.2023.07.015
Gubbala, V.B., Jytosana, N., Trinh, V.Q., Maurer, H.C., Naeem, R.F., Lytle, N.K., Ma, Z., Zhao, S., Lin, W., Han, H., Shi, Y., Hunter, T., Singh, P.K., Olive, K.P., Tan, M.C.B., Kaech, S.M., Wahl, G.M., DelGiorno, K.E. Eicosanoids in the pancreatic tumor microenvironment - a multicellular, multifaceted progression. (2022) Gastro Hep Adv. 1(4):682-697. DOI: 10.1016/j.gastha.2022.02.007
Hunter, T. A journey from phosphotyrosine to phosphohistidine and beyond. (2022) 分子细胞. DOI: 10.1016/j.molcel.2022.05.007
Pozo, F.M., Hunter, T., Zhang, Y. The 'New (Nu)-clear' evidence for the tumor-driving role of PI3K. (2022) Acta Mater Med. 1(2):193-196. DOI: 10.15212/amm-2022-0013
Taylor, S.S., Hunter, T., Changeux, J.P. A tribute to Eddy Fischer (April 6, 1920-August 27, 2021): Passionate biochemist and mentor. (2022) 美国国家科学院院刊. 119(3). DOI: 10.1073/pnas.2121815119
Kalagiri, R., Hunter, T. The many ways that nature has exploited the unusual structural and chemical properties of phosphohistidine for use in proteins. (2021) Biochemical Journal. 478(19):3575-3596. DOI: 10.1042/BCJ20210533
Hara, T., Chanoch-Myers, R., Mathewson, N.D., Myskiw, C., Atta, L., Bussema, L., Eichhorn, S.W., Greenwald, A.C., Kinker, G.S., Rodman, C., Gonzalez Castro, L.N., Wakimoto, H., Rozenblatt-Rosen, O., Zhuang, X., Fan, J., Hunter, T., Verma, I.M., Wucherpfennig, K.W., Regev, A., Suvà, M.L., Tirosh, I. Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. (2021) Cancer Cell. DOI: 10.1016/j.ccell.2021.05.002
Hunter, S.A., McIntosh, B.J., Shi, Y., Sperberg, R.A.P., Funatogawa, C., Labanieh, L., Soon, E., Wastyk, H.C., Mehta, N., Carter, C., Hunter, T., Cochran, J.R. An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy. (2021) 传达生物学. 4(1):452. DOI: 10.1038/s42003-021-01928-2
Kalagiri, R., Stanfield, R.L., Meisenhelder, J., La Clair, J.J., Fuhs, S.R., Wilson, I.A., Hunter, T. Structural basis for differential recognition of phosphohistidine-containing peptides by 1-pHis and 3-pHis monoclonal antibodies. (2021) 美国国家科学院院刊. 118(6). DOI: 10.1073/pnas.2010644118
Ke, M., Yuan, X., He, A., Yu, P., Chen, W., Shi, Y., Hunter, T., Zou, P., Tian, R. Spatiotemporal profiling of cytosolic signaling complexes in living cells by selective proximity proteomics. (2021) 自然-通讯. 12(1):71. DOI: 10.1038/s41467-020-20367-x
French, M.E., Koehler, C.F., Hunter, T. Emerging functions of branched ubiquitin chains. (2021) Cell Discov. 7(1):6. DOI: 10.1038/s41421-020-00237-y
Adam, K., Ning, J., Reina, J., Hunter, T. NME/NM23/NDPK and Histidine Phosphorylation. (2020) International Journal of Molecular Sciences. 21(16). DOI: 10.3390/ijms21165848
Ogawa, J., Zhu, W., Tonnu, N., Singer, O., Hunter, T., Ryan, A.L., Pao, G.M. The D614G mutation in the SARS-CoV2 Spike protein increases infectivity in an ACE2 receptor dependent manner. (2020) bioRxiv. DOI: 10.1101/2020.07.21.214932
Adam, K., Lesperance, J., Hunter, T., Zage, P.E. The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis. (2020) International Journal of Molecular Sciences. 21(9). DOI: 10.3390/ijms21093319
DelGiorno, K.E., Naeem, R.F., Fang, L., Chung, C.Y., Ramos, C., Luhtala, N., O'Connor, C., Hunter, T., Manor, U., Wahl, G.M. Tuft Cell Formation Reflects Epithelial Plasticity in Pancreatic Injury: Implications for Modeling Human Pancreatitis. (2020) Frontiers in Physiology. 11:88. DOI: 10.3389/fphys.2020.00088
Adam, K., Hunter, T. Subcellular Localization of Histidine Phosphorylated Proteins Through Indirect Immunofluorescence. (2020) 分子生物学方法. 2077:209-224. DOI: 10.1007/978-1-4939-9884-5_14
Luhtala, N., Hunter, T. Immunohistochemistry (IHC): Chromogenic Detection of 3-Phosphohistidine Proteins in Formaldehyde-Fixed, Frozen Mouse Liver Tissue Sections. (2020) 分子生物学方法. 2077:193-208. DOI: 10.1007/978-1-4939-9884-5_13
Kalagiri, R., Adam, K., Hunter, T. Empirical Evidence of Cellular Histidine Phosphorylation by Immunoblotting Using pHis mAbs. (2020) 分子生物学方法. 2077:Methods in Molecular Biology. DOI: 10.1007/978-1-4939-9884-5_12
Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D.G., Egeblad, M., Evans, R.M., Fearon, D., Greten, F.R., Hingorani, S.R., Hunter, T., Hynes, R.O., Jain, R.K., Janowitz, T., Jorgensen, C., Kimmelman, A.C., Kolonin, M.G., Maki, R.G., Powers, R.S., Puré, E., Ramirez, D.C., Scherz-Shouval, R., Sherman, M.H., Stewart, S., Tlsty, T.D., Tuveson, D.A., Watt, F.M., Weaver, V., Weeraratna, A.T., Werb, Z. A framework for advancing our understanding of cancer-associated fibroblasts. (2020) Nature Reviews Cancer. DOI: 10.1038/s41568-019-0238-1
Shi, Y., Hunter, S., Hunter, T. Stem Cell Factor LIFted as a Promising Clinical Target for Cancer Therapy. (2019) Molecular Cancer Therapeutics. 18(8):1337-1340. DOI: 10.1158/1535-7163.MCT-19-0605
Neftel, C., Laffy, J., Filbin, M.G., Hara, T., Shore, M.E., Rahme, G.J., Richman, A.R., Silverbush, D., Shaw, M.L., Hebert, C.M., Dewitt, J., Gritsch, S., Perez, E.M., Gonzalez Castro, L.N., Lan, X., Druck, N., Rodman, C., Dionne, D., Kaplan, A., Bertalan, M.S., Small, J., Pelton, K., Becker, S., Bonal, D., Nguyen, Q.D., Servis, R.L., Fung, J.M., Mylvaganam, R., Mayr, L., Gojo, J., Haberler, C., Geyeregger, R., Czech, T., Slavc, I., Nahed, B.V., Curry, W.T., Carter, B.S., Wakimoto, H., Brastianos, P.K., Batchelor, T.T., Stemmer-Rachamimov, A., Martinez-Lage, M., Frosch, M.P., Stamenkovic, I., Riggi, N., Rheinbay, E., Monje, M., Rozenblatt-Rosen, O., Cahill, D.P., Patel, A.P., Hunter, T., Verma, I.M., Ligon, K.L., Louis, D.N., Regev, A., Bernstein, B.E., Tirosh, I., Suvà, M.L. An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma. (2019) 牢房. 178(4):835-849. DOI: 10.1016/j.cell.2019.06.024
Shi, Y., Gao, W., Lytle, N.K., Huang, P., Yuan, X., Dann, A.M., Ridinger-Saison, M., DelGiorno, K.E., Antal, C.E., Liang, G., Atkins, A.R., Erikson, G., Sun, H., Meisenhelder, J., Terenziani, E., Woo, G., Fang, L., Santisakultarm, T.P., Manor, U., Xu, R., Becerra, C.R., Borazanci, E., Von Hoff, D.D., Grandgenett, P.M., Hollingsworth, M.A., Leblanc, M., Umetsu, S.E., Collisson, E.A., Scadeng, M., Lowy, A.M., Donahue, T.R., Reya, T., Downes, M., Evans, R.M., Wahl, G.M., Pawson, T., Tian, R., Hunter, T. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. (2019) 自然. 569(7754):131-135. DOI: 10.1038/s41586-019-1130-6
Bonanomi, D., Valenza, F., Chivatakarn, O., Sternfeld, M.J., Driscoll, S.P., Aslanian, A., Lettieri, K., Gullo, M., Badaloni, A., Lewcock, J.W., Hunter, T., Pfaff, S.L. p190RhoGAP Filters Competing Signals to Resolve Axon Guidance Conflicts. (2019) 神经元. DOI: 10.1016/j.neuron.2019.02.034
Lamarche, B.J., Orazio, N.I., Goben, B., Meisenhelder, J., You, Z., Weitzman, M.D., Hunter, T. Repair of protein-linked DNA double strand breaks: Using the adenovirus genome as a model substrate in cell-based assays. (2018) DNA Repair. DOI: 10.1016/j.dnarep.2018.12.001
Chou, A.C., Aslanian, A., Sun, H., Hunter, T. An internal ribosome entry site in the coding region of tyrosyl-DNA phosphodiesterase 2 drives alternative translation start. (2018) 生物化学杂志. DOI: 10.1074/jbc.RA118.006269
Luhtala, N., Hunter, T. Failure to detect functional transfer of active K-Ras protein from extracellular vesicles into recipient cells in culture. (2018) PLOS One. 13(9):e0203290. DOI: 10.1371/journal.pone.0203290
Wang, Z., Wu, C., Aslanian, A., Yates, J.R., Hunter, T. Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway. (2018) Elife. 7. DOI: 10.7554/eLife.35447
Chu, B., He, A., Tian, Y., He, W., Chen, P., Hu, J., Xu, R., Zhou, W., Zhang, M., Yang, P., Li, S.S.C., Sun, Y., Li, P., Hunter, T., Tian, R. Photoaffinity-engineered protein scaffold for systematically exploring native phosphotyrosine signaling complexes in tumor samples. (2018) 美国国家科学院院刊. 115(38)::E8863-E8872. DOI: 10.1073/pnas.1805633115
Kim, Y., Zheng, X., Ansari, Z., Bunnell, M.C., Herdy, J.R., Traxler, L., Lee, H., Paquola, A.C.M., Blithikioti, C., Ku, M., Schlachetzki, J.C.M., Winkler, J., Edenhofer, F., Glass, C.K., Paucar, A.A., Jaeger, B.N., Pham, S., Boyer, L., Campbell, B.C., Hunter, T., Mertens, J., Gage, F.H. Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile. (2018) 细胞报告. 23(9):2550-2558. DOI: 10.1016/j.celrep.2018.04.105
Zhu, Q., Hoong, N., Aslanian, A., Hara, T., Benner, C., Heinz, S., Miga, K.H., Ke, E., Verma, S., Soroczynski, J., Yates, J.R., Hunter, T., Verma, I.M. Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer. (2018) 分子细胞. DOI: 10.1016/j.molcel.2018.04.023
Hsu, C.L., Lee, E.X., Gordon, K.L., Paz, E.A., Shen, W.C., Ohnishi, K., Meisenhelder, J., Hunter, T., La Spada, A.R. MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. (2018) 自然-通讯. 9(1):942. DOI: 10.1038/s41467-018-03340-7
Hindupur, S.K., Colombi, M., Fuhs, S.R., Matter, M.S., Guri, Y., Adam, K., Cornu, M., Piscuoglio, S., Ng, C.K.Y., Betz, C., Liko, D., Quagliata, L., Moes, S., Jenoe, P., Terracciano, L.M., Heim, M.H., Hunter, T., Hall, M.N. The protein histidine phosphatase LHPP is a tumour suppressor. (2018) 自然. 555(7698):678-682. DOI: 10.1038/nature26140
Settleman, J., Sawyers, C.L., Hunter, T. Challenges in validating candidate therapeutic targets in cancer. (2018) Elife. 7. DOI: 10.7554/eLife.32402
Lu, Z., Hunter, T. Metabolic Kinases Moonlighting as Protein Kinases. (2018) 生物化学趋势. 43(4):301-310. DOI: 10.1016/j.tibs.2018.01.006
Adam, K., Hunter, T. Histidine kinases and the missing phosphoproteome from prokaryotes to eukaryotes. (2017) Lab. Invest. 98(2):233-247. DOI: 10.1038/labinvest.2017.118
Paudyal, S.C., Li, S., Yan, H., Hunter, T., You, Z. Dna2 initiates resection at clean DNA double-strand breaks. (2017) 核酸研究. 45(20):11766-11781. DOI: 10.1093/nar/gkx830
Hoppmann, C., Wong, A., Yang, B., Li, S., Hunter, T., Shokat, K.M., Wang, L. Site-specific incorporation of phosphotyrosine using an expanded genetic code. (2017) Nature Chemical Biology. 13(8):842-844. DOI: 10.1038/nchembio.2406
French, M.E., Klosowiak, J.L., Aslanian, A., Reed, S.I., Yates, J.R., Hunter, T. Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase. (2017) 生物化学杂志. 292(25):10398-10413. DOI: 10.1074/jbc.M117.789479
Fuhs, S.R., Hunter, T. pHisphorylation: the emergence of histidine phosphorylation as a reversible regulatory modification. (2017) 细胞生物学进展. 45:8-16. DOI: 10.1016/j.ceb.2016.12.010
Luhtala, N., Aslanian, A., Yates, J.R., Hunter, T. Secreted Glioblastoma Nanovesicles Contain Intracellular Signaling Proteins and Active Ras Incorporated in a Farnesylation-dependent Manner. (2017) 生物化学杂志. 292(2):611-628. DOI: 10.1074/jbc.M116.747618
Srivastava, S., Panda, S., Li, Z., Fuhs, S.R., Hunter, T., Thiele, D.J., Hubbard, S.R., Skolnik, E.Y. Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1. (2016) Elife. 5. DOI: 10.7554/eLife.16093
Panda, S., Srivastava, S., Li, Z., Vaeth, M., Fuhs, S.R., Hunter, T., Skolnik, E.Y. Identification of PGAM5 as a Mammalian Protein Histidine Phosphatase that Plays a Central Role to Negatively Regulate CD4(+) T Cells. (2016) 分子细胞. 63(3):457-69. DOI: 10.1016/j.molcel.2016.06.021
