教授兼主任
基因表达实验室
分子与发育生物学March of Dimes主席
Fan, W., Oh, T.G., Crossley, L., Robbins, H., He, M., Dai, Y., Truitt, M.L., Atkins, A.R., Downes, M., Evans, R.M. A scalable embryonic stem cell-based platform for efficient generation of mitochondrial DNA mutant mice. (2026) 美国国家科学院院刊. 123(15):e2535453123. DOI: 10.1073/pnas.2535453123
Yang, Y., Zhang, X., Venkadakrishnan, V.B., Zou, H., Zheng, X., Guo, S., Chen, C.Z., Borowsky, A.D., Corey, E., Evans, R.M., Gao, A.C., Dall'Era, M.A., Zoubeidi, A., Lara, P.N., Kung, H.J., Chen, X., Beltran, H., Chen, H.W. Targeting Wnt/β-Catenin and circadian regulator restores PRC2/EZH2 controlled chromatin bivalency and suppresses cell state diversity. (2026) 临床研究杂志. DOI: 10.1172/JCI200260
Sermikli, B.P., Liu, S., Kim, K., Hases, L., van Zutphen, T., Untereiner, A., Torres, J., He, M., Crossley, L., Dai, Y., Zhu, J., Koopari, C.L., Fan, W., Truitt, M.L., Jonker, J.W., Atkins, A.R., Downes, M., Evans, R.M. FGF1 orchestrates circadian hepatic triglyceride secretion. (2026) 自然-通讯. DOI: 10.1038/s41467-026-70849-7
van Zutphen, T., Struik, D., Liu, W., Liu, S., Sermikli, B.P., Wolters, J.C., Verkade, H.J., Atkins, A.R., Downes, M., Evans, R.M., Jonker, J.W. FGF1 ameliorates hepatic steatosis through acute activation of the unfolded protein response and VLDL production. (2026) JHEP Rep. 8(2):101660. DOI: 10.1016/j.jhepr.2025.101660
Son, S., Xu, C., Fu, H., Wisessaowapak, C., Valentine, J.M., An, G., Jang, J., Dinh, M., Dai, Y., Fan, W., Yu, R.T., Downes, M., Ying, W., Skorobogatko, Y., Evans, R.M., Saltiel, A.R. Neutrophils preserve energy storage in sympathetically activated adipocytes. (2025) 自然. DOI: 10.1038/s41586-025-09839-6
Fu, H., Lee, S., Zemke, N.R., Fan, W., Wang, Y., Garza, J., Tin, D., Villao, B., Zhang, B., Ma, X., Zhang, J., Dong, T., Ren, Y., Downes, M., Evans, R.M., Ren, B., Saltiel, A.R. Multi-layered transcriptional control of glycogen metabolism coordinates thermogenic remodeling of white adipocytes in male mice. (2025) 自然-通讯. DOI: 10.1038/s41467-025-67515-9
Zhang, X., Yang, Y., Zou, H., Cai, D., Corey, E., Zoubeidi, A., Lo, S.H., Yu, A.M., Evans, R.M., Chen, H.W. Circadian regulator REV-ERBα is a master regulator of tumor lineage plasticity and an effective therapeutic target. (2025) 美国国家科学院院刊. 122(46):e2513468122. DOI: 10.1073/pnas.2513468122
Osorio-Vasquez, V., Zhu, J., Lumibao, J.C., Lande, K., Peck, K.L., Stamp, M.K., Okhovat, S.R., Song, H., Ogawa, S., Kubota, C., Pantazopoulou, V., Dai, Y., Rock, A., Bottomley, C., Thomas, E., Hsu, J., Morales, A.H., Fowler, A., McGriff, T., Evensen, K.G., Larsen, S., Abdulla, M., Greer, P., Gibson, J., Downes, M., Evans, R., Lowy, A.M., Whitcomb, D.C., Zou, J., Molinolo, A., Oh, T.G., White, R., Bellin, M., Tiriac, H., Engle, D.D. 慢性胰腺炎患者来源的类器官揭示了精准治疗的新途径。. (2025) bioRxiv. DOI: 10.1101/2024.10.30.620903
Yu, C.J., Pessentheiner, A.R., Liu, S., Wax, S., Maciej-Hulme, M.L., Painter, C.D., Ramms, B., Sandoval, D.R., Quach, A., DeForest, N., Ducasa, G.M., Tognaccini, C., Labib, C., Al-Azzam, N., Haumann, F., Trieger, G., Secrest, P., Majithia, A., Petrey, A.C., Godula, K., Atkins, A.R., Downes, M., Evans, R.M., Gordts, P.L.S.M. Adipocyte Heparan Sulfate Determines Type 2 Diabetes Susceptibility in Mice via FGF1-Mediated Glucose Regulation. (2025) Molecular Metabolism.:102267 DOI: 10.1016/j.molmet.2025.102267
Jameson, G.S., LeGrand, S.D., Gordon, M.S., Roe, D.J., Wertheim, B.C., Olszewski, K., Rabinowitz, J., Evans, R., Downes, M., Truitt, M., Korn, R., Han, H., Miller, R.M., Barrett, M.T., Propper, D., Von Hoff, D.D., Borazanci, E. Phase IB trial of high dose ascorbic acid + nab-paclitaxel + cisplatin + gemcitabine in patients with untreated metastatic pancreatic cancer. (2025) Redox Biol. 88:103895. DOI: 10.1016/j.redox.2025.103895
Liu, B., Nguyen, H.V., Jiang, Y., Wang, A.X., Lensch, V., Sun, Z., Boyer, Z.H., Raftopoulos, P.A., Dai, Y., MacNicol, P.L., Wang, Y., Jyotsana, N., Wang, W., Bhagchandani, S., Hemdev, S., Shieh, P., Kristufek, S.L., Boucher, M., Downes, M., Evans, R.M., MacMillan, D.W.C., Johnson, J.A. Antibody-bottlebrush prodrug conjugates for targeted cancer therapy. (2025) Nature Biotechnology. DOI: 10.1038/s41587-025-02772-z
Kang, S.J., Liu, S., Kim, J.H., Kim, D.I., Oh, T.G., Peng, J., Ye, M., Lee, K.F., Evans, R.M., Goulding, M., Han, S. Thalamic CGRP neurons define a spinothalamic pathway for affective pain. (2025) 美国国家科学院院刊. 122(28):e2505889122. DOI: 10.1073/pnas.2505889122
Son, S., Xu, C., Jang, J., Dinh, M., Skorobogatko, Y., Fu, H., Valentine, J.M., An, G., Ying, W., Yu, R.T., Downes, M., Evans, R.M., Saltiel, A.R. Sympathetic activation of white adipose tissue recruits neutrophils to limit energy expenditure. (2025) Res Sq. DOI: 10.21203/rs.3.rs-6414640/v1
Wang, H.J., Fan, W., Liu, S., Kim, K., Matsushima, A., Ogawa, S., Kang, H.G., Zhu, J., Estepa, G., He, M., Crossley, L., Liddle, C., Kim, M.S., Truitt, M.L., Yu, R.T., Atkins, A.R., Downes, M., Evans, R.M. BCL6 coordinates muscle mass homeostasis with nutritional states. (2025) 美国国家科学院院刊. 122(4):e2408896122. DOI: 10.1073/pnas.2408896122
Chung, V., Alistar, A., Becerra, C., Kasi, A., Borazanci, E., Jameson, G.S., Roe, D.J., Wertheim, B.C., Cridebring, D., Truitt, M., Downes, M., Barrett, M.T., Korn, R., Lee, K., Han, H., Evans, R., Von Hoff, D.D. Pembrolizumab ± paricalcitol in metastatic pancreatic cancer postmaximal cytoreduction. (2025) Oncologist. 30(1). DOI: 10.1093/oncolo/oyae323
Yang, Y., Zhang, X., Cai, D., Zheng, X., Zhao, X., Zou, J.X., Zhang, J., Borowsky, A.D., Dall'Era, M.A., Corey, E., Mitsiades, N., Kung, H.J., Chen, X., Li, J.J., Downes, M., Evans, R.M., Chen, H.W. Functional inversion of circadian regulator REV-ERBα leads to tumorigenic gene reprogramming. (2024) 美国国家科学院院刊. 121(42):e2411321121. DOI: 10.1073/pnas.2411321121
Pessentheiner, A.R., Spann, N.J., Autran, C.A., Oh, T.G., Grunddal, K.V., Coker, J.K., Painter, C.D., Ramms, B., Chiang, A.W., Wang, C.Y., Hsiao, J., Wang, Y., Quach, A., Booshehri, L.M., Hammond, A., Tognaccini, C., Latasiewicz, J., Willemsen, L., Zengler, K., de Winther, M.P., Hoffman, H.M., Philpott, M., Cribbs, A.P., Oppermann, U., Lewis, N.E., Witztum, J.L., Yu, R., Atkins, A.R., Downes, M., Evans, R.M., Glass, C.K., Bode, L., Gordts, P.L. The human milk oligosaccharide 3'sialyllactose reduces low-grade inflammation and atherosclerosis development in mice. (2024) JCI 洞见. DOI: 10.1172/jci.insight.181329
Elangovan, H., Stokes, R.A., Keane, J., Chahal, S., Samer, C., Agoncillo, M., Yu, J., Chen, J., Downes, M., Evans, R.M., Liddle, C., Gunton, J.E. Vitamin D Receptor Regulates Liver Regeneration After Partial Hepatectomy in Male Mice. (2024) Endocrinology. DOI: 10.1210/endocr/bqae077
Rivier, C., Hunter, T., Evans, R.M. Roger Guillemin (1924 to 2024): Discoverer of brain hormones that control physiology. (2024) 美国国家科学院院刊. 121(20):e2407309121. DOI: 10.1073/pnas.2407309121
Hong, S.H., Castro, G., Wang, D., Nofsinger, R., Kane, M., Folias, A., Atkins, A.R., Yu, R.T., Napoli, J.L., Sassone-Corsi, P., de Rooij, D.G., Liddle, C., Downes, M., Evans, R.M. Targeting nuclear receptor corepressors for reversible male contraception. (2024) 美国国家科学院院刊. 121(9):e2320129121. DOI: 10.1073/pnas.2320129121
Abe, Y., Kofman, E.R., Ouyang, Z., Cruz-Becerra, G., Spann, N.J., Seidman, J.S., Troutman, T.D., Stender, J.D., Taylor, H., Fan, W., Link, V.M., Shen, Z., Sakai, J., Downes, M., Evans, R.M., Kadonaga, J.T., Rosenfeld, M.G., Glass, C.K. A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation. (2024) 美国国家科学院院刊. 121(2):e2316104121. DOI: 10.1073/pnas.2316104121
Xia, W., Veeragandham, P., Cao, Y., Xu, Y., Rhyne, T.E., Qian, J., Hung, C.W., Zhao, P., Jones, Y., Gao, H., Liddle, C., Yu, R.T., Downes, M., Evans, R.M., Rydén, M., Wabitsch, M., Wang, Z., Hakozaki, H., Schöneberg, J., Reilly, S.M., Huang, J., Saltiel, A.R. Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation. (2024) Nat Metab. DOI: 10.1038/s42255-024-00978-0
Liang, G., Oh, T.G., Hah, N., Tiriac, H., Shi, Y., Truitt, M.L., Antal, C.E., Atkins, A.R., Li, Y., Fraser, C., Ng, S., Pinto, A.F.M., Nelson, D.C., Estepa, G., Bashi, S., Banayo, E., Dai, Y., Liddle, C., Yu, R.T., Hunter, T., Engle, D.D., Han, H., Von Hoff, D.D., Downes, M., Evans, R.M. 抑制基质中I类HDAC会遏制胰腺癌的进展。. (2023) 自然-通讯. 14(1):7791. DOI: 10.1038/s41467-023-42178-6
Xu, W., Billon, C., Li, H., Wilderman, A., Qi, L., Graves, A., Rideb, J.R.D.C., Zhao, Y., Hayes, M., Yu, K., Losby, M., Hampton, C.S., Adeyemi, C.M., Hong, S.J., Nasiotis, E., Fu, C., Oh, T.G., Fan, W., Downes, M., Welch, R.D., Evans, R.M., Milosavljevic, A., Walker, J.K., Jensen, B.C., Pei, L., Burris, T., Zhang, L. Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function. (2023) Circulation. DOI: 10.1161/CIRCULATIONAHA.123.066542
Antal, C.E., Oh, T.G., Aigner, S., Luo, E.C., Yee, B.A., Campos, T., Tiriac, H., Rothamel, K.L., Cheng, Z., Jiao, H., Wang, A., Hah, N., Lenkiewicz, E., Lumibao, J.C., Truitt, M.L., Estepa, G., Banayo, E., Bashi, S., Esparza, E., Munoz, R.M., Diedrich, J.K., Sodir, N.M., Mueller, J.R., Fraser, C.R., Borazanci, E., Propper, D., Von Hoff, D.D., Liddle, C., Yu, R.T., Atkins, A.R., Han, H., Lowy, A.M., Barrett, M.T., Engle, D.D., Evan, G.I., Yeo, G.W., Downes, M., Evans, R.M. 超级增强子调控的RNA结合蛋白级联驱动胰腺癌。. (2023) 自然-通讯. 14(1):5195. DOI: 10.1038/s41467-023-40798-6
Abe, Y., Kofman, E.R., Almeida, M., Ouyang, Z., Ponte, F., Mueller, J.R., Cruz-Becerra, G., Sakai, M., Prohaska, T.A., Spann, N.J., Resende-Coelho, A., Seidman, J.S., Stender, J.D., Taylor, H., Fan, W., Link, V.M., Cobo, I., Schlachetzki, J.C.M., Hamakubo, T., Jepsen, K., Sakai, J., Downes, M., Evans, R.M., Yeo, G.W., Kadonaga, J.T., Manolagas, S.C., Rosenfeld, M.G., Glass, C.K. RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression. (2023) 分子细胞. DOI: 10.1016/j.molcel.2023.08.029
Kim, M.Y., Shin, H.Y., Cho, S.C., Yang, S., Intisar, A., Woo, H.J., Choi, Y.S., You, C.L., Kang, J.S., Lee, Y.I., Park, S.C., Yea, K., Oh, T.G., Downes, M., Evans, R.M., Kim, M.S. Silver electroceutical technology to treat sarcopenia. (2023) 美国国家科学院院刊. 120(33):e2300036120. DOI: 10.1073/pnas.2300036120
Fu, T., Huan, T., Rahman, G., Zhi, H., Xu, Z., Oh, T.G., Guo, J., Coulter, S., Tripathi, A., Martino, C., McCarville, J.L., Zhu, Q., Cayabyab, F., Low, B., He, M., Xing, S., Vargas, F., Yu, R.T., Atkins, A., Liddle, C., Ayres, J., Raffatellu, M., Dorrestein, P.C., Downes, M., Knight, R., Evans, R.M. Paired microbiome and metabolome analyses associate bile acid changes with colorectal cancer progression. (2023) 细胞报告.:112997 DOI: 10.1016/j.celrep.2023.112997
Kushwaha, P., Tran, A., Quintero, D., Song, M., Yu, Q., Yu, R., Downes, M., Evans, R.M., Babst-Kostecka, A., Schroeder, J.I., Maier, R.M. Zinc accumulation in Atriplex lentiformis is driven by plant genes and the soil microbiome. (2023) Science of the Total Environment.:165667 DOI: 10.1016/j.scitotenv.2023.165667
Xia, W., Veeragandham, P., Cao, Y., Xu, Y., Rhyne, T., Qian, J., Hung, C.W., Zhao, P., Jones, Y., Gao, H., Liddle, C., Yu, R., Downes, M., Evans, R., Ryden, M., Wabitsch, M., Reilly, S., Huang, J., Saltiel, A. Obesity-dependent increase in RalA activity disrupts mitochondrial dynamics in white adipocytes. (2023) Res Sq. DOI: 10.21203/rs.3.rs-2923510/v1
Yoon, B.K., Kim, H., Oh, T.G., Oh, S.K., Jo, S., Kim, M., Chun, K.H., Hwang, N., Lee, S., Jin, S., Atkins, A.R., Yu, R.T., Downes, M., Kim, J.W., Kim, H., Evans, R.M., Cheong, J.H., Fang, S. PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemoresistant gastric cancer during nutrient stress. (2023) 美国国家科学院院刊. 120(21):e2217826120. DOI: 10.1073/pnas.2217826120
Billon, C., Sitaula, S., Banerjee, S., Welch, R., Elgendy, B., Hegazy, L., Oh, T.G., Kazantzis, M., Chatterjee, A., Chrivia, J., Hayes, M.E., Xu, W., Hamilton, A., Huss, J.M., Zhang, L., Walker, J.K., Downes, M., Evans, R.M., Burris, T.P. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. (2023) ACS Chemical Biology. DOI: 10.1021/acschembio.2c00720
Fu, T., Li, Y., Oh, T.G., Cayabyab, F., He, N., Tang, Q., Coulter, S., Truitt, M., Medina, P., He, M., Yu, R.T., Atkins, A., Zheng, Y., Liddle, C., Downes, M., Evans, R.M. FXR mediates ILC-intrinsic responses to intestinal inflammation. (2022) 美国国家科学院院刊. 119(51):e2213041119. DOI: 10.1073/pnas.2213041119
Wang, H.J., Evans, R.M. Timed use of cardiac glycoside protects the heart. (2022) Nat Cardiovasc Res. 1(11):973-975. DOI: 10.1038/s44161-022-00158-x
Nies, V.J.M., Struik, D., Liu, S., Liu, W., Kruit, J.K., Downes, M., van Zutphen, T., Verkade, H.J., Evans, R.M., Jonker, J.W. Autocrine FGF1 signaling promotes glucose uptake in adipocytes. (2022) 美国国家科学院院刊. 119(40):e2122382119. DOI: 10.1073/pnas.2122382119
Sharpton, S.R., Oh, T.G., Madamba, E., Wang, C., Yu, R.T., Atkins, A.R., Huan, T., Downes, M., Evans, M.R., Loomba, R. Gut metagenome-derived signature predicts hepatic decompensation and mortality in NAFLD-related cirrhosis. (2022) Aliment Pharmacol Ther. DOI: 10.1111/apt.17236
Huang, D., Downes, M., Evans, R., Witztum, J., Glass, C., Loomba, R. Shared mechanisms between cardiovascular disease and NAFLD. (2022) Semin Liver Dis. DOI: 10.1055/a-1930-6658
Kim, J.Y., Wang, L.Q., Sladky, V.C., Oh, T.G., Liu, J., Trinh, K., Eichin, F., Downes, M., Hosseini, M., Jacotot, E.D., Evans, R.M., Villunger, A., Karin, M. PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis. (2022) Cell Metabolism. DOI: 10.1016/j.cmet.2022.08.005
Giguere, V., Evans, R.M. Chronicle of a discovery: the retinoic acid receptor. (2022) Journal of Molecular Endocrinology. DOI: 10.1530/JME-22-0117
Gasser, E., Sancar, G., Downes, M., Evans, R.M. Metabolic Messengers: fibroblast growth factor 1. (2022) Nat Metab. DOI: 10.1038/s42255-022-00580-2
Shi, Y., Evans, R.M., Gage, F.H. Oleic acid regulates hippocampal neurogenesis as a TLX ligand. (2022) 美国国家科学院院刊. 119(15):e2203038119. DOI: 10.1073/pnas.2203038119
Choi, J., Oh, T.G., Jung, H., Park, K.Y., Shin, H., Jo, T., Kang, D.S., Chanda, D., Hong, S., Kim, J., Hwang, H., Ji, M., Jung, M., Takashihoji, Matsushima, A., Kim, P., Mun, J.Y., Paik, M.J., Cho, S.J., Lee, I.K., Whitcomb, D.C., Greer, P., Blobner, B., Goodarzi, M.O., Pandol, S.J., Rotter, J.I., Fan, W., Bapat, S.P., Zheng, Y., Liddle, C., Yu, R.T., Atkins, A.R., Downes, M., Yoshihara, E., Evans, R.M., Suh, J.M. Estrogen-Related Receptor γ maintains pancreatic acinar cell function and identity by regulating cellular metabolism. (2022) Gastroenterology. DOI: 10.1053/j.gastro.2022.04.013
Casanova-Vallve, N., Duglan, D., Vaughan, M.E., Pariollaud, M., Handzlik, M.K., Fan, W., Yu, R.T., Liddle, C., Downes, M., Delezie, J., Mello, R., Chan, A.B., Westermark, P.O., Metallo, C.M., Evans, R.M., Lamia, K.A. Daily running enhances molecular and physiological circadian rhythms in skeletal muscle. (2022) Molecular Metabolism.:101504 DOI: 10.1016/j.molmet.2022.101504
Bapat, S.P., Whitty, C., Mowery, C.T., Liang, Y., Yoo, A., Jiang, Z., Peters, M.C., Zhang, L.J., Vogel, I., Zhou, C., Nguyen, V.Q., Li, Z., Chang, C., Zhu, W.S., Hastie, A.T., He, H., Ren, X., Qiu, W., Gayer, S.G., Liu, C., Choi, E.J., Fassett, M., Cohen, J.N., Sturgill, J.L., Crotty Alexander, L.E., Suh, J.M., Liddle, C., Atkins, A.R., Yu, R.T., Downes, M., Liu, S., Nikolajczyk, B.S., Lee, I.K., Guttman-Yassky, E., Ansel, K.M., Woodruff, P.G., Fahy, J.V., Sheppard, D., Gallo, R.L., Ye, C.J., Evans, R.M., Zheng, Y., Marson, A. Obesity alters pathology and treatment response in inflammatory disease. (2022) 自然. 604(7905):337-342. DOI: 10.1038/s41586-022-04536-0
Yang, L., TeSlaa, T., Ng, S., Nofal, M., Wang, L., Lan, T., Zeng, X., Cowan, A., McBride, M., Lu, W., Davidson, S., Liang, G., Oh, T.G., Downes, M., Evans, R., Von Hoff, D., Guo, J.Y., Han, H., Rabinowitz, J.D. Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth. (2022) Med (N Y). 3(2):119-136. DOI: 10.1016/j.medj.2021.12.008
Ahmed, N.S., Gatchalian, J., Ho, J., Burns, M.J., Hah, N., Wei, Z., Downes, M., Evans, R.M., Hargreaves, D.C. BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4. (2022) 美国国家科学院院刊. 119(1). DOI: 10.1073/pnas.2110812119
Sancar, G., Liu, S., Gasser, E., Alvarez, J.G., Moutos, C., Kim, K., van Zutphen, T., Wang, Y., Huddy, T.F., Ross, B., Dai, Y., Zepeda, D., Collins, B., Tilley, E., Kolar, M.J., Yu, R.T., Atkins, A.R., van Dijk, T.H., Saghatelian, A., Jonker, J.W., Downes, M., Evans, R.M. FGF1 and insulin control lipolysis by convergent pathways. (2022) Cell Metabolism. 34(1):171-183.e6. DOI: 10.1016/j.cmet.2021.12.004
