John B. Thomas, PhD

荣休教授

John B. Thomas
索尔克生物研究所 出版物

所有出版物


Osorio-Vasquez, V., Zhu, J., Lumibao, J.C., Lande, K., Peck, K.L., Stamp, M.K., Okhovat, S.R., Song, H., Ogawa, S., Kubota, C., Pantazopoulou, V., Dai, Y., Rock, A., Bottomley, C., Thomas, E., Hsu, J., Morales, A.H., Fowler, A., McGriff, T., Evensen, K.G., Larsen, S., Abdulla, M., Greer, P., Gibson, J., Downes, M., Evans, R., Lowy, A.M., Whitcomb, D.C., Zou, J., Molinolo, A., Oh, T.G., White, R., Bellin, M., Tiriac, H., Engle, D.D. 慢性胰腺炎患者来源的类器官揭示了精准治疗的新途径。. (2025) bioRxiv. DOI: 10.1101/2024.10.30.620903

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Dondi, C., Vogler, G., Gupta, A., Walls, S.M., Kervadec, A., Marchant, J., Romero, M.R., Diop, S., Goode, J., Thomas, J.B., Colas, A.R., Bodmer, R., Montminy, M., Ocorr, K. The nutrient sensor CRTC and Sarcalumenin/thinman represent an alternate pathway in cardiac hypertrophy. (2024) 细胞报告. 43(8):114549. DOI: 10.1016/j.celrep.2024.114549

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Thomas, S.T., Shin, Y., La Clair, J.J., Noel, J.P. Plant-based CO drawdown and storage as SiC. (2021) RSC Adv. 11(26):15512-15518. DOI: 10.1039/d1ra00954k

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Wang, T., Wiater, E., Zhang, X., Thomas, J.B., Montminy, M. Crtc modulates fasting programs associated with 1-C metabolism and inhibition of insulin signaling. (2021) 美国国家科学院院刊. 118(12). DOI: 10.1073/pnas.2024865118

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Babski, H., Jovanic, T., Surel, C., Yoshikawa, S., Zwart, M.F., Valmier, J., Thomas, J.B., Enriquez, J., Carroll, P., Garcès, A. A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila. (2019) 自然-通讯. 10(1):4796. DOI: 10.1038/s41467-019-12693-6

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Shen, R., Wang, B., Giribaldi, M.G., Ayres, J., Thomas, J.B., Montminy, M. Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance. (2016) 美国国家科学院院刊. 113(23):E3307-14. DOI: 10.1073/pnas.1606106113

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Long, H., Yoshikawa, S., Thomas, J.B. Equivalent Activities of Repulsive Axon Guidance Receptors. (2016) 神经科学杂志. 36(4):1140-1150. DOI: 10.1523/JNEUROSCI.3406-15.2016

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Yoshikawa, S., Long, H., Thomas, J.B. A subset of interneurons required for Drosophila larval locomotion. (2016) Molecular and Cellular Neurosciences. 70:22-29. DOI: 10.1016/j.mcn.2015.11.008

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Read, R.D., Fenton, T.R., Gomez, G.G., Wykosky, J., Vandenberg, S.R., Babic, I., Iwanami, A., Yang, H., Cavenee, W.K., Mischel, P.S., Furnari, F.B., Thomas, J.B. A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma. (2013) PLOS Genetics. 9(2). DOI: 10.1371/journal.pgen.1003253

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Wang, B., Moya, N., Niessen, S., Hoover, H., Mihaylova, M.M., Shaw, R.J., Yates, J.R., Fischer, W.H., Thomas, J.B., Montminy, M. A hormone-dependent module regulating energy balance. (2011) 牢房. 145(4):596-606. DOI: 10.1016/j.cell.2011.04.013

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Sakurai, M., Aoki, T., Yoshikawa, S., Santschi, L.A., Saito, H., Endo, K., Ishikawa, K., Kimura, K., Ito, K., Thomas, J.B., Hama, C. Differentially expressed Drl and Drl-2 play opposing roles in Wnt5 signaling during Drosophila olfactory system development. (2009) 神经科学杂志. 29(15):4972-4980. DOI: 10.1523/JNEUROSCI.2821-08.2009

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Read, R.D., Cavenee, W.K., Furnari, F.B., Thomas, J.B. A drosophila model for EGFR-Ras and PI3K-dependent human glioma. (2009) PLOS Genetics. 5(2). DOI: 10.1371/journal.pgen.1000374

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Wang, B., Goode, J., Best, J., Meltzer, J., Schilman, P.E., Chen, J., Garza, D., Thomas, J.B., Montminy, M. The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila. (2008) Cell Metabolism. 7(5):434-44. DOI: 10.1016/j.cmet.2008.02.010

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Inaki, M., Yoshikawa, S., Thomas, J.B., Aburatani, H., Nose, A. Wnt4 is a local repulsive cue that determines synaptic target specificity. (2007) 当前生物学。. 17(18):1574-9. DOI: 10.1016/j.cub.2007.08.013

