Van de Velde, S., Yu, J., Garrett Evensen, K., Pakhlevanyan, E., Williams, A.E., Shaw, R.J., Montminy, M. Med14 phosphorylation shapes genomic response to GLP-1 agonists. (2026) 美国国家科学院院刊. 123(10):e2536772123. DOI: 10.1073/pnas.2536772123

Van de Velde, S., Yu, J., Evensen, K.G., Pakhlevanyan, E., Williams, A.E., Shaw, R.J., Montminy, M. Med14 phosphorylation shapes genomic response to GLP-1 Agonist. (2025) bioRxiv. DOI: 10.1101/2025.06.17.660196

Dondi, C., Vogler, G., Gupta, A., Walls, S.M., Kervadec, A., Marchant, J., Romero, M.R., Diop, S., Goode, J., Thomas, J.B., Colas, A.R., Bodmer, R., Montminy, M., Ocorr, K. The nutrient sensor CRTC and Sarcalumenin/thinman represent an alternate pathway in cardiac hypertrophy. (2024) 细胞报告. 43(8):114549. DOI: 10.1016/j.celrep.2024.114549

Morgan, H.J.N., Delfino, H.B.P., Schavinski, A.Z., Malone, S.A., Charoy, C., Reis, N.G., Assis, A.P., Lautherbach, N., Silveira, W.A., Heck, L.C., Guton, D., Domingos, A.I., Kettelhut, I.C., Montminy, M., Navegantes, L.C.C. Hepatic noradrenergic innervation acts via CREB/CRTC2 to activate gluconeogenesis during cold. (2024) Metabolism.:155940 DOI: 10.1016/j.metabol.2024.155940

Yoon, Y.S., Liu, W., Van de Velde, S., Matsumura, S., Wiater, E., Huang, L., Montminy, M. Activation of the adipocyte CREB/CRTC pathway in obesity. (2021) 传达生物学. 4(1):1214. DOI: 10.1038/s42003-021-02735-5

Ostojić, J., Yoon, Y.S., Sonntag, T., Nguyen, B., Vaughan, J.M., Shokhirev, M., Montminy, M. Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways. (2021) 细胞报告. 35(7):109136. DOI: 10.1016/j.celrep.2021.109136

Wang, T., Wiater, E., Zhang, X., Thomas, J.B., Montminy, M. Crtc modulates fasting programs associated with 1-C metabolism and inhibition of insulin signaling. (2021) 美国国家科学院院刊. 118(12). DOI: 10.1073/pnas.2024865118

Sonntag, T., Moresco, J.J., Yates, J.R., Montminy, M. The KLDpT activation loop motif is critical for MARK kinase activity. (2019) PLOS One. 14(12):e0225727. DOI: 10.1371/journal.pone.0225727

Rodón, L., Svensson, R.U., Wiater, E., Chun, M.G.H., Tsai, W.W., Eichner, L.J., Shaw, R.J., Montminy, M. The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer. (2019) 科学进展. 5(7):eaaw6455. DOI: 10.1126/sciadv.aaw6455

Van de Velde, S., Wiater, E., Tran, M., Hwang, Y., Cole, P.A., Montminy, M. CREB promotes beta cell gene expression by targeting Its coactivators to tissue-specific enhancers. (2019) 分子与细胞生物学. DOI: 10.1128/MCB.00200-19

Tasoulas, J., Rodon, L., Kaye, F.J., Montminy, M., Amelio, A.L. Adaptive Transcriptional Responses by CRTC Coactivators in Cancer. (2019) Trends in Cancer. 5(2):111-127. DOI: 10.1016/j.trecan.2018.12.002

Sonntag, T., Ostojić, J., Vaughan, J.M., Moresco, J.J., Yoon, Y.S., Yates, J.R., Montminy, M. Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. (2018) iScience. 11:134-145. DOI: 10.1016/j.isci.2018.12.012

Yoon, Y.S., Tsai, W.W., Van de Velde, S., Chen, Z., Lee, K.F., Morgan, D.A., Rahmouni, K., Matsumura, S., Wiater, E., Song, Y., Montminy, M. cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis. (2018) 美国国家科学院院刊. DOI: 10.1073/pnas.1805257115

Ritchie, A.I., Singanayagam, A., Wiater, E., Edwards, M.R., Montminy, M., Johnston, S.L. β2-Agonists Enhance Asthma-Relevant Inflammatory Mediators in Human Airway Epithelial Cells. (2018) Am. J. Respir. Cell Mol. Biol. 58(1):128-132. DOI: 10.1165/rcmb.2017-0315LE

Sonntag, T., Vaughan, J.M., Montminy, M. 14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs). (2017) FEBS Journal. DOI: 10.1111/febs.14351

Kim, J.H., Hedrick, S., Tsai, W.W., Wiater, E., Le Lay, J., Kaestner, K.H., Leblanc, M., Loar, A., Montminy, M. CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis. (2017) 美国国家科学院院刊. DOI: 10.1073/pnas.1712616114

Sonntag, T., Moresco, J.J., Vaughan, J.M., Matsumura, S., Yates, J.R., Montminy, M. Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members. (2017) PLOS One. 12(2):e0173013. DOI: 10.1371/journal.pone.0173013