Evans, R.M., Wei, Z. Inter-organ Crosstalk in Pancreatic Islet Function and Pathology. (2022) FEBS Lett. DOI: 10.1002/1873-3468.14282
Valentine, J.M., Ahmadian, M., Keinan, O., Abu-Odeh, M., Zhao, P., Zhou, X., Keller, M.P., Gao, H., Yu, R.T., Liddle, C., Downes, M., Zhang, J., Lusis, A.J., Attie, A.D., Evans, R.M., Rydén, M., Saltiel, A.R. β3-adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity. (2021) 临床研究杂志. DOI: 10.1172/JCI153357
Keinan, O., Valentine, J.M., Xiao, H., Mahata, S.K., Reilly, S.M., Abu-Odeh, M., Deluca, J.H., Dadpey, B., Cho, L., Pan, A., Yu, R.T., Dai, Y., Liddle, C., Downes, M., Evans, R.M., Lusis, A.J., Laakso, M., Chouchani, E.T., Ryde'n, M., Saltiel, A.R. Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes. (2021) 自然. DOI: 10.1038/s41586-021-04019-8
Iwamoto, M., Masuya, T., Hosose, M., Tagawa, K., Ishibashi, T., Yoshihara, E., Downes, M., Evans, R.M., Matsushima, A. Bisphenol A derivatives act as novel coactivator binding inhibitors for estrogen receptor β. (2021) 生物化学杂志.:101173 DOI: 10.1016/j.jbc.2021.101173
Tang, Q., Evans, R.M. Colon cancer checks in when bile acids check out: the bile acid-nuclear receptor axis in colon cancer. (2021) Essays Biochem. DOI: 10.1042/EBC20210038
Wang, L., Oh, T.G., Magida, J., Estepa, G., Obayomi, S.M.B., Chong, L.W., Gatchalian, J., Yu, R.T., Atkins, A.R., Hargreaves, D., Downes, M., Wei, Z., Evans, R.M. Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity. (2021) 美国国家科学院院刊. 118(35). DOI: 10.1073/pnas.2109517118
Liu, S., Kim, D.I., Oh, T.G., Pao, G.M., Kim, J.H., Palmiter, R.D., Banghart, M.R., Lee, K.F., Evans, R.M., Han, S. Neural basis of opioid-induced respiratory depression and its rescue. (2021) 美国国家科学院院刊. 118(23). DOI: 10.1073/pnas.2022134118
Abu-Odeh, M., Zhang, Y., Reilly, S.M., Ebadat, N., Keinan, O., Valentine, J.M., Hafezi-Bakhtiari, M., Ashayer, H., Mamoun, L., Zhou, X., Zhang, J., Yu, R.T., Dai, Y., Liddle, C., Downes, M., Evans, R.M., Kliewer, S.A., Mangelsdorf, D.J., Saltiel, A.R. FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes. (2021) 细胞报告. 35(13):109331. DOI: 10.1016/j.celrep.2021.109331
Xu, S., Chaudhary, O., Rodríguez-Morales, P., Sun, X., Chen, D., Zappasodi, R., Xu, Z., Pinto, A.F.M., Williams, A., Schulze, I., Farsakoglu, Y., Varanasi, S.K., Low, J.S., Tang, W., Wang, H., McDonald, B., Tripple, V., Downes, M., Evans, R.M., Abumrad, N.A., Merghoub, T., Wolchok, J.D., Shokhirev, M.N., Ho, P.C., Witztum, J.L., Emu, B., Cui, G., Kaech, S.M. Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8 T cells in tumors. (2021) Immunity. DOI: 10.1016/j.immuni.2021.05.003
Oh, T.G., Kim, S.M., Atkins, A.R., Yu, R.T., Downes, M., Evans, R.M. Proton pump inhibitor use status does not modify the microbiome signature for cirrhosis. (2021) Cell Metabolism. 33(3):457. DOI: 10.1016/j.cmet.2021.02.013
Zhou, R., Llorente, C., Cao, J., Zaramela, L.S., Zeng, S., Gao, B., Li, S.Z., Welch, R.D., Huang, F.Q., Qi, L.W., Pan, C., Huang, Y., Zhou, P., Beussen, I., Zhang, Y., Bryam, G., Fiehn, O., Wang, L., Liu, E.H., Yu, R.T., Downes, M., Evans, R.M., Goglin, K., Fouts, D.E., Brenner, D.A., Bode, L., Fan, X., Zengler, K., Schnabl, B. Intestinal α1-2-fucosylation contributes to obesity and steatohepatitis in mice. (2021) Cell Mol Gastroenterol Hepatol. DOI: 10.1016/j.jcmgh.2021.02.009
Noel, P., Hussein, S., Ng, S., Antal, C.E., Lin, W., Rodela, E., Delgado, P., Naveed, S., Downes, M., Lin, Y., Evans, R.M., Von Hoff, D.D., Han, H. Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts. (2020) Oncogenesis. 9(11):100. DOI: 10.1038/s41389-020-00285-9
Evans, R.M., Lippman, S.M. Shining Light on the COVID-19 Pandemic: A Vitamin D Receptor Checkpoint in Defense of Unregulated Wound Healing. (2020) Cell Metabolism. DOI: 10.1016/j.cmet.2020.09.007
Lenkiewicz, E., Malasi, S., Hogenson, T.L., Flores, L.F., Barham, W., Phillips, W.J., Roesler, A.S., Chambers, K.R., Rajbhandari, N., Hayashi, A., Antal, C.E., Downes, M., Grandgenett, P.M., Hollingsworth, M.A., Cridebring, D., Xiong, Y., Lee, J.H., Ye, Z., Yan, H., Hernandez, M.C., Leiting, J.L., Evans, R.M., Ordog, T., Truty, M.J., Borad, M.J., Reya, T., Von Hoff, D.D., Fernandez-Zapico, M.E., Barrett, M.T. Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas. (2020) 癌症研究. DOI: 10.1158/0008-5472.CAN-20-0078
Yoshihara, E., O'Connor, C., Gasser, E., Wei, Z., Oh, T.G., Tseng, T.W., Wang, D., Cayabyab, F., Dai, Y., Yu, R.T., Liddle, C., Atkins, A.R., Downes, M., Evans, R.M. Immune-evasive human islet-like organoids ameliorate diabetes. (2020) 自然. DOI: 10.1038/s41586-020-2631-z
Oh, T.G., Kim, S.M., Caussy, C., Fu, T., Guo, J., Bassirian, S., Singh, S., Madamba, E.V., Bettencourt, R., Richards, L., Raffatellu, M., Dorrestein, P.C., Yu, R.T., Atkins, A.R., Huan, T., Brenner, D.A., Sirlin, C.B., Knight, R., Downes, M., Evans, R.M., Loomba, R. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. (2020) Cell Metabolism. DOI: 10.1016/j.cmet.2020.06.005
Paschoal, V.A., Walenta, E., Talukdar, S., Pessentheiner, A.R., Osborn, O., Hah, N., Chi, T.J., Tye, G.L., Armando, A.M., Evans, R.M., Chi, N.W., Quehenberger, O., Olefsky, J.M., Oh, D.Y. Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity. (2020) Cell Metabolism. DOI: 10.1016/j.cmet.2020.04.020
Seidman, J.S., Troutman, T.D., Sakai, M., Gola, A., Spann, N.J., Bennett, H., Bruni, C.M., Ouyang, Z., Li, R.Z., Sun, X., Vu, B.T., Pasillas, M.P., Ego, K.M., Gosselin, D., Link, V.M., Chong, L.W., Evans, R.M., Thompson, B.M., McDonald, J.G., Hosseini, M., Witztum, J.L., Germain, R.N., Glass, C.K. Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis. (2020) Immunity. DOI: 10.1016/j.immuni.2020.04.001
Quinn, R.A., Melnik, A.V., Vrbanac, A., Fu, T., Patras, K.A., Christy, M.P., Bodai, Z., Belda-Ferre, P., Tripathi, A., Chung, L.K., Downes, M., Welch, R.D., Quinn, M., Humphrey, G., Panitchpakdi, M., Weldon, K.C., Aksenov, A., da Silva, R., Avila-Pacheco, J., Clish, C., Bae, S., Mallick, H., Franzosa, E.A., Lloyd-Price, J., Bussell, R., Thron, T., Nelson, A.T., Wang, M., Leszczynski, E., Vargas, F., Gauglitz, J.M., Meehan, M.J., Gentry, E., Arthur, T.D., Komor, A.C., Poulsen, O., Boland, B.S., Chang, J.T., Sandborn, W.J., Lim, M., Garg, N., Lumeng, J.C., Xavier, R.J., Kazmierczak, B.I., Jain, R., Egan, M., Rhee, K.E., Ferguson, D., Raffatellu, M., Vlamakis, H., Haddad, G.G., Siegel, D., Huttenhower, C., Mazmanian, S.K., Evans, R.M., Nizet, V., Knight, R., Dorrestein, P.C. Global chemical effects of the microbiome include new bile-acid conjugations. (2020) 自然. DOI: 10.1038/s41586-020-2047-9
Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D.G., Egeblad, M., Evans, R.M., Fearon, D., Greten, F.R., Hingorani, S.R., Hunter, T., Hynes, R.O., Jain, R.K., Janowitz, T., Jorgensen, C., Kimmelman, A.C., Kolonin, M.G., Maki, R.G., Powers, R.S., Puré, E., Ramirez, D.C., Scherz-Shouval, R., Sherman, M.H., Stewart, S., Tlsty, T.D., Tuveson, D.A., Watt, F.M., Weaver, V., Weeraratna, A.T., Werb, Z. A framework for advancing our understanding of cancer-associated fibroblasts. (2020) Nature Reviews Cancer. DOI: 10.1038/s41568-019-0238-1
Sun, X., Seidman, J.S., Zhao, P., Troutman, T.D., Spann, N.J., Que, X., Zhou, F., Liao, Z., Pasillas, M., Yang, X., Magida, J.A., Kisseleva, T., Brenner, D.A., Downes, M., Evans, R.M., Saltiel, A.R., Tsimikas, S., Glass, C.K., Witztum, J.L. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. (2019) Cell Metabolism. 31:189–206. DOI: 10.1016/j.cmet.2019.10.014
Cai, D., Wang, J., Gao, B., Li, J., Wu, F., Zou, J.X., Xu, J., Jiang, Y., Zou, H., Huang, Z., Borowsky, A.D., Bold, R.J., Lara, P.N., Li, J.J., Chen, X., Lam, K.S., To, K.F., Kung, H.J., Fiehn, O., Zhao, R., Evans, R.M., Chen, H.W. RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. (2019) 自然-通讯. 10(1):4621. DOI: 10.1038/s41467-019-12529-3
Chang, C., Loo, C.S., Zhao, X., Solt, L.A., Liang, Y., Bapat, S.P., Cho, H., Kamenecka, T.M., Leblanc, M., Atkins, A.R., Yu, R.T., Downes, M., Burris, T.P., Evans, R.M., Zheng, Y. The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease. (2019) 美国国家科学院院刊. 116(37):18528-18536. DOI: 10.1073/pnas.1907563116
Wang, L., Mazagova, M., Pan, C., Yang, S., Brandl, K., Liu, J., Reilly, S.M., Wang, Y., Miao, Z., Loomba, R., Lu, N., Guo, Q., Liu, J., Yu, R.T., Downes, M., Evans, R.M., Brenner, D.A., Saltiel, A.R., Beutler, B., Schnabl, B. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. (2019) 美国国家科学院院刊. 116(30):15184-15193. DOI: 10.1073/pnas.1904360116
Shi, Y., Gao, W., Lytle, N.K., Huang, P., Yuan, X., Dann, A.M., Ridinger-Saison, M., DelGiorno, K.E., Antal, C.E., Liang, G., Atkins, A.R., Erikson, G., Sun, H., Meisenhelder, J., Terenziani, E., Woo, G., Fang, L., Santisakultarm, T.P., Manor, U., Xu, R., Becerra, C.R., Borazanci, E., Von Hoff, D.D., Grandgenett, P.M., Hollingsworth, M.A., Leblanc, M., Umetsu, S.E., Collisson, E.A., Scadeng, M., Lowy, A.M., Donahue, T.R., Reya, T., Downes, M., Evans, R.M., Wahl, G.M., Pawson, T., Tian, R., Hunter, T. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. (2019) 自然. 569(7754):131-135. DOI: 10.1038/s41586-019-1130-6
Auciello, F.R., Bulusu, V., Oon, C., Tait-Mulder, J., Berry, M., Bhattacharyya, S., Tumanov, S., Allen-Petersen, B.L., Link, J., Kendsersky, N.D., Vringer, E., Schug, M., Novo, D., Hwang, R.F., Evans, R.M., Nixon, C., Dorrell, C., Morton, J.P., Norman, J.C., Sears, R.C., Kamphorst, J.J., Sherman, M.H. A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression. (2019) 癌症发现. 9(5):617-627. DOI: 10.1158/2159-8290.CD-18-1212
Caussy, C., Tripathi, A., Humphrey, G., Bassirian, S., Singh, S., Faulkner, C., Bettencourt, R., Rizo, E., Richards, L., Xu, Z.Z., Downes, M.R., Evans, R.M., Brenner, D.A., Sirlin, C.B., Knight, R., Loomba, R. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. (2019) 自然-通讯. 10(1):1406. DOI: 10.1038/s41467-019-09455-9
Fu, F., Coulter, S., Yoshihara, E., Oh, T.G., Fang, S., Cayabyab, F., Zhu, Q., Zhang, T., Leblanc, M., Liu, He, M., Waizenegger, W., Gasser, E., Schnabl, B., Atkins, A.R., Yu, R.T., Knight, B., Liddle, C., Downes, Evans, M. FXR Regulates Intestinal Cancer Stem Cell Proliferation. (2019) 牢房. 176(5):1098-1112. DOI: 10.1016/j.cell.2019.01.036
Hemmer, M.C., Wierer, M., Schachtrup, K., Downes, M., Hübner, N., Evans, R.M., Uhlenhaut, N.H. E47 modulates hepatic glucocorticoid action. (2019) 自然-通讯. 10(1):306. DOI: 10.1038/s41467-018-08196-5
Cui, S., Li, L., Yu, R.T., Downes, M., Evans, R.M., Hulin, J.A., Makarenkova, H.P., Meech, R. β-catenin is essential for differentiation of primary myoblasts via cooperation with MyoD and α-catenin. (2019) Development. 146(6). DOI: 10.1242/dev.167080
Ward, J.M., Stoyas, C.A., Switonski, P.M., Ichou, F., Fan, W., Collins, B., Wall, C.E., Adanyeguh, I., Niu, C., Sopher, B.L., Kinoshita, C., Morrison, R.S., Durr, A., Muotri, A.R., Evans, R.M., Mochel, F., La Spada, A.R. Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease. (2019) 细胞报告. 26(5):1189-1202.e6. DOI: 10.1016/j.celrep.2019.01.028
Senagolage, M.D., Sommars, M.A., Ramachandran, K., Futtner, C.R., Omura, Y., Allred, A.L., Wang, J., Yang, C., Procissi, D., Evans, R.M., Han, X., Bederman, I.R., Barish, G.D. Loss of Transcriptional Repression by BCL6 Confers Insulin Sensitivity in the Setting of Obesity. (2018) 细胞报告. 25(12):3283-3298.e6. DOI: 10.1016/j.celrep.2018.11.074
Elbel, E.E., Lavine, J.E., Downes, M., Van Natta, M., Yu, R., Schwimmer, J.B., Behling, C., Brunt, E.M., Tonascia, J., Evans, R. Hepatic Nuclear Receptor Expression Associates with Features of Histology in Pediatric Nonalcoholic Fatty Liver Disease. (2018) Hepatology Communications. 2(10):1213-1226. DOI: 10.1002/hep4.1232
Hong, S.H., Fang, S., Lu, B.C., Nofsinger, R., Kawakami, Y., Castro, G.L., Yin, Y., Lin, C., Yu, R.T., Downes, M., Izpisúa Belmonte, J.C., Shilatifard, A., Evans, R.M. Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis. (2018) 美国国家科学院院刊. 115(41):10381-10386. DOI: 10.1073/pnas.1809480115
Wei, Z., Yoshihara, E., He, N., Hah, N., Fan, W., Pinto, A.F.M., Huddy, T., Wang, Y., Ross, B., Estepa, G., Dai, Y., Ding, N., Sherman, M.H., Fang, S., Zhao, X., Liddle, C., Atkins, A.R., Yu, R.T., Downes, M., Evans, R.M. Vitamin D Switches BAF Complexes to Protect β Cells. (2018) 牢房. 173(5):1135-1149. DOI: 10.1016/j.cell.2018.04.013
Magida, J.A., Evans, R.M. Rational application of macrophage-specific LXR agonists avoids the pitfalls of SREBP-induced lipogenesis. (2018) 美国国家科学院院刊. 115(20):5051-5053. DOI: 10.1073/pnas.1805128115
De Magalhaes Filho, C.D., Henriquez, B., Seah, N.E., Evans, R.M., Lapierre, L.R., Dillin, A. Visible light reduces C. elegans longevity. (2018) 自然-通讯. 9(1):927. DOI: 10.1038/s41467-018-02934-5
Fan, W., He, N., Lin, C.S., Wei, Z., Hah, N., Waizenegger, W., He, M.X., Liddle, C., Yu, R.T., Atkins, A.R., Downes, M., Evans, R.M. ERRγ Promotes Angiogenesis, Mitochondrial Biogenesis, and Oxidative Remodeling in PGC1α/β-Deficient Muscle. (2018) 细胞报告. 22(10):2521-2529. DOI: 10.1016/j.celrep.2018.02.047
Ahmadian, M., Liu, S., Reilly, S.M., Hah, N., Fan, W., Yoshihara, E., Jha, P., De Magalhaes Filho, C.D., Jacinto, S., Gomez, A.V., Dai, Y., Yu, R.T., Liddle, C., Atkins, A.R., Auwerx, J., Saltiel, A.R., Downes, M., Evans, R.M. ERRγ Preserves Brown Fat Innate Thermogenic Activity. (2018) 细胞报告. 22(11):2849-2859. DOI: 10.1016/j.celrep.2018.02.061
Shalom-Barak, T., Liersemann, J., Memari, B., Flechner, L., Devor, C., Bernardo, T.M., Kim, S., Matsumoto, N., Friedman, S.L., Evans, R.M., White, J.H., Barak, Y. Ligand-Dependent Corepressor (LCoR) Is A Rexinoid-Inhibited PPARγ-RXRα Coactivator. (2018) 分子与细胞生物学. 38(9). DOI: 10.1128/MCB.00107-17
Saison-Ridinger, M., DelGiorno, K.E., Zhang, T., Kraus, A., French, R., Jaquish, D., Tsui, C., Erikson, G., Spike, B.T., Shokhirev, M.N., Liddle, C., Yu, R.T., Downes, M., Evans, R.M., Saghatelian, A., Lowy, A.M., Wahl, G.M. Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. (2017) PLOS One. 12(12):e0189051. DOI: 10.1371/journal.pone.0189051
Dickey, A.S., Sanchez, D.N., Arreola, M., Sampat, K.R., Fan, W., Arbez, N., Akimov, S., Van Kanegan, M.J., Ohnishi, K., Gilmore-Hall, S.K., Flores, A.L., Nguyen, J.M., Lomas, N., Hsu, C.L., Lo, D.C., Ross, C.A., Masliah, E., Evans, R.M., La Spada, A.R. PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis. (2017) Science Translational Medicine. 9(419). DOI: 10.1126/scitranslmed.aal2332
Cao, Q., Zhao, X., Bai, J., Gery, S., Sun, H., Lin, D.C., Chen, Q., Chen, Z., Mack, L., Yang, H., Deng, R., Shi, X., Chong, L.W., Cho, H., Xie, J., Li, Q.Z., Müschen, M., Atkins, A.R., Liddle, C., Yu, R.T., Alkan, S., Said, J.W., Zheng, Y., Downes, M., Evans, R.M., Koeffler, H.P. Circadian clock cryptochrome proteins regulate autoimmunity. (2017) 美国国家科学院院刊. 114(47):12548-12553. DOI: 10.1073/pnas.1619119114
He, N., Fan, W., Henriquez, B., Yu, R.T., Atkins, A.R., Liddle, C., Zheng, Y., Downes, M., Evans, R.M. Metabolic control of regulatory T cell (Treg) survival and function by Lkb1. (2017) Proc. Natl. Acad. Sci. U.S.A. 114(47):12542-12547. DOI: 10.1073/pnas.1715363114
Shalapour, S., Lin, X.J., Bastian, I.N., Brain, J., Burt, A.D., Aksenov, A.A., Vrbanac, A.F., Li, W., Perkins, A., Matsutani, T., Zhong, Z., Dhar, D., Navas-Molina, J.A., Xu, J., Loomba, R., Downes, M., Yu, R.T., Evans, R.M., Dorrestein, P.C., Knight, R., Benner, C., Anstee, Q.M., Karin, M. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. (2017) 自然. 551(7680):340-345. DOI: 10.1038/nature24302
Hartmann, P., Hochrath, K., Horvath, A., Chen, P., Seebauer, C.T., Llorente, C., Wang, L., Alnouti, Y., Fouts, D.E., Stärkel, P., Loomba, R., Coulter, S., Liddle, C., Yu, R.T., Ling, L., Rossi, S.J., DePaoli, A.M., Downes, M., Evans, R.M., Brenner, D.A., Schnabl, B. Modulation of the intestinal bile acid-FXR-FGF15 axis improves alcoholic liver disease in mice. (2017) Hepatology. 67(6):2150-2166. DOI: 10.1002/hep.29676
Shalapour, S., Lin, X.J., Bastian, I.N., Brain, J., Burt, A.D., Aksenov, A.A., Vrbanac, A.F., Li, W., Perkins, A., Matsutani, T., Zhong, Z., Dhar, D., Navas-Molina, J.A., Xu, J., Loomba, R., Downes, M., Yu, R.T., Evans, R.M., Dorrestein, P.C., Knight, R., Benner, C., Anstee, Q.M., Karin, M. Erratum: Inflammation-induced IgA(+) cells dismantle anti-liver cancer immunity. (2017) 自然. DOI: 10.1038/nature25028
Wang, J., He, N., Zhang, N., Quan, D., Zhang, S., Zhang, C., Yu, R.T., Atkins, A.R., Zhu, R., Yang, C., Cui, Y., Liddle, C., Downes, M., Xiao, H., Zheng, Y., Auwerx, J., Evans, R.M., Leng, Q. NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection. (2017) 自然-通讯. 8(1):959. DOI: 10.1038/s41467-017-00931-8