Zheng, X., Boyer, L., Jin, M., Mertens, J., Kim, Y., Ma, L., Ma, L., Hamm, M., Gage, F.H., Hunter, T. Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation. (2016) Elife. 5. DOI: 10.7554/eLife.13374
Zheng, X., Boyer, L., Jin, M., Kim, Y., Fan, W., Bardy, C., Berggren, T., Evans, R.M., Gage, F.H., Hunter, T. Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration. (2016) Elife. 5. DOI: 10.7554/eLife.13378
Li, X., Jiang, Y., Meisenhelder, J., Yang, W., Hawke, D.H., Zheng, Y., Xia, Y., Aldape, K., He, J., Hunter, T., Wang, L., Lu, Z. Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis. (2016) 分子细胞. 61(5):705-719. DOI: 10.1016/j.molcel.2016.02.009
Marusiak, A.A., Stephenson, N.L., Baik, H., Trotter, E.W., Li, Y., Blyth, K., Mason, S., Chapman, P., Puto, L.A., Read, J.A., Brassington, C., Pollard, H.K., Phillips, C., Green, I., Overman, R., Collier, M., Testoni, E., Miller, C.J., Hunter, T., Sansom, O.J., Brognard, J. Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis. (2016) 癌症研究. 76(3):724-35. DOI: 10.1158/0008-5472.CAN-15-0701-T
Heimbucher, T., Hunter, T. The C. elegans Ortholog of USP7 controls DAF-16 stability in Insulin/IGF-1-like signaling. (2015) 蠕虫. 4(4):e1103429. DOI: 10.1080/21624054.2015.1103429
Denli, A.M., Narvaiza, I., Kerman, B.E., Pena, M., Benner, C., Marchetto, M.C., Diedrich, J.K., Aslanian, A., Ma, J., Moresco, J.J., Moore, L., Hunter, T., Saghatelian, A., Gage, F.H. Primate-specific ORF0 contributes to retrotransposon-mediated diversity. (2015) 牢房. 163(3):583-93. DOI: 10.1016/j.cell.2015.09.025
Zheng, X., Hunter, T. How phosphoubiquitin activates Parkin. (2015) Cell Research. 25(10):1087-8. DOI: 10.1038/cr.2015.97
Carrano, A.C., Hunter, T. Fitting WWP-1 in the dietary restriction network. (2015) Cell Cycle. 14(10):1485-6. DOI: 10.1080/15384101.2015.1032642
Heimbucher, T., Liu, Z., Bossard, C., McCloskey, R., Carrano, A.C., Riedel, C.G., Tanasa, B., Klammt, C., Fonslow, B.R., Riera, C.E., Lillemeier, B.F., Kemphues, K., Yates, J.R., O'Shea, C.C., Hunter, T., Dillin, A. The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity. (2015) Cell Metabolism. 22(1):151-63. DOI: 10.1016/j.cmet.2015.06.002
Fuhs, S.R., Meisenhelder, J., Aslanian, A., Ma, L., Zagorska, A., Stankova, M., Binnie, A., Al-Obeidi, F., Mauger, J., Lemke, G., Yates, J.R., Hunter, T. Monoclonal 1- and 3-Phosphohistidine Antibodies: New Tools to Study Histidine Phosphorylation. (2015) 牢房. 162(1):198-210. DOI: 10.1016/j.cell.2015.05.046
Hunter, T. Discovering the first tyrosine kinase. (2015) 美国国家科学院院刊. 112(26):7877-82. DOI: 10.1073/pnas.1508223112
Puto, L.A., Brognard, J., Hunter, T. Transcriptional Repressor DAXX Promotes Prostate Cancer Tumorigenicity via Suppression of Autophagy. (2015) 生物化学杂志. 290(25):15406-20. DOI: 10.1074/jbc.M115.658765
Puto, L.A., Benner, C., Hunter, T. The DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer. (2015) Oncoscience. 2(4):362-72. DOI: 10.18632/oncoscience.152
Tian, R., Wang, H., Gish, G.D., Petsalaki, E., Pasculescu, A., Shi, Y., Mollenauer, M., Bagshaw, R.D., Yosef, N., Hunter, T., Gingras, A.C., Weiss, A., Pawson, T. Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor. (2015) 美国国家科学院院刊. 112(13):E1594-603. DOI: 10.1073/pnas.1503286112
Antal, C.E., Hudson, A.M., Kang, E., Zanca, C., Wirth, C., Stephenson, N.L., Trotter, E.W., Gallegos, L.L., Miller, C.J., Furnari, F.B., Hunter, T., Brognard, J., Newton, A.C. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. (2015) 牢房. 160(3):489-502. DOI: 10.1016/j.cell.2015.01.001
Wilkinson, D.S., Jariwala, J.S., Anderson, E., Mitra, K., Meisenhelder, J., Chang, J.T., Ideker, T., Hunter, T., Nizet, V., Dillin, A., Hansen, M. Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy. (2015) 分子细胞. 57(1):55-68. DOI: 10.1016/j.molcel.2014.11.019
Basnet, H., Su, X.B., Tan, Y., Meisenhelder, J., Merkurjev, D., Ohgi, K.A., Hunter, T., Pillus, L., Rosenfeld, M.G. Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation. (2014) 自然. 516(7530):267-71. DOI: 10.1038/nature13736
Thorner, J., Hunter, T., Cantley, L.C., Sever, R. Signal transduction: From the atomic age to the post-genomic era. (2014) 冷泉港生物学述评. 6(12):a022913. DOI: 10.1101/cshperspect.a022913
Sherman, M.H., Yu, R.T., Engle, D.D., Ding, N., Atkins, A.R., Tiriac, H., Collisson, E.A., Connor, F., Van Dyke, T., Kozlov, S., Martin, P., Tseng, T.W., Dawson, D.W., Donahue, T.R., Masamune, A., Shimosegawa, T., Apte, M.V., Wilson, J.S., Ng, B., Lau, S.L., Gunton, J.E., Wahl, G.M., Hunter, T., Drebin, J.A., O'Dwyer, P.J., Liddle, C., Tuveson, D.A., Downes, M., Evans, R.M. 维生素D受体介导的基质重编程可抑制胰腺炎并增强胰腺癌治疗效果。. (2014) 牢房. 159(1):80-93. DOI: 10.1016/j.cell.2014.08.007
Lu, Z., Hunter, T. Prolyl isomerase Pin1 in cancer. (2014) Cell Research. 24(9):1033-49. DOI: 10.1038/cr.2014.109
Zheng, X., Hunter, T. Pink1, the first ubiquitin kinase. (2014) EMBO 期刊. 33(15):1621-3. DOI: 10.15252/embj.201489185
Sun, H., Liu, Y., Hunter, T. Multiple Arkadia/RNF111 structures coordinate its Polycomb body association and transcriptional control. (2014) 分子与细胞生物学. 34(16):2981-95. DOI: 10.1128/MCB.00036-14
Yang, W., Xia, Y., Hawke, D., Li, X., Liang, J., Xing, D., Aldape, K., Hunter, T., Yung, W.K.A., Lu, Z. PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis. (2014) 牢房. 158(5):1210. DOI: 10.1016/j.cell.2014.08.003
Ma, L., Aslanian, A., Sun, H., Jin, M., Shi, Y., Yates, J.R., Hunter, T. Identification of small ubiquitin-like modifier substrates with diverse functions using the Xenopus egg extract system. (2014) Molecular & Cellular Proteomics. 13(7):1659-75. DOI: 10.1074/mcp.M113.035626
Carrano, A.C., Dillin, A., Hunter, T. A Krüppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans. (2014) 自然-通讯. 5:3772. DOI: 10.1038/ncomms4772
Voog, J., Sandall, S.L., Hime, G.R., Resende, L.P., Loza-Coll, M., Aslanian, A., Yates, J.R., Hunter, T., Fuller, M.T., Jones, D.L. Escargot restricts niche cell to stem cell conversion in the Drosophila testis. (2014) 细胞报告. 7(3):722-34. DOI: 10.1016/j.celrep.2014.04.025
Hunter, T. The genesis of tyrosine phosphorylation. (2014) 冷泉港生物学述评. 6(5):a020644. DOI: 10.1101/cshperspect.a020644
Aslanian, A., Yates, J.R., Hunter, T. Mass spectrometry-based quantification of the cellular response to methyl methanesulfonate treatment in human cells. (2014) DNA Repair. 15:29-38. DOI: 10.1016/j.dnarep.2013.12.007
Zhang, Y., Hunter, T. Roles of Chk1 in cell biology and cancer therapy. (2014) International Journal of Cancer. 134(5):1013-23. DOI: 10.1002/ijc.28226
Ma, H., Han, B.K., Guaderrama, M., Aslanian, A., Yates, J.R., Hunter, T., Wittenberg, C. Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression. (2014) 分子与细胞生物学. 34(3):452-63. DOI: 10.1128/MCB.00279-13
Hunter, T. Retrospective. Tony Pawson (1952-2013). (2013) 科学. 341(6150):1078. DOI: 10.1126/science.1244986
Zheng, X., Hunter, T. Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism. (2013) Cell Research. 23(7):886-97. DOI: 10.1038/cr.2013.66
Hunter, T. Translating experience: thinking outside the box. (2013) 自然-细胞生物学. 15(6):545. DOI: 10.1038/ncb2771
Sun, H., Hunter, T. Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search. (2012) 生物化学杂志. 287(50):42071-83. DOI: 10.1074/jbc.M112.410985
Lu, C.S., Truong, L.N., Aslanian, A., Shi, L.Z., Li, Y., Hwang, P.Y., Koh, K.H., Hunter, T., Yates, J.R., Berns, M.W., Wu, X. The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination. (2012) 生物化学杂志. 287(52):43984-94. DOI: 10.1074/jbc.M112.421545
Zhu, W., Pao, G.M., Satoh, A., Cummings, G., Monaghan, J.R., Harkins, T.T., Bryant, S.V., Randal Voss, S., Gardiner, D.M., Hunter, T. Activation of germline-specific genes is required for limb regeneration in the Mexican axolotl. (2012) Developmental Biology. 370(1):42-51. DOI: 10.1016/j.ydbio.2012.07.021
Zhang, Q.C., Petrey, D., Deng, L., Qiang, L., Shi, Y., Thu, C.A., Bisikirska, B., Lefebvre, C., Accili, D., Hunter, T., Maniatis, T., Califano, A., Honig, B. Structure-based prediction of protein-protein interactions on a genome-wide scale. (2012) 自然. 490(7421):556-60. DOI: 10.1038/nature11503
Zhu, W., Kuo, D., Nathanson, J., Satoh, A., Pao, G.M., Yeo, G.W., Bryant, S.V., Voss, S.R., Gardiner, D.M., Hunter, T. Retrotransposon long interspersed nucleotide element-1 (LINE-1) is activated during salamander limb regeneration. (2012) Dev. Growth Differ. 54(7):673-85. DOI: 10.1111/j.1440-169X.2012.01368.x
Hunter, T. Why nature chose phosphate to modify proteins. (2012) Philos. Trans. R. Soc. Lond., B, Biol. Sci. 367(1602):2513-6. DOI: 10.1098/rstb.2012.0013
Hunter, T., Pawson, T. The evolution of protein phosphorylation. Preface. (2012) Philos. Trans. R. Soc. Lond., B, Biol. Sci. 367(1602):2512. DOI: 10.1098/rstb.2012.0374
Yang, W., Xia, Y., Hawke, D., Li, X., Liang, J., Xing, D., Aldape, K., Hunter, T., Alfred Yung, W.K., Lu, Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. (2012) 牢房. 150(4):685-96. DOI: 10.1016/j.cell.2012.07.018
Wang, Z., Shah, O.J., Hunter, T. The transcriptional coactivators p/CIP and SRC-1 control insulin resistance through IRS1 in obesity models. (2012) PLOS One. 7(7):e36961. DOI: 10.1371/journal.pone.0036961
Chaurushiya, M.S., Lilley, C.E., Aslanian, A., Meisenhelder, J., Scott, D.C., Landry, S., Ticau, S., Boutell, C., Yates, J.R., Schulman, B.A., Hunter, T., 韦茨曼医生. Viral E3 ubiquitin ligase-mediated degradation of a cellular E3: viral mimicry of a cellular phosphorylation mark targets the RNF8 FHA domain. (2012) 分子细胞. 46(1):79-90. DOI: 10.1016/j.molcel.2012.02.004
Brognard, J., Zhang, Y.W., Puto, L.A., Hunter, T. Cancer-associated loss-of-function mutations implicate DAPK3 as a tumor-suppressing kinase. (2011) 癌症研究. 71(8):3152-61. DOI: 10.1158/0008-5472.CAN-10-3543
Brognard, J., Hunter, T. Protein kinase signaling networks in cancer. (2011) 遗传与发育意见。. 21(1):4-11. DOI: 10.1016/j.gde.2010.10.012
Olson, B.J., Oberholzer, M., Li, Y., Zones, J.M., Kohli, H.S., Bisova, K., Fang, S.C., Meisenhelder, J., Hunter, T., Umen, J.G. Regulation of the Chlamydomonas cell cycle by a stable, chromatin-associated retinoblastoma tumor suppressor complex. (2010) Plant Cell. 22(10):3331-47. DOI: 10.1105/tpc.110.076067
Yoon, Y.S., Lee, M.W., Ryu, D., Kim, J.H., Ma, H., Seo, W.Y., Kim, Y.N., Kim, S.S., Lee, C.H., Hunter, T., Choi, C.S., Montminy, M.R., Koo, S.H. Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis. (2010) 美国国家科学院院刊. 107(41):17704-9. DOI: 10.1073/pnas.1012665107
Liew, C.W., Sun, H., Hunter, T., Day, C.L. RING domain dimerization is essential for RNF4 function. (2010) Biochemical Journal. 431(1):23-9. DOI: 10.1042/BJ20100957
Lu, Z., Hunter, T. Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors. (2010) Cell Cycle. 9(12):2342-52. DOI: 10.4161/cc.9.12.11988
López-Otín, C., Hunter, T. The regulatory crosstalk between kinases and proteases in cancer. (2010) Nature Reviews Cancer. 10(4):278-92. DOI: 10.1038/nrc2823
