Katherine Jones, PhD

Professor Emerita

索尔克生物研究所 出版物

所有出版物


Podvin, S., Jones, J., Kang, A., Goodman, R., Reed, P., Lietz, C.B., Then, J., Lee, K.C., Eyler, L.T., Jeste, D.V., Gage, F.H., Hook, V. Human iN neuronal model of schizophrenia displays dysregulation of chromogranin B and related neuropeptide transmitter signatures. (2024) Molecular Psychiatry. DOI: 10.1038/s41380-024-02422-x

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Traxler, L., Lucciola, R., Herdy, J.R., Jones, J.R., Mertens, J., Gage, F.H. Neural cell state shifts and fate loss in ageing and age-related diseases. (2023) Nat Rev Neurol. DOI: 10.1038/s41582-023-00815-0

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Stronati, E., Giraldez, S., Huang, L., Abraham, E., McGuire, G.R., Hsu, H.T., Jones, K.A., Estarás, C. YAP1 regulates the self-organized fate patterning of hESC-derived gastruloids. (2022) Stem Cell Reports. DOI: 10.1016/j.stemcr.2021.12.012

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Choi, S.H., Kim, S., Jones, K.A. Gene expression regulation by CDK12: a versatile kinase in cancer with functions beyond CTD phosphorylation. (2020) Experimental & Molecular Medicine. DOI: 10.1038/s12276-020-0442-9

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Choi, S.H., Martinez, T.F., Kim, S., Donaldson, C., Shokhirev, M.N., Saghatelian, A., Jones, K.A. CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability. (2019) 基因与发展. 33(7-8):418-435. DOI: 10.1101/gad.322339.118

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Hsu, H.T., Estarás, C., Huang, L., Jones, K.A. Specifying the Anterior Primitive Streak by Modulating YAP1 Levels in Human Pluripotent Stem Cells. (2018) Stem Cell Reports. 11(6):1357-1364. DOI: 10.1016/j.stemcr.2018.10.013

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Xu, M., Moresco, J.J., Chang, M., Mukim, A., Smith, D., Diedrich, J.K., Yates, J.R., Jones, K.A. SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy. (2018) PLOS pathogens. 14(5):e1007071. DOI: 10.1371/journal.ppat.1007071

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Estarás, C., Hsu, H.T., Huang, L., Jones, K.A. YAP repression of the WNT3 gene controls hESC differentiation along the cardiac mesoderm lineage. (2017) 基因与发展. 31(22):2250-2263. DOI: 10.1101/gad.307512.117

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Estarás, C., Benner, C., Jones, K.A. SMADs and YAP compete to control elongation of β-catenin:LEF-1-recruited RNAPII during hESC differentiation. (2015) 分子细胞. 58(5):780-93. DOI: 10.1016/j.molcel.2015.04.001

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Chen, Y., Zhang, L., Estarás, C., Choi, S.H., Moreno, L., Karn, J., Moresco, J.J., Yates, J.R., Jones, K.A. A gene-specific role for the Ssu72 RNAPII CTD phosphatase in HIV-1 Tat transactivation. (2014) 基因与发展. 28(20):2261-75. DOI: 10.1101/gad.250449.114

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Jones, K.A. Changing the core of transcription. (2014) Elife. 3:e03575.

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Choi, S.H., Estarás, C., Moresco, J.J., Yates, J.R., Jones, K.A. α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes. (2013) 基因与发展. 27(22):2473-88. DOI: 10.1101/gad.229062.113

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Türbachova, I., Schwachula, T., Vasconcelos, I., Mustea, A., Baldinger, T., Jones, K.A., Bujard, H., Olek, A., Olek, K., Gellhaus, K., Braicu, I., Könsgen, D., Fryer, C., Ravot, E., Hellwag, A., Westerfeld, N., Gruss, O.J., Meissner, M., Hasan, M.T., Weber, M., Hoffmüller, U., Zimmermann, S., Loddenkemper, C., Mahner, S., Babel, N., Berns, E., Adams, R., Zeilinger, R., Baron, U., Vergote, I., Maughan, T., Marme, F., Dickhaus, T., Sehouli, J., Olek, S. The cellular ratio of immune tolerance (immunoCRIT) is a definite marker for aggressiveness of solid tumors and may explain tumor dissemination patterns. (2013) 表观遗传学. 8(11):1226-35. DOI: 10.4161/epi.26334