Kriebs, A., Jordan, S.D., Soto, E., Henriksson, E., Sandate, C.R., Vaughan, M.E., Chan, A.B., Duglan, D., Papp, S.J., Huber, A.L., Afetian, M.E., Yu, R.T., Zhao, X., Downes, M., Evans, R.M., Lamia, K.A. Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. (2017) 美国国家科学院院刊. 114(33):8776-8781. DOI: 10.1073/pnas.1704955114
Jordan, S.D., Kriebs, A., Vaughan, M., Duglan, D., Fan, W., Henriksson, E., Huber, A.L., Papp, S.J., Nguyen, M., Afetian, M., Downes, M., Yu, R.T., Kralli, A., Evans, R.M., Lamia, K.A. CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity. (2017) Cell Metabolism. 26(1):243-255.e6. DOI: 10.1016/j.cmet.2017.06.002
Oral, E.A., Reilly, S.M., Gomez, A.V., Meral, R., Butz, L., Ajluni, N., Chenevert, T.L., Korytnaya, E., Neidert, A.H., Hench, R., Rus, D., Horowitz, J.F., Poirier, B., Zhao, P., Lehmann, K., Jain, M., Yu, R., Liddle, C., Ahmadian, M., Downes, M., Evans, R.M., Saltiel, A.R. Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. (2017) Cell Metabolism. 26(1):157-170.e7. DOI: 10.1016/j.cmet.2017.06.006
Evans, R.M. 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Short reflections on the discovery of the mineralocorticoid receptor. (2017) Journal of Endocrinology. 234(1):E1-E2. DOI: 10.1530/JOE-17-0287
Gasser, E., Moutos, C.P., Downes, M., Evans, R.M. FGF1 - a new weapon to control type 2 diabetes mellitus. (2017) Nature Reviews Endocrinology. 13(10):599-609. DOI: 10.1038/nrendo.2017.78
Liu, H., Naxerova, K., Pinter, M., Incio, J., Lee, H., Shigeta, K., Ho, W.W., Crain, J.A., Jacobson, A., Michelakos, T., Dias-Santos, D., Zanconato, A., Hong, T.S., Clark, J.W., Murphy, J.E., Ryan, D.P., Deshpande, V., Lillemoe, K.D., Fernandez-Del Castillo, C., Downes, M., Evans, R.M., Michaelson, J., Ferrone, C.R., Boucher, Y., Jain, R.K. Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma. (2017) 临床癌症研究. 23(19):5959-5969. DOI: 10.1158/1078-0432.CCR-17-0256
Fan, W., Waizenegger, W., Lin, C.S., Sorrentino, V., He, M.X., Wall, C.E., Li, H., Liddle, C., Yu, R.T., Atkins, A.R., Auwerx, J., Downes, M., Evans, R.M. PPARδ Promotes Running Endurance by Preserving Glucose. (2017) Cell Metabolism. 25(5):1186-1193.e4. DOI: 10.1016/j.cmet.2017.04.006
Doktorova, M., Zwarts, I., Zutphen, T.V., Dijk, T.H., Bloks, V.W., Harkema, L., Bruin, A., Downes, M., Evans, R.M., Verkade, H.J., Jonker, J.W. Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia. (2017) 科学报告. 7(1):846. DOI: 10.1038/s41598-017-00889-z
Evan, G.I., Hah, N., Littlewood, T.D., Sodir, N.M., Campos, T., Downes, M., Evans, R.M. Re-engineering the Pancreas Tumor Microenvironment: A "Regenerative Program" Hacked. (2017) 临床癌症研究. 23(7):1647-1655. DOI: 10.1158/1078-0432.CCR-16-3275
Wu, C.C., Baiga, T.J., Downes, M., La Clair, J.J., Atkins, A.R., Richard, S.B., Fan, W., Stockley-Noel, T.A., Bowman, M.E., Noel, J.P., Evans, R.M. Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ. (2017) 美国国家科学院院刊. 114(13):E2563-E2570. DOI: 10.1073/pnas.1621513114
De Magalhaes Filho, C.D., Downes, M., Evans, R.M. Farnesoid X Receptor an Emerging Target to Combat Obesity. (2017) Digestive Diseases. 35(3):185-190. DOI: 10.1159/000450909
Chen, S., Lu, W., Yueh, M.F., Rettenmeier, E., Liu, M., Auwerx, J., Yu, R.T., Evans, R.M., Wang, K., Karin, M., Tukey, R.H. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. (2017) 美国国家科学院院刊. 114(8):E1432-E1440. DOI: 10.1073/pnas.1700232114
Fan, W., Evans, R.M. Exercise Mimetics: Impact on Health and Performance. (2017) Cell Metabolism. 25(2):242-247. DOI: 10.1016/j.cmet.2016.10.022
Sherman, M.H., Yu, R.T., Tseng, T.W., Sousa, C.M., Liu, S., Truitt, M.L., He, N., Ding, N., Liddle, C., Atkins, A.R., Leblanc, M., Collisson, E.A., Asara, J.M., Kimmelman, A.C., Downes, M., Evans, R.M. Stromal cues regulate the pancreatic cancer epigenome and metabolome. (2017) 美国国家科学院院刊. 114(5):1129-1134. DOI: 10.1073/pnas.1620164114
Chung, H.K., Ryu, D., Kim, K.S., Chang, J.Y., Kim, Y.K., Yi, H.S., Kang, S.G., Choi, M.J., Lee, S.E., Jung, S.B., Ryu, M.J., Kim, S.J., Kweon, G.R., Kim, H., Hwang, J.H., Lee, C.H., Lee, S.J., Wall, C.E., Downes, M., Evans, R.M., Auwerx, J., Shong, M. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. (2017) Journal of Cell Biology. 216(1):149-165. DOI: 10.1083/jcb.201607110
Fu, T., Zhao, X., Evans, R.M. Liver Cancer Checks in When Bile Acid Clocks Out. (2016) Cancer Cell. 30(6):827-828. DOI: 10.1016/j.ccell.2016.11.012
Xia, X., Kumru, O.S., Blaber, S.I., Middaugh, C.R., Li, L., Ornitz, D.M., Suh, J.M., Atkins, A.R., Downes, M., Evans, R.M., Tenorio, C.A., Bienkiewicz, E., Blaber, M. An S116R Phosphorylation Site Mutation in Human Fibroblast Growth Factor-1 Differentially Affects Mitogenic and Glucose-Lowering Activities. (2016) Journal of Pharmaceutical Sciences. 105(12):3507-3519. DOI: 10.1016/j.xphs.2016.09.005
Evans, R.M., Wan, Y. Reply to "PPAR-γ regulates pharmacological but not physiological or pathological osteoclast formation". (2016) Nature Medicine. 22(11):1205. DOI: 10.1038/nm.4207
Fan, W., Evans, R. METABOLISM. The quest to burn fat, effortlessly and safely. (2016) 科学. 353(6301):749-50. DOI: 10.1126/science.aah6189
De Magalhaes Filho, C.D., Downes, M., Evans, R. Bile Acid Analog Intercepts Liver Fibrosis. (2016) 牢房. 166(4):789. DOI: 10.1016/j.cell.2016.08.001
Hulin, J.A., Nguyen, T.D., Cui, S., Marri, S., Yu, R.T., Downes, M., Evans, R.M., Makarenkova, H., Meech, R. Barx2 and Pax7 Regulate Axin2 Expression in Myoblasts by Interaction with β-Catenin and Chromatin Remodelling. (2016) 干细胞. 34(8):2169-82. DOI: 10.1002/stem.2396
Sousa, C.M., Biancur, D.E., Wang, X., Halbrook, C.J., Sherman, M.H., Zhang, L., Kremer, D., Hwang, R.F., Witkiewicz, A.K., Ying, H., Asara, J.M., Evans, R.M., Cantley, L.C., Lyssiotis, C.A., Kimmelman, A.C. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. (2016) 自然. 536(7617):479-83. DOI: 10.1038/nature19084
Eichenfield, D.Z., Troutman, T.D., Link, V.M., Lam, M.T., Cho, H., Gosselin, D., Spann, N.J., Lesch, H.P., Tao, J., Muto, J., Gallo, R.L., Evans, R.M., Glass, C.K. Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages. (2016) Elife. 5. DOI: 10.7554/eLife.13024
Wall, C.E., Yu, R.T., Atkins, A.R., Downes, M., Evans, R.M. Nuclear receptors and AMPK: can exercise mimetics cure diabetes? (2016) Journal of Molecular Endocrinology. 57(1):R49-58. DOI: 10.1530/JME-16-0073
Zhao, X., Hirota, T., Han, X., Cho, H., Chong, L.W., Lamia, K., Liu, S., Atkins, A.R., Banayo, E., Liddle, C., Yu, R.T., Yates, J.R., Kay, S.A., Downes, M., Evans, R.M. Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation. (2016) 牢房. 165(7):1644-1657. DOI: 10.1016/j.cell.2016.05.012
Booth, D.R., Ding, N., Parnell, G.P., Shahijanian, F., Coulter, S., Schibeci, S.D., Atkins, A.R., Stewart, G.J., Evans, R.M., Downes, M., Liddle, C. Cistromic and genetic evidence that the vitamin D receptor mediates susceptibility to latitude-dependent autoimmune diseases. (2016) Genes and Immunity. 17(4):213-9. DOI: 10.1038/gene.2016.12
Wang, J., Zou, J.X., Xue, X., Cai, D., Zhang, Y., Duan, Z., Xiang, Q., Yang, J.C., Louie, M.C., Borowsky, A.D., Gao, A.C., Evans, C.P., Lam, K.S., Xu, J., Kung, H.J., Evans, R.M., Xu, Y., Chen, H.W. ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. (2016) Nature Medicine. 22(5):488-96. DOI: 10.1038/nm.4070
Yoshihara, E., Wei, Z., Lin, C.S., Fang, S., Ahmadian, M., Kida, Y., Tseng, T., Dai, Y., Yu, R.T., Liddle, C., Atkins, A.R., Downes, M., Evans, R.M. ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells. (2016) Cell Metabolism. 23(4):622-34. DOI: 10.1016/j.cmet.2016.03.005
Heldin, C.H., Lu, B., Evans, R., Gutkind, J.S. Signals and Receptors. (2016) 冷泉港生物学述评. 8(4):a005900. DOI: 10.1101/cshperspect.a005900
Zheng, X., Boyer, L., Jin, M., Kim, Y., Fan, W., Bardy, C., Berggren, T., Evans, R.M., Gage, F.H., Hunter, T. Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration. (2016) Elife. 5. DOI: 10.7554/eLife.13378
Liu, W., Struik, D., Nies, V.J., Jurdzinski, A., Harkema, L., de Bruin, A., Verkade, H.J., Downes, M., Evans, R.M., van Zutphen, T., Jonker, J.W. Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease. (2016) 美国国家科学院院刊. 113(8):2288-93. DOI: 10.1073/pnas.1525093113
Kim, J.A., Roy, R.R., Zhong, H., Alaynick, W.A., Embler, E., Jang, C., Gomez, G., Sonoda, T., Evans, R.M., Edgerton, V.R. PPARδ preserves a high resistance to fatigue in the mouse medial gastrocnemius after spinal cord transection. (2016) Muscle Nerve. 53(2):287-96. DOI: 10.1002/mus.24723
Nies, V.J., Sancar, G., Liu, W., van Zutphen, T., Struik, D., Yu, R.T., Atkins, A.R., Evans, R.M., Jonker, J.W., Downes, M.R. Fibroblast Growth Factor Signaling in Metabolic Regulation. (2016) Frontiers in Endocrinology. 6:193. DOI: 10.3389/fendo.2015.00193
Hah, N., Sherman, M.H., Yu, R.T., Downes, M., Evans, R.M. Targeting Transcriptional and Epigenetic Reprogramming in Stromal Cells in Fibrosis and Cancer. (2016) 冷泉港定量生物学研讨会。. 80:249-55. DOI: 10.1101/sqb.2015.80.027185
Ding, N., Hah, N., Yu, R.T., Sherman, M.H., Benner, C., Leblanc, M., He, M., Liddle, C., Downes, M., Evans, R.M. BRD4 is a novel therapeutic target for liver fibrosis. (2015) 美国国家科学院院刊. 112(51):15713-8. DOI: 10.1073/pnas.1522163112
Bapat, S.P., Myoung Suh, J., Fang, S., Liu, S., Zhang, Y., Cheng, A., Zhou, C., Liang, Y., LeBlanc, M., Liddle, C., Atkins, A.R., Yu, R.T., Downes, M., Evans, R.M., Zheng, Y. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. (2015) 自然. 528(7580):137-41. DOI: 10.1038/nature16151
Arensman, M.D., Nguyen, P., Kershaw, K.M., Lay, A.R., Ostertag-Hill, C.A., Sherman, M.H., Downes, M., Liddle, C., Evans, R.M., Dawson, D.W. Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer. (2015) Molecular Cancer Research. 13(11):1509-19. DOI: 10.1158/1541-7786.MCR-15-0204
Jo, Y.S., Ryu, D., Maida, A., Wang, X., Evans, R.M., Schoonjans, K., Auwerx, J. Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice. (2015) Hepatology. 62(5):1606-18. DOI: 10.1002/hep.27907
Schieber, A.M., Lee, Y.M., Chang, M.W., Leblanc, M., Collins, B., Downes, M., Evans, R.M., Ayres, J.S. Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling. (2015) 科学. 350(6260):558-63. DOI: 10.1126/science.aac6468
Ranjit, S., Dvornikov, A., Stakic, M., Hong, S.H., Levi, M., Evans, R.M., Gratton, E. Imaging Fibrosis and Separating Collagens using Second Harmonic Generation and Phasor Approach to Fluorescence Lifetime Imaging. (2015) 科学报告. 5:13378. DOI: 10.1038/srep13378
Mounsey, R.B., Martin, H.L., Nelson, M.C., Evans, R.M., Teismann, P. The effect of neuronal conditional knock-out of peroxisome proliferator-activated receptors in the MPTP mouse model of Parkinson's disease. (2015) Neuroscience. 300:576-84. DOI: 10.1016/j.neuroscience.2015.05.048
Wall, C.E., Whyte, J., Suh, J.M., Fan, W., Collins, B., Liddle, C., Yu, R.T., Atkins, A.R., Naviaux, J.C., Li, K., Bright, A.T., Alaynick, W.A., Downes, M., Naviaux, R.K., Evans, R.M. High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice. (2015) 美国国家科学院院刊. 112(28):8714-9. DOI: 10.1073/pnas.1509930112
Fan, W., Evans, R.M. Turning up the heat on membrane fluidity. (2015) 牢房. 161(5):962-3. DOI: 10.1016/j.cell.2015.04.046
Kida, Y.S., Kawamura, T., Wei, Z., Sogo, T., Jacinto, S., Shigeno, A., Kushige, H., Yoshihara, E., Liddle, C., Ecker, J.R., Yu, R.T., Atkins, A.R., Downes, M., Evans, R.M. ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency. (2015) 细胞干细胞. 16(5):547-55. DOI: 10.1016/j.stem.2015.03.001
Pei, L., Mu, Y., Leblanc, M., Alaynick, W., Barish, G.D., Pankratz, M., Tseng, T.W., Kaufman, S., Liddle, C., Yu, R.T., Downes, M., Pfaff, S.L., Auwerx, J., Gage, F.H., Evans, R.M. Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolism. (2015) Cell Metabolism. 21(4):628-36. DOI: 10.1016/j.cmet.2015.03.004
Wang, T., McDonald, C., Petrenko, N.B., Leblanc, M., Wang, T., Giguere, V., Evans, R.M., Patel, V.V., Pei, L. Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and function. (2015) 分子与细胞生物学. 35(7):1281-98. DOI: 10.1128/MCB.01156-14
Fan, W., Evans, R. PPARs and ERRs: molecular mediators of mitochondrial metabolism. (2015) 细胞生物学进展. 33:49-54. DOI: 10.1016/j.ceb.2014.11.002
Morinaga, H., Mayoral, R., Heinrichsdorff, J., Osborn, O., Franck, N., Hah, N., Walenta, E., Bandyopadhyay, G., Pessentheiner, A.R., Chi, T.J., Chung, H., Bogner-Strauss, J.G., Evans, R.M., Olefsky, J.M., Oh, D.Y. Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. (2015) Diabetes. 64(4):1120-30. DOI: 10.2337/db14-1238
Hutchison, A.M., Topliss, C., Beard, D., Evans, R.M., Williams, P. The treatment of a rupture of the Achilles tendon using a dedicated management programme. (2015) Bone Joint J. 97-B(4):510-515. DOI: 10.1302/0301-620X.97B4.35314
Fang, S., Suh, J.M., Reilly, S.M., Yu, E., Osborn, O., Lackey, D., Yoshihara, E., Perino, A., Jacinto, S., Lukasheva, Y., Atkins, A.R., Khvat, A., Schnabl, B., Yu, R.T., Brenner, D.A., Coulter, S., Liddle, C., Schoonjans, K., Olefsky, J.M., Saltiel, A.R., Downes, M., Evans, R.M. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. (2015) Nature Medicine. 21(2):159-65. DOI: 10.1038/nm.3760
Reilly, S.M., Ahmadian, M., Zamarron, B.F., Chang, L., Uhm, M., Poirier, B., Peng, X., Krause, D.M., Korytnaya, E., Neidert, A., Liddle, C., Yu, R.T., Lumeng, C.N., Oral, E.A., Downes, M., Evans, R.M., Saltiel, A.R. A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. (2015) 自然-通讯. 6:6047. DOI: 10.1038/ncomms7047
Hah, N., Benner, C., Chong, L.W., Yu, R.T., Downes, M., Evans, R.M. Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs. (2015) 美国国家科学院院刊. 112(3):E297-302. DOI: 10.1073/pnas.1424028112
McKenna, N.J., Evans, R.M., O'Malley, B.W. Nuclear Receptor Signaling: a home for nuclear receptor and coregulator signaling research. (2014) Nuclear Receptor Signaling. 12:e006. DOI: 10.1621/nrs.12006
Yueh, M.F., Taniguchi, K., Chen, S., Evans, R.M., Hammock, B.D., Karin, M., Tukey, R.H. The commonly used antimicrobial additive triclosan is a liver tumor promoter. (2014) 美国国家科学院院刊. 111(48):17200-5. DOI: 10.1073/pnas.1419119111
Williamson, J.J., Evans, R.M. Measuring local volume fraction, long-wavelength correlations, and fractionation in a phase-separating polydisperse fluid. (2014) J Chem Phys. 141(16):164901. DOI: 10.1063/1.4897560
Sherman, M.H., Yu, R.T., Engle, D.D., Ding, N., Atkins, A.R., Tiriac, H., Collisson, E.A., Connor, F., Van Dyke, T., Kozlov, S., Martin, P., Tseng, T.W., Dawson, D.W., Donahue, T.R., Masamune, A., Shimosegawa, T., Apte, M.V., Wilson, J.S., Ng, B., Lau, S.L., Gunton, J.E., Wahl, G.M., Hunter, T., Drebin, J.A., O'Dwyer, P.J., Liddle, C., Tuveson, D.A., Downes, M., Evans, R.M. 维生素D受体介导的基质重编程可抑制胰腺炎并增强胰腺癌治疗效果。. (2014) 牢房. 159(1):80-93. DOI: 10.1016/j.cell.2014.08.007
Takada, H., Saito, Y., Mituyama, T., Wei, Z., Yoshihara, E., Jacinto, S., Downes, M., Evans, R.M., Kida, Y.S. Methylome, transcriptome, and PPAR(γ) cistrome analyses reveal two epigenetic transitions in fat cells. (2014) 表观遗传学. 9(9):1195-206. DOI: 10.4161/epi.29856
Suh, J.M., Jonker, J.W., Ahmadian, M., Goetz, R., Lackey, D., Osborn, O., Huang, Z., Liu, W., Yoshihara, E., van Dijk, T.H., Havinga, R., Fan, W., Yin, Y.Q., Yu, R.T., Liddle, C., Atkins, A.R., Olefsky, J.M., Mohammadi, M., Downes, M., Evans, R.M. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. (2014) 自然. 513(7518):436-9. DOI: 10.1038/nature13540
Lu, B., Bridges, D., Yang, Y., Fisher, K., Cheng, A., Chang, L., Meng, Z.X., Lin, J.D., Downes, M., Yu, R.T., Liddle, C., Evans, R.M., Saltiel, A.R. Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity. (2014) Diabetes. 63(9):2935-48. DOI: 10.2337/db13-1531
Korf, K., Wodrich, H., Haschke, A., Ocampo, C., Harder, L., Gieseke, F., Pollmann, A., Dierck, K., Prall, S., Staege, H., Ma, H., Horstmann, M.A., Evans, R.M., Sternsdorf, T. The PML domain of PML-RARα blocks senescence to promote leukemia. (2014) 美国国家科学院院刊. 111(33):12133-8. DOI: 10.1073/pnas.1412944111
Oh, D.Y., Walenta, E., Akiyama, T.E., Lagakos, W.S., Lackey, D., Pessentheiner, A.R., Sasik, R., Hah, N., Chi, T.J., Cox, J.M., Powels, M.A., Di Salvo, J., Sinz, C., Watkins, S.M., Armando, A.M., Chung, H., Evans, R.M., Quehenberger, O., McNelis, J., Bogner-Strauss, J.G., Olefsky, J.M. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. (2014) Nature Medicine. 20(8):942-7. DOI: 10.1038/nm.3614
Daniel, B., Nagy, G., Hah, N., Horvath, A., Czimmerer, Z., Poliska, S., Gyuris, T., Keirsse, J., Gysemans, C., Van Ginderachter, J.A., Balint, B.L., Evans, R.M., Barta, E., Nagy, L. The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages. (2014) 基因与发展. 28(14):1562-77. DOI: 10.1101/gad.242685.114