Hunter, T., Marais, R. Genetic and cellular mechanisms of oncogenesis. (2010) 遗传与发育意见。. 20(1):1-3. DOI: 10.1016/j.gde.2010.01.001
You, Z., Shi, L.Z., Zhu, Q., Wu, P., Zhang, Y.W., Basilio, A., Tonnu, N., Verma, I.M., Berns, M.W., Hunter, T. CtIP links DNA double-strand break sensing to resection. (2009) 分子细胞. 36(6):954-69. DOI: 10.1016/j.molcel.2009.12.002
Malumbres, M., Harlow, E., Hunt, T., Hunter, T., Lahti, J.M., Manning, G., Morgan, D.O., Tsai, L.H., Wolgemuth, D.J. Cyclin-dependent kinases: a family portrait. (2009) 自然-细胞生物学. 11(11):1275-6. DOI: 10.1038/ncb1109-1275
Zhang, Y.W., Brognard, J., Coughlin, C., You, Z., Dolled-Filhart, M., Aslanian, A., Manning, G., Abraham, R.T., Hunter, T. The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. (2009) 分子细胞. 35(4):442-53. DOI: 10.1016/j.molcel.2009.06.030
Carrano, A.C., Liu, Z., Dillin, A., Hunter, T. A conserved ubiquitination pathway determines longevity in response to diet restriction. (2009) 自然. 460(7253):396-9. DOI: 10.1038/nature08130
Lu, Z., Hunter, T. Degradation of activated protein kinases by ubiquitination. (2009) Annual Review of Biochemistry. 78:435-75. DOI: 10.1146/annurev.biochem.013008.092711
Pearson, G.W., Hunter, T. PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture. (2009) Breast Cancer Research. 11(3):R29. DOI: 10.1186/bcr2259
Hunter, T. Tyrosine phosphorylation: thirty years and counting. (2009) 细胞生物学进展. 21(2):140-6. DOI: 10.1016/j.ceb.2009.01.028
Copp, J., Manning, G., Hunter, T. TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. (2009) 癌症研究. 69(5):1821-7. DOI: 10.1158/0008-5472.CAN-08-3014
Smith, J.J., Putta, S., Zhu, W., Pao, G.M., Verma, I.M., Hunter, T., Bryant, S.V., Gardiner, D.M., Harkins, T.T., Voss, S.R. Genic regions of a large salamander genome contain long introns and novel genes. (2009) BMC Genomics. 10:19. DOI: 10.1186/1471-2164-10-19
Monaghan, J.R., Epp, L.G., Putta, S., Page, R.B., Walker, J.A., Beachy, C.K., Zhu, W., Pao, G.M., Verma, I.M., Hunter, T., Bryant, S.V., Gardiner, D.M., Harkins, T.T., Voss, S.R. Microarray and cDNA sequence analysis of transcription during nerve-dependent limb regeneration. (2009) BMC Biology. 7:1. DOI: 10.1186/1741-7007-7-1
Hunter, T., Sun, H. Crosstalk between the SUMO and ubiquitin pathways. (2008) Ernst Schering Found Symp Proc.(1):1-16
Hashimoto, T., Yamauchi, L., Hunter, T., Kikkawa, U., Kamada, S. Possible involvement of caspase-7 in cell cycle progression at mitosis. (2008) Genes to Cells. 13(6):609-21. DOI: 10.1111/j.1365-2443.2008.01192.x
Hunter, T. Tony Hunter: kinase king. Interview by Ruth Williams. (2008) Journal of Cell Biology. 181(4):572-3. DOI: 10.1083/jcb.1814pi
Bailis, J.M., Luche, D.D., Hunter, T., Forsburg, S.L. Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote s-phase genome stability. (2008) 分子与细胞生物学. 28(5):1724-38. DOI: 10.1128/MCB.01717-07
Ghosh, S., Marquardt, T., Thaler, J.P., Carter, N., Andrews, S.E., Pfaff, S.L., Hunter, T. Instructive role of aPKCzeta subcellular localization in the assembly of adherens junctions in neural progenitors. (2008) 美国国家科学院院刊. 105(1):335-40. DOI: 10.1073/pnas.0705713105
Pearson, G.W., Hunter, T. Real-time imaging reveals that noninvasive mammary epithelial acini can contain motile cells. (2007) Journal of Cell Biology. 179(7):1555-67. DOI: 10.1083/jcb.200706099
Hunter, T. The age of crosstalk: phosphorylation, ubiquitination, and beyond. (2007) 分子细胞. 28(5):730-8. DOI: 10.1016/j.molcel.2007.11.019
You, Z., Bailis, J.M., Johnson, S.A., Dilworth, S.M., Hunter, T. Rapid activation of ATM on DNA flanking double-strand breaks. (2007) 自然-细胞生物学. 9(11):1311-8. DOI: 10.1038/ncb1651
Sun, H., Leverson, J.D., Hunter, T. Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins. (2007) EMBO 期刊. 26(18):4102-12. DOI: 10.1038/sj.emboj.7601839
Johnson, S.A., You, Z., Hunter, T. Monitoring ATM kinase activity in living cells. (2007) DNA Repair. 6(9):1277-84. DOI: 10.1016/j.dnarep.2007.02.025
Hunter, T. Treatment for chronic myelogenous leukemia: the long road to imatinib. (2007) 临床研究杂志. 117(8):2036-43. DOI: 10.1172/JCI31691
Zhang, Y., Daum, S., Wildemann, D., Zhou, X.Z., Verdecia, M.A., Bowman, M.E., Lücke, C., Hunter, T., Lu, K.P., Fischer, G., Noel, J.P. Structural basis for high-affinity peptide inhibition of human Pin1. (2007) ACS Chemical Biology. 2(5):320-8. DOI: 10.1021/cb7000044
Fang, D., Hawke, D., Zheng, Y., Xia, Y., Meisenhelder, J., Nika, H., Mills, G.B., Kobayashi, R., Hunter, T., Lu, Z. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. (2007) 生物化学杂志. 282(15):11221-9. DOI: 10.1074/jbc.M611871200
Hunter, T., Simon, J. A not so brief history of the Oncogene Meeting and its cartoons. (2007) 癌基因. 26(9):1260-7. DOI: 10.1038/sj.onc.1210262
Bozulic, L., Morin, P., Hunter, T., Hemmings, B.A. Meeting report: targeting the kinome--20 years of tyrosine kinase inhibitor research in Basel. (2007) Sci. STKE. 2007(374):pe8. DOI: 10.1126/stke.3742007pe8
Xia, Y., Wang, J., Liu, T.J., Yung, W.K., Hunter, T., Lu, Z. c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis. (2007) 分子细胞. 25(2):219-32. DOI: 10.1016/j.molcel.2007.01.005
Xia, Y., Wang, J., Xu, S., Johnson, G.L., Hunter, T., Lu, Z. MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress. (2007) 分子与细胞生物学. 27(2):510-7. DOI: 10.1128/MCB.01355-06
Ghosh, S., Tergaonkar, V., Rothlin, C.V., Correa, R.G., Bottero, V., Bist, P., Verma, I.M., Hunter, T. Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. (2006) Cancer Cell. 10(3):215-26. DOI: 10.1016/j.ccr.2006.08.007
Shah, O.J., Hunter, T. Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis. (2006) 分子与细胞生物学. 26(17):6425-34. DOI: 10.1128/MCB.01254-05
Joazeiro, C.A., Anderson, K.C., Hunter, T. Proteasome inhibitor drugs on the rise. (2006) 癌症研究. 66(16):7840-2. DOI: 10.1158/0008-5472.CAN-06-2033
Wolff, S., Ma, H., Burch, D., Maciel, G.A., Hunter, T., Dillin, A. SMK-1, an essential regulator of DAF-16-mediated longevity. (2006) 牢房. 124(5):1039-53. DOI: 10.1016/j.cell.2005.12.042
Petersen, P., Chou, D.M., You, Z., Hunter, T., Walter, J.C., Walter, G. Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. (2006) 分子与细胞生物学. 26(5):1997-2011. DOI: 10.1128/MCB.26.5.1997-2011.2006
Wang, Z., Qi, C., Krones, A., Woodring, P., Zhu, X., Reddy, J.K., Evans, R.M., Rosenfeld, M.G., Hunter, T. Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance. (2006) Cell Metabolism. 3(2):111-22. DOI: 10.1016/j.cmet.2006.01.002
Zhang, Y.W., Hunter, T., Abraham, R.T. Turning the replication checkpoint on and off. (2006) Cell Cycle. 5(2):125-8. DOI: 10.4161/cc.5.2.2308
Hunter, T., Schulman, H. CaMKII structure--an elegant design. (2005) 牢房. 123(5):765-7. DOI: 10.1016/j.cell.2005.11.017
Kamada, S., Kikkawa, U., Tsujimoto, Y., Hunter, T. A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association. (2005) 分子与细胞生物学. 25(21):9469-77. DOI: 10.1128/MCB.25.21.9469-9477.2005
Huang, H.K., Bailis, J.M., Leverson, J.D., Gómez, E.B., Forsburg, S.L., Hunter, T. Suppressors of Bir1p (Survivin) identify roles for the chromosomal passenger protein Pic1p (INCENP) and the replication initiation factor Psf2p in chromosome segregation. (2005) 分子与细胞生物学. 25(20):9000-15. DOI: 10.1128/MCB.25.20.9000-9015.2005
Watanabe, N., Arai, H., Iwasaki, J., Shiina, M., Ogata, K., Hunter, T., Osada, H. Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways. (2005) 美国国家科学院院刊. 102(33):11663-8. DOI: 10.1073/pnas.0500410102
You, Z., Chahwan, C., Bailis, J., Hunter, T., Russell, P. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. (2005) 分子与细胞生物学. 25(13):5363-79. DOI: 10.1128/MCB.25.13.5363-5379.2005
Wang, X., Li, X., Meisenhelder, J., Hunter, T., Yoshida, S., Asami, T., Chory, J. Autoregulation and homodimerization are involved in the activation of the plant steroid receptor BRI1. (2005) 发育细胞. 8(6):855-65. DOI: 10.1016/j.devcel.2005.05.001
Marquardt, T., Shirasaki, R., Ghosh, S., Andrews, S.E., Carter, N., Hunter, T., Pfaff, S.L. Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains. (2005) 牢房. 121(1):127-39. DOI: 10.1016/j.cell.2005.01.020
Takagi, Y., Masuda, C.A., Chang, W.H., Komori, H., Wang, D., Hunter, T., Joazeiro, C.A., Kornberg, R.D. Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage. (2005) 分子细胞. 18(2):237-43. DOI: 10.1016/j.molcel.2005.03.007
Woodring, P.J., Hunter, T., Wang, J.Y. Mitotic phosphorylation rescues Abl from F-actin-mediated inhibition. (2005) 生物化学杂志. 280(11):10318-25. DOI: 10.1074/jbc.M410658200
Papin, J.A., Hunter, T., Palsson, B.O., Subramaniam, S. Reconstruction of cellular signalling networks and analysis of their properties. (2005) 自然-学科前沿:分子细胞生物学. 6(2):99-111. DOI: 10.1038/nrm1570
Johnson, S.A., Hunter, T. Kinomics: methods for deciphering the kinome. (2005) 自然方法. 2(1):17-25. DOI: 10.1038/nmeth731
Shah, O.J., Hunter, T. Tuberous sclerosis and insulin resistance. Unlikely bedfellows reveal a TORrid affair. (2005) Cell Cycle. 4(1):46-51. DOI: 10.4161/cc.4.1.1343
Kamada, S., Kikkawa, U., Tsujimoto, Y., Hunter, T. Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s). (2005) 生物化学杂志. 280(2):857-60. DOI: 10.1074/jbc.C400538200
York, J.D., Hunter, T. Signal transduction. Unexpected mediators of protein phosphorylation. (2004) 科学. 306(5704):2053-5. DOI: 10.1126/science.1107225
Grabbe, C., Zervas, C.G., Hunter, T., Brown, N.H., Palmer, R.H. Focal adhesion kinase is not required for integrin function or viability in Drosophila. (2004) Development. 131(23):5795-805. DOI: 10.1242/dev.01462
Shah, O.J., Wang, Z., Hunter, T. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. (2004) 当前生物学。. 14(18):1650-6. DOI: 10.1016/j.cub.2004.08.026
Johnson, S.A., Hunter, T. Phosphoproteomics finds its timing. (2004) Nature Biotechnology. 22(9):1093-4. DOI: 10.1038/nbt0904-1093
Caenepeel, S., Charydczak, G., Sudarsanam, S., Hunter, T., Manning, G. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. (2004) 美国国家科学院院刊. 101(32):11707-12. DOI: 10.1073/pnas.0306880101
Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J., Mustelin, T. Protein tyrosine phosphatases in the human genome. (2004) 牢房. 117(6):699-711. DOI: 10.1016/j.cell.2004.05.018
Fukunaga, R., Hunter, T. Identification of MAPK substrates by expression screening with solid-phase phosphorylation. (2004) 分子生物学方法. 250:211-36. DOI: 10.1385/1-59259-671-1:211
Woodring, P.J., Meisenhelder, J., Johnson, S.A., Zhou, G.L., Field, J., Shah, K., Bladt, F., Pawson, T., Niki, M., Pandolfi, P.P., Wang, J.Y., Hunter, T. c-Abl phosphorylates Dok1 to promote filopodia during cell spreading. (2004) Journal of Cell Biology. 165(4):493-503. DOI: 10.1083/jcb.200312171
Shah, O.J., Hunter, T. Critical role of T-loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the tuberous sclerosis complex. (2004) 生物化学杂志. 279(20):20816-23. DOI: 10.1074/jbc.M400957200
Lu, Z., Hunter, T. Wnt-independent beta-catenin transactivation in tumor development. (2004) Cell Cycle. 3(5):571-3.
