助理教授
整合生物学实验室
Hearst Foundations Developmental Chair
Liu, Y., Coles, A.M., Castiglione, J., Thiyagarajan, V.V., Clifton, K., Goyal, D., Wu, J., Sheridan, A., Vujic, A., Harris, K.M., Manor, U., Pereira, T.D., Fan, J., Lee, R.T., Kosuri, P. Spatial imprints of emergent cardiomyocyte states in the pressure-overloaded heart. (2026) bioRxiv. DOI: 10.64898/2026.05.04.721738
Wacker, A., Fantasia, R.J., Tenner, B.J., Wu, J., Monell, N.A., Kosuri, P. Dye-cycling DNA origami rotors for long-term tracking of transcription at base-pair resolution. (2026) bioRxiv. DOI: 10.64898/2026.01.21.700733
Kosuri, P. Single-molecule DNA dynamics with graphene energy transfer. (2024) 自然方法. DOI: 10.1038/s41592-024-02560-8
Lee, H., Yu, C.C., Boyden, E.S., Zhuang, X., Kosuri, P. Tetra-gel enables superior accuracy in combined super-resolution imaging and expansion microscopy. (2021) 科学报告. 11(1):16944. DOI: 10.1038/s41598-021-96258-y
Kosuri, P., Altheimer, B.D., Dai, M., Yin, P., Zhuang, X. Rotation tracking of genome-processing enzymes using DNA origami rotors. (2019) 自然. 572(7767):136-140. DOI: 10.1038/s41586-019-1397-7
Rivas-Pardo, J.A., Eckels, E.C., Popa, I., Kosuri, P., Linke, W.A., Fernández, J.M. Work Done by Titin Protein Folding Assists Muscle Contraction. (2016) 细胞报告. 14(6):1339-1347. DOI: 10.1016/j.celrep.2016.01.025
Inouye, S., Bouras, V., Shouldis, E., Johnstone, A., Silverzweig, Z., Kosuri, P. Predicting readmission of heart failure patients using automated follow-up calls. (2015) BMC Med Inform Decis Mak. 15:22. DOI: 10.1186/s12911-015-0144-8
Lee, L., Kosuri, P., Arancio, O. Picomolar amyloid-β peptides enhance spontaneous astrocyte calcium transients. (2013) J Alzheimers Dis. 38(1):49-62. DOI: 10.3233/JAD-130740
Popa, I., Kosuri, P., Alegre-Cebollada, J., Garcia-Manyes, S., Fernandez, J.M. Force dependency of biochemical reactions measured by single-molecule force-clamp spectroscopy. (2013) Nature Protocols. 8(7):1261-76. DOI: 10.1038/nprot.2013.056
Kosuri, P., Alegre-Cebollada, J., Feng, J., Kaplan, A., Inglés-Prieto, A., Badilla, C.L., Stockwell, B.R., Sanchez-Ruiz, J.M., Holmgren, A., Fernández, J.M. Protein folding drives disulfide formation. (2012) 牢房. 151(4):794-806. DOI: 10.1016/j.cell.2012.09.036
Alegre-Cebollada, J., Kosuri, P., Rivas-Pardo, J.A., Fernández, J.M. Direct observation of disulfide isomerization in a single protein. (2011) Nature Chemistry. 3(11):882-7. DOI: 10.1038/nchem.1155
Perez-Jimenez, R., Inglés-Prieto, A., Zhao, Z.M., Sanchez-Romero, I., Alegre-Cebollada, J., Kosuri, P., Garcia-Manyes, S., Kappock, T.J., Tanokura, M., Holmgren, A., Sanchez-Ruiz, J.M., Gaucher, E.A., Fernandez, J.M. Single-molecule paleoenzymology probes the chemistry of resurrected enzymes. (2011) 自然结构与分子生物学. 18(5):592-6. DOI: 10.1038/nsmb.2020
Alegre-Cebollada, J., Kosuri, P., Fernández, J.M. Protease power strokes force proteins to unfold. (2011) 牢房. 145(3):339-40. DOI: 10.1016/j.cell.2011.04.007
Alegre-Cebollada, J., Perez-Jimenez, R., Kosuri, P., Fernandez, J.M. Single-molecule force spectroscopy approach to enzyme catalysis. (2010) 生物化学杂志. 285(25):18961-6. DOI: 10.1074/jbc.R109.011932
Fernandez, V.I., Kosuri, P., Parot, V., Fernandez, J.M. Extended Kalman filter estimates the contour length of a protein in single molecule atomic force microscopy experiments. (2009) Rev Sci Instrum. 80(11):113104. DOI: 10.1063/1.3252982
O'Connell, N.E., Grey, M.J., Tang, Y., Kosuri, P., Miloushev, V.Z., Raleigh, D.P., Palmer, A.G. Partially folded equilibrium intermediate of the villin headpiece HP67 defined by 13C relaxation dispersion. (2009) J Biomol NMR. 45(1-2):85-98. DOI: 10.1007/s10858-009-9340-0
Perez-Jimenez, R., Li, J., Kosuri, P., Sanchez-Romero, I., Wiita, A.P., Rodriguez-Larrea, D., Chueca, A., Holmgren, A., Miranda-Vizuete, A., Becker, K., Cho, S.H., Beckwith, J., Gelhaye, E., Jacquot, J.P., Gaucher, E.A., Gaucher, E., Sanchez-Ruiz, J.M., Berne, B.J., Fernandez, J.M. Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. (2009) 自然结构与分子生物学. 16(8):890-6. DOI: 10.1038/nsmb.1627
Perez-Jimenez, R., Wiita, A.P., Rodriguez-Larrea, D., Kosuri, P., Gavira, J.A., Sanchez-Ruiz, J.M., Fernandez, J.M. Force-clamp spectroscopy detects residue co-evolution in enzyme catalysis. (2008) 生物化学杂志. 283(40):27121-9. DOI: 10.1074/jbc.M803746200
Fei, J., Kosuri, P., MacDougall, D.D., Gonzalez, R.L. Coupling of ribosomal L1 stalk and tRNA dynamics during translation elongation. (2008) 分子细胞. 30(3):348-59. DOI: 10.1016/j.molcel.2008.03.012
Postdoctoral Fellow, Harvard University
PhD, Biochemistry and Molecular Biophysics, Columbia University
MSc, Engineering Physics, KTH Royal Institute of Technology