Gerald Joyce, MD, PhD

President
教授
杰克 H. 斯基尔鲍尔化学与蛋白质组学中心

索尔克生物研究所 出版物

所有出版物


2024

Cochrane, W.G., Bare, G.A.L., Joyce, G.F., Horning, D.P. Cross-chiral exponential amplification of an RNA enzyme. (2024) 美国国家科学院院刊. 121(44):e2413668121. DOI: 10.1073/pnas.2413668121

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Papastavrou, N., Horning, D.P., Joyce, G.F. RNA-catalyzed evolution of catalytic RNA. (2024) 美国国家科学院院刊. 121(11):e2321592121. DOI: 10.1073/pnas.2321592121

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2023

Kakoti, A., Joyce, G.F. RNA Polymerase Ribozyme That Recognizes the Template-Primer Complex through Tertiary Interactions. (2023) Biochemistry. DOI: 10.1021/acs.biochem.3c00091

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2022

Menichelli, E., Lam, B.J., Wang, Y., Wang, V.S., Shaffer, J., Tjhung, K.F., Bursulaya, B., Nguyen, T.N., Vo, T., Alper, P.B., McAllister, C.S., Jones, D.H., Spraggon, G., Michellys, P.Y., Joslin, J., Joyce, G.F., Rogers, J. Discovery of small molecules that target a tertiary-structured RNA. (2022) 美国国家科学院院刊. 119(48):e2213117119. DOI: 10.1073/pnas.2213117119

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2021

Bare, G.A.L., Joyce, G.F. Cross-Chiral, RNA-Catalyzed Exponential Amplification of RNA. (2021) Journal of the American Chemical Society. DOI: 10.1021/jacs.1c09233

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Portillo, X., Huang, Y.T., Breaker, R.R., Horning, D.P., Joyce, G.F. Witnessing the structural evolution of an RNA enzyme. (2021) Elife. 10. DOI: 10.7554/eLife.71557

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2020

Setterholm, N.A., Haratipour, P., Kashemirov, B.A., McKenna, C.E., Joyce, G.F. Kinetic Effects of β,γ-Modified Deoxynucleoside 5'-Triphosphate Analogues on RNA-Catalyzed Polymerization of DNA. (2020) Biochemistry. DOI: 10.1021/acs.biochem.0c00779

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Tjhung, K.F., Sczepanski, J.T., Murtfeldt, E.R., Joyce, G.F. RNA-Catalyzed Cross-Chiral Polymerization of RNA. (2020) Journal of the American Chemical Society. DOI: 10.1021/jacs.0c05635

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Salditt, A., Keil, L.M.R., Horning, D.P., Mast, C.B., Joyce, G.F., Braun, D. Thermal Habitat for RNA Amplification and Accumulation. (2020) Phys. Rev. Lett. 125(4):048104. DOI: 10.1103/PhysRevLett.125.048104

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Tjhung, K.F., Shokhirev, M.N., Horning, D.P., Joyce, G.F. An RNA polymerase ribozyme that synthesizes its own ancestor. (2020) 美国国家科学院院刊. DOI: 10.1073/pnas.1914282117

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2019

Horning, D.P., Bala, S., Chaput, J.C., Joyce, G.F. RNA-Catalyzed Polymerization of Deoxyribose, Threose, and Arabinose Nucleic Acids. (2019) ACS Synthetic Biology. 8(5):955-961. DOI: 10.1021/acssynbio.9b00044

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Pressman, A.D., Liu, Z., Janzen, E., Blanco, C., Müller, U.F., Joyce, G.F., Pascal, R., Chen, I.A. Mapping a systematic ribozyme fitness landscape reveals a frustrated evolutionary network for self-aminoacylating RNA. (2019) Journal of the American Chemical Society. DOI: 10.1021/jacs.8b13298

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2018

Joyce, G.F., Szostak, J.W. Protocells and RNA Self-Replication. (2018) 冷泉港生物学述评. 10(9). DOI: 10.1101/cshperspect.a034801

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Samanta, B., Horning, D.P., Joyce, G.F. 3'-End labeling of nucleic acids by a polymerase ribozyme. (2018) 核酸研究. DOI: 10.1093/nar/gky513

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2017

Joyce, G.F., Samanta, B. A reverse transcriptase ribozyme. (2017) Elife. 6. DOI: 10.7554/eLife.31153

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2016

Olea, C., Joyce, G.F. Real-Time Detection of a Self-Replicating RNA Enzyme. (2016) Molecules. 21(10). DOI: 10.3390/molecules21101310