Watanabe, N., Arai, H., Nishihara, Y., Taniguchi, M., Watanabe, N., Hunter, T., Osada, H. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. (2004) 美国国家科学院院刊. 101(13):4419-24. DOI: 10.1073/pnas.0307700101
Hunter, T., Eckhart, W. The discovery of tyrosine phosphorylation: it's all in the buffer! (2004) 牢房. 116(2 Suppl):S35-9, 1 p following S48.
Lu, Z., Ghosh, S., Wang, Z., Hunter, T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. (2003) Cancer Cell. 4(6):499-515.
Lorén, C.E., Englund, C., Grabbe, C., Hallberg, B., Hunter, T., Palmer, R.H. A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster. (2003) EMBO 报告. 4(8):781-6. DOI: 10.1038/sj.embor.embor897
Sonnenburg, E.D., Bilwes, A., Hunter, T., Noel, J.P. The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region. (2003) Biochemistry. 42(26):7904-14. DOI: 10.1021/bi0340503
Woodring, P.J., Hunter, T., Wang, J.Y. Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases. (2003) 细胞科学杂志. 116(Pt 13):2613-26. DOI: 10.1242/jcs.00622
Liou, Y.C., Sun, A., Ryo, A., Zhou, X.Z., Yu, Z.X., Huang, H.K., Uchida, T., Bronson, R., Bing, G., Li, X., Hunter, T., Lu, K.P. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. (2003) 自然. 424(6948):556-61. DOI: 10.1038/nature01832
Shah, O.J., Ghosh, S., Hunter, T. Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and non-consensus sites by Cdc2. (2003) 生物化学杂志. 278(18):16433-42. DOI: 10.1074/jbc.M300435200
O'Connell, M.J., Krien, M.J., Hunter, T. Never say never. The NIMA-related protein kinases in mitotic control. (2003) Trends in Cell Biology. 13(5):221-8.
Xia, Y., Pao, G.M., Chen, H.W., Verma, I.M., Hunter, T. Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. (2003) 生物化学杂志. 278(7):5255-63. DOI: 10.1074/jbc.M204591200
Verdecia, M.A., Joazeiro, C.A., Wells, N.J., Ferrer, J.L., Bowman, M.E., Hunter, T., Noel, J.P. Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. (2003) 分子细胞. 11(1):249-59.
Uchida, T., Takamiya, M., Takahashi, M., Miyashita, H., Ikeda, H., Terada, T., Matsuo, Y., Shirouzu, M., Yokoyama, S., Fujimori, F., Hunter, T. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. (2003) Chemistry & Biology. 10(1):15-24.
Gilman, A.G., Simon, M.I., Bourne, H.R., Harris, B.A., Long, R., Ross, E.M., Stull, J.T., Taussig, R., Bourne, H.R., Arkin, A.P., Cobb, M.H., Cyster, J.G., Devreotes, P.N., Ferrell, J.E., Fruman, D., Gold, M., Weiss, A., Stull, J.T., Berridge, M.J., Cantley, L.C., Catterall, W.A., Coughlin, S.R., Olson, E.N., Smith, T.F., Brugge, J.S., Botstein, D., Dixon, J.E., Hunter, T., Lefkowitz, R.J., Pawson, A.J., Sternberg, P.W., Varmus, H., Subramaniam, S., Sinkovits, R.S., Li, J., Mock, D., Ning, Y., Saunders, B., Sternweis, P.C., Hilgemann, D., Scheuermann, R.H., DeCamp, D., Hsueh, R., Lin, K.M., Ni, Y., Seaman, W.E., Simpson, P.C., O'Connell, T.D., Roach, T., Simon, M.I., Choi, S., Eversole-Cire, P., Fraser, I., Mumby, M.C., Zhao, Y., Brekken, D., Shu, H., Meyer, T., Chandy, G., Heo, W.D., Liou, J., O'Rourke, N., Verghese, M., Mumby, S.M., Han, H., Brown, H.A., Forrester, J.S., Ivanova, P., Milne, S.B., Casey, P.J., Harden, T.K., Arkin, A.P., Doyle, J., Gray, M.L., Meyer, T., Michnick, S., Schmidt, M.A., Toner, M., Tsien, R.Y., Natarajan, M., Ranganathan, R., Sambrano, G.R. Overview of the Alliance for Cellular Signaling. (2002) 自然. 420(6916):703-6. DOI: 10.1038/nature01304
Manning, G., Whyte, D.B., Martinez, R., Hunter, T., Sudarsanam, S. The protein kinase complement of the human genome. (2002) 科学. 298(5600):1912-34. DOI: 10.1126/science.1075762
Manning, G., Plowman, G.D., Hunter, T., Sudarsanam, S. Evolution of protein kinase signaling from yeast to man. (2002) 生物化学趋势. 27(10):514-20.
Carter, N., Nakamoto, T., Hirai, H., Hunter, T. EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas). (2002) 自然-细胞生物学. 4(8):565-73. DOI: 10.1038/ncb823
Hunter, T. Tyrosine phosphorylation in cell signaling and disease. (2002) Keio J Med. 51(2):61-71.
Mollinari, C., Kleman, J.P., Jiang, W., Schoehn, G., Hunter, T., Margolis, R.L. PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone. (2002) Journal of Cell Biology. 157(7):1175-86. DOI: 10.1083/jcb.200111052
Lu, Z., Xu, S., Joazeiro, C., Cobb, M.H., Hunter, T. The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. (2002) 分子细胞. 9(5):945-56.
Asahara, H., Tartare-Deckert, S., Nakagawa, T., Ikehara, T., Hirose, F., Hunter, T., Ito, T., Montminy, M. Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. (2002) 分子与细胞生物学. 22(9):2974-83.
Leverson, J.D., Huang, H.K., Forsburg, S.L., Hunter, T. The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis. (2002) Molecular Biology of the Cell. 13(4):1132-43. DOI: 10.1091/mbc.01-07-0330
Woodring, P.J., Litwack, E.D., O'Leary, D.D., Lucero, G.R., Wang, J.Y., Hunter, T. Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. (2002) Journal of Cell Biology. 156(5):879-92. DOI: 10.1083/jcb.200110014
Fang, D., Elly, C., Gao, B., Fang, N., Altman, Y., Joazeiro, C., Hunter, T., Copeland, N., Jenkins, N., Liu, Y.C. Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. (2002) Nature Immunology. 3(3):281-7. DOI: 10.1038/ni763
Liou, Y.C., Ryo, A., Huang, H.K., Lu, P.J., Bronson, R., Fujimori, F., Uchida, T., Hunter, T., Lu, K.P. Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. (2002) 美国国家科学院院刊. 99(3):1335-40. DOI: 10.1073/pnas.032404099
Mustelin, T., Hunter, T. Meeting at mitosis: cell cycle-specific regulation of c-Src by RPTPalpha. (2002) Sci. STKE. 2002(115):pe3. DOI: 10.1126/stke.2002.115.pe3
Buck, M., Zhang, L., Halasz, N.A., Hunter, T., Chojkier, M. Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha. (2001) EMBO 期刊. 20(23):6712-23. DOI: 10.1093/emboj/20.23.6712
Huang, H.K., Forsburg, S.L., John, U.P., O'Connell, M.J., Hunter, T. Isolation and characterization of the Pin1/Ess1p homologue in Schizosaccharomyces pombe. (2001) 细胞科学杂志. 114(Pt 20):3779-88.
Buck, M., Poli, V., Hunter, T., Chojkier, M. C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival. (2001) 分子细胞. 8(4):807-16.
Woodring, P.J., Hunter, T., Wang, J.Y. Inhibition of c-Abl tyrosine kinase activity by filamentous actin. (2001) 生物化学杂志. 276(29):27104-10. DOI: 10.1074/jbc.M100559200
Lu, Z., Jiang, G., Blume-Jensen, P., Hunter, T. Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. (2001) 分子与细胞生物学. 21(12):4016-31. DOI: 10.1128/MCB.21.12.4016-4031.2001
Lorén, C.E., Scully, A., Grabbe, C., Edeen, P.T., Thomas, J., McKeown, M., Hunter, T., Palmer, R.H. Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo. (2001) Genes to Cells. 6(6):531-44.
Tertoolen, L.G., Blanchetot, C., Jiang, G., Overvoorde, J., Gadella, T.W., Hunter, T., den Hertog, J. Dimerization of receptor protein-tyrosine phosphatase alpha in living cells. (2001) BMC Cell Biology. 2:8.
Meisenhelder, J., Hunter, T., van der Geer, P. Phosphopeptide mapping and identification of phosphorylation sites. (2001) Current Protocols in Protein Science. Chapter 13:Unit13.9. DOI: 10.1002/0471140864.ps1309s18
Meisenhelder, J., Hunter, T., van der Geer, P. Phosphopeptide mapping and identification of phosphorylation sites. (2001) Current Protocols in Molecular Biology. Chapter 18:Unit 18.9. DOI: 10.1002/0471142727.mb1809s48
Blume-Jensen, P., Hunter, T. Oncogenic kinase signalling. (2001) 自然. 411(6835):355-65. DOI: 10.1038/35077225
Hauck, C.R., Hunter, T., Schlaepfer, D.D. The v-Src SH3 domain facilitates a cell adhesion-independent association with focal adhesion kinase. (2001) 生物化学杂志. 276(21):17653-62. DOI: 10.1074/jbc.M009329200
Ruffner, H., Joazeiro, C.A., Hemmati, D., Hunter, T., Verma, I.M. Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity. (2001) 美国国家科学院院刊. 98(9):5134-9. DOI: 10.1073/pnas.081068398
Blume-Jensen, P., Hunter, T. Two-dimensional phosphoamino acid analysis. (2001) 分子生物学方法. 124:49-65.
Moniakis, J., Funamoto, S., Fukuzawa, M., Meisenhelder, J., Araki, T., Abe, T., Meili, R., Hunter, T., Williams, J., Firtel, R.A. An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway. (2001) 基因与发展. 15(6):687-98. DOI: 10.1101/gad.871001
Potter, L.R., Hunter, T. Activation of protein kinase C stimulates the dephosphorylation of natriuretic peptide receptor-B at a single serine residue: a possible mechanism of heterologous desensitization. (2000) 生物化学杂志. 275(40):31099-106. DOI: 10.1074/jbc.M005506200
Joazeiro, C.A., Hunter, T. Biochemistry. Ubiquitination--more than two to tango. (2000) 科学. 289(5487):2061-2.
Huang, H.k., Joazeiro, C.A., Bonfoco, E., Kamada, S., Leverson, J.D., Hunter, T. The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7. (2000) 生物化学杂志. 275(35):26661-4. DOI: 10.1074/jbc.C000199200
Friedrichsen, D.M., Joazeiro, C.A., Li, J., Hunter, T., 乔里, J. Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase. (2000) Plant Physiology. 123(4):1247-56.
Jiang, G., den Hertog, J., Hunter, T. Receptor-like protein tyrosine phosphatase alpha homodimerizes on the cell surface. (2000) 分子与细胞生物学. 20(16):5917-29.
Verdecia, M.A., Bowman, M.E., Lu, K.P., Hunter, T., Noel, J.P. Structural basis for phosphoserine-proline recognition by group IV WW domains. (2000) Nature Structural Biology. 7(8):639-43. DOI: 10.1038/77929
Leverson, J.D., Joazeiro, C.A., Page, A.M., Huang, H.k., Hieter, P., Hunter, T. The APC11 RING-H2 finger mediates E2-dependent ubiquitination. (2000) Molecular Biology of the Cell. 11(7):2315-25.
Verdecia, M.A., Huang, H., Dutil, E., Kaiser, D.A., Hunter, T., Noel, J.P. Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. (2000) Nature Structural Biology. 7(7):602-8. DOI: 10.1038/76838
Xu, S., Huang, H.K., Kaiser, P., Latterich, M., Hunter, T. Phosphorylation and spindle pole body localization of the Cdc15p mitotic regulatory protein kinase in budding yeast. (2000) 当前生物学。. 10(6):329-32.
Pao, G.M., Janknecht, R., Ruffner, H., Hunter, T., Verma, I.M. CBP/p300 interact with and function as transcriptional coactivators of BRCA1. (2000) 美国国家科学院院刊. 97(3):1020-5.