Zhuang, L., Hulin, J.A., Gromova, A., Tran Nguyen, T.D., Yu, R.T., Liddle, C., Downes, M., Evans, R.M., Makarenkova, H.P., Meech, R. Barx2 and Pax7 have antagonistic functions in regulation of wnt signaling and satellite cell differentiation. (2014) 干细胞. 32(6):1661-73. DOI: 10.1002/stem.1674
Zhao, X., Cho, H., Yu, R.T., Atkins, A.R., Downes, M., Evans, R.M. Nuclear receptors rock around the clock. (2014) EMBO 报告. 15(5):518-28. DOI: 10.1002/embr.201338271
Hong, S.H., Ahmadian, M., Yu, R.T., Atkins, A.R., Downes, M., Evans, R.M. Nuclear receptors and metabolism: from feast to famine. (2014) Diabetologia. 57(5):860-7. DOI: 10.1007/s00125-014-3209-9
Liu, S., Evans, R.M. Metabolism: Tick, tock, a high-fat clock. (2014) Nature Reviews Endocrinology. 10(4):191-2. DOI: 10.1038/nrendo.2014.23
d'Uscio, L.V., He, T., Santhanam, A.V., Tai, L.J., Evans, R.M., Katusic, Z.S. Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-δ gene. (2014) Am. J. Physiol. Heart Circ. Physiol. 306(7):H1001-10. DOI: 10.1152/ajpheart.00761.2013
Evans, R.M., Mangelsdorf, D.J. Nuclear Receptors, RXR, and the Big Bang. (2014) 牢房. 157(1):255-66. DOI: 10.1016/j.cell.2014.03.012
Fan, W., Atkins, A.R., Yu, R.T., Downes, M., Evans, R.M. Road to exercise mimetics: targeting nuclear receptors in skeletal muscle. (2013) Journal of Molecular Endocrinology. 51(3):T87-T100. DOI: 10.1530/JME-13-0258
Evans, R.M. Journal of Molecular Endocrinology 25th anniversary special issue. (2013) Journal of Molecular Endocrinology. 51(3):E1-3. DOI: 10.1530/JME-13-0257
Hong, S.H., Dvorak-Ewell, M., Stevens, H.Y., Barish, G.D., Castro, G.L., Nofsinger, R., Frangos, J.A., Shoback, D., Evans, R.M. Rescue of a primary myelofibrosis model by retinoid-antagonist therapy. (2013) 美国国家科学院院刊. 110(47):18820-5. DOI: 10.1073/pnas.1318974110
Ding, N., Liddle, C., Evans, R.M., Downes, M. Hepatic actions of vitamin D receptor ligands: a sunshine option for chronic liver disease? (2013) Expert Rev Clin Pharmacol. 6(6):597-9. DOI: 10.1586/17512433.2013.841078
Kittayaruksakul, S., Zhao, W., Xu, M., Ren, S., Lu, J., Wang, J., Downes, M., Evans, R.M., Venkataramanan, R., Chatsudthipong, V., Xie, W. Identification of three novel natural product compounds that activate PXR and CAR and inhibit inflammation. (2013) Pharmaceutical Research. 30(9):2199-208. DOI: 10.1007/s11095-013-1101-9
Fang, S., Evans, R.M. Microbiology: Wealth management in the gut. (2013) 自然. 500(7464):538-9. DOI: 10.1038/500538a
Lam, M.T., Cho, H., Lesch, H.P., Gosselin, D., Heinz, S., Tanaka-Oishi, Y., Benner, C., Kaikkonen, M.U., Kim, A.S., Kosaka, M., Lee, C.Y., Watt, A., Grossman, T.R., Rosenfeld, M.G., Evans, R.M., Glass, C.K. Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. (2013) 自然. 498(7455):511-5. DOI: 10.1038/nature12209
Martin, H.L., Mounsey, R.B., Sathe, K., Mustafa, S., Nelson, M.C., Evans, R.M., Teismann, P. A peroxisome proliferator-activated receptor-δ agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. (2013) Neuroscience. 240:191-203. DOI: 10.1016/j.neuroscience.2013.02.058
Ahmadian, M., Suh, J.M., Hah, N., Liddle, C., Atkins, A.R., Downes, M., Evans, R.M. PPARγ signaling and metabolism: the good, the bad and the future. (2013) Nature Medicine. 19(5):557-66. DOI: 10.1038/nm.3159
Du, L., Bergsneider, M., Mirsadraei, L., Young, S.H., Jonker, J.W., Downes, M., Yong, W.H., Evans, R.M., Heaney, A.P. Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease. (2013) 美国国家科学院院刊. 110(21):8555-60. DOI: 10.1073/pnas.1306182110
Ding, N., Yu, R.T., Subramaniam, N., Sherman, M.H., Wilson, C., Rao, R., Leblanc, M., Coulter, S., He, M., Scott, C., Lau, S.L., Atkins, A.R., Barish, G.D., Gunton, J.E., Liddle, C., Downes, M., Evans, R.M. A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response. (2013) 牢房. 153(3):601-13. DOI: 10.1016/j.cell.2013.03.028
Reilly, S.M., Chiang, S.H., Decker, S.J., Chang, L., Uhm, M., Larsen, M.J., Rubin, J.R., Mowers, J., White, N.M., Hochberg, I., Downes, M., Yu, R.T., Liddle, C., Evans, R.M., Oh, D., Li, P., Olefsky, J.M., Saltiel, A.R. An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. (2013) Nature Medicine. 19(3):313-21. DOI: 10.1038/nm.3082
Chao, L.C., Soto, E., Hong, C., Ito, A., Pei, L., Chawla, A., Conneely, O.M., Tangirala, R.K., Evans, R.M., Tontonoz, P. Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice. (2013) Journal of Lipid Research. 54(3):806-15. DOI: 10.1194/jlr.M034157
Zhao, X., Cho, H., Evans, R.M. SRF'ing around the clock. (2013) 牢房. 152(3):381-2. DOI: 10.1016/j.cell.2013.01.028
Uhlenhaut, N.H., Barish, G.D., Yu, R.T., Downes, M., Karunasiri, M., Liddle, C., Schwalie, P., Hübner, N., Evans, R.M. Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes. (2013) 分子细胞. 49(1):158-71. DOI: 10.1016/j.molcel.2012.10.013
Chao, L.C., Wroblewski, K., Ilkayeva, O.R., Stevens, R.D., Bain, J., Meyer, G.A., Schenk, S., Martinez, L., Vergnes, L., Narkar, V.A., Drew, B.G., Hong, C., Boyadjian, R., Hevener, A.L., Evans, R.M., Reue, K., Spencer, M.J., Newgard, C.B., Tontonoz, P. Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. (2012) Journal of Lipid Research. 53(12):2610-9. DOI: 10.1194/jlr.M029355
Li, T., Yu, R.T., Atkins, A.R., Downes, M., Tukey, R.H., Evans, R.M. Targeting the pregnane X receptor in liver injury. (2012) Expert Opinion on Therapeutic Targets. 16(11):1075-83. DOI: 10.1517/14728222.2012.715634
Zhang, Y., Xie, Y., Berglund, E.D., Coate, K.C., He, T.T., Katafuchi, T., Xiao, G., Potthoff, M.J., Wei, W., Wan, Y., Yu, R.T., Evans, R.M., Kliewer, S.A., Mangelsdorf, D.J. The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. (2012) Elife. 1:e00065. DOI: 10.7554/eLife.00065
Ito, K., Carracedo, A., Weiss, D., Arai, F., Ala, U., Avigan, D.E., Schafer, Z.T., Evans, R.M., Suda, T., Lee, C.H., Pandolfi, P.P. A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. (2012) Nature Medicine. 18(9):1350-8. DOI: 10.1038/nm.2882
Chen, S., Yueh, M.F., Evans, R.M., Tukey, R.H. Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice. (2012) Hepatology. 56(2):658-67. DOI: 10.1002/hep.25671
Yueh, M.F., Li, T., Evans, R.M., Hammock, B., Tukey, R.H. Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. (2012) PLOS One. 7(6):e37705. DOI: 10.1371/journal.pone.0037705
Jonker, J.W., Suh, J.M., Atkins, A.R., Ahmadian, M., Li, P., Whyte, J., He, M., Juguilon, H., Yin, Y.Q., Phillips, C.T., Yu, R.T., Olefsky, J.M., Henry, R.R., Downes, M., Evans, R.M. A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. (2012) 自然. 485(7398):391-4. DOI: 10.1038/nature10998
Iwaisako, K., Haimerl, M., Paik, Y.H., Taura, K., Kodama, Y., Sirlin, C., Yu, E., Yu, R.T., Downes, M., Evans, R.M., Brenner, D.A., Schnabl, B. Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist. (2012) 美国国家科学院院刊. 109(21):E1369-76. DOI: 10.1073/pnas.1202464109
Barish, G.D., Yu, R.T., Karunasiri, M.S., Becerra, D., Kim, J., Tseng, T.W., Tai, L.J., Leblanc, M., Diehl, C., Cerchietti, L., Miller, Y.I., Witztum, J.L., Melnick, A.M., Dent, A.L., Tangirala, R.K., Evans, R.M. The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. (2012) Cell Metabolism. 15(4):554-62. DOI: 10.1016/j.cmet.2012.02.012
Matsakas, A., Yadav, V., Lorca, S., Evans, R.M., Narkar, V.A. Revascularization of ischemic skeletal muscle by estrogen-related receptor-γ. (2012) Circulation research. 110(8):1087-96. DOI: 10.1161/CIRCRESAHA.112.266478
Subramaniam, N., Sherman, M.H., Rao, R., Wilson, C., Coulter, S., Atkins, A.R., Evans, R.M., Liddle, C., Downes, M. Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling. (2012) Cancer Prevention Research. 5(4):553-61. DOI: 10.1158/1940-6207.CAPR-12-0053
Li, M.D., Ruan, H.B., Singh, J.P., Zhao, L., Zhao, T., Azarhoush, S., Wu, J., Evans, R.M., Yang, X. O-GlcNAc transferase is involved in glucocorticoid receptor-mediated transrepression. (2012) 生物化学杂志. 287(16):12904-12. DOI: 10.1074/jbc.M111.303792
Noreault-Conti, T.L., Fellows, A., Jacobs, J.M., Trask, H.W., Strom, S.C., Evans, R.M., Wrighton, S.A., Sinclair, P.R., Sinclair, J.F., Nichols, R.C. Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes. (2012) International Immunopharmacology. 12(4):651-6. DOI: 10.1016/j.intimp.2012.01.008
Cho, H., Zhao, X., Hatori, M., Yu, R.T., Barish, G.D., Lam, M.T., Chong, L.W., DiTacchio, L., Atkins, A.R., Glass, C.K., Liddle, C., Auwerx, J., Downes, M., Panda, S., Evans, R.M. Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. (2012) 自然. 485(7396):123-7. DOI: 10.1038/nature11048
Evans, R. Wylie Walker Vale Jr (1941-2012). (2012) 自然. 483(7391):542. DOI: 10.1038/483542a
Shimozaki, K., Zhang, C.L., Suh, H., Denli, A.M., Evans, R.M., Gage, F.H. SRY-box-containing gene 2 regulation of nuclear receptor tailless (Tlx) transcription in adult neural stem cells. (2012) 生物化学杂志. 287(8):5969-78. DOI: 10.1074/jbc.M111.290403
Panopoulos, A.D., Yanes, O., Ruiz, S., Kida, Y.S., Diep, D., Tautenhahn, R., Herrerías, A., Batchelder, E.M., Plongthongkum, N., Lutz, M., Berggren, W.T., Zhang, K., Evans, R.M., Siuzdak, G., Izpisua Belmonte, J.C. The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming. (2012) Cell Research. 22(1):168-77. DOI: 10.1038/cr.2011.177
Sherman, M.H., Downes, M., Evans, R.M. Nuclear receptors as modulators of the tumor microenvironment. (2012) Cancer Prevention Research. 5(1):3-10. DOI: 10.1158/1940-6207.CAPR-11-0528
Fan, W., Downes, M., Atkins, A., Yu, R., Evans, R.M. Nuclear receptors and AMPK: resetting metabolism. (2011) 冷泉港定量生物学研讨会。. 76:17-22. DOI: 10.1101/sqb.2012.76.010470
Lamia, K.A., Papp, S.J., Yu, R.T., Barish, G.D., Uhlenhaut, N.H., Jonker, J.W., Downes, M., Evans, R.M. Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. (2011) 自然. 480(7378):552-6. DOI: 10.1038/nature10700
Krebs, P., Fan, W., Chen, Y.H., Tobita, K., Downes, M.R., Wood, M.R., Sun, L., Li, X., Xia, Y., Ding, N., Spaeth, J.M., Moresco, E.M., Boyer, T.G., Lo, C.W., Yen, J., Evans, R.M., Beutler, B. Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. (2011) 美国国家科学院院刊. 108(49):19678-82. DOI: 10.1073/pnas.1117835108
Yamamoto, H., Williams, E.G., Mouchiroud, L., Cantó, C., Fan, W., Downes, M., Héligon, C., Barish, G.D., Desvergne, B., Evans, R.M., Schoonjans, K., Auwerx, J. NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. (2011) 牢房. 147(4):827-39. DOI: 10.1016/j.cell.2011.10.017
Pei, L., Leblanc, M., Barish, G., Atkins, A., Nofsinger, R., Whyte, J., Gold, D., He, M., Kawamura, K., Li, H.R., Downes, M., Yu, R.T., Powell, H.C., Lingrel, J.B., Evans, R.M. Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome. (2011) Nature Medicine. 17(11):1466-72. DOI: 10.1038/nm.2450
Murphy, S.H., Suzuki, K., Downes, M., Welch, G.L., De Jesus, P., Miraglia, L.J., Orth, A.P., Chanda, S.K., Evans, R.M., Verma, I.M. Tumor suppressor protein (p)53, is a regulator of NF-kappaB repression by the glucocorticoid receptor. (2011) 美国国家科学院院刊. 108(41):17117-22. DOI: 10.1073/pnas.1114420108
Sugii, S., Evans, R.M. Epigenetic codes of PPARγ in metabolic disease. (2011) FEBS Lett. 585(13):2121-8. DOI: 10.1016/j.febslet.2011.05.007
Mihaylova, M.M., Vasquez, D.S., Ravnskjaer, K., Denechaud, P.D., Yu, R.T., Alvarez, J.G., Downes, M., Evans, R.M., Montminy, M., Shaw, R.J. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. (2011) 牢房. 145(4):607-21. DOI: 10.1016/j.cell.2011.03.043
Kacevska, M., Downes, M.R., Sharma, R., Evans, R.M., Clarke, S.J., Liddle, C., Robertson, G.R. Extrahepatic cancer suppresses nuclear receptor-regulated drug metabolism. (2011) 临床癌症研究. 17(10):3170-80. DOI: 10.1158/1078-0432.CCR-10-3289
Sugii, S., Kida, Y., Berggren, W.T., Evans, R.M. Feeder-dependent and feeder-independent iPS cell derivation from human and mouse adipose stem cells. (2011) Nature Protocols. 6(3):346-58. DOI: 10.1038/nprot.2010.199
Narkar, V.A., Fan, W., Downes, M., Yu, R.T., Jonker, J.W., Alaynick, W.A., Banayo, E., Karunasiri, M.S., Lorca, S., Evans, R.M. Exercise and PGC-1α-independent synchronization of type I muscle metabolism and vasculature by ERRγ. (2011) Cell Metabolism. 13(3):283-93. DOI: 10.1016/j.cmet.2011.01.019
Lister, R., Pelizzola, M., Kida, Y.S., Hawkins, R.D., Nery, J.R., Hon, G., Antosiewicz-Bourget, J., O'Malley, R., Castanon, R., Klugman, S., Downes, M., Yu, R., Stewart, R., Ren, B., Thomson, J.A., Evans, R.M., Ecker, J.R. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. (2011) 自然. 471(7336):68-73. DOI: 10.1038/nature09798
Diehl, C.J., Barish, G.D., Downes, M., Chou, M.Y., Heinz, S., Glass, C.K., Evans, R.M., Witztum, J.L. Research resource: Comparative nuclear receptor atlas: basal and activated peritoneal B-1 and B-2 cells. (2011) Molecular Endocrinology. 25(3):529-45. DOI: 10.1210/me.2010-0384
Berry, R., Harewood, L., Pei, L., Fisher, M., Brownstein, D., Ross, A., Alaynick, W.A., Moss, J., Hastie, N.D., Hohenstein, P., Davies, J.A., Evans, R.M., FitzPatrick, D.R. Esrrg functions in early branch generation of the ureteric bud and is essential for normal development of the renal papilla. (2011) Human Molecular Genetics. 20(5):917-26. DOI: 10.1093/hmg/ddq530
Fang, S., Suh, J.M., Atkins, A.R., Hong, S.H., Leblanc, M., Nofsinger, R.R., Yu, R.T., Downes, M., Evans, R.M. Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance. (2011) 美国国家科学院院刊. 108(8):3412-7. DOI: 10.1073/pnas.1017707108
Barish, G.D., Yu, R.T., Karunasiri, M., Ocampo, C.B., Dixon, J., Benner, C., Dent, A.L., Tangirala, R.K., Evans, R.M. Bcl-6 and NF-kappaB cistromes mediate opposing regulation of the innate immune response. (2010) 基因与发展. 24(24):2760-5. DOI: 10.1101/gad.1998010
Reilly, S.M., Bhargava, P., Liu, S., Gangl, M.R., Gorgun, C., Nofsinger, R.R., Evans, R.M., Qi, L., Hu, F.B., Lee, C.H. Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration. (2010) Cell Metabolism. 12(6):643-53. DOI: 10.1016/j.cmet.2010.11.007
Szanto, A., Balint, B.L., Nagy, Z.S., Barta, E., Dezso, B., Pap, A., Szeles, L., Poliska, S., Oros, M., Evans, R.M., Barak, Y., Schwabe, J., Nagy, L. STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells. (2010) Immunity. 33(5):699-712. DOI: 10.1016/j.immuni.2010.11.009
Lamia, K.A., Evans, R.M. Metabolism: Tick, tock, a beta-cell clock. (2010) 自然. 466(7306):571-2. DOI: 10.1038/466571a
Wei, W., Wang, X., Yang, M., Smith, L.C., Dechow, P.C., Sonoda, J., Evans, R.M., Wan, Y. PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss. (2010) Cell Metabolism. 11(6):503-16. DOI: 10.1016/j.cmet.2010.04.015
Shaw, R.J., Evans, R.M., Simon, M.C. Metabolism and cancer in La Jolla. (2010) 癌症研究. 70(10):3864-9. DOI: 10.1158/0008-5472.CAN-09-4529
Sugii, S., Kida, Y., Kawamura, T., Suzuki, J., Vassena, R., Yin, Y.Q., Lutz, M.K., Berggren, W.T., Izpisúa Belmonte, J.C., Evans, R.M. Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells. (2010) 美国国家科学院院刊. 107(8):3558-63. DOI: 10.1073/pnas.0910172106
Alaynick, W.A., Way, J.M., Wilson, S.A., Benson, W.G., Pei, L., Downes, M., Yu, R., Jonker, J.W., Holt, J.A., Rajpal, D.K., Li, H., Stuart, J., McPherson, R., Remlinger, K.S., Chang, C.Y., McDonnell, D.P., Evans, R.M., Billin, A.N. ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. (2010) Molecular Endocrinology. 24(2):299-309. DOI: 10.1210/me.2009-0114
Wan, Y., Evans, R.M. Rosiglitazone activation of PPARgamma suppresses fractalkine signaling. (2010) Journal of Molecular Endocrinology. 44(2):135-42. DOI: 10.1677/JME-09-0090
Jiang, Y.J., Barish, G., Lu, B., Evans, R.M., Crumrine, D., Schmuth, M., Elias, P.M., Feingold, K.R. PPARδ activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation. (2010) 皮肤病学研究杂志. 130(2):511-9. DOI: 10.1038/jid.2009.245
Qu, Q., Sun, G., Li, W., Yang, S., Ye, P., Zhao, C., Yu, R.T., Gage, F.H., Evans, R.M., Shi, Y. Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal. (2010) 自然-细胞生物学. 12(1):31-40; sup pp 1-9. DOI: 10.1038/ncb2001
Sugii, S., Olson, P., Sears, D.D., Saberi, M., Atkins, A.R., Barish, G.D., Hong, S.H., Castro, G.L., Yin, Y.Q., Nelson, M.C., Hsiao, G., Greaves, D.R., Downes, M., Yu, R.T., Olefsky, J.M., Evans, R.M. PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. (2009) 美国国家科学院院刊. 106(52):22504-9. DOI: 10.1073/pnas.0912487106
Alaynick, W.A., Way, J.M., Wilson, S.A., Benson, W.G., Pei, L., Downes, M., Yu, R., Jonker, J.W., Holt, J.A., Rajpal, D.K., Li, H., Stuart, J., McPherson, R., Remlinger, K.S., Yi-Chang, C., McDonnell, D.P., Evans, R.M., Billin, A.N. ERRγ Regulates Cardiac, Gastric, and Renal Potassium Homeostasis. (2009) Endocrine Reviews. 30(7):931. DOI: 10.1210/edrv.30.7.9988