Shen, R., Wang, B., Giribaldi, M.G., Ayres, J., Thomas, J.B., Montminy, M. Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance. (2016) 美国国家科学院院刊. 113(23):E3307-14. DOI: 10.1073/pnas.1606106113

Ravnskjaer, K., Madiraju, A., Montminy, M. Role of the cAMP Pathway in Glucose and Lipid Metabolism. (2016) Handbook of Experimental Pharmacology. 233:29-49. DOI: 10.1007/164_2015_32

Luan, B., Yoon, Y.S., Le Lay, J., Kaestner, K.H., Hedrick, S., Montminy, M. CREB pathway links PGE2 signaling with macrophage polarization. (2015) 美国国家科学院院刊. 112(51):15642-7. DOI: 10.1073/pnas.1519644112

Hogan, M.F., Ravnskjaer, K., Matsumura, S., Huising, M.O., Hull, R.L., Kahn, S.E., Montminy, M. Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2. (2015) 生物化学杂志. 290(43):25997-6006. DOI: 10.1074/jbc.M115.679266

Hernandez, J.B., Chang, C., LeBlanc, M., Grimm, D., Le Lay, J., Kaestner, K.H., Zheng, Y., Montminy, M. The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation. (2015) 自然-通讯. 6:7216. DOI: 10.1038/ncomms8216

Tsai, W.W., Matsumura, S., Liu, W., Phillips, N.G., Sonntag, T., Hao, E., Lee, S., Hai, T., Montminy, M. ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis. (2015) 美国国家科学院院刊. 112(9):2699-704. DOI: 10.1073/pnas.1424641112

Blanchet, E., Van de Velde, S., Matsumura, S., Hao, E., LeLay, J., Kaestner, K., Montminy, M. Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance. (2015) 细胞报告. 10(7):1149-57. DOI: 10.1016/j.celrep.2015.01.046

Paz, J.C., Park, S., Phillips, N., Matsumura, S., Tsai, W.W., Kasper, L., Brindle, P.K., Zhang, G., Zhou, M.M., Wright, P.E., Montminy, M. Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation. (2014) 美国国家科学院院刊. 111(48):17116-21. DOI: 10.1073/pnas.1420389111

Luan, B., Goodarzi, M.O., Phillips, N.G., Guo, X., Chen, Y.D., Yao, J., Allison, M., Rotter, J.I., Shaw, R., Montminy, M. Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. (2014) Cell Metabolism. 19(6):1058-65. DOI: 10.1016/j.cmet.2014.03.024

Ravnskjaer, K., Hogan, M.F., Lackey, D., Tora, L., Dent, S.Y., Olefsky, J., Montminy, M. Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. (2013) 临床研究杂志. 123(10):4318-28. DOI: 10.1172/JCI69035

Tsai, W.W., Niessen, S., Goebel, N., Yates, J.R., Guccione, E., Montminy, M. PRMT5 modulates the metabolic response to fasting signals. (2013) 美国国家科学院院刊. 110(22):8870-5. DOI: 10.1073/pnas.1304602110

Yu, J., Deng, R., Zhu, H.H., Zhang, S.S., Zhu, C., Montminy, M., Davis, R., Feng, G.S. Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2. (2013) 生物化学杂志. 288(6):3823-30. DOI: 10.1074/jbc.M112.397885

Luo, Q., Viste, K., Urday-Zaa, J.C., Senthil Kumar, G., Tsai, W.W., Talai, A., Mayo, K.E., Montminy, M., Radhakrishnan, I. Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2. (2012) 美国国家科学院院刊. 109(51):20865-70. DOI: 10.1073/pnas.1219028109

Wang, Y., Li, G., Goode, J., Paz, J.C., Ouyang, K., Screaton, R., Fischer, W.H., Chen, J., Tabas, I., Montminy, M. Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes. (2012) 自然. 485(7396):128-32. DOI: 10.1038/nature10988

Montminy, M., Lee, K.F., Rivier, J.E., Rivier, C., Reichlin, S. Wylie Vale: neuroendocrine master. (2012) 美国国家科学院院刊. 109(10):3604-5. DOI: 10.1073/pnas.1201696109

Van de Velde, S., Hogan, M.F., Montminy, M. mTOR links incretin signaling to HIF induction in pancreatic beta cells. (2011) 美国国家科学院院刊. 108(41):16876-82. DOI: 10.1073/pnas.1114228108

Stewart, R., Flechner, L., Montminy, M., Berdeaux, R. CREB is activated by muscle injury and promotes muscle regeneration. (2011) PLOS One. 6(9):e24714. DOI: 10.1371/journal.pone.0024714

Mihaylova, M.M., Vasquez, D.S., Ravnskjaer, K., Denechaud, P.D., Yu, R.T., Alvarez, J.G., Downes, M., Evans, R.M., Montminy, M., Shaw, R.J. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. (2011) 牢房. 145(4):607-21. DOI: 10.1016/j.cell.2011.03.043

Wang, B., Moya, N., Niessen, S., Hoover, H., Mihaylova, M.M., Shaw, R.J., Yates, J.R., Fischer, W.H., Thomas, J.B., Montminy, M. A hormone-dependent module regulating energy balance. (2011) 牢房. 145(4):596-606. DOI: 10.1016/j.cell.2011.04.013