Blume-Jensen, P., Jiang, G., Hyman, R., Lee, K.F., O'Gorman, S., Hunter, T. Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility. (2000) 自然遗传学. 24(2):157-62. DOI: 10.1038/72814
Hunter, T. Signaling--2000 and beyond. (2000) 牢房. 100(1):113-27.
Buck, M., Poli, V., van der Geer, P., Chojkier, M., Hunter, T. Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha. (1999) 分子细胞. 4(6):1087-92.
Palmer, R.H., Fessler, L.I., Edeen, P.T., Madigan, S.J., McKeown, M., Hunter, T. DFak56 is a novel Drosophila melanogaster focal adhesion kinase. (1999) 生物化学杂志. 274(50):35621-9.
Potter, L.R., Hunter, T. Identification and characterization of the phosphorylation sites of the guanylyl cyclase-linked natriuretic peptide receptors A and B. (1999) Methods. 19(4):506-20. DOI: 10.1006/meth.1999.0893
Jiang, G., den Hertog, J., Su, J., Noel, J., Sap, J., Hunter, T. Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha. (1999) 自然. 401(6753):606-10. DOI: 10.1038/44170
Jiang, W., McDonald, D., Hope, T.J., Hunter, T. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. (1999) EMBO 期刊. 18(20):5703-13. DOI: 10.1093/emboj/18.20.5703
Joazeiro, C.A., Wing, S.S., Huang, H., Leverson, J.D., Hunter, T., Liu, Y.C. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. (1999) 科学. 286(5438):309-12.
Wells, N.J., Watanabe, N., Tokusumi, T., Jiang, W., Verdecia, M.A., Hunter, T. The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression. (1999) 细胞科学杂志. 112 ( Pt 1:3361-71.
Jiang, G., Hunter, T. Receptor signaling: when dimerization is not enough. (1999) 当前生物学。. 9(15):R568-71.
Ruffner, H., Jiang, W., Craig, A.G., Hunter, T., Verma, I.M. BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site. (1999) 分子与细胞生物学. 19(7):4843-54.
Potter, L.R., Hunter, T. A constitutively "phosphorylated" guanylyl cyclase-linked atrial natriuretic peptide receptor mutant is resistant to desensitization. (1999) Molecular Biology of the Cell. 10(6):1811-20.
Biggs, W.H., Meisenhelder, J., Hunter, T., Cavenee, W.K., Arden, K.C. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. (1999) 美国国家科学院院刊. 96(13):7421-6.
Jiang, W., Wells, N.J., Hunter, T. Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. (1999) 美国国家科学院院刊. 96(11):6193-8.
Sekiguchi, T., Nishimoto, T., Hunter, T. Overexpression of D-type cyclins, E2F-1, SV40 large T antigen and HPV16 E7 rescue cell cycle arrest of tsBN462 cells caused by the CCG1/TAF(II)250 mutation. (1999) 癌基因. 18(10):1797-806. DOI: 10.1038/sj.onc.1202508
Hunter, T. The role of tyrosine phosphorylation in cell growth and disease. (1998) Harvey Lect. 94:81-119.
Jiang, W., Jimenez, G., Wells, N.J., Hope, T.J., Wahl, G.M., Hunter, T., Fukunaga, R. PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. (1998) 分子细胞. 2(6):877-85.
Janknecht, R., Wells, N.J., Hunter, T. TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. (1998) 基因与发展. 12(14):2114-9.
Blume-Jensen, P., Janknecht, R., Hunter, T. The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. (1998) 当前生物学。. 8(13):779-82.
Potter, L.R., Hunter, T. Identification and characterization of the major phosphorylation sites of the B-type natriuretic peptide receptor. (1998) 生物化学杂志. 273(25):15533-9.
Hunter, T. The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease. (1998) Philos. Trans. R. Soc. Lond., B, Biol. Sci. 353(1368):583-605. DOI: 10.1098/rstb.1998.0228
Potter, L.R., Hunter, T. Phosphorylation of the kinase homology domain is essential for activation of the A-type natriuretic peptide receptor. (1998) 分子与细胞生物学. 18(4):2164-72.
Schlaepfer, D.D., Hunter, T. Integrin signalling and tyrosine phosphorylation: just the FAKs? (1998) Trends in Cell Biology. 8(4):151-7.
Jiang, W., Hunter, T. Analysis of cell-cycle profiles in transfected cells using a membrane-targeted GFP. (1998) BioTechniques. 24(3):349-50, 352, 354.
Sekiguchi, T., Hunter, T. Induction of growth arrest and cell death by overexpression of the cyclin-Cdk inhibitor p21 in hamster BHK21 cells. (1998) 癌基因. 16(3):369-80. DOI: 10.1038/sj.onc.1201539
Hunter, T. Prolyl isomerases and nuclear function. (1998) 牢房. 92(2):141-3.
Majeti, R., Bilwes, A.M., Noel, J.P., Hunter, T., Weiss, A. Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge. (1998) 科学. 279(5347):88-91.
Jiang, W., Hunter, T. Identification and characterization of a human protein kinase related to budding yeast Cdc7p. (1997) 美国国家科学院院刊. 94(26):14320-5.
Fischer, W.H., Hoeger, C.A., Meisenhelder, J., Hunter, T., Craig, A.G. Determination of phosphorylation sites in peptides and proteins employing a volatile Edman reagent. (1997) J. Protein Chem. 16(5):329-34.
Ranganathan, R., Lu, K.P., Hunter, T., Noel, J.P. Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. (1997) 牢房. 89(6):875-86.
Schlaepfer, D.D., Hunter, T. Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. (1997) 生物化学杂志. 272(20):13189-95.
Fukunaga, R., Hunter, T. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. (1997) EMBO 期刊. 16(8):1921-33. DOI: 10.1093/emboj/16.8.1921
Hunter, T., Poon, R.Y. Cdc37: a protein kinase chaperone? (1997) Trends in Cell Biology. 7(4):157-61. DOI: 10.1016/S0962-8924(97)01027-1
Janknecht, R., Hunter, T. Convergence of MAP kinase pathways on the ternary complex factor Sap-1a. (1997) EMBO 期刊. 16(7):1620-7. DOI: 10.1093/emboj/16.7.1620
Schlaepfer, D.D., Broome, M.A., Hunter, T. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. (1997) 分子与细胞生物学. 17(3):1702-13.
Poon, R.Y., Lew, J., Hunter, T. Identification of functional domains in the neuronal Cdk5 activator protein. (1997) 生物化学杂志. 272(9):5703-8.
Janknecht, R., Hunter, T. Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase. (1997) 生物化学杂志. 272(7):4219-24.
Hunter, T. Oncoprotein networks. (1997) 牢房. 88(3):333-46.
Broome, M.A., Hunter, T. The PDGF receptor phosphorylates Tyr 138 in the c-Src SH3 domain in vivo reducing peptide ligand binding. (1997) 癌基因. 14(1):17-34. DOI: 10.1038/sj.onc.1200798
Hunter, T., Plowman, G.D. The protein kinases of budding yeast: six score and more. (1997) 生物化学趋势. 22(1):18-22.
Poon, R.Y., Toyoshima, H., Hunter, T. On the masking of signals on immunoblots by cellular proteins. (1996) J. Immunol. Methods. 199(2):155-8.
Horwitz, A.F., Hunter, T. Cell adhesion: integrating circuitry. (1996) Trends in Cell Biology. 6(12):460-1.
Schlaepfer, D.D., Hunter, T. Signal transduction from the extracellular matrix--a role for the focal adhesion protein-tyrosine kinase FAK. (1996) Cell Structure and Function. 21(5):445-50.
Schlaepfer, D.D., Hunter, T. Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. (1996) 分子与细胞生物学. 16(10):5623-33.
Bilwes, A.M., den Hertog, J., Hunter, T., Noel, J.P. Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization. (1996) 自然. 382(6591):555-9. DOI: 10.1038/382555a0
Janknecht, R., Hunter, T. Versatile molecular glue. Transcriptional control. (1996) 当前生物学。. 6(8):951-4.
Broome, M.A., Hunter, T. Requirement for c-Src catalytic activity and the SH3 domain in platelet-derived growth factor BB and epidermal growth factor mitogenic signaling. (1996) 生物化学杂志. 271(28):16798-806.
Hunter, T. Solid-state protein networks? (1996) Trends in Cell Biology. 6(7):254-5.
Sekiguchi, T., Noguchi, E., Hayashida, T., Nakashima, T., Toyoshima, H., Nishimoto, T., Hunter, T. D-type cyclin expression is decreased and p21 and p27 CDK inhibitor expression is increased when tsBN462 CCG1/TAFII250 mutant cells arrest in G1 at the restrictive temperature. (1996) Genes to Cells. 1(7):687-705.
Winston, L.A., Hunter, T. Intracellular signalling: putting JAKs on the kinase MAP. (1996) 当前生物学。. 6(6):668-71.
Poon, R.Y., Jiang, W., Toyoshima, H., Hunter, T. Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage. (1996) 生物化学杂志. 271(22):13283-91.
Hunter, T. Tyrosine phosphorylation: past, present and future. (1996) Biochemical Society Transactions. 24(2):307-27.
Fey, M.F., Moffat, G.J., Vik, D.P., Meisenhelder, J., Saris, C.J., Hunter, T., Tack, B.F. Complete structure of the murine p36 (annexin II) gene. Identification of mRNAs for both the murine and the human gene with alternatively spliced 5' noncoding exons. (1996) Biochimica et Biophysica Acta. 1306(2-3):160-70.
Lu, K.P., Hanes, S.D., Hunter, T. A human peptidyl-prolyl isomerase essential for regulation of mitosis. (1996) 自然. 380(6574):544-7. DOI: 10.1038/380544a0
Ofir, R., Weinstein, Y., Bazarsky, E., Blagerman, S., Wolfson, M., Hunter, T., Rager-Zisman, B. Tyrosine phosphorylation of measles virus P-phosphoprotein in persistently infected neuroblastoma cells. (1996) Virus Genes. 13(3):203-10.
Neet, K., Hunter, T. Vertebrate non-receptor protein-tyrosine kinase families. (1996) Genes to Cells. 1(2):147-69.
Winston, L.A., Hunter, T. JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone. (1995) 生物化学杂志. 270(52):30837-40.
Poon, R.Y., Hunter, T. Cell regulation. Innocent bystanders or chosen collaborators? (1995) 当前生物学。. 5(11):1243-7.
Haley, A., Hunter, T., Kiberstis, P., Zimmern, D. Multiple serine phosphorylation sites on the 30 kDa TMV cell-to-cell movement protein synthesized in tobacco protoplasts. (1995) Plant Journal. 8(5):715-24.
Poon, R.Y., Hunter, T. Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin. (1995) 科学. 270(5233):90-3.
Hunter, T. When is a lipid kinase not a lipid kinase? When it is a protein kinase. (1995) 牢房. 83(1):1-4.
Poon, R.Y., Toyoshima, H., Hunter, T. Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. (1995) Molecular Biology of the Cell. 6(9):1197-213.
Lu, K.P., Hunter, T. The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells. (1995) Progress in Cell Cycle Research. 1:187-205.
Lu, K.P., Hunter, T. Evidence for a NIMA-like mitotic pathway in vertebrate cells. (1995) 牢房. 81(3):413-24.
Tracy, S., van der Geer, P., Hunter, T. The receptor-like protein-tyrosine phosphatase, RPTP alpha, is phosphorylated by protein kinase C on two serines close to the inner face of the plasma membrane. (1995) 生物化学杂志. 270(18):10587-94.
Watanabe, N., Broome, M., Hunter, T. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. (1995) EMBO 期刊. 14(9):1878-91.
Hunter, T. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. (1995) 牢房. 80(2):225-36.
Schlaepfer, D.D., Hanks, S.K., Hunter, T., van der Geer, P. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. (1994) 自然. 372(6508):786-91.
Hunter, T. 1001 protein kinases redux--towards 2000. (1994) Seminars in Cell Biology. 5(6):367-76.
Hunter, T., Pines, J. Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. (1994) 牢房. 79(4):573-82.
Toyoshima, H., Hunter, T. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. (1994) 牢房. 78(1):67-74.
Zhang, S.H., Broome, M.A., Lawton, M.A., Hunter, T., Lamb, C.J. atpk1, a novel ribosomal protein kinase gene from Arabidopsis. II. Functional and biochemical analysis of the encoded protein. (1994) 生物化学杂志. 269(26):17593-9.
Zhang, S.H., Lawton, M.A., Hunter, T., Lamb, C.J. atpk1, a novel ribosomal protein kinase gene from Arabidopsis. I. Isolation, characterization, and expression. (1994) 生物化学杂志. 269(26):17586-92.
den Hertog, J., Tracy, S., Hunter, T. Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo. (1994) EMBO 期刊. 13(13):3020-32.
Rigaudy, P., Simon, S., Hunter, T., Sollazzo, M., Billetta, R., Zanetti, M., Eckhart, W. Antibodies specific for the neuronal form of the Src protein elicited by an antigenized antibody. (1994) DNA and Cell Biology. 13(6):585-91. DOI: 10.1089/dna.1994.13.585
van der Geer, P., Hunter, T., Lindberg, R.A. Receptor protein-tyrosine kinases and their signal transduction pathways. (1994) Annual Review of Cell Biology. 10:251-337. DOI: 10.1146/annurev.cb.10.110194.001343
van der Geer, P., Hunter, T. Phosphopeptide mapping and phosphoamino acid analysis by electrophoresis and chromatography on thin-layer cellulose plates. (1994) Electrophoresis. 15(3-4):544-54.
