Sung Han 博士

副教授

克莱顿基金会肽生物学实验室

Pioneer Fund Developmental Chair

Sung Han
索尔克生物研究所 出版物

所有出版物


Kang, S.J., Liu, S., Kim, J.H., Kim, D.I., Oh, T.G., Peng, J., Ye, M., Lee, K.F., Evans, R.M., Goulding, M., Han, S. Thalamic CGRP neurons define a spinothalamic pathway for affective pain. (2025) 美国国家科学院院刊. 122(28):e2505889122. DOI: 10.1073/pnas.2505889122

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Lorsung, R., Cramer, N., Alipio, J.B., Ji, Y., Han, S., Masri, R., Keller, A. Sex differences in central amygdala glutamate responses to calcitonin gene-related peptide. (2024) 神经科学杂志. DOI: 10.1523/JNEUROSCI.1898-24.2024

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Jhang, J., Park, S., Liu, S., O'Keefe, D.D., Han, S. A top-down slow breathing circuit that alleviates negative affect in mice. (2024) 自然神经科学. DOI: 10.1038/s41593-024-01799-w

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Kim, D.I., Kang, S.J., Jhang, J., Jo, Y.S., Park, S., Ye, M., Pyeon, G.H., Im, G.H., Kim, S.G., Han, S. Encoding opposing valences through frequency-dependent transmitter switching in single peptidergic neurons. (2024) bioRxiv. DOI: 10.1101/2024.11.09.622790

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Lorsung, R., Cramer, N., Alipio, J.B., Ji, Y., Han, S., Masri, R., Keller, A. Sex differences in central amygdala glutamate responses to calcitonin gene-related peptide. (2024) bioRxiv. DOI: 10.1101/2024.11.09.622728

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Kim, D.I., Park, S., Park, S., Ye, M., Chen, J.Y., Kang, S.J., Jhang, J., Hunker, A.C., Zweifel, L.S., Caron, K.M., Vaughan, J.M., Saghatelian, A., Palmiter, R.D., Han, S. Presynaptic sensor and silencer of peptidergic transmission reveal neuropeptides as primary transmitters in pontine fear circuit. (2024) 牢房. DOI: 10.1016/j.cell.2024.06.035

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Kang, S.J., Kim, J.H., Kim, D.I., Roberts, B.Z., Han, S. A pontomesencephalic PACAPergic pathway underlying panic-like behavioral and somatic symptoms in mice. (2024) 自然神经科学. DOI: 10.1038/s41593-023-01504-3

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Ren, X., Liu, S., Virlogeux, A., Kang, S.J., Brusch, J., Liu, Y., Dymecki, S.M., Han, S., Goulding, M., Acton, D. Identification of an essential spinoparabrachial pathway for mechanical itch. (2023) 神经元. DOI: 10.1016/j.neuron.2023.03.013

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Jhang, J., Liu, S., O'Keefe, D.D., Han, S. A top-down slow breathing circuit that alleviates negative affect. (2023) bioRxiv. DOI: 10.1101/2023.02.25.529925

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Kim, D.I., Park, S., Ye, M., Chen, J.Y., Jhang, J., Hunker, A.C., Zweifel, L.S., Palmiter, R.D., Han, S. Novel genetically encoded tools for imaging or silencing neuropeptide release from presynaptic terminals . (2023) bioRxiv. DOI: 10.1101/2023.01.19.524797

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Kang, S.J., Liu, S., Ye, M., Kim, D.I., Pao, G.M., Copits, B.A., Roberts, B.Z., Lee, K.F., Bruchas, M.R., Han, S. A central alarm system that gates multi-sensory innate threat cues to the amygdala. (2022) 细胞报告. 40(7):111222. DOI: 10.1016/j.celrep.2022.111222

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Liu, S., Han, S. Simultaneous recording of breathing and neural activity in awake behaving mice. (2022) STAR Protoc. 3(2):101412. DOI: 10.1016/j.xpro.2022.101412