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Jones, K.A. A SirT'N repression for Notch. (2011) 分子细胞. 42(5):559-60. DOI: 10.1016/j.molcel.2011.05.017

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Chen, Y., Zhang, L., Jones, K.A. SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing. (2011) 基因与发展. 25(7):701-16. DOI: 10.1101/gad.2002611

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Jones, K.A. Outsmarting a mastermind. (2009) 发育细胞. 17(6):750-2. DOI: 10.1016/j.devcel.2009.12.002

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Brès, V., Yoshida, T., Pickle, L., Jones, K.A. SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation. (2009) 分子细胞. 36(1):75-87. DOI: 10.1016/j.molcel.2009.08.015

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Yoh, S.M., Lucas, J.S., Jones, K.A. The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation. (2008) 基因与发展. 22(24):3422-34. DOI: 10.1101/gad.1720008

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Jones, K.A., Kemp, C.R. Wnt-induced proteolytic targeting. (2008) 基因与发展. 22(22):3077-81. DOI: 10.1101/gad.1741008

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Brès, V., Yoh, S.M., Jones, K.A. The multi-tasking P-TEFb complex. (2008) 细胞生物学进展. 20(3):334-40. DOI: 10.1016/j.ceb.2008.04.008

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Jones, K.A. Transcription strategies in terminally differentiated cells: shaken to the core. (2007) 基因与发展. 21(17):2113-7. DOI: 10.1101/gad.1598007


Yoh, S.M., Cho, H., Pickle, L., Evans, R.M., Jones, K.A. The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. (2007) 基因与发展. 21(2):160-74. DOI: 10.1101/gad.1503107

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Wang, S., Jones, K.A. CK2 controls the recruitment of Wnt regulators to target genes in vivo. (2006) 当前生物学。. 16(22):2239-44. DOI: 10.1016/j.cub.2006.09.034

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Willert, K., Jones, K.A. Wnt signaling: is the party in the nucleus? (2006) 基因与发展. 20(11):1394-404. DOI: 10.1101/gad.1424006

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Sierra, J., Yoshida, T., Joazeiro, C.A., Jones, K.A. The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. (2006) 基因与发展. 20(5):586-600. DOI: 10.1101/gad.1385806

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Brès, V., Gomes, N., Pickle, L., Jones, K.A. A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat. (2005) 基因与发展. 19(10):1211-26. DOI: 10.1101/gad.1291705

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Fryer, C.J., White, J.B., Jones, K.A. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. (2004) 分子细胞. 16(4):509-20. DOI: 10.1016/j.molcel.2004.10.014

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Gomes, N., Garber, M.E., Jones, K.A. Techniques to analyze the HIV-1 Tat and TAR RNA-dependent recruitment and activation of the cyclin T1: CDK9 (P-TEFb) transcription elongation factor. (2003) Methods in Enzymology. 371:324-36. DOI: 10.1016/S0076-6879(03)71024-6


Orlando, V., Jones, K.A. Wild chromatin: regulation of eukaryotic genes in their natural chromatin context. (2002) 基因与发展. 16(16):2039-44. DOI: 10.1101/gad.1017402


Fryer, C.J., Lamar, E., Turbachova, I., Kintner, C., Jones, K.A. Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. (2002) 基因与发展. 16(11):1397-411. DOI: 10.1101/gad.991602

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Tutter, A.V., Fryer, C.J., Jones, K.A. Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro. (2001) 基因与发展. 15(24):3342-54. DOI: 10.1101/gad.946501

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Zhang, J., Tamilarasu, N., Hwang, S., Garber, M.E., Huq, I., Jones, K.A., Rana, T.M. HIV-1 TAR RNA enhances the interaction between Tat and cyclin T1. (2000) 生物化学杂志. 275(44):34314-9. DOI: 10.1074/jbc.M006804200

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Kadam, S., McAlpine, G.S., Phelan, M.L., Kingston, R.E., Jones, K.A., Emerson, B.M. Functional selectivity of recombinant mammalian SWI/SNF subunits. (2000) 基因与发展. 14(19):2441-51.