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Horning, D.P., Joyce, G.F. Amplification of RNA by an RNA polymerase ribozyme. (2016) 美国国家科学院院刊. 113(35):9786-91. DOI: 10.1073/pnas.1610103113

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2015

Sczepanski, J.T., Joyce, G.F. Specific Inhibition of MicroRNA Processing Using L-RNA Aptamers. (2015) Journal of the American Chemical Society. 137(51):16032-7. DOI: 10.1021/jacs.5b06696

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Joyce, G.F. Reflections of a Darwinian Engineer. (2015) Journal of Molecular Evolution. 81(5-6):146-9. DOI: 10.1007/s00239-015-9724-6


Olea, C., Weidmann, J., Dawson, P.E., Joyce, G.F. An L-RNA Aptamer that Binds and Inhibits RNase. (2015) Chemistry & Biology. 22(11):1437-1441. DOI: 10.1016/j.chembiol.2015.09.017

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Olea, C., Joyce, G.F. Ligand-dependent exponential amplification of self-replicating RNA enzymes. (2015) Meth. Enzymol. 550:23-39. DOI: 10.1016/bs.mie.2014.10.030

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2014

Sczepanski, J.T., Joyce, G.F. A cross-chiral RNA polymerase ribozyme. (2014) 自然. 515(7527):440-2. DOI: 10.1038/nature13900

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Petrie, K.L., Joyce, G.F. Limits of neutral drift: lessons from the in vitro evolution of two ribozymes. (2014) J. Mol. Evol. 79(3-4):75-90. DOI: 10.1007/s00239-014-9642-z

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Breaker, R.R., Joyce, G.F. The expanding view of RNA and DNA function. (2014) Chemistry & Biology. 21(9):1059-65. DOI: 10.1016/j.chembiol.2014.07.008

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Robertson, M.P., Joyce, G.F. Highly efficient self-replicating RNA enzymes. (2014) Chemistry & Biology. 21(2):238-45. DOI: 10.1016/j.chembiol.2013.12.004

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2013

Sczepanski, J.T., Joyce, G.F. Binding of a structured D-RNA molecule by an L-RNA aptamer. (2013) Journal of the American Chemical Society. 135(36):13290-3. DOI: 10.1021/ja406634g

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Ferretti, A.C., Joyce, G.F. Kinetic properties of an RNA enzyme that undergoes self-sustained exponential amplification. (2013) Biochemistry. 52(7):1227-35. DOI: 10.1021/bi301646n

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2012

Sczepanski, J.T., Joyce, G.F. Synthetic evolving systems that implement a user-specified genetic code of arbitrary design. (2012) Chemistry & Biology. 19(10):1324-32. DOI: 10.1016/j.chembiol.2012.08.017

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Joyce, G.F. Bit by bit: the Darwinian basis of life. (2012) PLOS Biology. 10(5):e1001323. DOI: 10.1371/journal.pbio.1001323

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Olea, C., Horning, D.P., Joyce, G.F. Ligand-dependent exponential amplification of a self-replicating L-RNA enzyme. (2012) Journal of the American Chemical Society. 134(19):8050-3. DOI: 10.1021/ja302197x

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Joyce, G.F. Evolution. Toward an alternative biology. (2012) 科学. 336(6079):307-8. DOI: 10.1126/science.1221724


2011

Lam, B.J., Joyce, G.F. An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification. (2011) Journal of the American Chemical Society. 133(9):3191-7. DOI: 10.1021/ja111136d

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2010

Petrie, K.L., Joyce, G.F. Deep sequencing analysis of mutations resulting from the incorporation of dNTP analogs. (2010) 核酸研究. 38(22):8095-104. DOI: 10.1093/nar/gkq685

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Paegel, B.M., Joyce, G.F. Microfluidic compartmentalized directed evolution. (2010) Chemistry & Biology. 17(7):717-24. DOI: 10.1016/j.chembiol.2010.05.021

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2009

Joyce, G.F. Evolution in an RNA world. (2009) 冷泉港定量生物学研讨会。. 74:17-23. DOI: 10.1101/sqb.2009.74.004

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Voytek, S.B., Joyce, G.F. Niche partitioning in the coevolution of 2 distinct RNA enzymes. (2009) 美国国家科学院院刊. 106(19):7780-5. DOI: 10.1073/pnas.0903397106

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Lam, B.J., Joyce, G.F. Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA. (2009) Nature Biotechnology. 27(3):288-92. DOI: 10.1038/nbt.1528