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Liu, S., Ye, M., Pao, G.M., Song, S.M., Jhang, J., Jiang, H., Kim, J.H., Kang, S.J., Kim, D.I., Han, S. Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions. (2021) 神经元. DOI: 10.1016/j.neuron.2021.11.029

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Liu, S., Kim, D.I., Oh, T.G., Pao, G.M., Kim, J.H., Palmiter, R.D., Banghart, M.R., Lee, K.F., Evans, R.M., Han, S. Neural basis of opioid-induced respiratory depression and its rescue. (2021) 美国国家科学院院刊. 118(23). DOI: 10.1073/pnas.2022134118

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Campos, C.A., Bowen, A.J., Han, S., Wisse, B.E., Palmiter, R.D., Schwartz, M.W. Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus. (2017) 自然神经科学. 20(7):934-942. DOI: 10.1038/nn.4574

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Rubinstein, M.*, Han, S.*, Tai, C., Westenbroek, R.E., Hunker, A., Scheuer, T., Catterall, W.A. Dissecting the phenotypes of Dravet syndrome by gene deletion. (2015) Brain : A Journal of Neurology. 138(Pt 8):2219-33. DOI: 10.1093/brain/awv142

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Han, S., Soleiman, M.T., Soden, M.E., Zweifel, L.S., Palmiter, R.D. Elucidating an Affective Pain Circuit that Creates a Threat Memory. (2015) 牢房. 162(2):363-374. DOI: 10.1016/j.cell.2015.05.057

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Carter, M.E., Han, S., Palmiter, R.D. Parabrachial calcitonin gene-related peptide neurons mediate conditioned taste aversion. (2015) 神经科学杂志. 35(11):4582-6. DOI: 10.1523/JNEUROSCI.3729-14.2015

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Han, S., Tai, C., Jones, C.J., Scheuer, T., Catterall, W.A. Enhancement of inhibitory neurotransmission by GABAA receptors having α2,3-subunits ameliorates behavioral deficits in a mouse model of autism. (2014) 神经元. 81(6):1282-1289. DOI: 10.1016/j.neuron.2014.01.016

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Han, S., Tai, C., Westenbroek, R.E., Yu, F.H., Cheah, C.S., Potter, G.B., Rubenstein, J.L., Scheuer, T., de la Iglesia, H.O., Catterall, W.A. Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission. (2012) 自然. 489(7416):385-90. DOI: 10.1038/nature11356

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Han, S., Yu, F.H., Schwartz, M.D., Linton, J.D., Bosma, M.M., Hurley, J.B., Catterall, W.A., de la Iglesia, H.O. Na(V)1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms. (2012) 美国国家科学院院刊. 109(6):E368-77. DOI: 10.1073/pnas.1115729109

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Eckel-Mahan, K.L., Phan, T., Han, S., Wang, H., Chan, G.C., Scheiner, Z.S., Storm, D.R. Circadian oscillation of hippocampal MAPK activity and cAmp: implications for memory persistence. (2008) 自然神经科学. 11(9):1074-82.

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Han, S., Kim, T.D., Ha, D.C., Kim, K.T. Rhythmic expression of adenylyl cyclase VI contributes to the differential regulation of serotonin N-acetyltransferase by bradykinin in rat pineal glands. (2005) 生物化学杂志. 280(46):38228-34. DOI: 10.1074/jbc.M508130200

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教育

BS, Genetic Engineering, Kyungpook National University, Korea
MS, Neuroscience, Pohang University of Science and Technology, Korea
PhD, Neurobiology & Behavior, University of Washington, Seattle


奖项与荣誉

  • NIMH Biobehavioral Research Award for Innovative New Scientist (Brains), 2018
  • SFARI, Bridge to Independence Award, 2016
  • Life Sciences Research Foundation, Postdoctoral Fellowship, 2015-2018
  • KBRI Postdoctoral Research Award, Association of Korean Neuroscientists, 2012
  • Korea Research Foundation Research Grant, 2005