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Garber, M.E., Mayall, T.P., Suess, E.M., Meisenhelder, J., Thompson, N.E., Jones, K.A. CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA. (2000) 分子与细胞生物学. 20(18):6958-69.

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Jones, K.A., Kadonaga, J.T. Exploring the transcription-chromatin interface. (2000) 基因与发展. 14(16):1992-6.


Garber, M.E., Jones, K.A. HIV-1 Tat: coping with negative elongation factors. (1999) Current Opinion in Immunology. 11(4):460-5. DOI: 10.1016/S0952-7915(99)80077-6

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Tutter, A., McAlpine, G.S., Jones, K.A. Mechanism of chromatin recognition and transcriptional regulation by LEF-1 and the Wnt/Wg-responsive LEF-1:beta-catenin complex. (1999) 冷泉港定量生物学研讨会。. 64:445-452.


Garber, M.E., Wei, P., Caderas, G., Jones, K.A. Protein and RNA affinity selection techniques using HIV-1 Tat. (1999) Methods in Enzymology. 306:352-64.


Herrmann, C.H., Carroll, R.G., Wei, P., Jones, K.A., Rice, A.P. Tat-associated kinase, TAK, activity is regulated by distinct mechanisms in peripheral blood lymphocytes and promonocytic cell lines. (1998) 病毒学杂志. 72(12):9881-8.

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Garber, M.E., Wei, P., KewalRamani, V.N., Mayall, T.P., Herrmann, C.H., Rice, A.P., Littman, D.R., Jones, K.A. The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. (1998) 基因与发展. 12(22):3512-27.

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Tutter, A., Jones, K.A. Chemicals that footprint DNA: hitting HIV-1 in the minor groove. (1998) 美国国家科学院院刊. 95(22):12739-41.


Garber, M.E., Wei, P., Jones, K.A. HIV-1 Tat interacts with cyclin T1 to direct the P-TEFb CTD kinase complex to TAR RNA. (1998) 冷泉港定量生物学研讨会。. 63:371-380.


Wei, P., Garber, M.E., Fang, S.M., Fischer, W.H., Jones, K.A. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. (1998) 牢房. 92(4):451-462.

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Sheridan, P.L., Mayall, T.P., Verdin, E., Jones, K.A. Histone acetyltransferases regulate HIV-1 enhancer activity in vitro. (1997) 基因与发展. 11(24):3327-40.

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Jones, K.A. Taking a new TAK on tat transactivation. (1997) 基因与发展. 11(20):2593-9.


Mayall, T.P., Sheridan, P.L., Montminy, M.R., Jones, K.A. Distinct roles for P-CREB and LEF-1 in TCR alpha enhancer assembly and activation on chromatin templates in vitro. (1997) 基因与发展. 11(7):887-99.

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Jones, K.A. Taking out Tat. (1996) Nature Biotechnology. 14(11):1542-3. DOI: 10.1038/nbt1196-1542


Okamoto, H., Sheline, C.T., Corden, J.L., Jones, K.A., Peterlin, B.M. Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II. (1996) 美国国家科学院院刊. 93(21):11575-9.

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Pazin, M.J., Sheridan, P.L., Cannon, K., Cao, Z., Keck, J.G., Kadonaga, J.T., Jones, K.A. NF-kappa B-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro. (1996) 基因与发展. 10(1):37-49.

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Sheridan, P.L., Sheline, C.T., Cannon, K., Voz, M.L., Pazin, M.J., Kadonaga, J.T., Jones, K.A. Activation of the HIV-1 enhancer by the LEF-1 HMG protein on nucleosome-assembled DNA in vitro. (1995) 基因与发展. 9(17):2090-104.

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Lin, Y., Sheridan, P.L., Jones, K.A., Evans, G.A. The HIP116 SNF2/SW12-related transcription factor gene (SNF2L3) is located on human chromosome 3q25.1-q26.1. (1995) Genomics. 27(2):381-2. DOI: 10.1006/geno.1995.1064


Sheridan, P.L., Schorpp, M., Voz, M.L., Jones, K.A. Cloning of an SNF2/SWI2-related protein that binds specifically to the SPH motifs of the SV40 enhancer and to the HIV-1 promoter. (1995) 生物化学杂志. 270(9):4575-87.