Lamia, K.A., Sachdeva, U.M., DiTacchio, L., Williams, E.C., Alvarez, J.G., Egan, D.F., Vasquez, D.S., Juguilon, H., Panda, S., Shaw, R.J., Thompson, C.B., Evans, R.M. AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. (2009) 科学. 326(5951):437-40. DOI: 10.1126/science.1172156
Evans, R.M. Nuclear receptors: past, present, and future. Preface. (2009) Progress in Molecular Biology and Translational Science. 87:xi-xiii. DOI: 10.1016/S1877-1173(09)87015-4
Pei, L., Evans, R.M. Retrofitting fat metabolism. (2009) Cell Metabolism. 9(6):483-4. DOI: 10.1016/j.cmet.2009.05.006
McKenna, N.J., Cooney, A.J., DeMayo, F.J., Downes, M., Glass, C.K., Lanz, R.B., Lazar, M.A., Mangelsdorf, D.J., Moore, D.D., Qin, J., Steffen, D.L., Tsai, M.J., Tsai, S.Y., Yu, R., Margolis, R.N., Evans, R.M., O'Malley, B.W. Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. (2009) Molecular Endocrinology. 23(6):740-6. DOI: 10.1210/me.2009-0135
Nofsinger, R.R., Li, P., Hong, S.H., Jonker, J.W., Barish, G.D., Ying, H., Cheng, S.Y., Leblanc, M., Xu, W., Pei, L., Kang, Y.J., Nelson, M., Downes, M., Yu, R.T., Olefsky, J.M., Lee, C.H., Evans, R.M. SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. (2008) 美国国家科学院院刊. 105(50):20021-6. DOI: 10.1073/pnas.0811012105
Davies, B.S., Waki, H., Beigneux, A.P., Farber, E., Weinstein, M.M., Wilpitz, D.C., Tai, L.J., Evans, R.M., Fong, L.G., Tontonoz, P., Young, S.G. The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. (2008) Molecular Endocrinology. 22(11):2496-504. DOI: 10.1210/me.2008-0146
Kleiner, H.E., Xia, X., Sonoda, J., Zhang, J., Pontius, E., Abey, J., Evans, R.M., Moore, D.D., DiGiovanni, J. Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice. (2008) Toxicology and Applied Pharmacology. 232(2):337-50. DOI: 10.1016/j.taap.2008.07.004
Yang, C.S., Ko, S.R., Cho, B.G., Shin, D.M., Yuk, J.M., Li, S., Kim, J.M., Evans, R.M., Jung, J.S., Song, D.K., Jo, E.K. The ginsenoside metabolite compound K, a novel agonist of glucocorticoid receptor, induces tolerance to endotoxin-induced lethal shock. (2008) J. Cell. Mol. Med. 12(5A):1739-53. DOI: 10.1111/j.1582-4934.2007.00181.x
Narkar, V.A., Downes, M., Yu, R.T., Embler, E., Wang, Y.X., Banayo, E., Mihaylova, M.M., Nelson, M.C., Zou, Y., Juguilon, H., Kang, H., Shaw, R.J., Evans, R.M. AMPK and PPARdelta agonists are exercise mimetics. (2008) 牢房. 134(3):405-15. DOI: 10.1016/j.cell.2008.06.051
Barish, G.D., Atkins, A.R., Downes, M., Olson, P., Chong, L.W., Nelson, M., Zou, Y., Hwang, H., Kang, H., Curtiss, L., Evans, R.M., Lee, C.H. PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis. (2008) 美国国家科学院院刊. 105(11):4271-6. DOI: 10.1073/pnas.0711875105
Downes, M., Evans, R.M. Staying the distance: avoiding the proteasomal trap. (2008) Cancer Cell. 13(3):184-5. DOI: 10.1016/j.ccr.2008.02.014
Takata, Y., Liu, J., Yin, F., Collins, A.R., Lyon, C.J., Lee, C.H., Atkins, A.R., Downes, M., Barish, G.D., Evans, R.M., Hsueh, W.A., Tangirala, R.K. PPARdelta-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis. (2008) 美国国家科学院院刊. 105(11):4277-82. DOI: 10.1073/pnas.0708647105
Yang, X., Ongusaha, P.P., Miles, P.D., Havstad, J.C., Zhang, F., So, W.V., Kudlow, J.E., Michell, R.H., Olefsky, J.M., Field, S.J., Evans, R.M. Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. (2008) 自然. 451(7181):964-9. DOI: 10.1038/nature06668
Zhang, C.L., Zou, Y., He, W., Gage, F.H., Evans, R.M. A role for adult TLX-positive neural stem cells in learning and behaviour. (2008) 自然. 451(7181):1004-7. DOI: 10.1038/nature06562
Man, M.Q., Barish, G.D., Schmuth, M., Crumrine, D., Barak, Y., Chang, S., Jiang, Y., Evans, R.M., Elias, P.M., Feingold, K.R. Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation. (2008) 皮肤病学研究杂志. 128(2):370-7. DOI: 10.1038/sj.jid.5701026
Sonoda, J., Pei, L., Evans, R.M. Nuclear receptors: decoding metabolic disease. (2008) FEBS Lett. 582(1):2-9. DOI: 10.1016/j.febslet.2007.11.016
Wan, Y., Chong, L.W., Evans, R.M. PPAR-gamma regulates osteoclastogenesis in mice. (2007) Nature Medicine. 13(12):1496-503. DOI: 10.1038/nm1672
Ding, G., Fu, M., Qin, Q., Lewis, W., Kim, H.W., Fukai, T., Bacanamwo, M., Chen, Y.E., Schneider, M.D., Mangelsdorf, D.J., Evans, R.M., Yang, Q. Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage. (2007) Cardiovascular Research. 76(2):269-79. DOI: 10.1016/j.cardiores.2007.06.027
Sun, G., Yu, R.T., Evans, R.M., Shi, Y. Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation. (2007) 美国国家科学院院刊. 104(39):15282-7. DOI: 10.1073/pnas.0704089104
Sonoda, J., Laganière, J., Mehl, I.R., Barish, G.D., Chong, L.W., Li, X., Scheffler, I.E., Mock, D.C., Bataille, A.R., Robert, F., Lee, C.H., Giguère, V., Evans, R.M. Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense. (2007) 基因与发展. 21(15):1909-20. DOI: 10.1101/gad.1553007
Wan, Y., Saghatelian, A., Chong, L.W., Zhang, C.L., Cravatt, B.F., Evans, R.M. Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk. (2007) 基因与发展. 21(15):1895-908. DOI: 10.1101/gad.1567207
Alaynick, W.A., Kondo, R.P., Xie, W., He, W., Dufour, C.R., Downes, M., Jonker, J.W., Giles, W., Naviaux, R.K., Giguère, V., Evans, R.M. ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart. (2007) Cell Metabolism. 6(1):13-24. DOI: 10.1016/j.cmet.2007.06.007
Yang, X., Lamia, K.A., Evans, R.M. Nuclear receptors, metabolism, and the circadian clock. (2007) 冷泉港定量生物学研讨会。. 72:387-94. DOI: 10.1101/sqb.2007.72.058
Dufour, C.R., Wilson, B.J., Huss, J.M., Kelly, D.P., Alaynick, W.A., Downes, M., Evans, R.M., Blanchette, M., Giguère, V. Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. (2007) Cell Metabolism. 5(5):345-56. DOI: 10.1016/j.cmet.2007.03.007
Sonoda, J., Mehl, I.R., Chong, L.W., Nofsinger, R.R., Evans, R.M. PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. (2007) 美国国家科学院院刊. 104(12):5223-8. DOI: 10.1073/pnas.0611623104
Yoh, S.M., Cho, H., Pickle, L., Evans, R.M., Jones, K.A. The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. (2007) 基因与发展. 21(2):160-74. DOI: 10.1101/gad.1503107
Germain, P., Chambon, P., Eichele, G., Evans, R.M., Lazar, M.A., Leid, M., De Lera, A.R., Lotan, R., Mangelsdorf, D.J., Gronemeyer, H. International Union of Pharmacology. LXIII. Retinoid X receptors. (2006) Pharmacol. Rev. 58(4):760-72. DOI: 10.1124/pr.58.4.7
Germain, P., Chambon, P., Eichele, G., Evans, R.M., Lazar, M.A., Leid, M., De Lera, A.R., Lotan, R., Mangelsdorf, D.J., Gronemeyer, H. International Union of Pharmacology. LX. Retinoic acid receptors. (2006) Pharmacol. Rev. 58(4):712-25. DOI: 10.1124/pr.58.4.4
Kharroubi, I., Lee, C.H., Hekerman, P., Darville, M.I., Evans, R.M., Eizirik, D.L., Cnop, M. BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells. (2006) Diabetologia. 49(10):2350-8. DOI: 10.1007/s00125-006-0366-5
Yang, X., Downes, M., Yu, R.T., Bookout, A.L., He, W., Straume, M., Mangelsdorf, D.J., Evans, R.M. Nuclear receptor expression links the circadian clock to metabolism. (2006) 牢房. 126(4):801-10. DOI: 10.1016/j.cell.2006.06.050
Bookout, A.L., Jeong, Y., Downes, M., Yu, R.T., Evans, R.M., Mangelsdorf, D.J. Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. (2006) 牢房. 126(4):789-99. DOI: 10.1016/j.cell.2006.06.049
Stedman, C., Liddle, C., Coulter, S., Sonoda, J., Alvarez, J.G., Evans, R.M., Downes, M. Benefit of farnesoid X receptor inhibition in obstructive cholestasis. (2006) 美国国家科学院院刊. 103(30):11323-8. DOI: 10.1073/pnas.0604772103
Qi, L., Heredia, J.E., Altarejos, J.Y., Screaton, R., Goebel, N., Niessen, S., Macleod, I.X., Liew, C.W., Kulkarni, R.N., Bain, J., Newgard, C., Nelson, M., Evans, R.M., Yates, J., Montminy, M. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. (2006) 科学. 312(5781):1763-6. DOI: 10.1126/science.1123374
Zhang, C.L., Zou, Y., Yu, R.T., Gage, F.H., Evans, R.M. Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1. (2006) 基因与发展. 20(10):1308-20. DOI: 10.1101/gad.1413606
Zhou, J., Zhai, Y., Mu, Y., Gong, H., Uppal, H., Toma, D., Ren, S., Evans, R.M., Xie, W. A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. (2006) 生物化学杂志. 281(21):15013-20. DOI: 10.1074/jbc.M511116200
Barish, G.D., Narkar, V.A., Evans, R.M. PPAR delta: a dagger in the heart of the metabolic syndrome. (2006) 临床研究杂志. 116(3):590-7. DOI: 10.1172/JCI27955
Jacobs, S., Lie, D.C., DeCicco, K.L., Shi, Y., DeLuca, L.M., Gage, F.H., Evans, R.M. Retinoic acid is required early during adult neurogenesis in the dentate gyrus. (2006) 美国国家科学院院刊. 103(10):3902-7. DOI: 10.1073/pnas.0511294103
Sternsdorf, T., Phan, V.T., Maunakea, M.L., Ocampo, C.B., Sohal, J., Silletto, A., Galimi, F., Le Beau, M.M., Evans, R.M., Kogan, S.C. Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia. (2006) Cancer Cell. 9(2):81-94. DOI: 10.1016/j.ccr.2005.12.030
Wang, Z., Qi, C., Krones, A., Woodring, P., Zhu, X., Reddy, J.K., Evans, R.M., Rosenfeld, M.G., Hunter, T. Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance. (2006) Cell Metabolism. 3(2):111-22. DOI: 10.1016/j.cmet.2006.01.002
Lee, C.H., Olson, P., Hevener, A., Mehl, I., Chong, L.W., Olefsky, J.M., Gonzalez, F.J., Ham, J., Kang, H., Peters, J.M., Evans, R.M. PPARdelta regulates glucose metabolism and insulin sensitivity. (2006) 美国国家科学院院刊. 103(9):3444-9. DOI: 10.1073/pnas.0511253103
Lee, C.H., Kang, K., Mehl, I.R., Nofsinger, R., Alaynick, W.A., Chong, L.W., Rosenfeld, J.M., Evans, R.M. Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage. (2006) 美国国家科学院院刊. 103(7):2434-9. DOI: 10.1073/pnas.0510815103
Wolf, K.K., Wood, S.G., Hunt, J.A., Walton-Strong, B.W., Yasuda, K., Lan, L., Duan, S.X., Hao, Q., Wrighton, S.A., Jeffery, E.H., Evans, R.M., Szakacs, J.G., von Moltke, L.L., Greenblatt, D.J., Court, M.H., Schuetz, E.G., Sinclair, P.R., Sinclair, J.F. Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity. (2005) Drug Metab. Dispos. 33(12):1827-36. DOI: 10.1124/dmd.105.005256
Noreault, T.L., Jacobs, J.M., Nichols, R.C., Trask, H.W., Wrighton, S.A., Sinclair, P.R., Evans, R.M., Sinclair, J.F. Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms. (2005) Toxicol. Appl. Pharmacol. 209(2):174-82. DOI: 10.1016/j.taap.2005.04.008
Barish, G.D., Downes, M., Alaynick, W.A., Yu, R.T., Ocampo, C.B., Bookout, A.L., Mangelsdorf, D.J., Evans, R.M. A Nuclear Receptor Atlas: macrophage activation. (2005) Molecular Endocrinology. 19(10):2466-77. DOI: 10.1210/me.2004-0529
Zhao, X., Sternsdorf, T., Bolger, T.A., Evans, R.M., Yao, T.P. Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. (2005) 分子与细胞生物学. 25(19):8456-64. DOI: 10.1128/MCB.25.19.8456-8464.2005
Margolis, R.N., Evans, R.M., O'Malley, B.W. The Nuclear Receptor Signaling Atlas: development of a functional atlas of nuclear receptors. (2005) Molecular Endocrinology. 19(10):2433-6. DOI: 10.1210/me.2004-0461
Fu, M., Sun, T., Bookout, A.L., Downes, M., Yu, R.T., Evans, R.M., Mangelsdorf, D.J. A Nuclear Receptor Atlas: 3T3-L1 adipogenesis. (2005) Molecular Endocrinology. 19(10):2437-50. DOI: 10.1210/me.2004-0539
Noreault, T.L., Kostrubsky, V.E., Wood, S.G., Nichols, R.C., Strom, S.C., Trask, H.W., Wrighton, S.A., Evans, R.M., Jacobs, J.M., Sinclair, P.R., Sinclair, J.F. Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes. (2005) Drug Metab. Dispos. 33(7):993-1003. DOI: 10.1124/dmd.105.003954
Evans, R.M. The nuclear receptor superfamily: a rosetta stone for physiology. (2005) Molecular Endocrinology. 19(6):1429-38. DOI: 10.1210/me.2005-0046
Pavri, R., Lewis, B., Kim, T.K., Dilworth, F.J., Erdjument-Bromage, H., Tempst, P., de Murcia, G., Evans, R., Chambon, P., Reinberg, D. PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. (2005) 分子细胞. 18(1):83-96. DOI: 10.1016/j.molcel.2005.02.034
Sonoda, J., Chong, L.W., Downes, M., Barish, G.D., Coulter, S., Liddle, C., Lee, C.H., Evans, R.M. Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites. (2005) 美国国家科学院院刊. 102(6):2198-203. DOI: 10.1073/pnas.0409481102
Stedman, C.A., Liddle, C., Coulter, S.A., Sonoda, J., Alvarez, J.G., Moore, D.D., Evans, R.M., Downes, M. Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury. (2005) 美国国家科学院院刊. 102(6):2063-8. DOI: 10.1073/pnas.0409794102
Galimi, F., Saez, E., Gall, J., Hoong, N., Cho, G., Evans, R.M., Verma, I.M. Development of ecdysone-regulated lentiviral vectors. (2005) Mol. Ther. 11(1):142-8. DOI: 10.1016/j.ymthe.2004.08.021
Shalom-Barak, T., Nicholas, J.M., Wang, Y., Zhang, X., Ong, E.S., Young, T.H., Gendler, S.J., Evans, R.M., Barak, Y. Peroxisome proliferator-activated receptor gamma controls Muc1 transcription in trophoblasts. (2004) 分子与细胞生物学. 24(24):10661-9. DOI: 10.1128/MCB.24.24.10661-10669.2004
Cheng, L., Ding, G., Qin, Q., Huang, Y., Lewis, W., He, N., Evans, R.M., Schneider, M.D., Brako, F.A., Xiao, Y., Chen, Y.E., Yang, Q. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. (2004) Nature Medicine. 10(11):1245-50. DOI: 10.1038/nm1116
Zhang, J., Huang, W., Qatanani, M., Evans, R.M., Moore, D.D. The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. (2004) 生物化学杂志. 279(47):49517-22. DOI: 10.1074/jbc.M409041200
Barish, G.D., Evans, R.M. A nuclear strike against Listeria--the evolving life of LXR. (2004) 牢房. 119(2):149-51. DOI: 10.1016/j.cell.2004.10.003
Evans, R. A transcriptional basis for physiology. (2004) Nature Medicine. 10(10):1022-6. DOI: 10.1038/nm1004-1022
Wang, Y.X., Zhang, C.L., Yu, R.T., Cho, H.K., Nelson, M.C., Bayuga-Ocampo, C.R., Ham, J., Kang, H., Evans, R.M. Regulation of muscle fiber type and running endurance by PPARdelta. (2004) PLOS Biology. 2(10):e294. DOI: 10.1371/journal.pbio.0020294
Evans, R.M. 2003 Keio Medical Science Prize commemorative lecture. PPARs and the complex journey to obesity. (2004) Keio J Med. 53(2):53-8.
Barish, G.D., Evans, R.M. PPARs and LXRs: atherosclerosis goes nuclear. (2004) Trends in Endocrinology and Metabolism. 15(4):158-65. DOI: 10.1016/j.tem.2004.03.003
Koo, S.H., Satoh, H., Herzig, S., Lee, C.H., Hedrick, S., Kulkarni, R., Evans, R.M., Olefsky, J., Montminy, M. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. (2004) Nature Medicine. 10(5):530-4. DOI: 10.1038/nm1044
Assem, M., Schuetz, E.G., Leggas, M., Sun, D., Yasuda, K., Reid, G., Zelcer, N., Adachi, M., Strom, S., Evans, R.M., Moore, D.D., Borst, P., Schuetz, J.D. Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. (2004) 生物化学杂志. 279(21):22250-7. DOI: 10.1074/jbc.M314111200
Evans, R.M., Barish, G.D., Wang, Y.X. PPARs and the complex journey to obesity. (2004) Nature Medicine. 10(4):355-61. DOI: 10.1038/nm1025
Saez, E., Rosenfeld, J., Livolsi, A., Olson, P., Lombardo, E., Nelson, M., Banayo, E., Cardiff, R.D., Izpisua-Belmonte, J.C., Evans, R.M. PPAR gamma signaling exacerbates mammary gland tumor development. (2004) 基因与发展. 18(5):528-40. DOI: 10.1101/gad.1167804
Tsai, C.C., Kao, H.Y., Mitzutani, A., Banayo, E., Rajan, H., McKeown, M., Evans, R.M. Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors. (2004) 美国国家科学院院刊. 101(12):4047-52. DOI: 10.1073/pnas.0400615101
Saini, S.P., Sonoda, J., Xu, L., Toma, D., Uppal, H., Mu, Y., Ren, S., Moore, D.D., Evans, R.M., Xie, W. A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. (2004) Molecular Pharmacology. 65(2):292-300. DOI: 10.1124/mol.65.2.292
Xu, W., Cho, H., Kadam, S., Banayo, E.M., Anderson, S., Yates, J.R., Emerson, B.M., Evans, R.M. A methylation-mediator complex in hormone signaling. (2004) 基因与发展. 18(2):144-56. DOI: 10.1101/gad.1141704
Shi, Y., Chichung Lie, D., Taupin, P., Nakashima, K., Ray, J., Yu, R.T., Gage, F.H., Evans, R.M. Expression and function of orphan nuclear receptor TLX in adult neural stem cells. (2004) 自然. 427(6969):78-83. DOI: 10.1038/nature02211
Demarest, S.J., Deechongkit, S., Dyson, H.J., Evans, R.M., Wright, P.E. Packing, specificity, and mutability at the binding interface between the p160 coactivator and CREB-binding protein. (2004) Protein Sci. 13(1):203-10. DOI: 10.1110/ps.03366504
Evans, R.M. An interview with Ronald M. Evans, Ph.D. Investigator, the Salk Institute for Biological Studies. (2003) Assay Drug Dev Technol. 1(6):749-54. DOI: 10.1089/154065803772613381
He, W., Barak, Y., Hevener, A., Olson, P., Liao, D., Le, J., Nelson, M., Ong, E., Olefsky, J.M., Evans, R.M. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. (2003) 美国国家科学院院刊. 100(26):15712-7. DOI: 10.1073/pnas.2536828100
Natarajan, C., Muthian, G., Barak, Y., Evans, R.M., Bright, J.J. Peroxisome proliferator-activated receptor-gamma-deficient heterozygous mice develop an exacerbated neural antigen-induced Th1 response and experimental allergic encephalomyelitis. (2003) Journal of Immunology. 171(11):5743-50.
