LA JOLLA – Ya sea que tome decisiones precipitadas o se sienta malhumorado, el hambre puede hacernos pensar y actuar de manera diferente, incluso “hangry”. Pero se sabe poco sobre cómo las señales de hambre en el intestino se comunican con el cerebro para cambiar el comportamiento. Ahora, científicos del Salk utilizan gusanos como modelo para examinar los fundamentos moleculares y ayudar a explicar cómo el hambre hace que un organismo sacrifique la comodidad y tome decisiones arriesgadas para conseguir una comida.
LA JOLLA—Mammals can’t typically regenerate organs as efficiently as other vertebrates, such as fish and lizards. Now, Salk scientists have found a way to partially reset liver cells to more youthful states—allowing them to heal damaged tissue at a faster rate than previously observed. The results, published in Cell Reports on April 26, 2022, reveal that the use of reprogramming molecules can improve cell growth, leading to better liver tissue regeneration in mice.
LA JOLLA—For years, the brain has been thought of as a biological computer that processes information through traditional circuits, whereby data zips straight from one cell to another. While that model is still accurate, a new study led by Salk Professor Thomas Albright and Staff Scientist Sergei Gepshtein shows that there’s also a second, very different way that the brain parses information: through the interactions of waves of neural activity. The findings, published in Science Advances on April 22, 2022, help researchers better understand how the brain processes information.
LA JOLLA—Every day, your pancreas produces about one cup of digestive juices, a mixture of molecules that can break down the food you eat. But if these powerful molecules become activated before they make their way to the gut, they can damage the pancreas itself—digesting the very cells that created them, leading to the painful inflammation known as pancreatitis, and predisposing a person to pancreatic cancer.
LA JOLLA—Úrsula Bellugi, Distinguished Professor Emerita and Founder’s Chair at the Salk Institute, 2008 inductee to the National Academy of Sciences and winner of the Jacob Javits Neuroscience Investigator Award, died peacefully on April 17, 2022, in La Jolla, CA, at the age of 91.
LA JOLLA—When mice with atopic dermatitis—a common type of allergic skin inflammation—are treated with drugs that target the immune system, their thickened, itchy skin generally heals quickly. But scientists have now discovered that the same treatment in obese mice makes their skin worse, instead. That is because obesity changes the molecular underpinnings of allergic inflammation, both in mice and humans.
LA JOLLA—The Salk Institute mourns the loss of Richard “Rich” Murphy, who died March 24, 2022, in La Quinta, California at the age of 77. Murphy served as the Institute’s president and CEO from 2000 to 2007.
LA JOLLA—Salk Institute Professor Tony Hunter will receive the 2022 American Association for Cancer Research (AACR) Award for Lifetime Achievement in Cancer Research at the April annual meeting of AACR, the largest cancer research organization in the world dedicated to preventing and curing all cancers. This major award is a significant recognition of Hunter’s contributions to cancer research, which have led to the development of the highly effective leukemia drug GleevecTM.
LA JOLLA—The Salk Institute announced today the appointment of Sue Bacino as Vice President of Human Resources (HR) to advance the overall mission of Salk through the acquisition, retention and support of a diverse, world-class faculty and staff.
LA JOLLA—If you’re reaching for the last piece of pizza at a party and see another hand going for it at the same time, your next move probably depends both on how you feel and whom the hand belongs to. Your little sister—you might go ahead and grab the pizza. Your boss—you’re probably more likely to step back and give up the slice. But if you’re hungry and feeling particularly confident, you might go for it.
LA JOLLA—Professors Reuben Shaw, Susan Kaech, Christian Metallo y Alan Saghatelian have received a 2022 Mark Foundation for Cancer Research Endeavor Award to support their research exploring the metabolic changes that help lung cancers develop. The $3 million Endeavor Award promotes collaborative science to tackle some of the toughest challenges in cancer research. The Salk team—one of four teams chosen out of nearly 200 applications submitted by institutions around the world—hopes their work will lead to the development of more effective lung cancer treatments.
