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Recent Salk news from the Conquering Cancer team
Could this enzyme help remove “zombie” cells from our tissues?
Highlights Salk scientists identify two cellular programs linked to age-related dysfunction, ferroptosis and senescence, are mechanistically linked through the enzyme acid ceramidase The team finds that senescent “zombie” cells are more vulnerable …
Are lung cancer tumors hijacking the nervous system?
Highlights Cachexia, a syndrome marked by unwanted weight loss, sickness, and loss of appetite that accompanies and amplifies chronic illness, affects roughly half of all cancer patients and is responsible for …
Can a personalized disease-in-a-dish improve a pancreatitis patient’s therapeutic path?
Highlights Chronic pancreatitis, which affects around three million people worldwide, is especially difficult to treat because the molecular drivers of the disease vary from patient to patient Salk researchers have created a …
Foundational research points to new therapeutic strategies for an emerging cancer drug
Highlights Salk researchers investigated the impacts of entinostat, a drug that targets HDAC proteins, and found it inactivates DNA damage repair genes in pancreatic cancer cells The discovery led to new treatment …
Keck Foundation funds three innovative early-career Salk projects
Highlights W. M. Keck Foundation Bridge Funding Initiative grants $600,000 to Salk scientist, graduate student pairings The three teams will each tackle their own projects, spanning cancer, neuroscience, and genetics The grants accelerate …
From Salk Institute discovery to patient care: Vitamin D analog shuts down pancreatic cancer’s shield in clinical trial
Highlights Preclinical studies at the Salk Institute laid the foundation for a question now being tested in patients: Can a vitamin D-based therapy “reprogram” a pancreatic tumor’s protective microenvironment, making tumors …
Spitzenkrebsforscher Thales “PapaG” Papagiannakopoulos tritt dem Salk Institute bei
LA JOLLA—The Salk Institute has recruited globally renowned cancer scientist Thales “PapaG” Papagiannakopoulos, PhD, to join its faculty as a professor beginning in September 2026. Papagiannakopoulos has served as a …
Beeinflusst die Bewegung unserer DNA ihre Aktivität?
Highlights The genome’s dynamic 3D shape influences the expression of very specific genes The protein NIPBL is a key facilitator of genome structures that inform cell identity Findings may inform new therapeutics for …
Könnten diese beiden Gene die T-Zellen unaufhaltsam machen?
Highlights Scientists discovered key genetic factors that determine whether a T cell acts as a powerful disease fighter or enters an ineffective, exhausted state. Turning off two transcription factors allowed exhausted T …
Acht Salk-Wissenschaftler gehören zu den meistzitierten Forschern der Welt
LA JOLLA—Salk faculty members Joseph Ecker, PhD, Ronald Evans, PhD, Rusty Gage, PhD, Christian Metallo, PhD, Satchidananda Panda, PhD, Reuben Shaw, PhD, and Kay Tye, PhD, as well as research assistant Joseph Nery have all …
Könnte die Steigerung dieses Moleküls das Fortschreiten von Bauchspeicheldrüsenkrebs verlangsamen?
LA JOLLA – Bauchspeicheldrüsenkrebs hat die höchste Sterblichkeitsrate aller großen Krebsarten und seine Inzidenz steigt. Da er in frühen Stadien typischerweise asymptomatisch ist, ist Bauchspeicheldrüsenkrebs besonders schwierig …
Salk-Professorin Diana Hargreaves erhält Preis der V Foundation für Bauchspeicheldrüsenkrebsforschung
LA JOLLA—Salk Institute Professor Diana Hargreaves was named a 2025 All-Star Translational Award Program grantee by the V Foundation for Cancer Research. The award comes as a recognition of Hargreaves’ …
Boosting this molecule could help retain muscle while losing fat
LA JOLLA—About one in eight adults in the United States has tried or currently uses a GLP-1 medication, and a quarter of those users cite weight loss as their main …
Bile acids exacerbate liver cancer, dietary supplement may offer relief
LA JOLLA—Immunotherapy is a modern approach to cancer treatment that uses a patient’s own immune system to help fight tumors. It has made an incredible impact on treating cancers in …
Putting a lid on excess cholesterol to halt bladder cancer cell growth
LA JOLLA—Like all cancers, bladder cancer develops when abnormal cells start to multiply out of control. But what if we could put a lid on their growth?
Previous studies showed that …
Ihre Immunzellen sind, was sie essen
LA JOLLA—The decision between scrambled eggs or an apple for breakfast probably won’t make or break your day. However, for your cells, a decision between similar microscopic nutrients could determine …
Unveiling Telo-seq: A breakthrough in telomere research on aging and cancer
LA JOLLA—Within each of our cells, long strands of DNA are folded into chromosomes and capped with protective structures called telomeres. But telomeres shorten as we age, eventually getting so …
Salk scientist Jesse Dixon named 2024 Pew Biomedical Scholar
LA JOLLA—Salk Institute Assistant Professor Jesse Dixon has been named a 2024 Pew Biomedical Scholar by The Pew Charitable Trusts. This honor provides funding to early-career investigators who demonstrate outstanding …