Hevener, A.L., He, W., Barak, Y., Le, J., Bandyopadhyay, G., Olson, P., Wilkes, J., Evans, R.M., Olefsky, J. Muscle-specific Pparg deletion causes insulin resistance. (2003) Nature Medicine. 9(12):1491-7. DOI: 10.1038/nm956
Lee, C.H., Chawla, A., Urbiztondo, N., Liao, D., Boisvert, W.A., Evans, R.M., Curtiss, L.K. Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. (2003) 科学. 302(5644):453-7. DOI: 10.1126/science.1087344
Saez, E., Olson, P., Evans, R.M. Genetic deficiency in Pparg does not alter development of experimental prostate cancer. (2003) Nature Medicine. 9(10):1265-6. DOI: 10.1038/nm928
Rosenfeld, J.M., Vargas, R., Xie, W., Evans, R.M. Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor. (2003) Molecular Endocrinology. 17(7):1268-82. DOI: 10.1210/me.2002-0421
Xu, W., Cho, H., Evans, R.M. Acetylation and methylation in nuclear receptor gene activation. (2003) Meth. Enzymol. 364:205-23.
Lee, C.H., Olson, P., Evans, R.M. Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. (2003) Endocrinology. 144(6):2201-7. DOI: 10.1210/en.2003-0288
Wang, Y.X., Lee, C.H., Tiep, S., Yu, R.T., Ham, J., Kang, H., Evans, R.M. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. (2003) 牢房. 113(2):159-70.
Downes, M., Verdecia, M.A., Roecker, A.J., Hughes, R., Hogenesch, J.B., Kast-Woelbern, H.R., Bowman, M.E., Ferrer, J.L., Anisfeld, A.M., Edwards, P.A., Rosenfeld, J.M., Alvarez, J.G., Noel, J.P., Nicolaou, K.C., Evans, R.M. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. (2003) 分子细胞. 11(4):1079-92.
Gearhart, M.D., Holmbeck, S.M., Evans, R.M., Dyson, H.J., Wright, P.E. Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition. (2003) 分子生物学杂志. 327(4):819-32.
Xie, W., Yeuh, M.F., Radominska-Pandya, A., Saini, S.P., Negishi, Y., Bottroff, B.S., Cabrera, G.Y., Tukey, R.H., Evans, R.M. Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. (2003) 美国国家科学院院刊. 100(7):4150-5. DOI: 10.1073/pnas.0438010100
Nicolaou, K.C., Evans, R.M., Roecker, A.J., Hughes, R., Downes, M., Pfefferkorn, J.A. Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. (2003) Organic & Biomolecular Chemistry. 1(6):908-20.
Stenman, J., Yu, R.T., Evans, R.M., Campbell, K. Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon. (2003) Development. 130(6):1113-22.
Miles, P.D., Barak, Y., Evans, R.M., Olefsky, J.M. Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding. (2003) Am. J. Physiol. Endocrinol. Metab. 284(3):E618-26. DOI: 10.1152/ajpendo.00312.2002
Chawla, A., Lee, C.H., Barak, Y., He, W., Rosenfeld, J., Liao, D., Han, J., Kang, H., Evans, R.M. PPARdelta is a very low-density lipoprotein sensor in macrophages. (2003) 美国国家科学院院刊. 100(3):1268-73. DOI: 10.1073/pnas.0337331100
Kao, H.Y., Han, C.C., Komar, A.A., Evans, R.M. Co-repressor release but not ligand binding is a prerequisite for transcription activation by human retinoid acid receptor alpha ligand-binding domain. (2003) 生物化学杂志. 278(9):7366-73. DOI: 10.1074/jbc.M207569200
Sonoda, J., Xie, W., Rosenfeld, J.M., Barwick, J.L., Guzelian, P.S., Evans, R.M. Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR). (2002) 美国国家科学院院刊. 99(21):13801-6. DOI: 10.1073/pnas.212494599
Lee, C.H., Evans, R.M. Peroxisome proliferator-activated receptor-gamma in macrophage lipid homeostasis. (2002) Trends in Endocrinology and Metabolism. 13(8):331-5.
Xie, W., Evans, R.M. Pharmaceutical use of mouse models humanized for the xenobiotic receptor. (2002) Drug Discov. Today. 7(9):509-15.
Makishima, M., Lu, T.T., Xie, W., Whitfield, G.K., Domoto, H., Evans, R.M., Haussler, M.R., Mangelsdorf, D.J. Vitamin D receptor as an intestinal bile acid sensor. (2002) 科学. 296(5571):1313-6. DOI: 10.1126/science.1070477
Pitman, J.L., Tsai, C.C., Edeen, P.T., Finley, K.D., Evans, R.M., McKeown, M. DSF nuclear receptor acts as a repressor in culture and in vivo. (2002) Developmental Biology. 245(2):315-28. DOI: 10.1006/dbio.2002.0648
Shi, Y., Hon, M., Evans, R.M. The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. (2002) 美国国家科学院院刊. 99(5):2613-8. DOI: 10.1073/pnas.052707099
Love, J.D., Gooch, J.T., Benko, S., Li, C., Nagy, L., Chatterjee, V.K., Evans, R.M., Schwabe, J.W. The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12. (2002) 生物化学杂志. 277(13):11385-91. DOI: 10.1074/jbc.M110869200
Tini, M., Benecke, A., Um, S.J., Torchia, J., Evans, R.M., Chambon, P. Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. (2002) 分子细胞. 9(2):265-77.
Barak, Y., Liao, D., He, W., Ong, E.S., Nelson, M.C., Olefsky, J.M., Boland, R., Evans, R.M. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. (2002) 美国国家科学院院刊. 99(1):303-8. DOI: 10.1073/pnas.012610299
Demarest, S.J., Martinez-Yamout, M., Chung, J., Chen, H., Xu, W., Dyson, H.J., Evans, R.M., Wright, P.E. Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. (2002) 自然. 415(6871):549-53. DOI: 10.1038/415549a
Kao, H.Y., Lee, C.H., Komarov, A., Han, C.C., Evans, R.M. Isolation and characterization of mammalian HDAC10, a novel histone deacetylase. (2002) 生物化学杂志. 277(1):187-93. DOI: 10.1074/jbc.M108931200
Xu, W., Chen, H., Du, K., Asahara, H., Tini, M., Emerson, B.M., Montminy, M., Evans, R.M. A transcriptional switch mediated by cofactor methylation. (2001) 科学. 294(5551):2507-11. DOI: 10.1126/science.1065961
Chawla, A., Repa, J.J., Evans, R.M., Mangelsdorf, D.J. Nuclear receptors and lipid physiology: opening the X-files. (2001) 科学. 294(5548):1866-70. DOI: 10.1126/science.294.5548.1866
Lin, R.J., Sternsdorf, T., Tini, M., Evans, R.M. Transcriptional regulation in acute promyelocytic leukemia. (2001) 癌基因. 20(49):7204-15. DOI: 10.1038/sj.onc.1204853
Xie, W., Evans, R.M. Orphan nuclear receptors: the exotics of xenobiotics. (2001) 生物化学杂志. 276(41):37739-42. DOI: 10.1074/jbc.R100033200
Misner, D.L., Jacobs, S., Shimizu, Y., de Urquiza, A.M., Solomin, L., Perlmann, T., De Luca, L.M., Stevens, C.F., Evans, R.M. Vitamin A deprivation results in reversible loss of hippocampal long-term synaptic plasticity. (2001) 美国国家科学院院刊. 98(20):11714-9. DOI: 10.1073/pnas.191369798
Ordentlich, P., Downes, M., Evans, R.M. Corepressors and nuclear hormone receptor function. (2001) Current Topics in Microbiology and Immunology. 254:101-16.
Turelli, P., Doucas, V., Craig, E., Mangeat, B., Klages, N., Evans, R., Kalpana, G., Trono, D. Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication. (2001) 分子细胞. 7(6):1245-54.
Shi, Y., Downes, M., Xie, W., Kao, H.Y., Ordentlich, P., Tsai, C.C., Hon, M., Evans, R.M. Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. (2001) 基因与发展. 15(9):1140-51. DOI: 10.1101/gad.871201
Xie, W., Radominska-Pandya, A., Shi, Y., Simon, C.M., Nelson, M.C., Ong, E.S., Waxman, D.J., Evans, R.M. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. (2001) 美国国家科学院院刊. 98(6):3375-80. DOI: 10.1073/pnas.051014398
Ghbeish, N., Tsai, C.C., Schubiger, M., Zhou, J.Y., Evans, R.M., McKeown, M. The dual role of ultraspiracle, the Drosophila retinoid X receptor, in the ecdysone response. (2001) 美国国家科学院院刊. 98(7):3867-72. DOI: 10.1073/pnas.061437798
Clayton, G.M., Peak-Chew, S.Y., Evans, R.M., Schwabe, J.W. The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation. (2001) 美国国家科学院院刊. 98(4):1549-54. DOI: 10.1073/pnas.041611298
Chawla, A., Boisvert, W.A., Lee, C.H., Laffitte, B.A., Barak, Y., Joseph, S.B., Liao, D., Nagy, L., Edwards, P.A., Curtiss, L.K., Evans, R.M., Tontonoz, P. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. (2001) 分子细胞. 7(1):161-71.
Chawla, A., Barak, Y., Nagy, L., Liao, D., Tontonoz, P., Evans, R.M. PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. (2001) Nature Medicine. 7(1):48-52. DOI: 10.1038/83336
Xie, W., Barwick, J.L., Simon, C.M., Pierce, A.M., Safe, S., Blumberg, B., Guzelian, P.S., Evans, R.M. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. (2000) 基因与发展. 14(23):3014-23.
Saez, E., Nelson, M.C., Eshelman, B., Banayo, E., Koder, A., Cho, G.J., Evans, R.M. Identification of ligands and coligands for the ecdysone-regulated gene switch. (2000) 美国国家科学院院刊. 97(26):14512-7. DOI: 10.1073/pnas.260499497
Chawla, A., Saez, E., Evans, R.M. "Don't know much bile-ology". (2000) 牢房. 103(1):1-4.
Downes, M., Ordentlich, P., Kao, H.Y., Alvarez, J.G., Evans, R.M. Identification of a nuclear domain with deacetylase activity. (2000) 美国国家科学院院刊. 97(19):10330-5.
Lee, H., Shi, W., Tontonoz, P., Wang, S., Subbanagounder, G., Hedrick, C.C., Hama, S., Borromeo, C., Evans, R.M., Berliner, J.A., Nagy, L. Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells. (2000) Circulation research. 87(6):516-21.
Xie, W., Barwick, J.L., Downes, M., Blumberg, B., Simon, C.M., Nelson, M.C., Neuschwander-Tetri, B.A., Brunt, E.M., Guzelian, P.S., Evans, R.M. Humanized xenobiotic response in mice expressing nuclear receptor SXR. (2000) 自然. 406(6794):435-9. DOI: 10.1038/35019116
Lin, R.J., Evans, R.M. Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers. (2000) 分子细胞. 5(5):821-30.
Takada, I., Yu, R.T., Xu, H.E., Lambert, M.H., Montana, V.G., Kliewer, S.A., Evans, R.M., Umesono, K. Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype. (2000) Molecular Endocrinology. 14(5):733-40. DOI: 10.1210/mend.14.5.0456
Yu, R.T., Chiang, M.Y., Tanabe, T., Kobayashi, M., Yasuda, K., Evans, R.M., Umesono, K. The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision. (2000) 美国国家科学院院刊. 97(6):2621-5. DOI: 10.1073/pnas.050566897
Miles, P.D., Barak, Y., He, W., Evans, R.M., Olefsky, J.M. Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency. (2000) 临床研究杂志. 105(3):287-92. DOI: 10.1172/JCI8538
Kao, H.Y., Downes, M., Ordentlich, P., Evans, R.M. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. (2000) 基因与发展. 14(1):55-66.
Nagy, L., Kao, H.Y., Love, J.D., Li, C., Banayo, E., Gooch, J.T., Krishna, V., Chatterjee, K., Evans, R.M., Schwabe, J.W. Mechanism of corepressor binding and release from nuclear hormone receptors. (1999) 基因与发展. 13(24):3209-16.
Xie, W., Hong, H., Yang, N.N., Lin, R.J., Simon, C.M., Stallcup, M.R., Evans, R.M. Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2. (1999) Molecular Endocrinology. 13(12):2151-62. DOI: 10.1210/mend.13.12.0381
Asahara, H., Dutta, S., Kao, H.Y., Evans, R.M., Montminy, M. Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner. (1999) 分子与细胞生物学. 19(12):8219-25.
Barak, Y., Nelson, M.C., Ong, E.S., Jones, Y.Z., Ruiz-Lozano, P., Chien, K.R., Koder, A., Evans, R.M. PPAR gamma is required for placental, cardiac, and adipose tissue development. (1999) 分子细胞. 4(4):585-95.
Tsukui, T., Capdevila, J., Tamura, K., Ruiz-Lozano, P., Rodriguez-Esteban, C., Yonei-Tamura, S., Magallón, J., Chandraratna, R.A., Chien, K., Blumberg, B., Evans, R.M., Belmonte, J.C. Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. (1999) 美国国家科学院院刊. 96(20):11376-81.
Chen, H., Lin, R.J., Xie, W., Wilpitz, D., Evans, R.M. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. (1999) 牢房. 98(5):675-86.
Tsai, C.C., Kao, H.Y., Yao, T.P., McKeown, M., Evans, R.M. SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development. (1999) 分子细胞. 4(2):175-86.
Egan, D.A., Evans, R.M. Target acquisition and acute promyelocytic leukemia. (1999) 临床研究杂志. 103(10):1367-8. DOI: 10.1172/JCI7118
Lin, R.J., Egan, D.A., Evans, R.M. Molecular genetics of acute promyelocytic leukemia. (1999) Trends in Genetics. 15(5):179-84.
Ordentlich, P., Downes, M., Xie, W., Genin, A., Spinner, N.B., Evans, R.M. Unique forms of human and mouse nuclear receptor corepressor SMRT. (1999) 美国国家科学院院刊. 96(6):2639-44.
Doucas, V., Tini, M., Egan, D.A., Evans, R.M. Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. (1999) 美国国家科学院院刊. 96(6):2627-32.
Chakravarti, D., Ogryzko, V., Kao, H.Y., Nash, A., Chen, H., Nakatani, Y., Evans, R.M. A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity. (1999) 牢房. 96(3):393-403.
Chiang, M.Y., Misner, D., Kempermann, G., Schikorski, T., Giguère, V., Sucov, H.M., Gage, F.H., Stevens, C.F., Evans, R.M. An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression. (1998) 神经元. 21(6):1353-61.
Blumberg, B., Sabbagh, W., Juguilon, H., Bolado, J., van Meter, C.M., Ong, E.S., Evans, R.M. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. (1998) 基因与发展. 12(20):3195-205.
Blumberg, B., Evans, R.M. Orphan nuclear receptors--new ligands and new possibilities. (1998) 基因与发展. 12(20):3149-55.
Dhordain, P., Lin, R.J., Quief, S., Lantoine, D., Kerckaert, J.P., Evans, R.M., Albagli, O. The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression. (1998) 核酸研究. 26(20):4645-51.
Forman, B.M., Tzameli, I., Choi, H.S., Chen, J., Simha, D., Seol, W., Evans, R.M., Moore, D.D. Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. (1998) 自然. 395(6702):612-5. DOI: 10.1038/26996
Saez, E., Tontonoz, P., Nelson, M.C., Alvarez, J.G., Ming, U.T., Baird, S.M., Thomazy, V.A., Evans, R.M. Activators of the nuclear receptor PPARgamma enhance colon polyp formation. (1998) Nature Medicine. 4(9):1058-61. DOI: 10.1038/2042
Kao, H.Y., Ordentlich, P., Koyano-Nakagawa, N., Tang, Z., Downes, M., Kintner, C.R., Evans, R.M., Kadesch, T. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. (1998) 基因与发展. 12(15):2269-77.
Ryan, A.K., Blumberg, B., Rodriguez-Esteban, C., Yonei-Tamura, S., Tamura, K., Tsukui, T., de la Peña, J., Sabbagh, W., Greenwald, J., Choe, S., Norris, D.P., Robertson, E.J., Evans, R.M., Rosenfeld, M.G., Izpisúa Belmonte, J.C. Pitx2 determines left-right asymmetry of internal organs in vertebrates. (1998) 自然. 394(6693):545-51. DOI: 10.1038/29004
Lin, R.J., Kao, H.Y., Ordentlich, P., Evans, R.M. The transcriptional basis of steroid physiology. (1998) 冷泉港定量生物学研讨会。. 63:577-85.
Blanco, J.C., Minucci, S., Lu, J., Yang, X.J., Walker, K.K., Chen, H., Evans, R.M., Nakatani, Y., Ozato, K. The histone acetylase PCAF is a nuclear receptor coactivator. (1998) 基因与发展. 12(11):1638-51.
Blumberg, B., Kang, H., Bolado, J., Chen, H., Craig, A.G., Moreno, T.A., Umesono, K., Perlmann, T., De Robertis, E.M., Evans, R.M. BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites. (1998) 基因与发展. 12(9):1269-77.
LaMorte, V.J., Dyck, J.A., Ochs, R.L., Evans, R.M. Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body. (1998) 美国国家科学院院刊. 95(9):4991-6.
Tontonoz, P., Nagy, L., Alvarez, J.G., Thomazy, V.A., Evans, R.M. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. (1998) 牢房. 93(2):241-52.
Nagy, L., Tontonoz, P., Alvarez, J.G., Chen, H., Evans, R.M. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. (1998) 牢房. 93(2):229-40.
Lin, R.J., Nagy, L., Inoue, S., Shao, W., Miller, W.H., Evans, R.M. Role of the histone deacetylase complex in acute promyelocytic leukaemia. (1998) 自然. 391(6669):811-4. DOI: 10.1038/35895
Ruiz-Lozano, P., Smith, S.M., Perkins, G., Kubalak, S.W., Boss, G.R., Sucov, H.M., Evans, R.M., Chien, K.R. Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRalpha-/- embryos. (1998) Development. 125(3):533-44.
Saez, E., No, D., West, A., Evans, R.M. Inducible gene expression in mammalian cells and transgenic mice. (1997) Curr. Opin. Biotechnol. 8(5):608-16.
Li, C., Evans, R.M. Ligation independent cloning irrespective of restriction site compatibility. (1997) 核酸研究. 25(20):4165-6.
Forman, B.M., Ruan, B., Chen, J., Schroepfer, G.J., Evans, R.M. The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism. (1997) 美国国家科学院院刊. 94(20):10588-93.
Dhordain, P., Albagli, O., Lin, R.J., Ansieau, S., Quief, S., Leutz, A., Kerckaert, J.P., Evans, R.M., Leprince, D. Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein. (1997) 美国国家科学院院刊. 94(20):10762-7.
Chen, H., Lin, R.J., Schiltz, R.L., Chakravarti, D., Nash, A., Nagy, L., Privalsky, M.L., Nakatani, Y., Evans, R.M. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. (1997) 牢房. 90(3):569-80.
Perlmann, T., Evans, R.M. Nuclear receptors in Sicily: all in the famiglia. (1997) 牢房. 90(3):391-7.
Zelhof, A.C., Ghbeish, N., Tsai, C., Evans, R.M., McKeown, M. A role for ultraspiracle, the Drosophila RXR, in morphogenetic furrow movement and photoreceptor cluster formation. (1997) Development. 124(13):2499-506.
Sem, D.S., Casimiro, D.R., Kliewer, S.A., Provencal, J., Evans, R.M., Wright, P.E. NMR spectroscopic studies of the DNA-binding domain of the monomer-binding nuclear orphan receptor, human estrogen related receptor-2. The carboxyl-terminal extension to the zinc-finger region is unst (1997) 生物化学杂志. 272(29):18038-43.
Lee, R.Y., Luo, J., Evans, R.M., Giguere, V., Sucov, H.M. Compartment-selective sensitivity of cardiovascular morphogenesis to combinations of retinoic acid receptor gene mutations. (1997) Circulation research. 80(6):757-764.
Nagy, L., Kao, H.Y., Chakravarti, D., Lin, R.J., Hassig, C.A., Ayer, D.E., Schreiber, S.L., Evans, R.M. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. (1997) 牢房. 89(3):373-80.
Forman, B.M., Chen, J., Evans, R.M. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. (1997) 美国国家科学院院刊. 94(9):4312-7.
Schulman, I.G., Evans, R.M. Retinoid receptors in development and disease. (1997) Leukemia. 11 Suppl 3:376-7.
Li, C., Schwabe, J.W., Banayo, E., Evans, R.M. Coexpression of nuclear receptor partners increases their solubility and biological activities. (1997) 美国国家科学院院刊. 94(6):2278-83.
Schulman, I.G., Li, C., Schwabe, J.W., Evans, R.M. The phantom ligand effect: allosteric control of transcription by the retinoid X receptor. (1997) 基因与发展. 11(3):299-308.
Blumberg, B., Bolado, J., Moreno, T.A., Kintner, C., Evans, R.M., Papalopulu, N. An essential role for retinoid signaling in anteroposterior neural patterning. (1997) Development. 124(2):373-9.