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Jones, K.A., Peterlin, B.M. Control of RNA initiation and elongation at the HIV-1 promoter. (1994) Annual Review of Biochemistry. 63:717-43. DOI: 10.1146/annurev.bi.63.070194.003441


Carlsson, P., Waterman, M.L., Jones, K.A. The hLEF/TCF-1 alpha HMG protein contains a context-dependent transcriptional activation domain that induces the TCR alpha enhancer in T cells. (1993) 基因与发展. 7(12A):2418-30.

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Zenzie-Gregory, B., Sheridan, P., Jones, K.A., Smale, S.T. HIV-1 core promoter lacks a simple initiator element but contains a bipartite activator at the transcription start site. (1993) 生物化学杂志. 268(21):15823-32.

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Jones, K.A. Tat and the HIV-1 promoter. (1993) 细胞生物学进展. 5(3):461-8.

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Sheridan, P.L., Sheline, C.T., Milocco, L.H., Jones, K.A. Tat and the HIV-1 promoter: A model for RNA-mediated regulation of transcription (1993) Seminars in Virology. 4(1):690808. DOI: 10.1016/1044-5773(93)80010-L

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Sheline, C.T., Milocco, L.H., Jones, K.A. Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin. (1991) 基因与发展. 5(12B):2508-20.

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Waterman, M.L., Fischer, W.H., Jones, K.A. A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer. (1991) 基因与发展. 5(4):656-69.

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Waterman, M.L., Jones, K.A. Purification of TCF-1 alpha, a T-cell-specific transcription factor that activates the T-cell receptor C alpha gene enhancer in a context-dependent manner. (1990) New Biologist. 2(7):621-636.

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Jones, K.A. HIV trans-activation and transcription control mechanisms. (1989) New Biologist. 1(2):127-135.

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Toohey, M.G., Jones, K.A. In vitro formation of short RNA polymerase II transcripts that terminate within the HIV-1 and HIV-2 promoter-proximal downstream regions. (1989) 基因与发展. 3(3):265-82.

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Jones, K.A., Luciw, P.A., Duchange, N. Structural arrangements of transcription control domains within the 5'-untranslated leader regions of the HIV-1 and HIV-2 promoters. (1988) 基因与发展. 2(9):1101-14.

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Dinter, H., Chiu, R., Imagawa, M., Karin, M., Jones, K.A. In vitro activation of the HIV-1 enhancer in extracts from cells treated with a phorbol ester tumor promoter. (1987) EMBO 期刊. 6(13):4067-71.

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Jones, K.A., Kadonaga, J.T., Rosenfeld, P.J., Kelly, T.J., Tjian, R. A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication. (1987) 牢房. 48(1):79-89.

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Jones, K.A., Kadonaga, J.T., Luciw, P.A., Tjian, R. Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1. (1986) 科学. 232(4751):755-9.

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Kadonaga, J.T., Jones, K.A., Tjian, R. Promoter-specific activation of RNA polymerase II transcription by Sp1 (1986) 生物化学趋势. 11(1):20-23. DOI: 10.1016/0968-0004(86)90226-4

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Jones, K.A., Tjian, R. Sp1 binds to promoter sequences and activates herpes simplex virus 'immediate-early' gene transcription in vitro. (1985) 自然. 317(6033):179-82.

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Jones, K.A., Yamamoto, K.R., Tjian, R. Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro. (1985) 牢房. 42(2):559-72.

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Jones, K.A., Myers, R.M., Tjian, R. Mutational analysis of simian virus 40 large T antigen DNA binding sites. (1984) EMBO 期刊. 3(13):3247-55.

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Jones, K.A., Tjian, R. Essential contact residues within SV40 large T antigen binding sites I and II identified by alkylation-interference. (1984) 牢房. 36(1):155-62.

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教育

PhD, Biochemistry, University of California, Riverside
Postdoctoral Research, University of California, Berkeley