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Hughes, C.L., Thomas, J.B. A sensory feedback circuit coordinates muscle activity in Drosophila. (2007) Molecular and Cellular Neurosciences. 35(2):383-396. DOI: 10.1016/j.mcn.2007.04.001

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Boyle, M., Nighorn, A., Thomas, J.B. Drosophila Eph receptor guides specific axon branches of mushroom body neurons. (2006) Development. 133(9):1845-1854. DOI: 10.1242/dev.02353

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Fradkin, L.G., Garriga, G., Salinas, P.C., Thomas, J.B., Yu, X., Zou, Y. Wnt signaling in neural circuit development. (2005) 神经科学杂志. 25(45):10376-10378. DOI: 10.1523/JNEUROSCI.3429-05.2005


Labrador, J.P., O'keefe, D., Yoshikawa, S., McKinnon, R.D., Thomas, J.B., Bashaw, G.J. The homeobox transcription factor even-skipped regulates netrin-receptor expression to control dorsal motor-axon projections in Drosophila. (2005) 当前生物学。. 15(15):1413-1419. DOI: 10.1016/j.cub.2005.06.058

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Yoshikawa, S., Thomas, J.B. Secreted cell signaling molecules in axon guidance. (2004) 当前神经生物学评论. 14(1):45-50. DOI: 10.1016/j.conb.2004.01.005

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Imondi, R., Thomas, J.B. Neuroscience. The ups and downs of Wnt signaling. (2003) 科学. 302(5652):1903-1904. DOI: 10.1126/science.1092976


van Meyel, D.J., Thomas, J.B., Agulnick, A.D. Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo. (2003) Development. 130(9):1915-1925.

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Yoshikawa, S., McKinnon, R.D., Kokel, M., Thomas, J.B. Wnt-mediated axon guidance via the Drosophila Derailed receptor. (2003) 自然. 422(6932):583-588. DOI: 10.1038/nature01522

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Thor, S., Thomas, J.B. Motor neuron specification in worms, flies and mice: conserved and 'lost' mechanisms. (2002) 遗传与发育意见。. 12(5):558-564.

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Diagana, T.T., Thomas, U., Prokopenko, S.N., Xiao, B., Worley, P.F., Thomas, J.B. Mutation of Drosophila homer disrupts control of locomotor activity and behavioral plasticity. (2002) 神经科学杂志. 22(2):428-436.

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Herzig, M.C., Thor, S., Thomas, J.B., Reichert, H., Hirth, F. Expression and function of the LIM homeodomain protein Apterous during embryonic brain development of Drosophila. (2001) Dev. Genes Evol. 211(11):545-554. DOI: 10.1007/s00427-001-0195-y

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O'Keefe, D.D., Thomas, J.B. Drosophila wing development in the absence of dorsal identity. (2001) Development. 128(5):703-710.

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Yoshikawa, S., Bonkowsky, J.L., Kokel, M., Shyn, S., Thomas, J.B. The derailed guidance receptor does not require kinase activity in vivo. (2001) 神经科学杂志. 21(1):RC119.

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van Meyel, D.J., O'Keefe, D.D., Thor, S., Jurata, L.W., Gill, G.N., Thomas, J.B. Chip is an essential cofactor for apterous in the regulation of axon guidance in Drosophila. (2000) Development. 127(9):1823-1831.

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Jurata, L.W., Thomas, J.B., Pfaff, S.L. Transcriptional mechanisms in the development of motor control. (2000) 当前神经生物学评论. 10(1):72-9.

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Bonkowsky, J.L., Yoshikawa, S., O'Keefe, D.D., Scully, A.L., Thomas, J.B. Axon routing across the midline controlled by the Drosophila Derailed receptor. (1999) 自然. 402(6761):540-544. DOI: 10.1038/990122

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Lilly, B., O'Keefe, D.D., Thomas, J.B., Botas, J. The LIM homeodomain protein dLim1 defines a subclass of neurons within the embryonic ventral nerve cord of Drosophila. (1999) Mech. Dev. 88(2):195-205.

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van Meyel, D.J., O'Keefe, D.D., Jurata, L.W., Thor, S., Gill, G.N., Thomas, J.B. Chip and apterous physically interact to form a functional complex during Drosophila development. (1999) 分子细胞. 4(2):259-265.

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Scully, A.L., McKeown, M., Thomas, J.B. Isolation and characterization of Dek, a Drosophila eph receptor protein tyrosine kinase. (1999) Molecular and Cellular Neurosciences. 13(5):337-347. DOI: 10.1006/mcne.1999.0752

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Bonkowsky, J.L., Thomas, J.B. Cell-type specific modular regulation of derailed in the Drosophila nervous system. (1999) Mech. Dev. 82(1-2):181-184.