Middlemas, D.S., Meisenhelder, J., Hunter, T. Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor. (1994) 生物化学杂志. 269(7):5458-66.
van der Geer, P., Hunter, T. Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts. (1993) EMBO 期刊. 12(13):5161-72.
Hunter, T. Braking the cycle. (1993) 牢房. 75(5):839-41.
Sebastian, B., Kakizuka, A., Hunter, T. Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15. (1993) 美国国家科学院院刊. 90(8):3521-4.
Lindberg, R.A., Fischer, W.H., Hunter, T. Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine. (1993) 癌基因. 8(2):351-9.
Meisenhelder, J., Hunter, T. The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth fact (1992) 分子与细胞生物学. 12(12):5843-56.
Kikkawa, U., Mann, S.K., Firtel, R.A., Hunter, T. Molecular cloning of casein kinase II alpha subunit from Dictyostelium discoideum and its expression in the life cycle. (1992) 分子与细胞生物学. 12(12):5711-23.
Pines, J., Hunter, T. Cyclins A and B1 in the human cell cycle. (1992) Ciba Found. Symp. 170:187-96; discussion 196-204.
Hunter, T. Regulation of the eukaryotic cell cycle. Introduction. (1992) Ciba Found. Symp. 170:1-6.
Krieg, J., Hunter, T. Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin. (1992) 生物化学杂志. 267(27):19258-65.
Hunter, T., Karin, M. The regulation of transcription by phosphorylation. (1992) 牢房. 70(3):375-87.
DeMaggio, A.J., Lindberg, R.A., Hunter, T., Hoekstra, M.F. The budding yeast HRR25 gene product is a casein kinase I isoform. (1992) 美国国家科学院院刊. 89(15):7008-12.
Hunter, T., Lindberg, R.A., Middlemas, D.S., Tracy, S., van der Geer, P. Receptor protein tyrosine kinases and phosphatases. (1992) 冷泉港定量生物学研讨会。. 57:25-41.
Kakizuka, A., Sebastian, B., Borgmeyer, U., Hermans-Borgmeyer, I., Bolado, J., Hunter, T., Hoekstra, M.F., Evans, R.M. A mouse cdc25 homolog is differentially and developmentally expressed. (1992) 基因与发展. 6(4):578-90.
Freed, E., Hunter, T. A 41-kilodalton protein is a potential substrate for the p210bcr-abl protein-tyrosine kinase in chronic myelogenous leukemia cells. (1992) 分子与细胞生物学. 12(3):1312-23.
Lindberg, R.A., Quinn, A.M., Hunter, T. Dual-specificity protein kinases: will any hydroxyl do? (1992) 生物化学趋势. 17(3):114-9.
Pines, J., Hunter, T. Cyclin-dependent kinases: a new cell cycle motif? (1991) Trends in Cell Biology. 1(5):117-21.
Pines, J., Hunter, T. Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. (1991) Journal of Cell Biology. 115(1):1-17.
Hunter, T., Pines, J. Cyclins and cancer. (1991) 牢房. 66(6):1071-4.
van der Geer, P., Hunter, T. Tyrosine 706 and 807 phosphorylation site mutants in the murine colony-stimulating factor-1 receptor are unaffected in their ability to bind or phosphorylate phosphatidylinositol-3 kinase but show dif (1991) 分子与细胞生物学. 11(9):4698-709.
Jähner, D., Hunter, T. The stimulation of quiescent rat fibroblasts by v-src and v-fps oncogenic protein-tyrosine kinases leads to the induction of a subset of immediate early genes. (1991) 癌基因. 6(7):1259-68.
Jähner, D., Hunter, T. The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts. (1991) 分子与细胞生物学. 11(7):3682-90.
Pines, J., Hunter, T. Human cell division: the involvement of cyclins A and B1, and multiple cdc2s. (1991) 冷泉港定量生物学研讨会。. 56:449-63.
Meisenhelder, J., Hunter, T. Phosphorylation of phospholipase C in vivo and in vitro. (1991) Meth. Enzymol. 197:288-305.
Boyle, W.J., van der Geer, P., Hunter, T. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. (1991) Meth. Enzymol. 201:110-49.
Nevins, J.R., Chellappan, S.P., Mudryj, M., Hiebert, S., Devoto, S., Horowitz, J., Hunter, T., Pines, J. E2F transcription factor is a target for the RB protein and the cyclin A protein. (1991) 冷泉港定量生物学研讨会。. 56:157-62.
Hunter, T. Protein kinase classification. (1991) Meth. Enzymol. 200:3-37.
Inoue, J., Kerr, L.D., Ransone, L.J., Bengal, E., Hunter, T., Verma, I.M. c-rel activates but v-rel suppresses transcription from kappa B sites. (1991) 美国国家科学院院刊. 88(9):3715-9.
Boyle, W.J., Smeal, T., Defize, L.H., Angel, P., Woodgett, J.R., Karin, M., Hunter, T. Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. (1991) 牢房. 64(3):573-84.
Hunter, T. Protein-serine kinase receptors? (1991) 当前生物学。. 1(1):15-6.
Hunter, T. Cooperation between oncogenes. (1991) 牢房. 64(2):249-70.
Middlemas, D.S., Lindberg, R.A., Hunter, T. trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. (1991) 分子与细胞生物学. 11(1):143-53.
Cochet, C., Filhol, O., Payrastre, B., Hunter, T., Gill, G.N. Interaction between the epidermal growth factor receptor and phosphoinositide kinases. (1991) 生物化学杂志. 266(1):637-44.
Lindberg, R.A., Hunter, T. cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. (1990) 分子与细胞生物学. 10(12):6316-24.
Yamashita, K., Yasuda, H., Pines, J., Yasumoto, K., Nishitani, H., Ohtsubo, M., Hunter, T., Sugimura, T., Nishimoto, T. Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells. (1990) EMBO 期刊. 9(13):4331-8.
Bull, P., Morley, K.L., Hoekstra, M.F., Hunter, T., Verma, I.M. The mouse c-rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain. (1990) 分子与细胞生物学. 10(10):5473-85.
Pines, J., Hunter, T. Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. (1990) 自然. 346(6286):760-3. DOI: 10.1038/346760a0
van der Geer, P., Hunter, T. Identification of tyrosine 706 in the kinase insert as the major colony-stimulating factor 1 (CSF-1)-stimulated autophosphorylation site in the CSF-1 receptor in a murine macrophage cell line. (1990) 分子与细胞生物学. 10(6):2991-3002.
Isacke, C.M., van der Geer, P., Hunter, T., Trowbridge, I.S. p180, a novel recycling transmembrane glycoprotein with restricted cell type expression. (1990) 分子与细胞生物学. 10(6):2606-18.
Pines, J., Hunter, T. p34cdc2: the S and M kinase? (1990) New Biol. 2(5):389-401.
Hunter, T., Lindberg, R.A., Middlemas, D.S. Novel receptor protein-tyrosine kinases. (1990) Adv. Second Messenger Phosphoprotein Res. 24:260-5.
Amiguet, P., D'Eustachio, P., Kristensen, T., Wetsel, R.A., Saris, C.J., Hunter, T., Chaplin, D.D., Tack, B.F. Structure and chromosome assignment of the murine p36 (calpactin I heavy chain) gene. (1990) Biochemistry. 29(5):1226-32.
Gould, K.L., Bretscher, A., Esch, F.S., Hunter, T. cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1. (1989) EMBO 期刊. 8(13):4133-42.
Hunter, T. Protein modification: phosphorylation on tyrosine residues. (1989) 细胞生物学进展. 1(6):1168-81.
Bull, P., Hunter, T., Verma, I.M. Transcriptional induction of the murine c-rel gene with serum and phorbol-12-myristate-13-acetate in fibroblasts. (1989) 分子与细胞生物学. 9(11):5239-43.
Defize, L.H., Boonstra, J., Meisenhelder, J., Kruijer, W., Tertoolen, L.G., Tilly, B.C., Hunter, T., van Bergen en Henegouwen, P.M., Moolenaar, W.H., de Laat, S.W. Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptors. (1989) Journal of Cell Biology. 109(5):2495-507.
Freed, E., Gailit, J., van der Geer, P., Ruoslahti, E., Hunter, T. A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C. (1989) EMBO 期刊. 8(10):2955-65.
Hunter, T. Protein-tyrosine phosphatases: the other side of the coin. (1989) 牢房. 58(6):1013-6.
Pines, J., Hunter, T. Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. (1989) 牢房. 58(5):833-46.
Meisenhelder, J., Suh, P.G., Rhee, S.G., Hunter, T. Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro. (1989) 牢房. 57(7):1109-22.
Hunter, T. The functions of oncogene products. (1989) Prog. Clin. Biol. Res. 288:25-34.
Nunn, M.F., Hunter, T. The ets sequence is required for induction of erythroblastosis in chickens by avian retrovirus E26. (1989) 病毒学杂志. 63(1):398-402.
Isacke, C.M., Lindberg, R.A., Hunter, T. Synthesis of p36 and p35 is increased when U-937 cells differentiate in culture but expression is not inducible by glucocorticoids. (1989) 分子与细胞生物学. 9(1):232-40.
Gould, K.L., Bilezikjian, L.M., Hunter, T. AtT20 cells express modified forms of pp60c-src. (1989) Molecular Endocrinology. 3(1):79-88. DOI: 10.1210/mend-3-1-79
Lindberg, R.A., Thompson, D.P., Hunter, T. Identification of cDNA clones that code for protein-tyrosine kinases by screening expression libraries with antibodies against phosphotyrosine. (1988) 癌基因. 3(6):629-33.
Weinmaster, G.A., Hunter, T. Investigation of the role of P130gag-fps in transformation: generation and use of a temperature-sensitive mutant P130gag-fps. (1988) 病毒学杂志. 62(10):3849-54.
Meisenhelder, J., Hunter, T. Radioactive protein-labelling techniques. (1988) 自然. 335(6186):120. DOI: 10.1038/335120a0
Defize, L.H., Arndt-Jovin, D.J., Jovin, T.M., Boonstra, J., Meisenhelder, J., Hunter, T., de Hey, H.T., de Laat, S.W. A431 cell variants lacking the blood group A antigen display increased high affinity epidermal growth factor-receptor number, protein-tyrosine kinase activity, and receptor turnover. (1988) Journal of Cell Biology. 107(3):939-49.
Gould, K.L., Hunter, T. Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity. (1988) 分子与细胞生物学. 8(8):3345-56.
Chiu, R., Boyle, W.J., Meek, J., Smeal, T., Hunter, T., Karin, M. The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. (1988) 牢房. 54(4):541-52.
Hanks, S.K., Quinn, A.M., Hunter, T. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. (1988) 科学. 241(4861):42-52.
Weinmaster, G.A., Middlemas, D.S., Hunter, T. A major site of tyrosine phosphorylation within the SH2 domain of Fujinami sarcoma virus P130gag-fps is not required for protein-tyrosine kinase activity or transforming potential. (1988) 病毒学杂志. 62(6):2016-25.
Hunter, T., Angel, P., Boyle, W.J., Chiu, R., Freed, E., Gould, K.L., Isacke, C.M., Karin, M., Lindberg, R.A., van der Geer, P. Targets for signal-transducing protein kinases. (1988) 冷泉港定量生物学研讨会。. 53 Pt 1:131-42.
Cartwright, C.A., Simantov, R., Cowan, W.M., Hunter, T., Eckhart, W. pp60c-src expression in the developing rat brain. (1988) 美国国家科学院院刊. 85(10):3348-52.
Hunter, T. The Ca2+/phospholipid-binding proteins of the submembraneous skeleton. (1988) Advances in Experimental Medicine and Biology. 234:169-93.
Angel, P., Allegretto, E.A., Okino, S.T., Hattori, K., Boyle, W.J., Hunter, T., Karin, M. Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. (1988) 自然. 332(6160):166-71. DOI: 10.1038/332166a0
Hunter, T. A thousand and one protein kinases. (1987) 牢房. 50(6):823-9.
Bilezikjian, L.M., Woodgett, J.R., Hunter, T., Vale, W.W. Phorbol ester-induced down-regulation of protein kinase C abolishes vasopressin-mediated responses in rat anterior pituitary cells. (1987) Molecular Endocrinology. 1(8):555-60. DOI: 10.1210/mend-1-8-555
Saris, C.J., Kristensen, T., D'Eustachio, P., Hicks, L.J., Noonan, D.J., Hunter, T., Tack, B.F. cDNA sequence and tissue distribution of the mRNA for bovine and murine p11, the S100-related light chain of the protein-tyrosine kinase substrate p36 (calpactin I). (1987) 生物化学杂志. 262(22):10663-71.
Woodgett, J.R., Hunter, T. Regulation of protein kinase C by activators, Ca2+, and phosphorylation. (1987) Prog. Clin. Biol. Res. 249:237-47.
Cartwright, C.A., Simantov, R., Kaplan, P.L., Hunter, T., Eckhart, W. Alterations in pp60c-src accompany differentiation of neurons from rat embryo striatum. (1987) 分子与细胞生物学. 7(5):1830-40.
Woodgett, J.R., Hunter, T. Isolation and characterization of two distinct forms of protein kinase C. (1987) 生物化学杂志. 262(10):4836-43.
Woodgett, J.R., Hunter, T. Immunological evidence for two physiological forms of protein kinase C. (1987) 分子与细胞生物学. 7(1):85-96.
Woodgett, J.R., Gould, K.L., Hunter, T. Substrate specificity of protein kinase C. Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements. (1986) European Journal of Biochemistry. 161(1):177-84.
Isacke, C.M., Meisenhelder, J., Brown, K.D., Gould, K.L., Gould, S.J., Hunter, T. Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide. (1986) EMBO 期刊. 5(11):2889-98.