Tontonoz, P., Singer, S., Forman, B.M., Sarraf, P., Fletcher, J.A., Fletcher, C.D., Brun, R.P., Mueller, E., Altiok, S., Oppenheim, H., Evans, R.M., Spiegelman, B.M. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor. (1997) 美国国家科学院院刊. 94(1):237-41.
Süsens, U., Aguiluz, J.B., Evans, R.M., Borgmeyer, U. The germ cell nuclear factor mGCNF is expressed in the developing nervous system. (1997) Developmental Neuroscience. 19(5):410-20.
Forman, B.M., Chen, J., Evans, R.M. The peroxisome proliferator-activated receptors: ligands and activators. (1996) Ann. N. Y. Acad. Sci. 804:266-75.
Doucas, V., Evans, R.M. The PML nuclear compartment and cancer. (1996) Biochimica et Biophysica Acta. 1288(3):M25-9.
Lala, D.S., Mukherjee, R., Schulman, I.G., Koch, S.S., Dardashti, L.J., Nadzan, A.M., Croston, G.E., Evans, R.M., Heyman, R.A. Activation of specific RXR heterodimers by an antagonist of RXR homodimers. (1996) 自然. 383(6599):450-3. DOI: 10.1038/383450a0
Chakravarti, D., LaMorte, V.J., Nelson, M.C., Nakajima, T., Schulman, I.G., Juguilon, H., Montminy, M., Evans, R.M. Role of CBP/P300 in nuclear receptor signalling. (1996) 自然. 383(6595):99-103. DOI: 10.1038/383099a0
Gruber, P.J., Kubalak, S.W., Pexieder, T., Sucov, H.M., Evans, R.M., Chien, K.R. RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice. (1996) 临床研究杂志. 98(6):1332-43. DOI: 10.1172/JCI118920
Perlmann, T., Umesono, K., Rangarajan, P.N., Forman, B.M., Evans, R.M. Two distinct dimerization interfaces differentially modulate target gene specificity of nuclear hormone receptors. (1996) Molecular Endocrinology. 10(8):958-66. DOI: 10.1210/mend.10.8.8843412
Chen, J.D., Umesono, K., Evans, R.M. SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers. (1996) 美国国家科学院院刊. 93(15):7567-71.
Schulman, I.G., Juguilon, H., Evans, R.M. Activation and repression by nuclear hormone receptors: hormone modulates an equilibrium between active and repressive states. (1996) 分子与细胞生物学. 16(7):3807-13.
Early, E., Moore, M.A., Kakizuka, A., Nason-Burchenal, K., Martin, P., Evans, R.M., Dmitrovsky, E. Transgenic expression of PML/RARalpha impairs myelopoiesis. (1996) 美国国家科学院院刊. 93(15):7900-4.
Blumberg, B., Bolado, J., Derguini, F., Craig, A.G., Moreno, T.A., Chakravarti, D., Heyman, R.A., Buck, J., Evans, R.M. Novel retinoic acid receptor ligands in Xenopus embryos. (1996) 美国国家科学院院刊. 93(10):4873-8.
Achkar, C.C., Derguini, F., Blumberg, B., Langston, A., Levin, A.A., Speck, J., Evans, R.M., Bolado, J., Nakanishi, K., Buck, J., Gudas, L.J. 4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors. (1996) 美国国家科学院院刊. 93(10):4879-84.
No, D., Yao, T.P., Evans, R.M. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. (1996) 美国国家科学院院刊. 93(8):3346-51.
Brun, R.P., Tontonoz, P., Forman, B.M., Ellis, R., Chen, J., Evans, R.M., Spiegelman, B.M. Differential activation of adipogenesis by multiple PPAR isoforms. (1996) 基因与发展. 10(8):974-84.
Göttlicher, M., Heck, S., Doucas, V., Wade, E., Kullmann, M., Cato, A.C., Evans, R.M., Herrlich, P. Interaction of the Ubc9 human homologue with c-Jun and with the glucocorticoid receptor. (1996) Steroids. 61(4):257-62.
Luo, J., Sucov, H.M., Bader, J.A., Evans, R.M., Giguère, V. Compound mutants for retinoic acid receptor (RAR) beta and RAR alpha 1 reveal developmental functions for multiple RAR beta isoforms. (1996) Mech. Dev. 55(1):33-44.
Ogura, T., Alvarez, I.S., Vogel, A., Rodríguez, C., Evans, R.M., Izpisúa Belmonte, J.C. Evidence that Shh cooperates with a retinoic acid inducible co-factor to establish ZPA-like activity. (1996) Development. 122(2):537-42.
Parker, D., Ferreri, K., Nakajima, T., LaMorte, V.J., Evans, R.M., Koerber, S.C., Hoeger, C., Montminy, M.R. Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism. (1996) 分子与细胞生物学. 16(2):694-703.
Doucas, V., Ishov, A.M., Romo, A., Juguilon, H., Weitzman, M.D., Evans, R.M., Maul, G.G. Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure. (1996) 基因与发展. 10(2):196-207.
Sucov, H.M., Lou, J., Gruber, P.J., Kubalak, S.W., Dyson, E., Gumeringer, C.L., Lee, R.Y., Moles, S.A., Chien, K.R., Giguere, V., Evans, R.M. The molecular genetics of retinoic acid receptors: cardiovascular and limb development. (1996) Biochem. Soc. Symp. 62:143-56.
Sucov, H.M., Izpisúa-Belmonte, J.C., Gañan, Y., Evans, R.M. Mouse embryos lacking RXR alpha are resistant to retinoic-acid-induced limb defects. (1995) Development. 121(12):3997-4003.
Forman, B.M., Tontonoz, P., Chen, J., Brun, R.P., Spiegelman, B.M., Evans, R.M. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. (1995) 牢房. 83(5):803-12.
Mangelsdorf, D.J., Evans, R.M. The RXR heterodimers and orphan receptors. (1995) 牢房. 83(6):841-50.
Mangelsdorf, D.J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., Evans, R.M. The nuclear receptor superfamily: the second decade. (1995) 牢房. 83(6):835-9.
Zelhof, A.C., Yao, T.P., Chen, J.D., Evans, R.M., McKeown, M. Seven-up inhibits ultraspiracle-based signaling pathways in vitro and in vivo. (1995) 分子与细胞生物学. 15(12):6736-45.
Stern, C.D., Yu, R.T., Kakizuka, A., Kintner, C.R., Mathews, L.S., Vale, W.W., Evans, R.M., Umesono, K. Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo. (1995) Developmental Biology. 172(1):192-205. DOI: 10.1006/dbio.1995.0015
Zelhof, A.C., Yao, T.P., Evans, R.M., McKeown, M. Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response. (1995) 美国国家科学院院刊. 92(23):10477-81.
Chen, J.D., Evans, R.M. A transcriptional co-repressor that interacts with nuclear hormone receptors. (1995) 自然. 377(6548):454-7. DOI: 10.1038/377454a0
Schulman, I.G., Chakravarti, D., Juguilon, H., Romo, A., Evans, R.M. Interactions between the retinoid X receptor and a conserved region of the TATA-binding protein mediate hormone-dependent transactivation. (1995) 美国国家科学院院刊. 92(18):8288-92.
Dyck, J.A., Warrell, R.P., Evans, R.M., Miller, W.H. Rapid diagnosis of acute promyelocytic leukemia by immunohistochemical localization of PML/RAR-alpha protein. (1995) Blood. 86(3):862-7.
Zhou, M.D., Sucov, H.M., Evans, R.M., Chien, K.R. Retinoid-dependent pathways suppress myocardial cell hypertrophy. (1995) 美国国家科学院院刊. 92(16):7391-5.
Dyson, E., Sucov, H.M., Kubalak, S.W., Schmid-Schönbein, G.W., DeLano, F.A., Evans, R.M., Ross, J., Chien, K.R. Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice. (1995) 美国国家科学院院刊. 92(16):7386-90.
Forman, B.M., Goode, E., Chen, J., Oro, A.E., Bradley, D.J., Perlmann, T., Noonan, D.J., Burka, L.T., McMorris, T., Lamph, W.W., Evans, R.M., Weinberger, C. Identification of a nuclear receptor that is activated by farnesol metabolites. (1995) 牢房. 81(5):687-93.
Forman, B.M., Umesono, K., Chen, J., Evans, R.M. Unique response pathways are established by allosteric interactions among nuclear hormone receptors. (1995) 牢房. 81(4):541-50.
Rastinejad, F., Perlmann, T., Evans, R.M., Sigler, P.B. Structural determinants of nuclear receptor assembly on DNA direct repeats. (1995) 自然. 375(6528):203-11. DOI: 10.1038/375203a0
Sucov, H.M., Evans, R.M. Retinoic acid and retinoic acid receptors in development. (1995) Molecular Neurobiology. 10(2-3):169-84. DOI: 10.1007/BF02740674
Imakado, S., Bickenbach, J.R., Bundman, D.S., Rothnagel, J.A., Attar, P.S., Wang, X.J., Walczak, V.R., Wisniewski, S., Pote, J., Evans, R.M. Targeting expression of a dominant-negative retinoic acid receptor mutant in the epidermis of transgenic mice results in loss of barrier function. (1995) 基因与发展. 9(3):317-29.
Ogura, T., Evans, R.M. Evidence for two distinct retinoic acid response pathways for HOXB1 gene regulation. (1995) 美国国家科学院院刊. 92(2):392-6.
Ogura, T., Evans, R.M. A retinoic acid-triggered cascade of HOXB1 gene activation. (1995) 美国国家科学院院刊. 92(2):387-91.
Kotomura, N., Okada, M., Ninomiya, Y., Tsukiyama, T., Umesono, K., Evans, R.M., Niwa, O. Repression of retinoic acid-induced transactivation by embryonal LTR binding protein. (1994) J. Biochem. 116(6):1309-16.
Kitabayashi, I., Chiu, R., Umesono, K., Evans, R.M., Gachelin, G., Yokoyama, K. A novel pathway for retinoic acid-induced differentiation of F9 cells that is distinct from receptor-mediated trans-activation. (1994) In Vitro Cell. Dev. Biol. Anim. 30A(11):761-8.
Forman, B.M., Chen, J., Blumberg, B., Kliewer, S.A., Henshaw, R., Ong, E.S., Evans, R.M. Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors. (1994) Molecular Endocrinology. 8(9):1253-61. DOI: 10.1210/mend.8.9.7838158
Lee, M.S., Sem, D.S., Kliewer, S.A., Provencal, J., Evans, R.M., Wright, P.E. NMR assignments and secondary structure of the retinoid X receptor alpha DNA-binding domain. Evidence for the novel C-terminal helix. (1994) European Journal of Biochemistry. 224(2):639-50.
Yu, R.T., McKeown, M., Evans, R.M., Umesono, K. Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor Tlx. (1994) 自然. 370(6488):375-9. DOI: 10.1038/370375a0
Kliewer, S.A., Forman, B.M., Blumberg, B., Ong, E.S., Borgmeyer, U., Mangelsdorf, D.J., Umesono, K., Evans, R.M. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. (1994) 美国国家科学院院刊. 91(15):7355-9.
Sucov, H.M., Dyson, E., Gumeringer, C.L., Price, J., Chien, K.R., Evans, R.M. RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. (1994) 基因与发展. 8(9):1007-18.
Almasan, A., Mangelsdorf, D.J., Ong, E.S., Wahl, G.M., Evans, R.M. Chromosomal localization of the human retinoid X receptors. (1994) Genomics. 20(3):397-403. DOI: 10.1006/geno.1994.1193
Evans, R.M. The molecular basis of signaling by vitamin A and its metabolites. (1994) Harvey Lect. 90:105-17.
Dyck, J.A., Maul, G.G., Miller, W.H., Chen, J.D., Kakizuka, A., Evans, R.M. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. (1994) 牢房. 76(2):333-43.
Yao, T.P., Forman, B.M., Jiang, Z., Cherbas, L., Chen, J.D., McKeown, M., Cherbas, P., Evans, R.M. Functional ecdysone receptor is the product of EcR and Ultraspiracle genes. (1993) 自然. 366(6454):476-9. DOI: 10.1038/366476a0
Damm, K., Evans, R.M. Identification of a domain required for oncogenic activity and transcriptional suppression by v-erbA and thyroid-hormone receptor alpha. (1993) 美国国家科学院院刊. 90(22):10668-72.
Perlmann, T., Rangarajan, P.N., Umesono, K., Evans, R.M. Determinants for selective RAR and TR recognition of direct repeat HREs. (1993) 基因与发展. 7(7B):1411-22.
Lee, M.S., Kliewer, S.A., Provencal, J., Wright, P.E., Evans, R.M. Structure of the retinoid X receptor alpha DNA binding domain: a helix required for homodimeric DNA binding. (1993) 科学. 260(5111):1117-21.
Damm, K., Heyman, R.A., Umesono, K., Evans, R.M. Functional inhibition of retinoic acid response by dominant negative retinoic acid receptor mutants. (1993) 美国国家科学院院刊. 90(7):2989-93.
Rupprecht, R., Arriza, J.L., Spengler, D., Reul, J.M., Evans, R.M., Holsboer, F., Damm, K. Transactivation and synergistic properties of the mineralocorticoid receptor: relationship to the glucocorticoid receptor. (1993) Molecular Endocrinology. 7(4):597-603. DOI: 10.1210/mend.7.4.8388999
Li, E., Sucov, H.M., Lee, K.F., Evans, R.M., Jaenisch, R. Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene. (1993) 美国国家科学院院刊. 90(4):1590-4.
Mangelsdorf, D.J., Kliewer, S.A., Kakizuka, A., Umesono, K., Evans, R.M. Retinoid receptors. (1993) Recent Prog. Horm. Res. 48:99-121.
Tsai, S., Bartelmez, S., Heyman, R., Damm, K., Evans, M., Collins, S.J. A mutated retinoic acid receptor-alpha exhibiting dominant-negative activity alters the lineage development of a multipotent hematopoietic cell line. (1992) 基因与发展. 6(12A):2258-69.
Yao, T.P., Segraves, W.A., Oro, A.E., McKeown, M., Evans, R.M. Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation. (1992) 牢房. 71(1):63-72.
Rangarajan, P.N., Umesono, K., Evans, R.M. Modulation of glucocorticoid receptor function by protein kinase A. (1992) Molecular Endocrinology. 6(9):1451-7. DOI: 10.1210/mend.6.9.1435789
Kliewer, S.A., Umesono, K., Noonan, D.J., Heyman, R.A., Evans, R.M. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. (1992) 自然. 358(6389):771-4. DOI: 10.1038/358771a0
Ghazal, P., DeMattei, C., Giulietti, E., Kliewer, S.A., Umesono, K., Evans, R.M. Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells. (1992) 美国国家科学院院刊. 89(16):7630-4.
Cadepond, F., Gasc, J.M., Delahaye, F., Jibard, N., Schweizer-Groyer, G., Segard-Maurel, I., Evans, M., Baulieu, E.E. Hormonal regulation of the nuclear localization signals of the human glucocorticosteroid receptor. (1992) Experimental Cell Research. 201(1):99-108.
Oro, A.E., McKeown, M., Evans, R.M. The Drosophila retinoid X receptor homolog ultraspiracle functions in both female reproduction and eye morphogenesis. (1992) Development. 115(2):449-62.
Borrelli, E., Sawchenko, P.E., Evans, R.M. Pituitary hyperplasia induced by ectopic expression of nerve growth factor. (1992) 美国国家科学院院刊. 89(7):2764-8.
Kakizuka, A., Sebastian, B., Borgmeyer, U., Hermans-Borgmeyer, I., Bolado, J., Hunter, T., Hoekstra, M.F., Evans, R.M. A mouse cdc25 homolog is differentially and developmentally expressed. (1992) 基因与发展. 6(4):578-90.
Miller, W.H., Kakizuka, A., Frankel, S.R., Warrell, R.P., DeBlasio, A., Levine, K., Evans, R.M., Dmitrovsky, E. Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia. (1992) 美国国家科学院院刊. 89(7):2694-8.
Oro, A.E., McKeown, M., Evans, R.M. The Drosophila nuclear receptors: new insight into the actions of nuclear receptors in development. (1992) 遗传与发育意见。. 2(2):269-74.
Mangelsdorf, D.J., Borgmeyer, U., Heyman, R.A., Zhou, J.Y., Ong, E.S., Oro, A.E., Kakizuka, A., Evans, R.M. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. (1992) 基因与发展. 6(3):329-44.
Blumberg, B., Mangelsdorf, D.J., Dyck, J.A., Bittner, D.A., Evans, R.M., De Robertis, E.M. Multiple retinoid-responsive receptors in a single cell: families of retinoid "X" receptors and retinoic acid receptors in the Xenopus egg. (1992) 美国国家科学院院刊. 89(6):2321-5.
Kliewer, S.A., Umesono, K., Heyman, R.A., Mangelsdorf, D.J., Dyck, J.A., Evans, R.M. Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling. (1992) 美国国家科学院院刊. 89(4):1448-52.
Kliewer, S.A., Umesono, K., Mangelsdorf, D.J., Evans, R.M. Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. (1992) 自然. 355(6359):446-9. DOI: 10.1038/355446a0
Heyman, R.A., Mangelsdorf, D.J., Dyck, J.A., Stein, R.B., Eichele, G., Evans, R.M., Thaller, C. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. (1992) 牢房. 68(2):397-406.
Kitabayashi, I., Kawakami, Z., Chiu, R., Ozawa, K., Matsuoka, T., Toyoshima, S., Umesono, K., Evans, R.M., Gachelin, G., Yokoyama, K. Transcriptional regulation of the c-jun gene by retinoic acid and E1A during differentiation of F9 cells. (1992) EMBO 期刊. 11(1):167-75.
Schüle, R., Evans, R.M. Cross-coupling of signal transduction pathways: zinc finger meets leucine zipper. (1991) Trends in Genetics. 7(11-12):377-81.
Kakizuka, A., Miller, W.H., Umesono, K., Warrell, R.P., Frankel, S.R., Murty, V.V., Dmitrovsky, E., Evans, R.M. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. (1991) 牢房. 66(4):663-74.
Mangelsdorf, D.J., Umesono, K., Kliewer, S.A., Borgmeyer, U., Ong, E.S., Evans, R.M. A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR. (1991) 牢房. 66(3):555-61.
Schüle, R., Rangarajan, P., Yang, N., Kliewer, S., Ransone, L.J., Bolado, J., Verma, I.M., Evans, R.M. Retinoic acid is a negative regulator of AP-1-responsive genes. (1991) 美国国家科学院院刊. 88(14):6092-6.
Umesono, K., Murakami, K.K., Thompson, C.C., Evans, R.M. Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. (1991) 牢房. 65(7):1255-66.
Yang, N., Schüle, R., Mangelsdorf, D.J., Evans, R.M. Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor. (1991) 美国国家科学院院刊. 88(9):3559-63.
Cadepond, F., Schweizer-Groyer, G., Segard-Maurel, I., Jibard, N., Hollenberg, S.M., Giguère, V., Evans, R.M., Baulieu, E.E. Heat shock protein 90 as a critical factor in maintaining glucocorticosteroid receptor in a nonfunctional state. (1991) 生物化学杂志. 266(9):5834-41.
Schüle, R., Evans, R.M. Functional antagonism between oncoprotein c-Jun and steroid hormone receptors. (1991) 冷泉港定量生物学研讨会。. 56:119-27. DOI: 10.1101/SQB.1991.056.01.016
Schüle, R., Rangarajan, P., Kliewer, S., Ransone, L.J., Bolado, J., Yang, N., Verma, I.M., Evans, R.M. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. (1990) 牢房. 62(6):1217-26.
Oro, A.E., McKeown, M., Evans, R.M. Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoid X receptor. (1990) 自然. 347(6290):298-301. DOI: 10.1038/347298a0
Sucov, H.M., Murakami, K.K., Evans, R.M. Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene. (1990) 美国国家科学院院刊. 87(14):5392-6.
Moolten, F.L., Wells, J.M., Heyman, R.A., Evans, R.M. Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene. (1990) Human Gene Therapy. 1(2):125-34. DOI: 10.1089/hum.1990.1.2-125
Ishikawa, T., Umesono, K., Mangelsdorf, D.J., Aburatani, H., Stanger, B.Z., Shibasaki, Y., Imawari, M., Evans, R.M., Takaku, F. A functional retinoic acid receptor encoded by the gene on human chromosome 12. (1990) Molecular Endocrinology. 4(6):837-44. DOI: 10.1210/mend-4-6-837
Mangelsdorf, D.J., Ong, E.S., Dyck, J.A., Evans, R.M. Nuclear receptor that identifies a novel retinoic acid response pathway. (1990) 自然. 345(6272):224-9. DOI: 10.1038/345224a0
Schüle, R., Umesono, K., Mangelsdorf, D.J., Bolado, J., Pike, J.W., Evans, R.M. Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene. (1990) 牢房. 61(3):497-504.
Giguère, V., Evans, R.M. Identification of receptors for retinoids as members of the steroid and thyroid hormone receptor family. (1990) Meth. Enzymol. 189:223-32.
Evans, R.M. Molecular characterization of the glucocorticoid receptor. (1989) Recent Progress in Hormone Research. 45:1-22; discussion 22-7.
Umesono, K., Evans, R.M. Determinants of target gene specificity for steroid/thyroid hormone receptors. (1989) 牢房. 57(7):1139-46.
Borrelli, E., Heyman, R.A., Arias, C., Sawchenko, P.E., Evans, R.M. Transgenic mice with inducible dwarfism. (1989) 自然. 339(6225):538-41. DOI: 10.1038/339538a0
Damm, K., Thompson, C.C., Evans, R.M. Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist. (1989) 自然. 339(6226):593-7. DOI: 10.1038/339593a0
Thompson, C.C., Evans, R.M. Trans-activation by thyroid hormone receptors: functional parallels with steroid hormone receptors. (1989) 美国国家科学院院刊. 86(10):3494-8.
