迪普希卡·拉马南,博士

助理教授

NOMIS 免疫生物学和微生物致病机理中心

William Scandling Developmental Chair

Deepshika Ramanan
索尔克生物研究所 出版物

所有出版物


Jaquish, A., Ramanan, D. Got milk? how T cells shape lactation and beyond. (2026) Trends in Immunology. DOI: 10.1016/j.it.2026.01.007

+ 扩展摘要


Frascoli, M., Nicholas, D., Weinstock, A., Hsu, C.L., Dongre, A., Osterhout, J.A., Globig, A.M., Ramanan, D., Therrien, M., McCubbrey, A. Women in STEM becoming independent: Asking for help creates opportunities for connections and kindness. (2025) 实验医学杂志. 222(10). DOI: 10.1084/jem.20251668


Jaquish, A., Phung, E., Gong, X., Baldominos, P., Galván-Peña, S., Magill, I., Bursulaya, I., Marina, E., , Bertrand, K., Chambers, C., Muñoz-Rojas, A.R., Agudo, J., Mathis, D., Benoist, C., Ramanan, D. Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis. (2025) Nature Immunology. 26(8):1411-1422. DOI: 10.1038/s41590-025-02218-3

+ 扩展摘要


Wong, S.Y., Estevinho, M.M., Heaney, T., Marshall, A.A., Giselbrecht, E., Daniel, S.G., Zhou, C., Rosas-Villegas, A., Jang, K.K., Yang, H., Mabel Ko, H., Paulson, J.D., Ding, Y., Bittinger, K., Cho, J.H., Lewis, J.D., Ramanan, D., Cadwell, K. Goblet cell loss linked to NOD2 and secondary resection in Crohn's disease is induced by dysbiosis and epithelial MyD88. (2025) Cell Mol Gastroenterol Hepatol.:101533 DOI: 10.1016/j.jcmgh.2025.101533

+ 扩展摘要


Jaquish, A., Phung, E., Gong, X., Baldominos-Flores, P., Galvan-Pena, S., Bursulaya, I., Magill, I., , Bertrand, K., Chambers, C., Agudo, J., Mathis, D., Benoist, C., Ramanan, D. Expansion of mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis. (2024) bioRxiv. DOI: 10.1101/2024.07.09.602739

+ 扩展摘要


Ramanan, D., Chowdhary, K., Candéias, S.M., Sassone-Corsi, M., Gelineau, A., Mathis, D., Benoist, C. Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets. (2023) 美国国家科学院院刊. 120(50):e2311566120. DOI: 10.1073/pnas.2311566120

+ 扩展摘要


Ramanan, D., Pratama, A., Zhu, Y., Venezia, O., Sassone-Corsi, M., Chowdhary, K., Galván-Peña, S., Sefik, E., Brown, C., Gélineau, A., Mathis, D., Benoist, C. Regulatory T cells in the face of the intestinal microbiota. (2023) Nature Reviews. Immunology. DOI: 10.1038/s41577-023-00890-w

+ 扩展摘要


Ramanan, D., Chowdhary, K., Candéias, S.M., Sassone-Corsi, M., Mathis, D., Benoist, C. Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets. (2023) bioRxiv. DOI: 10.1101/2023.05.17.541199

+ 扩展摘要


Wu, M., Zheng, W., Song, X., Bao, B., Wang, Y., Ramanan, D., Yang, D., Liu, R., Macbeth, J.C., Do, E.A., Andrade, W.A., Yang, T., Cho, H.S., Gazzaniga, F.S., Ilves, M., Coronado, D., Thompson, C., Hang, S., Chiu, I.M., Moffitt, J.R., Hsiao, A., Mekalanos, J.J., Benoist, C., Kasper, D.L. Microbiome induced complement synthesized in the gut protects against enteric infections. (2023) bioRxiv. DOI: 10.1101/2023.02.02.523770

+ 扩展摘要


Sassone-Corsi, M., Azriel, S., Simon, A., Ramanan, D., Ortiz-Lopez, A., Chen, F., Yissachar, N., Mathis, D., Benoist, C. Sequestration of gut pathobionts in intraluminal casts, a mechanism to avoid dysregulated T cell activation by pathobionts. (2022) 美国国家科学院院刊. 119(41):e2209624119. DOI: 10.1073/pnas.2209624119

+ 扩展摘要


Yan, Y., Ramanan, D., Rozenberg, M., McGovern, K., Rastelli, D., Vijaykumar, B., Yaghi, O., Voisin, T., Mosaheb, M., Chiu, I., Itzkovitz, S., Rao, M., Mathis, D., Benoist, C. Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut. (2021) Immunity. 54(3):499-513.e5. DOI: 10.1016/j.immuni.2021.02.002

+ 扩展摘要


Ramanan, D., Sefik, E., Galván-Peña, S., Wu, M., Yang, L., Yang, Z., Kostic, A., Golovkina, T.V., Kasper, D.L., Mathis, D., Benoist, C. An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint. (2020) 牢房. 181(6):1276-1290.e13. DOI: 10.1016/j.cell.2020.04.030

+ 扩展摘要


Wong, S.Y., Coffre, M., Ramanan, D., Hines, M.J., Gomez, L.E., Peters, L.A., Schadt, E.E., Koralov, S.B., Cadwell, K. B Cell Defects Observed in Knockout Mice Are a Consequence of a Mutation Frequently Found in Inbred Strains. (2018) Journal of immunology. 201(5):1442-1451. DOI: 10.4049/jimmunol.1800014

+ 扩展摘要


Ramanan, D., Bowcutt, R., Lee, S.C., Tang, M.S., Kurtz, Z.D., Ding, Y., Honda, K., Gause, W.C., Blaser, M.J., Bonneau, R.A., Lim, Y.A., Loke, P., Cadwell, K. Helminth infection promotes colonization resistance via type 2 immunity. (2016) 科学. 352(6285):608-12. DOI: 10.1126/science.aaf3229

+ 扩展摘要


Ramanan, D., Cadwell, K. Intrinsic Defense Mechanisms of the Intestinal Epithelium. (2016) 细胞宿主与微生物. 19(4):434-41. DOI: 10.1016/j.chom.2016.03.003

+ 扩展摘要


Marchiando, A.M., Ramanan, D., Ding, Y., Gomez, L.E., Hubbard-Lucey, V.M., Maurer, K., Wang, C., Ziel, J.W., van Rooijen, N., Nuñez, G., Finlay, B.B., Mysorekar, I.U., Cadwell, K. A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection. (2013) 细胞宿主与微生物. 14(2):216-24. DOI: 10.1016/j.chom.2013.07.013

+ 扩展摘要


Zhang, Z., Wu, Y., Wang, Z., Dunning, F.M., Rehfuss, J., Ramanan, D., Chapman, E.R., Jackson, M.B. Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells. (2011) Molecular Biology of the Cell. 22(13):2324-36. DOI: 10.1091/mbc.E11-02-0159

+ 扩展摘要


教育

哈佛医学院博士后研究员
PhD, Immunology and Inflammation, New York University
BS, Cell and Molecular Biology, Winona State University


奖项与荣誉

  • National Institute of Allergy and Infectious Diseases (NIAID) Director's New Innovators Award, 2025
  • Rita Allen Foundation Scholar, 2025
  • V Foundation for Cancer Research, V Scholar, 2023
  • Damon Runyon Dale F. Frey Breakthrough Scientist Award
  • STAT Wunderkind Award
  • The Harold M. Weintraub Graduate Student Award