Glenney, J.R., Boudreau, M., Galyean, R., Hunter, T., Tack, B. Association of the S-100-related calpactin I light chain with the NH2-terminal tail of the 36-kDa heavy chain. (1986) 生物化学杂志. 261(23):10485-8.
Kristensen, T., Saris, C.J., Hunter, T., Hicks, L.J., Noonan, D.J., Glenney, J.R., Tack, B.F. Primary structure of bovine calpactin I heavy chain (p36), a major cellular substrate for retroviral protein-tyrosine kinases: homology with the human phospholipase A2 inhibitor lipocortin. (1986) Biochemistry. 25(16):4497-503.
Tripp, M.L., Piñon, R., Meisenhelder, J., Hunter, T. Identification of phosphoproteins correlated with proliferation and cell cycle arrest in Saccharomyces cerevisiae: positive and negative regulation by cAMP-dependent protein kinase. (1986) 美国国家科学院院刊. 83(16):5973-7.
Saris, C.J., Tack, B.F., Kristensen, T., Glenney, J.R., Hunter, T. The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats. (1986) 牢房. 46(2):201-12.
Hunter, T. Cancer. Cell growth control mechanisms. (1986) 自然. 322(6074):14-6. DOI: 10.1038/322014a0
Isacke, C.M., Trowbridge, I.S., Hunter, T. Modulation of p36 phosphorylation in human cells: studies using anti-p36 monoclonal antibodies. (1986) 分子与细胞生物学. 6(7):2745-51.
Gould, K.L., Woodgett, J.R., Isacke, C.M., Hunter, T. The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo. (1986) 分子与细胞生物学. 6(7):2738-44.
Patschinsky, T., Hunter, T., Sefton, B.M. Phosphorylation of the transforming protein of Rous sarcoma virus: direct demonstration of phosphorylation of serine 17 and identification of an additional site of tyrosine phosphorylation in p60v-src (1986) 病毒学杂志. 59(1):73-81.
Sefton, B.M., Hunter, T. From c-src to v-src, or the case of the missing C terminus. (1986) Cancer Surveys. 5(2):159-72.
Cartwright, C.A., Kaplan, P.L., Cooper, J.A., Hunter, T., Eckhart, W. Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigen. (1986) 分子与细胞生物学. 6(5):1562-70.
Cooper, J.A., Gould, K.L., Cartwright, C.A., Hunter, T. Tyr527 is phosphorylated in pp60c-src: implications for regulation. (1986) 科学. 231(4744):1431-4.
Gould, K.L., Cooper, J.A., Bretscher, A., Hunter, T. The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein. (1986) Journal of Cell Biology. 102(2):660-9.
Cooper, J.A., Hunter, T. Major substrate for growth factor-activated protein-tyrosine kinases is a low-abundance protein. (1985) 分子与细胞生物学. 5(11):3304-9.
Gould, K.L., Woodgett, J.R., Cooper, J.A., Buss, J.E., Shalloway, D., Hunter, T. Protein kinase C phosphorylates pp60src at a novel site. (1985) 牢房. 42(3):849-57.
Coussens, P.M., Cooper, J.A., Hunter, T., Shalloway, D. Restriction of the in vitro and in vivo tyrosine protein kinase activities of pp60c-src relative to pp60v-src. (1985) 分子与细胞生物学. 5(10):2753-63.
Hunter, T., Cooper, J.A. Protein-tyrosine kinases. (1985) Annual Review of Biochemistry. 54:897-930. DOI: 10.1146/annurev.bi.54.070185.004341
Hunter, T. Cell-surface proteins. At last the insulin receptor. (1985) 自然. 313(6005):740-1.
Hunter, T., Alexander, C.B., Cooper, J.A. Protein phosphorylation and growth control. (1985) Ciba Found. Symp. 116:188-204.
Kruijer, W., Cooper, J.A., Hunter, T., Verma, I.M. Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. (1984) 自然. 312(5996):711-6.
Voronova, A.F., Buss, J.E., Patschinsky, T., Hunter, T., Sefton, B.M. Characterization of the protein apparently responsible for the elevated tyrosine protein kinase activity in LSTRA cells. (1984) 分子与细胞生物学. 4(12):2705-13.
Hunter, T., Ling, N., Cooper, J.A. Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane. (1984) 自然. 311(5985):480-3.
Hunter, T. The epidermal growth factor receptor gene and its product. (1984) 自然. 311(5985):414-6.
Hunter, T., Gould, K.L., Cooper, J.A. Tyrosine protein kinases, viral transformation and the control of cell proliferation. (1984) Biochemical Society Transactions. 12(5):757-9.
Hunter, T. Oncogenes and proto-oncogenes: how do they differ? (1984) J. Natl. Cancer Inst. 73(4):773-86.
Hunter, T. The proteins of oncogenes. (1984) Sci. Am. 251(2):70-9.
Cooper, J.A., Esch, F.S., Taylor, S.S., Hunter, T. Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. (1984) 生物化学杂志. 259(12):7835-41.
Hunter, T., Cooper, J.A. Tyrosine protein kinases and their substrates: an overview. (1984) Adv Cyclic Nucleotide Protein Phosphorylation Res. 17:443-55.
Donoghue, D.J., Anderson, C., Hunter, T., Kaplan, P.L. Transmission of the polyoma virus middle T gene as the oncogene of a murine retrovirus. (1984) 自然. 308(5961):748-50.
Cochet, C., Gill, G.N., Meisenhelder, J., Cooper, J.A., Hunter, T. C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity. (1984) 生物化学杂志. 259(4):2553-8.
Gould, K.L., Cooper, J.A., Hunter, T. The 46,000-dalton tyrosine protein kinase substrate is widespread, whereas the 36,000-dalton substrate is only expressed at high levels in certain rodent tissues. (1984) Journal of Cell Biology. 98(2):487-97.
Hunter, T., Hutchinson, M.A., Eckhart, W. Polyoma middle-sized T antigen can be phosphorylated on tyrosine at multiple sites in vitro. (1984) EMBO 期刊. 3(1):73-9.
Cooper, J.A., Sefton, B.M., Hunter, T. Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells. (1984) 分子与细胞生物学. 4(1):30-7.
Sefton, B.M., Hunter, T. Tyrosine protein kinases. (1984) Adv Cyclic Nucleotide Protein Phosphorylation Res. 18:195-226.
Cooper, J.A., Scolnick, E.M., Ozanne, B., Hunter, T. Epidermal growth factor receptor metabolism and protein kinase activity in human A431 cells infected with Snyder-Theilen feline sarcoma virus or harvey or Kirsten murine sarcoma virus. (1983) 病毒学杂志. 48(3):752-64.
Kiberstis, P.A., Pessi, A., Atherton, E., Jackson, R., Hunter, T., Zimmern, D. Analysis of in vitro and in vivo products of the TMV 30kDa open reading frame using antisera raised against a synthetic peptide. (1983) FEBS Lett. 164(2):355-360. DOI: 10.1016/0014-5793(83)80316-0
Zimmern, D., Hunter, T. Point mutation in the 30-K open reading frame of TMV implicated in temperature-sensitive assembly and local lesion spreading of mutant Ni 2519. (1983) EMBO 期刊. 2(11):1893-900.
Nigg, E.A., Cooper, J.A., Hunter, T. Immunofluorescent localization of a 39,000-dalton substrate of tyrosine protein kinases to the cytoplasmic surface of the plasma membrane. (1983) Journal of Cell Biology. 96(6):1601-9.
Cooper, J.A., Sefton, B.M., Hunter, T. Detection and quantification of phosphotyrosine in proteins. (1983) Meth. Enzymol. 99:387-402.
Papkoff, J., Nigg, E.A., Hunter, T. The transforming protein of Moloney murine sarcoma virus is a soluble cytoplasmic protein. (1983) 牢房. 33(1):161-72.
Cooper, J., Nakamura, K.D., Hunter, T., Weber, M.J. Phosphotyrosine-containing proteins and expression of transformation parameters in cells infected with partial transformation mutants of Rous sarcoma virus. (1983) 病毒学杂志. 46(1):15-28.
Cooper, J.A., Reiss, N.A., Schwartz, R.J., Hunter, T. Three glycolytic enzymes are phosphorylated at tyrosine in cells transformed by Rous sarcoma virus. (1983) 自然. 302(5905):218-23.
Papkoff, J., Hunter, T. Detection of an 85,000-dalton phosphoprotein in ts110 murine sarcoma virus-infected cells with antiserum against a v-mos peptide. (1983) 病毒学杂志. 45(3):1177-82.
Hunter, T., Cooper, J.A. Role of tyrosine phosphorylation in malignant transformation by viruses and in cellular growth control. (1983) Progress in Nucleic Acid Research and Molecular Biology. 29:221-32.
Hunter, T., Jackson, R., Zimmern, D. Multiple proteins and subgenomic mRNAs may be derived from a single open reading frame on tobacco mosaic virus RNA. (1983) 核酸研究. 11(3):801-21.
Donoghue, D.J., Hunter, T. Recombinational junctions of variants of Moloney murine sarcoma virus: generation and divergence of a mammalian transforming gene. (1983) 病毒学杂志. 45(2):607-17.
Cooper, J.A., Hunter, T. Regulation of cell growth and transformation by tyrosine-specific protein kinases: the search for important cellular substrate proteins. (1983) Current Topics in Microbiology and Immunology. 107:125-61.
Cooper, J.A., Hunter, T. Identification and characterization of cellular targets for tyrosine protein kinases. (1983) 生物化学杂志. 258(2):1108-15.
Sefton, B.M., Hunter, T., Cooper, J.A. Some lymphoid cell lines transformed by Abelson murine leukemia virus lack a major 36,000-dalton tyrosine protein kinase substrate. (1983) 分子与细胞生物学. 3(1):56-63.
Cooper, J.A., Bowen-Pope, D.F., Raines, E., Ross, R., Hunter, T. Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins. (1982) 牢房. 31(1):263-73.
Nigg, E.A., Sefton, B.M., Hunter, T., Walter, G., Singer, S.J. Immunofluorescent localization of the transforming protein of Rous sarcoma virus with antibodies against a synthetic src peptide. (1982) 美国国家科学院院刊. 79(17):5322-6.
Adkins, B., Hunter, T. Two structurally and functionally different forms of the transforming protein of PRC II avian sarcoma virus. (1982) 分子与细胞生物学. 2(8):890-6.
Papkoff, J., Hunter, T. Identification of proteins encoded by the Gazdar murine sarcoma virus genome by in vitro translation and comparison with Moloney murine sarcoma virus 124. (1982) 病毒学杂志. 43(2):533-43.
Adkins, B., Hunter, T., Sefton, B.M. The transforming proteins of PRCII virus and Rous sarcoma virus form a complex with the same two cellular phosphoproteins. (1982) 病毒学杂志. 43(2):448-55.
Cooper, J.A., Hunter, T. Discrete primary locations of a tyrosine-protein kinase and of three proteins that contain phosphotyrosine in virally transformed chick fibroblasts. (1982) Journal of Cell Biology. 94(2):287-96.
Walter, G., Hutchinson, M.A., Hunter, T., Eckhart, W. Purification of polyoma virus medium-size tumor antigen by immunoaffinity chromatography. (1982) 美国国家科学院院刊. 79(13):4025-9.
Hunter, T. Phosphotyrosine - a new protein modification. (1982) 生物化学趋势. 7(7):246-249. DOI: 10.1016/0968-0004(82)90035-4
Papkoff, J., Verma, I.M., Hunter, T. Detection of a transforming gene product in cells transformed by Moloney murine sarcoma virus. (1982) 牢房. 29(2):417-26.
Sefton, B.M., Hunter, T., Nigg, E.A., Singer, S.J., Walter, G. Cytoskeletal targets for viral transforming proteins with tyrosine protein kinase activity. (1982) 冷泉港定量生物学研讨会。. 46 Pt 2:939-51.
Hunter, T. Synthetic peptide substrates for a tyrosine protein kinase. (1982) 生物化学杂志. 257(9):4843-8.
Donoghue, D.J., Hunter, T. A generalized method of subcloning DNA fragments by restriction site reconstruction: application to sequencing the amino-terminal coding region of the transforming gene of Gazdar murine sarcoma virus. (1982) 核酸研究. 10(8):2549-64.
Papkoff, J., Lai, M.H., Hunter, T. Analysis of v-mos encoded proteins in cells transformed by several related murine sarcoma viruses. (1982) J. Cell. Biochem. 19(4):349-62. DOI: 10.1002/jcb.240190405
Sefton, B.M., Patschinsky, T., Berdot, C., Hunter, T., Elliott, T. Phosphorylation and metabolism of the transforming protein of Rous sarcoma virus. (1982) 病毒学杂志. 41(3):813-20.
Patschinsky, T., Hunter, T., Esch, F.S., Cooper, J.A., Sefton, B.M. Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation. (1982) 美国国家科学院院刊. 79(4):973-7.
Donoghue, D.J., Hunter, T. Expression of transforming region of Moloney murine sarcoma virus in Escherichia coli as a fusion protein with small tumor antigen of polyoma virus. (1982) 美国国家科学院院刊. 79(3):800-4.
Cooper, J.A., Hunter, T. Similarities and differences between the effects of epidermal growth factor and Rous sarcoma virus. (1981) Journal of Cell Biology. 91(3 Pt 1):878-83.
Papkoff, J., Lai, M.H., Hunter, T., Verma, I.M. Analysis of transforming gene products from Moloney murine sarcoma virus. (1981) 牢房. 27(1 Pt 2):109-19.
Walter, G., Hutchinson, M.A., Hunter, T., Eckhart, W. Antibodies specific for the polyoma virus middle-size tumor antigen. (1981) 美国国家科学院院刊. 78(8):4882-6.