LA JOLLA—Investigadores del Instituto Salk han desarrollado una nueva tecnología genómica para analizar simultáneamente el ADN, ARN y la cromatina —una combinación de ADN y proteínas— de una sola célula. El método, que tardó cinco años en desarrollarse, representa un avance importante para las colaboraciones a gran escala en las que varios equipos trabajan simultáneamente para clasificar miles de nuevos tipos de células. La nueva tecnología, publicada en Genómica celular el 9 de marzo de 2022, ayudará a agilizar los análisis.
LA JOLLA—La edad puede ser solo un número, pero es un número que a menudo conlleva efectos secundarios no deseados, desde huesos frágiles y músculos más débiles hasta un mayor riesgo de enfermedades cardiovasculares y cáncer. Ahora, científicos del Instituto Salk, en colaboración con Genentech, miembro del grupo Roche, han demostrado que pueden revertir de forma segura y eficaz el proceso de envejecimiento en ratones de mediana y avanzada edad, restableciendo parcialmente sus células a estados más juveniles. El estudio se publicó en Envejecimiento Natural el 7 de marzo de 2022.
LA JOLLA—¿Cómo toma decisiones un animal? Los científicos han dedicado décadas a intentar responder esta pregunta centrándose en las células y conexiones del cerebro que podrían estar involucradas. Los científicos del Salk están adoptando un enfoque diferente: analizar el comportamiento, no las neuronas. Les sorprendió descubrir que los gusanos pueden tener en cuenta múltiples factores y elegir entre dos acciones diferentes, a pesar de tener solo 302 neuronas en comparación con aproximadamente 86 mil millones en los humanos.
LA JOLLA—Salk Institute Professor Martyn Goulding will receive the 2022 Brain Prize for pioneering research on the neuronal circuits that control movement, the Lundbeck Foundation announced today.
LA JOLLA—The Salk Institute mourns the loss of Paul Farmer, MD, PhD, a champion of global health equity and recipient of the inaugural Salk Institute Medal for Health and Humanity in 2005 (now known as the Salk Medal for Public Service). Farmer died in his sleep in Rwanda on February 21. He was co-founder and chief strategist of Partners In Health, an international non-profit organization that provides health care, infrastructure and advocacy for the communities that need it most. He was also professor of medicine at Harvard Medical School and chief of the Division of Global Health Equity at Brigham and Women’s Hospital.
LA JOLLA—El Salk Institute anunció hoy el nombramiento de David Lawrence como director ejecutivo de Iniciativa de Aprovechamiento de Plantas (IAP). En su nuevo cargo, Lawrence supervisará la gestión de programas y el apoyo administrativo para el proyecto, además de ayudar a entregar aplicaciones del mundo real basadas en los hallazgos de investigación de Salk. Por ejemplo, ayudará a escalar y desplegar las Salk Ideal Plants™ a nivel mundial, cultivos que pueden capturar el exceso de dióxido de carbono de la atmósfera y almacenarlo en las profundidades de sus sistemas radiculares.
LA JOLLA/NEW YORK—The Lustgarten Foundation and Salk Institute today announced a new strategic partnership supported by a $5 million grant and focused on identifying and validating potential targets for new pancreatic cancer drugs. The effort will be led by four co-principal investigators, all prominent cancer researchers in the Salk Dedicated Program in Pancreatic Cancer: Professors Reuben Shaw, Ronald Evans, Tony Hunter and Assistant Professor Dannielle Engle. The partnership is part of the Lustgarten Advancing Breakthrough Science (LABS) Program.
LA JOLLA—Salk scientists have engineered mammalian cells to be activated using ultrasound. The method, which the team used to activate human cells in a dish and brain cells inside living mice, paves the way toward non-invasive versions of deep brain stimulation, pacemakers and insulin pumps. The findings were published in Comunicaciones de la Naturaleza on February 9, 2022.
LA JOLLA—Marna C. Whittington, the former CEO of Allianz Global Investors Capital, was elected as chair of the Salk Institute’s Board of Trustees on November 12, 2021. Whittington replaces Daniel C. Lewis, former president of the global commercial management-consulting firm Booz Allen Hamilton.