Altarejos, J.Y., Montminy, M. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. (2011) 自然-学科前沿：分子细胞生物学. 12(3):141-51. DOI: 10.1038/nrm3072

Mair, W., Morantte, I., Rodrigues, A.P., Manning, G., Montminy, M., Shaw, R.J., Dillin, A. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. (2011) 自然. 470(7334):404-8. DOI: 10.1038/nature09706

Song, Y., Altarejos, J., Goodarzi, M.O., Inoue, H., Guo, X., Berdeaux, R., Kim, J.H., Goode, J., Igata, M., Paz, J.C., Hogan, M.F., Singh, P.K., Goebel, N., Vera, L., Miller, N., Cui, J., Jones, M.R., , , Chen, Y.D., Taylor, K.D., Hsueh, W.A., Rotter, J.I., Montminy, M. CRTC3 links catecholamine signalling to energy balance. (2010) 自然. 468(7326):933-9. DOI: 10.1038/nature09564

Yoon, Y.S., Lee, M.W., Ryu, D., Kim, J.H., Ma, H., Seo, W.Y., Kim, Y.N., Kim, S.S., Lee, C.H., Hunter, T., Choi, C.S., Montminy, M.R., Koo, S.H. Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis. (2010) 美国国家科学院院刊. 107(41):17704-9. DOI: 10.1073/pnas.1012665107

Zhang, E.E., Liu, Y., Dentin, R., Pongsawakul, P.Y., Liu, A.C., Hirota, T., Nusinow, D.A., Sun, X., Landais, S., Kodama, Y., Brenner, D.A., Montminy, M., Kay, S.A. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. (2010) Nature Medicine. 16(10):1152-6. DOI: 10.1038/nm.2214

Zmuda, E.J., Qi, L., Zhu, M.X., Mirmira, R.G., Montminy, M.R., Hai, T. The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction. (2010) Molecular Endocrinology. 24(7):1423-33. DOI: 10.1210/me.2009-0463

Wang, Y., Inoue, H., Ravnskjaer, K., Viste, K., Miller, N., Liu, Y., Hedrick, S., Vera, L., Montminy, M. Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. (2010) 美国国家科学院院刊. 107(7):3087-92. DOI: 10.1073/pnas.0914897107

Wang, Y., Vera, L., Fischer, W.H., Montminy, M. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. (2009) 自然. 460(7254):534-7. DOI: 10.1038/nature08111

Qi, L., Saberi, M., Zmuda, E., Wang, Y., Altarejos, J., Zhang, X., Dentin, R., Hedrick, S., Bandyopadhyay, G., Hai, T., Olefsky, J., Montminy, M. Adipocyte CREB promotes insulin resistance in obesity. (2009) Cell Metabolism. 9(3):277-86. DOI: 10.1016/j.cmet.2009.01.006

Ryu, D., Oh, K.J., Jo, H.Y., Hedrick, S., Kim, Y.N., Hwang, Y.J., Park, T.S., Han, J.S., Choi, C.S., Montminy, M., Koo, S.H. TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1. (2009) Cell Metabolism. 9(3):240-51. DOI: 10.1016/j.cmet.2009.01.007

Liu, Y., Dentin, R., Chen, D., Hedrick, S., Ravnskjaer, K., Schenk, S., Milne, J., Meyers, D.J., Cole, P., Yates, J., Olefsky, J., Guarente, L., Montminy, M. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. (2008) 自然. 456(7219):269-73. DOI: 10.1038/nature07349

Altarejos, J.Y., Goebel, N., Conkright, M.D., Inoue, H., Xie, J., Arias, C.M., Sawchenko, P.E., Montminy, M. The Creb1 coactivator Crtc1 is required for energy balance and fertility. (2008) Nature Medicine. 14(10):1112-7. DOI: 10.1038/nm.1866

Wang, B., Goode, J., Best, J., Meltzer, J., Schilman, P.E., Chen, J., Garza, D., Thomas, J.B., Montminy, M. The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila. (2008) Cell Metabolism. 7(5):434-44. DOI: 10.1016/j.cmet.2008.02.010

Dentin, R., Hedrick, S., Xie, J., Yates, J., Montminy, M. Hepatic glucose sensing via the CREB coactivator CRTC2. (2008) 科学. 319(5868):1402-5. DOI: 10.1126/science.1151363

Dentin, R., Liu, Y., Koo, S.H., Hedrick, S., Vargas, T., Heredia, J., Yates, J., Montminy, M. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. (2007) 自然. 449(7160):366-9. DOI: 10.1038/nature06128

Ravnskjaer, K., Kester, H., Liu, Y., Zhang, X., Lee, D., Yates, J.R., Montminy, M. Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. (2007) EMBO 期刊. 26(12):2880-9. DOI: 10.1038/sj.emboj.7601715

Berdeaux, R., Goebel, N., Banaszynski, L., Takemori, H., Wandless, T., Shelton, G.D., Montminy, M. SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. (2007) Nature Medicine. 13(5):597-603. DOI: 10.1038/nm1573

Koo, S.H., Montminy, M. In vino veritas: a tale of two sirt1s? (2006) 牢房. 127(6):1091-3. DOI: 10.1016/j.cell.2006.11.034