Heyman, R.A., Borrelli, E., Lesley, J., Anderson, D., Richman, D.D., Baird, S.M., Hyman, R., Evans, R.M. Thymidine kinase obliteration: creation of transgenic mice with controlled immune deficiency. (1989) 美国国家科学院院刊. 86(8):2698-702.
Giguère, V., Ong, E.S., Evans, R.M., Tabin, C.J. Spatial and temporal expression of the retinoic acid receptor in the regenerating amphibian limb. (1989) 自然. 337(6207):566-9. DOI: 10.1038/337566a0
Evans, R.M., Arriza, J.L. A molecular framework for the actions of glucocorticoid hormones in the nervous system. (1989) 神经元. 2(2):1105-12.
Oro, A.E., Umesono, K., Evans, R.M. Steroid hormone receptor homologs in development. (1989) Development. 107 Suppl:133-40.
Evans, R.M. The v-erbA oncogene is a thyroid hormone receptor antagonist. (1989) International Journal of Cancer. 4:26-8.
Oro, A.E., Hollenberg, S.M., Evans, R.M. Transcriptional inhibition by a glucocorticoid receptor-beta-galactosidase fusion protein. (1988) 牢房. 55(6):1109-14.
Hollenberg, S.M., Evans, R.M. Multiple and cooperative trans-activation domains of the human glucocorticoid receptor. (1988) 牢房. 55(5):899-906.
Oro, A.E., Ong, E.S., Margolis, J.S., Posakony, J.W., McKeown, M., Evans, R.M. The Drosophila gene knirps-related is a member of the steroid-receptor gene superfamily. (1988) 自然. 336(6198):493-6. DOI: 10.1038/336493a0
Drabkin, H., Kao, F.T., Hartz, J., Hart, I., Gazdar, A., Weinberger, C., Evans, R., Gerber, M. Localization of human ERBA2 to the 3p22----3p24.1 region of chromosome 3 and variable deletion in small cell lung cancer. (1988) 美国国家科学院院刊. 85(23):9258-62.
Arriza, J.L., Simerly, R.B., Swanson, L.W., Evans, R.M. The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response. (1988) 神经元. 1(9):887-900.
Umesono, K., Giguere, V., Glass, C.K., Rosenfeld, M.G., Evans, R.M. Retinoic acid and thyroid hormone induce gene expression through a common responsive element. (1988) 自然. 336(6196):262-5. DOI: 10.1038/336262a0
Borrelli, E., Heyman, R., Hsi, M., Evans, R.M. Targeting of an inducible toxic phenotype in animal cells. (1988) 美国国家科学院院刊. 85(20):7572-6.
Mayo, K.E., Hammer, R.E., Swanson, L.W., Brinster, R.L., Rosenfeld, M.G., Evans, R.M. Dramatic pituitary hyperplasia in transgenic mice expressing a human growth hormone-releasing factor gene. (1988) Molecular Endocrinology. 2(7):606-12. DOI: 10.1210/mend-2-7-606
Evans, R.M. The steroid and thyroid hormone receptor superfamily. (1988) 科学. 240(4854):889-95.
Evans, R.M., Hollenberg, S.M. Zinc fingers: gilt by association. (1988) 牢房. 52(1):1-3.
Giguère, V., Yang, N., Segui, P., Evans, R.M. Identification of a new class of steroid hormone receptors. (1988) 自然. 331(6151):91-4. DOI: 10.1038/331091a0
Evans, R.M., Hollenberg, S.M. Cooperative and positional independent trans-activation domains of the human glucocorticoid receptor. (1988) 冷泉港定量生物学研讨会。. 53 Pt 2:813-8. DOI: 10.1101/SQB.1988.053.01.092
Meunier, H., Rivier, C., Evans, R.M., Vale, W. Gonadal and extragonadal expression of inhibin alpha, beta A, and beta B subunits in various tissues predicts diverse functions. (1988) 美国国家科学院院刊. 85(1):247-51.
Pratt, W.B., Jolly, D.J., Pratt, D.V., Hollenberg, S.M., Giguere, V., Cadepond, F.M., Schweizer-Groyer, G., Catelli, M.G., Evans, R.M., Baulieu, E.E. A region in the steroid binding domain determines formation of the non-DNA-binding, 9 S glucocorticoid receptor complex. (1988) 生物化学杂志. 263(1):267-73.
Waterman, M.L., Adler, S., Nelson, C., Greene, G.L., Evans, R.M., Rosenfeld, M.G. A single domain of the estrogen receptor confers deoxyribonucleic acid binding and transcriptional activation of the rat prolactin gene. (1988) Molecular Endocrinology. 2(1):14-21. DOI: 10.1210/mend-2-1-14
Rosenfeld, M.G., Crenshaw, E.B., Lira, S.A., Swanson, L., Borrelli, E., Heyman, R., Evans, R.M. Transgenic mice: applications to the study of the nervous system. (1988) 神经科学年度评论》。. 11:353-72. DOI: 10.1146/annurev.ne.11.030188.002033
Giguere, V., Ong, E.S., Segui, P., Evans, R.M. Identification of a receptor for the morphogen retinoic acid. (1987) 自然. 330(6149):624-9. DOI: 10.1038/330624a0
Glass, C.K., Franco, R., Weinberger, C., Albert, V.R., Evans, R.M., Rosenfeld, M.G. A c-erb-A binding site in rat growth hormone gene mediates trans-activation by thyroid hormone. (1987) 自然. 329(6141):738-41. DOI: 10.1038/329738a0
Botteri, F.M., van der Putten, H., Wong, D.F., Sauvage, C.A., Evans, R.M. Unexpected thymic hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40 large T antigen. (1987) 分子与细胞生物学. 7(9):3178-84.
Thompson, C.C., Weinberger, C., Lebo, R., Evans, R.M. Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system. (1987) 科学. 237(4822):1610-4.
Arriza, J.L., Weinberger, C., Cerelli, G., Glaser, T.M., Handelin, B.L., Housman, D.E., Evans, R.M. Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. (1987) 科学. 237(4812):268-75.
Hollenberg, S.M., Giguere, V., Segui, P., Evans, R.M. Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor. (1987) 牢房. 49(1):39-46.
Leff, S.E., Evans, R.M., Rosenfeld, M.G. Splice commitment dictates neuron-specific alternative RNA processing in calcitonin/CGRP gene expression. (1987) 牢房. 48(3):517-24.
Weinberger, C., Giguère, V., Hollenberg, S.M., Thompson, C., Arriza, J., Evans, R.M. Human steroid receptors and erb-A gene products form a superfamily of enhancer-binding proteins. (1987) Clinical Physiology and Biochemistry. 5(3-4):179-89.
Elsholtz, H.P., Mangalam, H.J., Potter, E., Albert, V.R., Supowit, S., Evans, R.M., Rosenfeld, M.G. Two different cis-active elements transfer the transcriptional effects of both EGF and phorbol esters. (1986) 科学. 234(4783):1552-7.
Weinberger, C., Thompson, C.C., Ong, E.S., Lebo, R., Gruol, D.J., Evans, R.M. The c-erb-A gene encodes a thyroid hormone receptor. (1986) 自然. 324(6098):641-6. DOI: 10.1038/324641a0
Mayo, K.E., Cerelli, G.M., Spiess, J., Rivier, J., Rosenfeld, M.G., Evans, R.M., Vale, W. Inhibin A-subunit cDNAs from porcine ovary and human placenta. (1986) 美国国家科学院院刊. 83(16):5849-53.
Giguère, V., Hollenberg, S.M., Rosenfeld, M.G., Evans, R.M. Functional domains of the human glucocorticoid receptor. (1986) 牢房. 46(5):645-52.
Nelson, C., Crenshaw, E.B., Franco, R., Lira, S.A., Albert, V.R., Evans, R.M., Rosenfeld, M.G. Discrete cis-active genomic sequences dictate the pituitary cell type-specific expression of rat prolactin and growth hormone genes. (1986) 自然. 322(6079):557-62. DOI: 10.1038/322557a0
Mayo, K.E., Evans, R.M., Rosenfeld, G.M. Genes encoding mammalian neuroendocrine peptides: strategies toward their identification and analysis. (1986) Annual Review of Physiology. 48:431-46. DOI: 10.1146/annurev.ph.48.030186.002243
Weinberger, C., Giguere, V., Hollenberg, S., Rosenfeld, M.G., Evans, R.M. Human steroid receptors and erbA proto-oncogene products: members of a new superfamily of enhancer binding proteins. (1986) 冷泉港定量生物学研讨会。. 51 Pt 2:759-72.
Lin, C.R., Chen, W.S., Lazar, C.S., Carpenter, C.D., Gill, G.N., Evans, R.M., Rosenfeld, M.G. Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms. (1986) 牢房. 44(6):839-48.
Leff, S.E., Rosenfeld, M.G., Evans, R.M. Complex transcriptional units: diversity in gene expression by alternative RNA processing. (1986) Annual Review of Biochemistry. 55:1091-117. DOI: 10.1146/annurev.bi.55.070186.005303
Hollenberg, S.M., Weinberger, C., Ong, E.S., Cerelli, G., Oro, A., Lebo, R., Thompson, E.B., Rosenfeld, M.G., Evans, R.M. Primary structure and expression of a functional human glucocorticoid receptor cDNA. (1985) 自然. 318(6047):635-41.
van der Putten, H., Botteri, F.M., Miller, A.D., Rosenfeld, M.G., Fan, H., Evans, R.M., Verma, I.M. Efficient insertion of genes into the mouse germ line via retroviral vectors. (1985) 美国国家科学院院刊. 82(18):6148-52.
Murdoch, G.H., Waterman, M., Evans, R.M., Rosenfeld, M.G. Molecular mechanisms of phorbol ester, thyrotropin-releasing hormone, and growth factor stimulation of prolactin gene transcription. (1985) 生物化学杂志. 260(21):11852-8.
Amara, S.G., Arriza, J.L., Leff, S.E., Swanson, L.W., Evans, R.M., Rosenfeld, M.G. Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptide. (1985) 科学. 229(4718):1094-7.
Swanson, L.W., Simmons, D.M., Arriza, J., Hammer, R., Brinster, R., Rosenfeld, M.G., Evans, R.M. Novel developmental specificity in the nervous system of transgenic animals expressing growth hormone fusion genes. (1985) 自然. 317(6035):363-6.
Waterman, M., Murdoch, G.H., Evans, R.M., Rosenfeld, M.G. Cyclic AMP regulation of eukaryotic gene transcription by two discrete molecular mechanisms. (1985) 科学. 229(4710):267-9.
Gill, G.N., Weber, W., Thompson, D.M., Lin, C., Evans, R.M., Rosenfeld, M.G., Gamou, S., Shimizu, N. Relationship between production of epidermal growth factor receptors, gene amplification, and chromosome 7 translocation in variant A431 cells. (1985) Somatic Cell and Molecular Genetics. 11(4):309-18.
Weinberger, C., Hollenberg, S.M., Rosenfeld, M.G., Evans, R.M. Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product. (1985) 自然. 318(6047):670-2.
Mayo, K.E., Cerelli, G.M., Rosenfeld, M.G., Evans, R.M. Characterization of cDNA and genomic clones encoding the precursor to rat hypothalamic growth hormone-releasing factor. (1985) 自然. 314(6010):464-7.
Evans, R.M., Swanson, L., Rosenfeld, M.G. Creation of transgenic animals to study development and as models for human disease. (1985) Recent Progress in Hormone Research. 41:317-37.
Barinaga, M., Bilezikjian, L.M., Vale, W.W., Rosenfeld, M.G., Evans, R.M. Hormonal regulation of gene expression: regulation of growth hormone gene transcription by growth hormone releasing factor. (1985) Oxford Surveys on Eukaryotic Genes. 2:49-73.
Weinberger, C., Hollenberg, S.M., Ong, E.S., Harmon, J.M., Brower, S.T., Cidlowski, J., Thompson, E.B., Rosenfeld, M.G., Evans, R.M. Identification of human glucocorticoid receptor complementary DNA clones by epitope selection. (1985) 科学. 228(4700):740-2.
Hammer, R.E., Brinster, R.L., Rosenfeld, M.G., Evans, R.M., Mayo, K.E. Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth. (1985) 自然. 315(6018):413-6.
Jonas, V., Lin, C.R., Kawashima, E., Semon, D., Swanson, L.W., Mermod, J.J., Evans, R.M., Rosenfeld, M.G. Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression. (1985) 美国国家科学院院刊. 82(7):1994-8.
Evans, R.M., Weinberger, C., Hollenberg, S., Swanson, L., Nelson, C., Rosenfeld, M.G. Inducible and developmental control of neuroendocrine genes. (1985) 冷泉港定量生物学研讨会。. 50:389-97.
Sabate, M.I., Stolarsky, L.S., Polak, J.M., Bloom, S.R., Varndell, I.M., Ghatei, M.A., Evans, R.M., Rosenfeld, M.G. Regulation of neuroendocrine gene expression by alternative RNA processing. Colocalization of calcitonin and calcitonin gene-related peptide in thyroid C-cells. (1985) 生物化学杂志. 260(5):2589-92.
Barinaga, M., Bilezikjian, L.M., Vale, W.W., Rosenfeld, M.G., Evans, R.M. Independent effects of growth hormone releasing factor on growth hormone release and gene transcription. (1985) 自然. 314(6008):279-81.
Mayo, K.E., Cerelli, G.M., Lebo, R.V., Bruce, B.D., Rosenfeld, M.G., Evans, R.M. Gene encoding human growth hormone-releasing factor precursor: structure, sequence, and chromosomal assignment. (1985) 美国国家科学院院刊. 82(1):63-7.
Amara, S.G., Evans, R.M., Rosenfeld, M.G. Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites. (1984) 分子与细胞生物学. 4(10):2151-60.
Miller, A.D., Ong, E.S., Rosenfeld, M.G., Verma, I.M., Evans, R.M. Infectious and selectable retrovirus containing an inducible rat growth hormone minigene. (1984) 科学. 225(4666):993-8.
Rosenfeld, M.G., Amara, S.G., Evans, R.M. Alternative RNA processing: determining neuronal phenotype. (1984) 科学. 225(4668):1315-20.
Lin, C.R., Chen, W.S., Kruiger, W., Stolarsky, L.S., Weber, W., Evans, R.M., Verma, I.M., Gill, G.N., Rosenfeld, M.G. Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells. (1984) 科学. 224(4651):843-8.
Supowit, S.C., Potter, E., Evans, R.M., Rosenfeld, M.G. Polypeptide hormone regulation of gene transcription: specific 5' genomic sequences are required for epidermal growth factor and phorbol ester regulation of prolactin gene expression. (1984) 美国国家科学院院刊. 81(10):2975-9.
Rosenfeld, M.G., Amara, S.G., Evans, R.M. Alternative RNA processing events as a critical developmental regulatory strategy in neuroendocrine gene expression. (1984) Biochemical Society Symposium. 49:27-44.
Murdoch, G.H., Franco, R., Evans, R.M., Rosenfeld, M.G. Polypeptide hormone regulation of gene expression. Thyrotropin-releasing hormone rapidly stimulates both transcription of the prolactin gene and the phosphorylation of a specific nuclear protein. (1983) 生物化学杂志. 258(24):15329-35.
Barinaga, M., Yamonoto, G., Rivier, C., Vale, W., Evans, R., Rosenfeld, M.G. Transcriptional regulation of growth hormone gene expression by growth hormone-releasing factor. (1983) 自然. 306(5938):84-5.
Mayo, K.E., Vale, W., Rivier, J., Rosenfeld, M.G., Evans, R.M. Expression-cloning and sequence of a cDNA encoding human growth hormone-releasing factor. (1983) 自然. 306(5938):86-8.
Fisher, L.A., Kikkawa, D.O., Rivier, J.E., Amara, S.G., Evans, R.M., Rosenfeld, M.G., Vale, W.W., Brown, M.R. Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptide. (1983) 自然. 305(5934):534-6.
Rosenfeld, M.G., Mermod, J.J., Amara, S.G., Swanson, L.W., Sawchenko, P.E., Rivier, J., Vale, W.W., Evans, R.M. Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. (1983) 自然. 304(5922):129-35.
Rosenfeld, M.G., Amara, S.G., Birnberg, N.C., Mermod, J.J., Murdoch, G.H., Evans, R.M. Calcitonin, prolactin, and growth hormone gene expression as model systems for the characterization of neuroendocrine regulation. (1983) Recent Progress in Hormone Research. 39:305-51.
Evans, R.M., Amara, S., Rosenfeld, M.G. Molecular events in developmental regulation of neuroendocrine genes: characterization of the novel neuropeptide CGRP. (1983) 冷泉港定量生物学研讨会。. 48 Pt 1:413-7.
Palmiter, R.D., Brinster, R.L., Hammer, R.E., Trumbauer, M.E., Rosenfeld, M.G., Birnberg, N.C., Evans, R.M. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. (1982) 自然. 300(5893):611-5.
Evans, R.M., Birnberg, N.C., Rosenfeld, M.G. Glucocorticoid and thyroid hormones transcriptionally regulate growth hormone gene expression. (1982) 美国国家科学院院刊. 79(24):7659-63.
Murdoch, G.H., Evans, M. Eukaryotic transcriptional regulation and chromatin-associated protein phosphorylation by cyclic AMP. (1982) 科学. 218(4579):1315-7.
Murdoch, G.H., Potter, E., Nicolaisen, A.K., Evans, R.M., Rosenfeld, M.G. Epidermal growth factor rapidly stimulates prolactin gene transcription. (1982) 自然. 300(5888):192-4.
Amara, S.G., Jonas, V., Rosenfeld, M.G., Ong, E.S., Evans, R.M. Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. (1982) 自然. 298(5871):240-4.
Doehmer, J., Barinaga, M., Vale, W., Rosenfeld, M.G., Verma, I.M., Evans, R.M. Introduction of rat growth hormone gene into mouse fibroblasts via a retroviral DNA vector: expression and regulation. (1982) 美国国家科学院院刊. 79(7):2268-72.
Amara, S.G., Jonas, V., O'Neil, J.A., Vale, W., Rivier, J., Roos, B.A., Evans, R.M., Rosenfeld, M.G. Calcitonin COOH-terminal cleavage peptide as a model for identification of novel neuropeptides predicted by recombinant DNA analysis. (1982) J. Biol. Chem. 257(5):2129-32.
Rosenfeld, M.G., Lin, C.R., Amara, S.G., Stolarsky, L., Roos, B.A., Ong, E.S., Evans, R.M. Calcitonin mRNA polymorphism: peptide switching associated with alternative RNA splicing events. (1982) 美国国家科学院院刊. 79(6):1717-21.
Evans, R.M., Amara, S.G., Rosenfeld, M.G. RNA processing regulation of neuroendorcrine gene expression. (1982) DNA. 1(4):323-8. DOI: 10.1089/dna.1982.1.323
Potter, E., Nicolaisen, A.K., Ong, E.S., Evans, R.M., Rosenfeld, M.G. Thyrotropin-releasing hormone exerts rapid nuclear effects to increase production of the primary prolactin mRNA transcript. (1981) 美国国家科学院院刊. 78(11):6662-6.
Rosenfeld, M.G., Amara, S.G., Roos, B.A., Ong, E.S., Evans, R.M. Altered expression of the calcitonin gene associated with RNA polymorphism. (1981) 自然. 290(5801):63-5.
Amara, S.G., David, D.N., Rosenfeld, M.G., Roos, B.A., Evans, R.M. Characterization of rat calcitonin mRNA. (1980) 美国国家科学院院刊. 77(8):4444-8.
Harpold, M.M., Evans, R.M., Salditt-Georgieff, M., Darnell, J.E. Production of mRNA in Chinese hamster cells: relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences. (1979) 牢房. 17(4):1025-35.
Soreq, H., Harpold, M., Evans, R., Darnell, J.E., Bancroft, F.C. Rat growth hormone gene: intervening sequences separate the mRNA regions. (1979) 核酸研究. 6(7):2471-82.
Ziff, E.B., Evans, R.M. Coincidence of the promoter and capped 5' terminus of RNA from the adenovirus 2 major late transcription unit. (1978) 牢房. 15(4):1463-75.
Darnell, J.E., Evans, R., Fraser, N., Goldberg, S., Nevins, J., Salditt-Georgieff, M., Schwartz, H., Weber, J., Ziff, E. The definition of transcription units for mRNA. (1978) 冷泉港定量生物学研讨会。. 42 Pt 1:515-22.
Evans, R.M., Fraser, N., Ziff, E., Weber, J., Wilson, M., Darnell, J.E. The initiation sites for RNA transcription in Ad2 DNA. (1977) 牢房. 12(3):733-9.
Evans, R.M., Shoyab, M., Drohan, W.N., Baluda, M.A. Homogeneity and complexity of avian oncornavirus proviral DNA determined by molecular hybridization. (1977) 病毒学杂志. 21(3):942-9.
Evans, R.M., Shoyab, M., Baluda, M.A. Studies on characterization of the integration sites of avian RNA tumor virus-specific DNA. (1975) 冷泉港定量生物学研讨会。. 39 Pt 2:1005-7.
Evans, R.M., Baluda, M.A., Shoyab, M. Differences between the integration of avian myeloblastosis virus DNA in leukemic cells and of endogenous viral DNA in normal chicken cells. (1974) 美国国家科学院院刊. 71(8):3152-6.
Shoyab, M., Evans, R.M., Baluda, M.A. Presence in leukemic cells of avian myeloblastosis virus-specific DNA sequences absent in normal chicken cells. (1974) 病毒学杂志. 14(1):47-9.
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文学士，细菌学，加利福尼亚大学洛杉矶分校
哲学博士，微生物学与免疫学，加州大学洛杉矶分校
洛克菲勒大学博士后研究员