Adkins, B., Hunter, T. Identification of a packaged cellular mRNA in virions of rous sarcoma virus. (1981) 病毒学杂志. 39(2):471-80.
Hunter, T., Cooper, J.A. Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells. (1981) 牢房. 24(3):741-52.
Cooper, J.A., Hunter, T. Four different classes of retroviruses induce phosphorylation of tyrosines present in similar cellular proteins. (1981) 分子与细胞生物学. 1(5):394-407.
Sefton, B.M., Hunter, T., Ball, E.H., Singer, S.J. Vinculin: a cytoskeletal target of the transforming protein of Rous sarcoma virus. (1981) 牢房. 24(1):165-74.
Sefton, B.M., Hunter, T., Raschke, W.C. Evidence that the Abelson virus protein functions in vivo as a protein kinase that phosphorylates tyrosine. (1981) 美国国家科学院院刊. 78(3):1552-6.
Cooper, J.A., Hunter, T. Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells. (1981) 分子与细胞生物学. 1(2):165-78.
Eckhart, W., Delbrück, S., Deininger, P., Friedmann, T., Hunter, T. A mutation increasing the size of the polyoma virion proteins, VP2 and VP3. (1981) Virology. 109(1):35-46.
Hunter, T. Protein phosphorylated by the RSV transforming function. (1980) 牢房. 22(3):647-8.
Mann, K., Hunter, T. Phosphorylation of SV40 large T antigen in SV40 nucleoprotein complexes. (1980) Virology. 107(2):526-32.
Sefton, B.M., Hunter, T., Beemon, K., Eckhart, W. Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus. (1980) 牢房. 20(3):807-16.
Hunter, T., Sefton, B.M., Beemon, K. Studies on the structure and function of the avian sarcoma virus transforming-gene product. (1980) 冷泉港定量生物学研讨会。. 44 Pt 2,:931-41.
Sefton, B.M., Hunter, T., Beemon, K. Relationship of polypeptide products of the transforming gene of Rous sarcoma virus and the homologous gene of vertebrates. (1980) 美国国家科学院院刊. 77(4):2059-63.
Hunter, T., Hutchinson, M.A., Eckhart, W., Friedmann, T., Esty, A., La Porte, P., Deininger, P. Organization of T antigens in the polyoma virus genome. (1980) 冷泉港定量生物学研讨会。. 44 Pt 1,:131-9.
Hunter, T., Sefton, B.M. Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. (1980) 美国国家科学院院刊. 77(3):1311-5.
Papkoff, J., Hunter, T., Beemon, K. In vitro translation of virion RNA from Moloney murine sarcoma virus. (1980) Virology. 101(1):91-103.
Sefton, B.M., Hunter, T., Beemon, K. Temperature-sensitive transformation by Rous sarcoma virus and temperature-sensitive protein kinase activity. (1980) 病毒学杂志. 33(1):220-9.
Hunter, T., Hutchinson, M.A., Eckhart, W., Friedmann, T., Esty, A., LaPorte, P., Deininger, P. Regions of the polyoma genome coding for T antigens. (1979) 核酸研究. 7(8):2275-88.
Eckhart, W., Hutchinson, M.A., Hunter, T. An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates. (1979) 牢房. 18(4):925-33.
Garrels, J.I., Hunter, T. Post-translational modification of actins synthesized in vitro. (1979) Biochimica et Biophysica Acta. 564(3):517-25.
Lawrence, C., Hunter, T., Walter, G. Characterization of the simian virus 40-specific messenger RNAs isolated from HeLa cells infected with the non-defective adenovirus 2-simian virus 40 hybrid viruses Ad2+ND2 and Ad2+ND4. (1979) 分子生物学杂志. 134(1):95-108.
Hunter, T. Functional characterization of the early and late mRNAs of simian virus 40. (1979) Virology. 95(2):511-22.
Westphal, H., Lai, S.P., Lawrence, C., Hunter, T., Walter, G. Mosaic adenovirus-SV40 RNA specified by the non-defective hybrid virus Ad2+ND4. (1979) 分子生物学杂志. 130(3):337-51.
Sefton, B.M., Hunter, T., Beemon, K. Product of in vitro translation of the Rous sarcoma virus src gene has protein kinase activity. (1979) 病毒学杂志. 30(1):311-8.
Beemon, K., Hunter, T., Sefton, B.M. Polymorphism of avian sarcoma virus src proteins. (1979) 病毒学杂志. 30(1):190-200.
Linke, H.K., Hunter, T., Walter, G. Structural relationship between the 100,000- and 17,000- molecular-weight T antigens of simian virus 40 (SV40) as deduced by comparison with the SV40-specific proteins coded by the nondefective adenov (1979) 病毒学杂志. 29(1):390-4.
Mann, K., Hunter, T. Association of simian virus 40 T antigen with simian virus 40 nucleoprotein complexes. (1979) 病毒学杂志. 29(1):232-41.
Hunter, T., Hutchinson, M.A., Eckhart, W. Translation of polyoma virus T antigens in vitro. (1978) 美国国家科学院院刊. 75(12):5917-21.
Sefton, B.M., Beemon, K., Hunter, T. Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo. (1978) 病毒学杂志. 28(3):957-71.
Beemon, K., Hunter, T. Characterization of Rous sarcoma virus src gene products synthesized in vitro. (1978) 病毒学杂志. 28(2):551-66.
Hunter, T., Gibson, W. Characterization of the mRNA's for the polyoma virus capsid proteins VP1, VP2, and VP3. (1978) 病毒学杂志. 28(1):240-53.
Hutchinson, M.A., Hunter, T., Eckhart, W. Characterization of T antigens in polyoma-infected and transformed cells. (1978) 牢房. 15(1):65-77.
Elwood, W.J., Beveridge, M.D., Hunter, T.R., Sutherland, R.B., Ryder, T., Woodcock, R.C. The Bolton TV "hospital" series. 1. How did it happen? (1978) Hosp Health Serv Rev. 74(1):7-10.
Hunter, T., Francke, B., Bacheler, L. In vitro polyoma DNA synthesis: asymmetry of short DNA chains. (1977) 牢房. 12(4):1021-8.
Hunter, T., Garrels, J.I. Characterization of the mRNAs for alpha-, beta- and gamma-actin. (1977) 牢房. 12(3):767-81.
Mann, K., Hunter, T., Walter, G., Linke, H. Evidence for simian virus 40 (SV40) coding of SV40 T-antigen and the SV40-specific proteins in HeLa cells infected with nondefective adenovirus type 2-SV40 hybrid viruses. (1977) 病毒学杂志. 24(1):151-69.
Beemon, K., Hunter, T. In vitro translation yields a possible Rous sarcoma virus src gene product. (1977) 美国国家科学院院刊. 74(8):3302-6.
Gibson, W., Hunter, T., Cogen, B., Eckhart, W. Altered virion proteins of a temperature-sensitive mutant of polyoma virus, ts59. (1977) Virology. 80(1):21-41.
Hunter, A.R., Jackson, R.J., Hunt, T. The role of complexes between the 40-S ribosomal subunit and Met-tRNA-Met-f in the initiation of protein synthesis in the wheat-germ system. (1977) European Journal of Biochemistry. 75(1):159-70. DOI: 10.1111/j.1432-1033.1977.tb11513.x
Hunter, A.R., Farrell, P.J., Jackson, R.J., Hunt, T. The role of polyamines in cell-free protein synthesis in the wheat-germ system. (1977) European Journal of Biochemistry. 75(1):149-57. DOI: 10.1111/j.1432-1033.1977.tb11512.x
Hunter, T.R., Hunt, T., Knowland, J., Zimmern, D. Messenger RNA for the coat protein of tobacco mosaic virus. (1976) 自然. 260(5554):759-64.
Robbins, J.C., Hunter, T.R., Nicolson, G.L. Ricinus communis toxin-mediated inhibition of protein synthesis in cell-free extracts of a toxin-resistant variant mouse lymphoma cell line. (1976) Journal of Supramolecular Structure. 5(4):515(367)-520(372). DOI: 10.1002/jss.400050408
Hunter, A.R., Jackson, R.J. Control of haemoglobin synthesis. The effects of iron deprivation, cobalt and temperature on the rate and extent of globin synthesis in reticulocytes. (1975) European Journal of Biochemistry. 58(2):421-30. DOI: 10.1111/j.1432-1033.1975.tb02389.x
Rudland, P.S., Weil, S., Hunter, A.R. Changes in RNA metabolism and accumulation of presumptive messenger RNA during transition from the growing to the quiescent state of cultured mouse fibroblasts. (1975) 分子生物学杂志. 96(4):745-66. DOI: 10.1016/0022-2836(75)90150-3
Hunter, T., Francke, B. In vitro polyoma DNA synthesis: inhibition by 1-beta-d-arabinofuranosyl CTP. (1975) 病毒学杂志. 15(4):759-75.
Robertson, H.D., Hunter, T. Sensitive methods for the detection and characterization of double helical ribonucleic acid. (1975) 生物化学杂志. 250(2):418-25.
Hunter, T., Hunt, T., Jackson, R.J., Robertson, H.D. The characteristics of inhibition of protein synthesis by double-stranded ribonucleic acid in reticulocyte lysates. (1975) 生物化学杂志. 250(2):409-17.
Francke, B., Hunter, T. In vitro polyoma DNA synthesis: requirement for cytoplasmic factors. (1975) 病毒学杂志. 15(1):97-107.
Nicolson, G.L., Lacorbiere, M., Hunter, T.R. Mechanism of cell entry and toxicity of an affinity- purified lectin from Ricinus communis and its differential effects on normal and virus-transformed fibroblasts. (1975) 癌症研究. 35(1):144-55.
Francke, B., Hunter, T. In vitro polyoma DNA synthesis: discontinuous chain growth. (1974) 分子生物学杂志. 83(1):99-121.
Hunter, T., Francke, B. Letter: In vitro polyoma DNA synthesis: involvement of RNA in discontinuous chain growth. (1974) 分子生物学杂志. 83(1):123-30.
Francke, B., Hunter, T. In vitro polyoma DNA synthesis: studies on an early temperature-sensitive mutant. (1974) 病毒学杂志. 13(1):241-3.
Hunter, T., Francke, B. In vitro polyoma DNA synthesis: characterization of a system from infected 3T3 cells. (1974) 病毒学杂志. 13(1):125-39.
Hunter, A.R., Jackson, R.J. Control of haemoglobin synthesis: coordination of alpha and beta chain synthesis. (1972) Hamatol. Bluttransfus. 10:95-108.
Hunter, A.R., Hunt, R.T., Jackson, R.J., Robertson, H.D. Initiation of globin synthesis in rabbit reticulocyte cell-free systems: inhibition by double-stranded RNA. (1972) Hamatol. Bluttransfus. 10:133-45.
Hunter, A.R., Jackson, R.J. The origin and nature of the methionine residue initiating the synthesis of haemoglobin in vivo and in vitro. (1971) European Journal of Biochemistry. 19(3):316-22. DOI: 10.1111/j.1432-1033.1971.tb01321.x
Jackson, R., Hunter, T. Role of methionine in the initiation of haemoglobin synthesis. (1970) 自然. 227(5259):672-6.
Hunter, A.R., Jackson, R.J. Miscoding by Escherichia coli tRNAs for methionine, cysteine and valine in the synthesis of rabbit globin. (1970) European Journal of Biochemistry. 15(2):381-90. DOI: 10.1111/j.1432-1033.1970.tb01019.x
Jackson, R., Hunter, T. The effect of cobalt on the synthesis of globin and haem in reticulocytes. (1970) FEBS Lett. 9(2):61-63.
Hunter, T., Munro, A. Allelic variants in the amino-acid sequence of the alpha chain of rabbit haemoglobin. (1969) 自然. 223(5212):1270-2.
Hunt, R.T., Hunter, A.R., Munro, A.J. The control of haemoglobin synthesis: factors controlling the output of alpha and beta chains. (1969) Proc Nutr Soc. 28(2):248-54. DOI: 10.1079/pns19690046
Hunt, T., Hunter, T., Munro, A. Control of haemoglobin synthesis: rate of translation of the messenger RNA for the alpha and beta chains. (1969) 分子生物学杂志. 43(1):123-33.
Hunt, T., Hunter, A., Munro, A.J. Factors affecting haemoglobin biosynthesis. (1969) Biochemical Journal. 113(2):5P. DOI: 10.1042/bj1130005pa
Hunter, A.R., Korner, A. The response of rat liver polysomes to added homopolynucleotides: the removal of inactive ribosomes. (1969) Biochimica et Biophysica Acta. 179(1):115-28. DOI: 10.1016/0005-2787(69)90127-0
Hunter, A.R., Korner, A. Exonuclease activity in rat liver cell sap. (1968) Biochimica et Biophysica Acta. 169(2):488-93. DOI: 10.1016/0005-2787(68)90057-9
Hunt, R.T., Hunter, A.R., Munro, A.J. Control of haemoglobin synthesis: a difference in the size of the polysomes making alpha and beta chains. (1968) 自然. 220(5166):481-3. DOI: 10.1038/220481a0
Hunt, T., Hunter, T., Munro, A. Control of haemoglobin synthesis: distribution of ribosomes on the messenger RNA for alpha and beta chains. (1968) 分子生物学杂志. 36(1):31-45.
Hunter, A.R., Jefferson, L.S. Perfusion of rat liver with adenosine monophosphate. (1967) Biochemical Journal. 104(3):60P-61P.
BA, First Class Honors, University of Cambridge, England
PhD, University of Cambridge, England
Postdoctoral Fellow, The Salk Institute and University of Cambridge