Qi, L., Heredia, J.E., Altarejos, J.Y., Screaton, R., Goebel, N., Niessen, S., Macleod, I.X., Liew, C.W., Kulkarni, R.N., Bain, J., Newgard, C., Nelson, M., Evans, R.M., Yates, J., Montminy, M. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. (2006) 科学. 312(5781):1763-6. DOI: 10.1126/science.1123374

Liu, Y., Montminy, M. CAT in the HAT: catabolic inhibition by the histone acetyltransferase GCN5. (2006) Cell Metabolism. 3(6):387-8. DOI: 10.1016/j.cmet.2006.05.006

Cho, C.Y., Koo, S.H., Wang, Y., Callaway, S., Hedrick, S., Mak, P.A., Orth, A.P., Peters, E.C., Saez, E., Montminy, M., Schultz, P.G., Chanda, S.K. Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling. (2006) Cell Metabolism. 3(5):367-78. DOI: 10.1016/j.cmet.2006.03.006

Zhang, W., Patil, S., Chauhan, B., Guo, S., Powell, D.R., Le, J., Klotsas, A., Matika, R., Xiao, X., Franks, R., Heidenreich, K.A., Sajan, M.P., Farese, R.V., Stolz, D.B., Tso, P., Koo, S.H., Montminy, M., Unterman, T.G. FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. (2006) 生物化学杂志. 281(15):10105-17. DOI: 10.1074/jbc.M600272200

Koo, S.H., Montminy, M. Fatty acids and insulin resistance: a perfect storm. (2006) 分子细胞. 21(4):449-50. DOI: 10.1016/j.molcel.2006.02.001

Shaw, R.J., Lamia, K.A., Vasquez, D., Koo, S.H., Bardeesy, N., Depinho, R.A., Montminy, M., Cantley, L.C. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. (2005) 科学. 310(5754):1642-6. DOI: 10.1126/science.1120781

Canettieri, G., Koo, S.H., Berdeaux, R., Heredia, J., Hedrick, S., Zhang, X., Montminy, M. Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling. (2005) Cell Metabolism. 2(5):331-8. DOI: 10.1016/j.cmet.2005.09.008

Lebrun, P., Montminy, M.R., Van Obberghen, E. Regulation of the pancreatic duodenal homeobox-1 protein by DNA-dependent protein kinase. (2005) 生物化学杂志. 280(46):38203-10. DOI: 10.1074/jbc.M504842200

Koo, S.H., Flechner, L., Qi, L., Zhang, X., Screaton, R.A., Jeffries, S., Hedrick, S., Xu, W., Boussouar, F., Brindle, P., Takemori, H., Montminy, M. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. (2005) 自然. 437(7062):1109-11. DOI: 10.1038/nature03967

Conkright, M.D., Montminy, M. CREB: the unindicted cancer co-conspirator. (2005) Trends in Cell Biology. 15(9):457-9. DOI: 10.1016/j.tcb.2005.07.007

Park, J.M., Greten, F.R., Wong, A., Westrick, R.J., Arthur, J.S., Otsu, K., Hoffmann, A., Montminy, M., Karin, M. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. (2005) Immunity. 23(3):319-29. DOI: 10.1016/j.immuni.2005.08.010

Gardner, K.H., Montminy, M. Can you hear me now? Regulating transcriptional activators by phosphorylation. (2005) Science STKE. 2005(301):pe44. DOI: 10.1126/stke.3012005pe44

Mayr, B.M., Guzman, E., Montminy, M. Glutamine rich and basic region/leucine zipper (bZIP) domains stabilize cAMP-response element-binding protein (CREB) binding to chromatin. (2005) 生物化学杂志. 280(15):15103-10. DOI: 10.1074/jbc.M414144200

Zhang, X., Odom, D.T., Koo, S.H., Conkright, M.D., Canettieri, G., Best, J., Chen, H., Jenner, R., Herbolsheimer, E., Jacobsen, E., Kadam, S., Ecker, J.R., Emerson, B., Hogenesch, J.B., Unterman, T., Young, R.A., Montminy, M. Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. (2005) 美国国家科学院院刊. 102(12):4459-64. DOI: 10.1073/pnas.0501076102

Best, J.L., Amezcua, C.A., Mayr, B., Flechner, L., Murawsky, C.M., Emerson, B., Zor, T., Gardner, K.H., Montminy, M. Identification of small-molecule antagonists that inhibit an activator: coactivator interaction. (2004) 美国国家科学院院刊. 101(51):17622-7. DOI: 10.1073/pnas.0406374101

Montminy, M., Koo, S.H. Diabetes: outfoxing insulin resistance? (2004) 自然. 432(7020):958-9. DOI: 10.1038/432958a

Screaton, R.A., Conkright, M.D., Katoh, Y., Best, J.L., Canettieri, G., Jeffries, S., Guzman, E., Niessen, S., Yates, J.R., Takemori, H., Okamoto, M., Montminy, M. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (2004) 牢房. 119(1):61-74. DOI: 10.1016/j.cell.2004.09.015

Kulkarni, R.N., Jhala, U.S., Winnay, J.N., Krajewski, S., Montminy, M., Kahn, C.R. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. (2004) 临床研究杂志. 114(6):828-36. DOI: 10.1172/JCI21845

Koo, S.H., Satoh, H., Herzig, S., Lee, C.H., Hedrick, S., Kulkarni, R., Evans, R.M., Olefsky, J., Montminy, M. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. (2004) Nature Medicine. 10(5):530-4. DOI: 10.1038/nm1044

Montminy, M., Koo, S.H., Zhang, X. The CREB family: key regulators of hepatic metabolism. (2004) Ann. Endocrinol. (Paris). 65(1):73-5.

