Pallav Kosuri 博士

助理教授

整合生物学实验室

Hearst Foundations Developmental Chair

Pallav Kosuri
索尔克生物研究所 出版物

所有出版物


Liu, Y., Coles, A.M., Castiglione, J., Thiyagarajan, V.V., Clifton, K., Goyal, D., Wu, J., Sheridan, A., Vujic, A., Harris, K.M., Manor, U., Pereira, T.D., Fan, J., Lee, R.T., Kosuri, P. Spatial imprints of emergent cardiomyocyte states in the pressure-overloaded heart. (2026) bioRxiv. DOI: 10.64898/2026.05.04.721738

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Wacker, A., Fantasia, R.J., Tenner, B.J., Wu, J., Monell, N.A., Kosuri, P. Dye-cycling DNA origami rotors for long-term tracking of transcription at base-pair resolution. (2026) bioRxiv. DOI: 10.64898/2026.01.21.700733

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Kosuri, P. Single-molecule DNA dynamics with graphene energy transfer. (2024) 自然方法. DOI: 10.1038/s41592-024-02560-8


Lee, H., Yu, C.C., Boyden, E.S., Zhuang, X., Kosuri, P. Tetra-gel enables superior accuracy in combined super-resolution imaging and expansion microscopy. (2021) 科学报告. 11(1):16944. DOI: 10.1038/s41598-021-96258-y

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Kosuri, P., Altheimer, B.D., Dai, M., Yin, P., Zhuang, X. Rotation tracking of genome-processing enzymes using DNA origami rotors. (2019) 自然. 572(7767):136-140. DOI: 10.1038/s41586-019-1397-7

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Rivas-Pardo, J.A., Eckels, E.C., Popa, I., Kosuri, P., Linke, W.A., Fernández, J.M. Work Done by Titin Protein Folding Assists Muscle Contraction. (2016) 细胞报告. 14(6):1339-1347. DOI: 10.1016/j.celrep.2016.01.025

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Inouye, S., Bouras, V., Shouldis, E., Johnstone, A., Silverzweig, Z., Kosuri, P. Predicting readmission of heart failure patients using automated follow-up calls. (2015) BMC Med Inform Decis Mak. 15:22. DOI: 10.1186/s12911-015-0144-8

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Lee, L., Kosuri, P., Arancio, O. Picomolar amyloid-β peptides enhance spontaneous astrocyte calcium transients. (2013) J Alzheimers Dis. 38(1):49-62. DOI: 10.3233/JAD-130740

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Popa, I., Kosuri, P., Alegre-Cebollada, J., Garcia-Manyes, S., Fernandez, J.M. Force dependency of biochemical reactions measured by single-molecule force-clamp spectroscopy. (2013) Nature Protocols. 8(7):1261-76. DOI: 10.1038/nprot.2013.056

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Kosuri, P., Alegre-Cebollada, J., Feng, J., Kaplan, A., Inglés-Prieto, A., Badilla, C.L., Stockwell, B.R., Sanchez-Ruiz, J.M., Holmgren, A., Fernández, J.M. Protein folding drives disulfide formation. (2012) 牢房. 151(4):794-806. DOI: 10.1016/j.cell.2012.09.036

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Alegre-Cebollada, J., Kosuri, P., Rivas-Pardo, J.A., Fernández, J.M. Direct observation of disulfide isomerization in a single protein. (2011) Nature Chemistry. 3(11):882-7. DOI: 10.1038/nchem.1155

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Perez-Jimenez, R., Inglés-Prieto, A., Zhao, Z.M., Sanchez-Romero, I., Alegre-Cebollada, J., Kosuri, P., Garcia-Manyes, S., Kappock, T.J., Tanokura, M., Holmgren, A., Sanchez-Ruiz, J.M., Gaucher, E.A., Fernandez, J.M. Single-molecule paleoenzymology probes the chemistry of resurrected enzymes. (2011) 自然结构与分子生物学. 18(5):592-6. DOI: 10.1038/nsmb.2020

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Alegre-Cebollada, J., Kosuri, P., Fernández, J.M. Protease power strokes force proteins to unfold. (2011) 牢房. 145(3):339-40. DOI: 10.1016/j.cell.2011.04.007

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Alegre-Cebollada, J., Perez-Jimenez, R., Kosuri, P., Fernandez, J.M. Single-molecule force spectroscopy approach to enzyme catalysis. (2010) 生物化学杂志. 285(25):18961-6. DOI: 10.1074/jbc.R109.011932

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Fernandez, V.I., Kosuri, P., Parot, V., Fernandez, J.M. Extended Kalman filter estimates the contour length of a protein in single molecule atomic force microscopy experiments. (2009) Rev Sci Instrum. 80(11):113104. DOI: 10.1063/1.3252982

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O'Connell, N.E., Grey, M.J., Tang, Y., Kosuri, P., Miloushev, V.Z., Raleigh, D.P., Palmer, A.G. Partially folded equilibrium intermediate of the villin headpiece HP67 defined by 13C relaxation dispersion. (2009) J Biomol NMR. 45(1-2):85-98. DOI: 10.1007/s10858-009-9340-0

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Perez-Jimenez, R., Li, J., Kosuri, P., Sanchez-Romero, I., Wiita, A.P., Rodriguez-Larrea, D., Chueca, A., Holmgren, A., Miranda-Vizuete, A., Becker, K., Cho, S.H., Beckwith, J., Gelhaye, E., Jacquot, J.P., Gaucher, E.A., Gaucher, E., Sanchez-Ruiz, J.M., Berne, B.J., Fernandez, J.M. Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. (2009) 自然结构与分子生物学. 16(8):890-6. DOI: 10.1038/nsmb.1627

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Perez-Jimenez, R., Wiita, A.P., Rodriguez-Larrea, D., Kosuri, P., Gavira, J.A., Sanchez-Ruiz, J.M., Fernandez, J.M. Force-clamp spectroscopy detects residue co-evolution in enzyme catalysis. (2008) 生物化学杂志. 283(40):27121-9. DOI: 10.1074/jbc.M803746200

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Fei, J., Kosuri, P., MacDougall, D.D., Gonzalez, R.L. Coupling of ribosomal L1 stalk and tRNA dynamics during translation elongation. (2008) 分子细胞. 30(3):348-59. DOI: 10.1016/j.molcel.2008.03.012

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教育

Postdoctoral Fellow, Harvard University
PhD, Biochemistry and Molecular Biophysics, Columbia University
MSc, Engineering Physics, KTH Royal Institute of Technology


奖项与荣誉

  • W.M. Keck Foundation Award, 2024
  • Beckman Young Investigator Award, 2022
  • Titus M. Coan Prize for Excellence in Basic Research
  • The Columbia University Distinction Award for Doctoral Defense
  • Fulbright Scholarship

个人资料