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Thor, S., Andersson, S.G., Tomlinson, A., Thomas, J.B. A LIM-homeodomain combinatorial code for motor-neuron pathway selection. (1999) 自然. 397(6714):76-80. DOI: 10.1038/16275

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Benveniste, R.J., Thor, S., Thomas, J.B., Taghert, P.H. Cell type-specific regulation of the Drosophila FMRF-NH2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor. (1998) Development. 125(23):4757-4765.

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Oates, A.C., Bonkovsky, J.L., Irvine, D.V., Kelly, L.E., Thomas, J.B., Wilks, A.F. Embryonic expression and activity of doughnut, a second RYK homolog in Drosophila. (1998) Mech. Dev. 78(1-2):165-169.

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Callahan, C.A., Yoshikawa, S., Thomas, J.B. Tracing axons. (1998) 当前神经生物学评论. 8(5):582-586.

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O'Keefe, D.D., Thor, S., Thomas, J.B. Function and specificity of LIM domains in Drosophila nervous system and wing development. (1998) Development. 125(19):3915-3923.

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Thomas, J.B. Axon guidance: crossing the midline. (1998) 当前生物学。. 8(3):R102-R104.

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Thor, S., Thomas, J.B. The Drosophila islet gene governs axon pathfinding and neurotransmitter identity. (1997) 神经元. 18(3):397-409.

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Callahan, C.A., Bonkovsky, J.L., Scully, A.L., Thomas, J.B. derailed is required for muscle attachment site selection in Drosophila. (1996) Development. 122(9):2761-2767.

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Callahan, C.A., Muralidhar, M.G., Lundgren, S.E., Scully, A.L., Thomas, J.B. Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member. (1995) 自然. 376(6536):171-174. DOI: 10.1038/376171a0

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Lundgren, S.E., Callahan, C.A., Thor, S., Thomas, J.B. Control of neuronal pathway selection by the Drosophila LIM homeodomain gene apterous. (1995) Development. 121(6):1769-1773.

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Blair, S.S., Brower, D.L., Thomas, J.B., Zavortink, M. The role of apterous in the control of dorsoventral compartmentalization and PS integrin gene expression in the developing wing of Drosophila. (1994) Development. 120(7):1805-1815.

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Callahan, C.A., Thomas, J.B. Tau-beta-galactosidase, an axon-targeted fusion protein. (1994) 美国国家科学院院刊. 91(13):5972-5976.

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Muralidhar, M.G., Thomas, J.B. The Drosophila bendless gene encodes a neural protein related to ubiquitin-conjugating enzymes. (1993) 神经元. 11(2):253-266.

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Muralidhar, M.G., Callahan, C.A., Thomas, J.B. Single-minded regulation of genes in the embryonic midline of the Drosophila central nervous system. (1993) Mech. Dev. 41(2-3):129-138.

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Bourgouin, C., Lundgren, S.E., Thomas, J.B. Apterous is a Drosophila LIM domain gene required for the development of a subset of embryonic muscles. (1992) 神经元. 9(3):549-561.

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Thomas, J.B., Crews, S.T. Molecular genetics of neuronal development in the Drosophila embryo. (1990) FASEB Journal. 4(8):2476-2482.

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Crews, S.T., Thomas, J.B., Goodman, C.S. The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product. (1988) 牢房. 52(1):143-151.

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Thomas, J.B., Crews, S.T., Goodman, C.S. Molecular genetics of the single-minded locus: a gene involved in the development of the Drosophila nervous system. (1988) 牢房. 52(1):133-141.

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Goodman, C.S., Bastiani, M.J., Doe, C.Q., du Lac, S., Helfand, S.L., Kuwada, J.Y., Thomas, J.B. Cell recognition during neuronal development. (1984) 科学. 225(4668):1271-1279.

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Thomas, J.B., Bastiani, M.J., Bate, M., Goodman, C.S. From grasshopper to Drosophila: a common plan for neuronal development. (1984) 自然. 310(5974):203-207.

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Thomas, J.B., Wyman, R.J. Duplicated neural structure in bithorax mutant Drosophila. (1984) Developmental Biology. 102(2):531-3.

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Thomas, J.B., Wyman, R.J. Mutations altering synaptic connectivity between identified neurons in Drosophila. (1984) 神经科学杂志. 4(2):530-538.

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Wyman, R.J., Thomas, J.B. What genes are necessary to make an identified synapse? (1983) 冷泉港定量生物学研讨会。. 48 Pt 2:641-652.


Thomas, J.B., Wyman, R.J. A mutation in Drosophila alters normal connectivity between two identified neurones. (1982) 自然. 298(5875):650-651.


Wyman, R.J., Thomas, J.B. The mathematics of mosaic analysis. I: The relationship between sturts and distance. (1982) Genetics. 100(4):659-676.

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Koto, M., Tanouye, M.A., Ferrus, A., Thomas, J.B., Wyman, R.J. The morphology of the cervical giant fiber neuron of Drosophila. (1981) Brain Research. 221(2):213-217.

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教育

BA, Biology, Washington University
PhD, Biology, Yale University
斯坦福大学博士后研究员