Herzig, S., Hedrick, S., Morantte, I., Koo, S.H., Galimi, F., Montminy, M. CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma. (2003) 自然. 426(6963):190-3. DOI: 10.1038/nature02110

Conkright, M.D., Canettieri, G., Screaton, R., Guzman, E., Miraglia, L., Hogenesch, J.B., Montminy, M. TORCs: transducers of regulated CREB activity. (2003) 分子细胞. 12(2):413-23.

Jhala, U.S., Canettieri, G., Screaton, R.A., Kulkarni, R.N., Krajewski, S., Reed, J., Walker, J., Lin, X., White, M., Montminy, M. cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. (2003) 基因与发展. 17(13):1575-80. DOI: 10.1101/gad.1097103

Du, K., Herzig, S., Kulkarni, R.N., Montminy, M. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. (2003) 科学. 300(5625):1574-7. DOI: 10.1126/science.1079817

Conkright, M.D., Guzmán, E., Flechner, L., Su, A.I., Hogenesch, J.B., Montminy, M. Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness. (2003) 分子细胞. 11(4):1101-8.

Canettieri, G., Morantte, I., Guzmán, E., Asahara, H., Herzig, S., Anderson, S.D., Yates, J.R., Montminy, M. Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex. (2003) Nature Structural Biology. 10(3):175-81. DOI: 10.1038/nsb895

Zor, T., Mayr, B.M., Dyson, H.J., Montminy, M.R., Wright, P.E. Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators. (2002) 生物化学杂志. 277(44):42241-8. DOI: 10.1074/jbc.M207361200

Asahara, H., Tartare-Deckert, S., Nakagawa, T., Ikehara, T., Hirose, F., Hunter, T., Ito, T., Montminy, M. Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. (2002) 分子与细胞生物学. 22(9):2974-83.

Kushner, J.A., Ye, J., Schubert, M., Burks, D.J., Dow, M.A., Flint, C.L., Dutta, S., Wright, C.V., Montminy, M.R., White, M.F. Pdx1 restores beta cell function in Irs2 knockout mice. (2002) 临床研究杂志. 109(9):1193-201. DOI: 10.1172/JCI14439

Asahara, H., Santoso, B., Guzman, E., Du, K., Cole, P.A., Davidson, I., Montminy, M. Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB. (2001) 分子与细胞生物学. 21(23):7892-900. DOI: 10.1128/MCB.21.23.7892-7900.2001

Xu, W., Chen, H., Du, K., Asahara, H., Tini, M., Emerson, B.M., Montminy, M., Evans, R.M. A transcriptional switch mediated by cofactor methylation. (2001) 科学. 294(5551):2507-11. DOI: 10.1126/science.1065961

Herzig, S., Long, F., Jhala, U.S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., Spiegelman, B., Montminy, M. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. (2001) 自然. 413(6852):179-83. DOI: 10.1038/35093131

Mayr, B.M., Canettieri, G., Montminy, M.R. Distinct effects of cAMP and mitogenic signals on CREB-binding protein recruitment impart specificity to target gene activation via CREB. (2001) 美国国家科学院院刊. 98(19):10936-41. DOI: 10.1073/pnas.191152098

Mayr, B., Montminy, M. Transcriptional regulation by the phosphorylation-dependent factor CREB. (2001) 自然-学科前沿：分子细胞生物学. 2(8):599-609. DOI: 10.1038/35085068

Long, F., Schipani, E., Asahara, H., Kronenberg, H., Montminy, M. The CREB family of activators is required for endochondral bone development. (2001) Development. 128(4):541-50.

Dutta, S., Gannon, M., Peers, B., Wright, C., Bonner-Weir, S., Montminy, M. PDX:PBX complexes are required for normal proliferation of pancreatic cells during development. (2001) 美国国家科学院院刊. 98(3):1065-70. DOI: 10.1073/pnas.031561298

Frangioni, J.V., LaRiccia, L.M., Cantley, L.C., Montminy, M.R. Minimal activators that bind to the KIX domain of p300/CBP identified by phage display screening. (2000) Nature Biotechnology. 18(10):1080-5. DOI: 10.1038/80280

von Mikecz, A., Zhang, S., Montminy, M., Tan, E.M., Hemmerich, P. CREB-binding protein (CBP)/p300 and RNA polymerase II colocalize in transcriptionally active domains in the nucleus. (2000) Journal of Cell Biology. 150(1):265-73.

Du, K., Asahara, H., Jhala, U.S., Wagner, B.L., Montminy, M. Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo. (2000) 分子与细胞生物学. 20(12):4320-7.

Wagner, B.L., Bauer, A., Schütz, G., Montminy, M. Stimulus-specific interaction between activator-coactivator cognates revealed with a novel complex-specific antiserum. (2000) 生物化学杂志. 275(12):8263-6.

Michael, L.F., Asahara, H., Shulman, A.I., Kraus, W.L., Montminy, M. The phosphorylation status of a cyclic AMP-responsive activator is modulated via a chromatin-dependent mechanism. (2000) 分子与细胞生物学. 20(5):1596-603.

Asahara, H., Dutta, S., Kao, H.Y., Evans, R.M., Montminy, M. Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner. (1999) 分子与细胞生物学. 19(12):8219-25.

Malecki, M.T., Jhala, U.S., Antonellis, A., Fields, L., Doria, A., Orban, T., Saad, M., Warram, J.H., Montminy, M., Krolewski, A.S. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. (1999) 自然遗传学. 23(3):323-8. DOI: 10.1038/15500

Parker, D., Rivera, M., Zor, T., Henrion-Caude, A., Radhakrishnan, I., Kumar, A., Shapiro, L.H., Wright, P.E., Montminy, M., Brindle, P.K. Role of secondary structure in discrimination between constitutive and inducible activators. (1999) 分子与细胞生物学. 19(8):5601-7.

Radhakrishnan, I., Pérez-Alvarado, G.C., Parker, D., Dyson, H.J., Montminy, M.R., Wright, P.E. Structural analyses of CREB-CBP transcriptional activator-coactivator complexes by NMR spectroscopy: implications for mapping the boundaries of structural domains. (1999) 分子生物学杂志. 287(5):859-65. DOI: 10.1006/jmbi.1999.2658

Du, K., Montminy, M. CREB is a regulatory target for the protein kinase Akt/PKB. (1998) 生物化学杂志. 273(49):32377-9.

Parker, D., Jhala, U.S., Radhakrishnan, I., Yaffe, M.B., Reyes, C., Shulman, A.I., Cantley, L.C., Wright, P.E., Montminy, M. Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. (1998) 分子细胞. 2(3):353-9.

Dutta, S., Bonner-Weir, S., Montminy, M., Wright, C. Regulatory factor linked to late-onset diabetes? (1998) 自然. 392(6676):560. DOI: 10.1038/33311

Blobel, G.A., Nakajima, T., Eckner, R., Montminy, M., Orkin, S.H. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. (1998) 美国国家科学院院刊. 95(5):2061-6.

Radhakrishnan, I., Pérez-Alvarado, G.C., Parker, D., Dyson, H.J., Montminy, M.R., Wright, P.E. Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions. (1997) 牢房. 91(6):741-52.

Nakajima, T., Uchida, C., Anderson, S.F., Lee, C.G., Hurwitz, J., Parvin, J.D., Montminy, M. RNA helicase A mediates association of CBP with RNA polymerase II. (1997) 牢房. 90(6):1107-12.

Montminy, M. Transcriptional activation. Something new to hang your HAT on. (1997) 自然. 387(6634):654-5. DOI: 10.1038/42594

Montminy, M. Transcriptional regulation by cyclic AMP. (1997) Annual Review of Biochemistry. 66:807-22. DOI: 10.1146/annurev.biochem.66.1.807

Sharma, S., Jhala, U.S., Johnson, T., Ferreri, K., Leonard, J., Montminy, M. Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1. (1997) 分子与细胞生物学. 17(5):2598-604.

Mayall, T.P., Sheridan, P.L., Montminy, M.R., Jones, K.A. Distinct roles for P-CREB and LEF-1 in TCR alpha enhancer assembly and activation on chromatin templates in vitro. (1997) 基因与发展. 11(7):887-99.

Nakajima, T., Uchida, C., Anderson, S.F., Parvin, J.D., Montminy, M. Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors. (1997) 基因与发展. 11(6):738-47.

Chakravarti, D., LaMorte, V.J., Nelson, M.C., Nakajima, T., Schulman, I.G., Juguilon, H., Montminy, M., Evans, R.M. Role of CBP/P300 in nuclear receptor signalling. (1996) 自然. 383(6595):99-103. DOI: 10.1038/383099a0

Montminy, M., Brindle, P., Arias, J., Ferreri, K., Armstrong, R. Regulation of somatostatin gene transcription by cyclic adenosine monophosphate. (1996) Metab. Clin. Exp. 45(8 Suppl 1):4-7.

Nakajima, T., Fukamizu, A., Takahashi, J., Gage, F.H., Fisher, T., Blenis, J., Montminy, M.R. The signal-dependent coactivator CBP is a nuclear target for pp90RSK. (1996) 牢房. 86(3):465-74.

Montminy, M., Brindle, P., Arias, J., Ferreri, K., Armstrong, R. Regulation of somatostatin gene transcription by cAMP. (1996) Adv. Pharmacol. 36:1-13.

Kee, B.L., Arias, J., Montminy, M.R. Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator. (1996) 生物化学杂志. 271(5):2373-5.

Parker, D., Ferreri, K., Nakajima, T., LaMorte, V.J., Evans, R.M., Koerber, S.C., Hoeger, C., Montminy, M.R. Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism. (1996) 分子与细胞生物学. 16(2):694-703.

Sharma, S., Leonard, J., Lee, S., Chapman, H.D., Leiter, E.H., Montminy, M.R. Pancreatic islet expression of the homeobox factor STF-1 relies on an E-box motif that binds USF. (1996) 生物化学杂志. 271(4):2294-9.

Peers, B., Sharma, S., Johnson, T., Kamps, M., Montminy, M. The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain. (1995) 分子与细胞生物学. 15(12):7091-7.

Brindle, P., Nakajima, T., Montminy, M. Multiple protein kinase A-regulated events are required for transcriptional induction by cAMP. (1995) 美国国家科学院院刊. 92(23):10521-5.

Bertherat, J., Chanson, P., Montminy, M. The cyclic adenosine 3',5'-monophosphate-responsive factor CREB is constitutively activated in human somatotroph adenomas. (1995) Molecular Endocrinology. 9(7):777-83. DOI: 10.1210/mend.9.7.7476961

Montminy, M., Brindle, P., Arias, J., Ferreri, K., Armstrong, R. Regulation of somatostatin gene transcription by cAMP. (1995) Ciba Found. Symp. 190:7-20; discussion 20-5.

Armstrong, R., Wen, W., Meinkoth, J., Taylor, S., Montminy, M. A refractory phase in cyclic AMP-responsive transcription requires down regulation of protein kinase A. (1995) 分子与细胞生物学. 15(3):1826-32.

Guz, Y., Montminy, M.R., Stein, R., Leonard, J., Gamer, L.W., Wright, C.V., Teitelman, G. Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. (1995) Development. 121(1):11-8.

Peers, B., Leonard, J., Sharma, S., Teitelman, G., Montminy, M.R. Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. (1994) Molecular Endocrinology. 8(12):1798-806. DOI: 10.1210/mend.8.12.7708065

Arias, J., Alberts, A.S., Brindle, P., Claret, F.X., Smeal, T., Karin, M., Feramisco, J., Montminy, M. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. (1994) 自然. 370(6486):226-9. DOI: 10.1038/370226a0

Alberts, A.S., Montminy, M., Shenolikar, S., Feramisco, J.R. Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts. (1994) 分子与细胞生物学. 14(7):4398-407.

Alberts, A.S., Arias, J., Hagiwara, M., Montminy, M.R., Feramisco, J.R. Recombinant cyclic AMP response element binding protein (CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei. (1994) 生物化学杂志. 269(10):7623-30.

Ferreri, K., Gill, G., Montminy, M. The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complex. (1994) 美国国家科学院院刊. 91(4):1210-3.

Meinkoth, J.L., Alberts, A.S., Went, W., Fantozzi, D., Taylor, S.S., Hagiwara, M., Montminy, M., Feramisco, J.R. Signal transduction through the cAMP-dependent protein kinase. (1993) Molecular and Cellular Biochemistry. 127-128:179-86.

Chrivia, J.C., Kwok, R.P., Lamb, N., Hagiwara, M., Montminy, M.R., Goodman, R.H. Phosphorylated CREB binds specifically to the nuclear protein CBP. (1993) 自然. 365(6449):855-9. DOI: 10.1038/365855a0

Leonard, J., Peers, B., Johnson, T., Ferreri, K., Lee, S., Montminy, M.R. Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. (1993) Molecular Endocrinology. 7(10):1275-83. DOI: 10.1210/mend.7.10.7505393

Montminy, M. Trying on a new pair of SH2s. (1993) 科学. 261(5129):1694-5.

Brindle, P., Linke, S., Montminy, M. Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors. (1993) 自然. 364(6440):821-4. DOI: 10.1038/364821a0

Hagiwara, M., Brindle, P., Harootunian, A., Armstrong, R., Rivier, J., Vale, W., Tsien, R., Montminy, M.R. Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. (1993) 分子与细胞生物学. 13(8):4852-9.

Montminy, M. Cell differentiation. The road not taken. (1993) 自然. 364(6434):190-1. DOI: 10.1038/364190a0

Armstrong, R.C., Montminy, M.R. Transsynaptic control of gene expression. (1993) 神经科学年度评论》。. 16:17-29. DOI: 10.1146/annurev.ne.16.030193.000313

Leonard, J., Serup, P., Gonzalez, G., Edlund, T., Montminy, M. The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells. (1992) 美国国家科学院院刊. 89(14):6247-51.

Hagiwara, M., Alberts, A., Brindle, P., Meinkoth, J., Feramisco, J., Deng, T., Karin, M., Shenolikar, S., Montminy, M. Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. (1992) 牢房. 70(1):105-13.

Brindle, P.K., Montminy, M.R. The CREB family of transcription activators. (1992) 遗传与发育意见。. 2(2):199-204.

Leonard, J., Montminy, M.R. Control of gene expression by transmitters and peptide hormones. (1991) 当前神经生物学评论. 1(1):74-8.

Struthers, R.S., Vale, W.W., Arias, C., Sawchenko, P.E., Montminy, M.R. Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant. (1991) 自然. 350(6319):622-4. DOI: 10.1038/350622a0

Gonzalez, G.A., Menzel, P., Leonard, J., Fischer, W.H., Montminy, M.R. Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB. (1991) 分子与细胞生物学. 11(3):1306-12.

Meinkoth, J.L., Montminy, M.R., Fink, J.S., Feramisco, J.R. Induction of a cyclic AMP-responsive gene in living cells requires the nuclear factor CREB. (1991) 分子与细胞生物学. 11(3):1759-64.

Montminy, M.R., Gonzalez, G.A., Yamamoto, K.K. Characteristics of the cAMP response unit. (1990) Metab. Clin. Exp. 39(9 Suppl 2):6-12.

Lamph, W.W., Dwarki, V.J., Ofir, R., Montminy, M., Verma, I.M. Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation. (1990) 美国国家科学院院刊. 87(11):4320-4.

Montminy, M.R., Gonzalez, G.A., Yamamoto, K.K. Regulation of cAMP-inducible genes by CREB. (1990) 神经科学趋势. 13(5):184-8.

Yamamoto, K.K., Gonzalez, G.A., Menzel, P., Rivier, J., Montminy, M.R. Characterization of a bipartite activator domain in transcription factor CREB. (1990) 牢房. 60(4):611-7.

Montminy, M.R., Gonzalez, G.A., Yamamoto, K.K. Characteristics of the cAMP response unit. (1990) Recent Prog. Horm. Res. 46:219-229; discussion 229-230.

Dwarki, V.J., Montminy, M., Verma, I.M. Both the basic region and the 'leucine zipper' domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation. (1990) EMBO 期刊. 9(1):225-32.

Gonzalez, G.A., Montminy, M.R. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. (1989) 牢房. 59(4):675-80.

Gonzalez, G.A., Yamamoto, K.K., Fischer, W.H., Karr, D., Menzel, P., Biggs, W., Vale, W.W., Montminy, M.R. A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence. (1989) 自然. 337(6209):749-52. DOI: 10.1038/337749a0

Montminy, M.R. Regulation of eukaryotic genes by cyclic-AMP. (1988) Nihon Naibunpi Gakkai Zasshi. 64(12):1233-5.

Yamamoto, K.K., Gonzalez, G.A., Biggs, W.H., Montminy, M.R. Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. (1988) 自然. 334(6182):494-8. DOI: 10.1038/334494a0

Montminy, M.R., Bilezikjian, L.M. Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene. (1987) 自然. 328(6126):175-8. DOI: 10.1038/328175a0

Höfler, H., Childers, H., Montminy, M.R., Goodman, R.H., Lechan, R.M., DeLellis, R.A., Tischler, A.S., Wolfe, H.J. Localization of somatostatin mRNA in the gut, pancreas and thyroid gland of the rat using antisense RNA probes for in situ hybridization. (1987) Acta Histochemica. 34:101-5.

Sevarino, K.A., Felix, R., Banks, C.M., Low, M.J., Montminy, M.R., Mandel, G., Goodman, R.H. Cell-specific processing of preprosomatostatin in cultured neuroendocrine cells. (1987) 生物化学杂志. 262(11):4987-93.

Goodman, R.H., Leiter, A., Low, M.J., Montminy, M.R., Tsukada, T., Fink, J.S., Mandel, G. Biosynthesis of pancreatic islet hormones. (1987) Hepatology. 7(1 Suppl):36S-41S.

Hoefler, H., Childers, H., Montminy, M.R., Lechan, R.M., Goodman, R.H., Wolfe, H.J. In situ hybridization methods for the detection of somatostatin mRNA in tissue sections using antisense RNA probes. (1986) Histochem. J. 18(11-12):597-604.

Montminy, M.R., Sevarino, K.A., Wagner, J.A., Mandel, G., Goodman, R.H. Identification of a cyclic-AMP-responsive element within the rat somatostatin gene. (1986) 美国国家科学院院刊. 83(18):6682-6.

Montminy, M.R., Low, M.J., Tapia-Arancibia, L., Reichlin, S., Mandel, G., Goodman, R.H. Cyclic AMP regulates somatostatin mRNA accumulation in primary diencephalic cultures and in transfected fibroblast cells. (1986) 神经科学杂志. 6(4):1171-6.

Leiter, A.B., Montminy, M.R., Jamieson, E., Goodman, R.H. Exons of the human pancreatic polypeptide gene define functional domains of the precursor. (1985) 生物化学杂志. 260(24):13013-7.

Tsukada, T., Horovitch, S.J., Montminy, M.R., Mandel, G., Goodman, R.H. Structure of the human vasoactive intestinal polypeptide gene. (1985) DNA. 4(4):293-300. DOI: 10.1089/dna.1985.4.293

Goodman, R.H., Montminy, M.R., Low, M.J., Habener, J.F. Biosynthesis of rat preprosomatostatin. (1985) Advances in Experimental Medicine and Biology. 188:31-47.

Montminy, M.R., Goodman, R.H., Horovitch, S.J., Habener, J.F. Primary structure of the gene encoding rat preprosomatostatin. (1984) 美国国家科学院院刊. 81(11):3337-40.

Lund, P.K., Goodman, R.H., Montminy, M.R., Dee, P.C., Habener, J.F. Anglerfish islet pre-proglucagon II. Nucleotide and corresponding amino acid sequence of the cDNA. (1983) 生物化学杂志. 258(5):3280-4.

Montminy, M., Teres, D. Shock after phenothiazine administration in a pregnant patient with a pheochromocytoma. A case report and literature review. (1983) J Reprod Med. 28(2):159-62.