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Lincoln, T.A., Joyce, G.F. Self-sustained replication of an RNA enzyme. (2009) 科学. 323(5918):1229-32. DOI: 10.1126/science.1167856

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2008

Paegel, B.M., Joyce, G.F. Darwinian evolution on a chip. (2008) PLOS Biology. 6(4):e85. DOI: 10.1371/journal.pbio.0060085

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2007

Joyce, G.F. Obituary: Leslie Orgel (1927-2007). (2007) 自然. 450(7170):627. DOI: 10.1038/450627a


Voytek, S.B., Joyce, G.F. Emergence of a fast-reacting ribozyme that is capable of undergoing continuous evolution. (2007) 美国国家科学院院刊. 104(39):15288-93. DOI: 10.1073/pnas.0707490104

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Joyce, G.F. Forty years of in vitro evolution. (2007) Angew. Chem. Int. Ed. Engl. 46(34):6420-36. DOI: 10.1002/anie.200701369

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Joyce, G.F. Structural biology. A glimpse of biology's first enzyme. (2007) 科学. 315(5818):1507-8. DOI: 10.1126/science.1140736


2006

Paegel, B.M., Grover, W.H., Skelley, A.M., Mathies, R.A., Joyce, G.F. Microfluidic serial dilution circuit. (2006) Analytical Chemistry. 78(21):7522-7. DOI: 10.1021/ac0608265

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Cadwell, R.C., Joyce, G.F. Mutagenic PCR. (2006) CSH Protoc. 2006(1). DOI: 10.1101/pdb.prot4143


Paul, N., Springsteen, G., Joyce, G.F. Conversion of a ribozyme to a deoxyribozyme through in vitro evolution. (2006) Chemistry & Biology. 13(3):329-38. DOI: 10.1016/j.chembiol.2006.01.007

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2005

Oberhuber, M., Joyce, G.F. A DNA-templated aldol reaction as a model for the formation of pentose sugars in the RNA world. (2005) Angewandte Chemie. 44(46):7580-3. DOI: 10.1002/anie.200503387


Johns, G.C., Joyce, G.F. The promise and peril of continuous in vitro evolution. (2005) J. Mol. Evol. 61(2):253-63. DOI: 10.1007/s00239-004-0307-1

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2004

Paul, N., Joyce, G.F. Minimal self-replicating systems. (2004) Current Opinion in Chemical Biology. 8(6):634-9. DOI: 10.1016/j.cbpa.2004.09.005

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Kim, D.E., Joyce, G.F. Cross-catalytic replication of an RNA ligase ribozyme. (2004) Chemistry & Biology. 11(11):1505-12. DOI: 10.1016/j.chembiol.2004.08.021

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Springsteen, G., Joyce, G.F. Selective derivatization and sequestration of ribose from a prebiotic mix. (2004) Journal of the American Chemical Society. 126(31):9578-83. DOI: 10.1021/ja0483692

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Joyce, G.F. Directed evolution of nucleic acid enzymes. (2004) Annual Review of Biochemistry. 73:791-836. DOI: 10.1146/annurev.biochem.73.011303.073717

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Shih, W.M., Quispe, J.D., Joyce, G.F. A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron. (2004) 自然. 427(6975):618-21. DOI: 10.1038/nature02307

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2003

Kühne, H., Joyce, G.F. Continuous in vitro evolution of ribozymes that operate under conditions of extreme pH. (2003) J. Mol. Evol. 57(3):292-8. DOI: 10.1007/s00239-003-2480-z

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Kumar, R.M., Joyce, G.F. A modular, bifunctional RNA that integrates itself into a target RNA. (2003) 美国国家科学院院刊. 100(17):9738-43. DOI: 10.1073/pnas.1334190100

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Kuhns, S.T., Joyce, G.F. Perfectly complementary nucleic acid enzymes. (2003) J. Mol. Evol. 56(6):711-7. DOI: 10.1007/s00239-002-2445-7

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McGinness, K.E., Joyce, G.F. In search of an RNA replicase ribozyme. (2003) Chemistry & Biology. 10(1):5-14.

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Paul, N., Joyce, G.F. Self-replication. (2003) 当前生物学。. 13(2):R46.


2002

Reader, J.S., Joyce, G.F. A ribozyme composed of only two different nucleotides. (2002) 自然. 420(6917):841-4. DOI: 10.1038/nature01185

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Joyce, G.F. Molecular evolution: booting up life. (2002) 自然. 420(6913):278-9. DOI: 10.1038/420278a


Ordoukhanian, P., Joyce, G.F. RNA-cleaving DNA enzymes with altered regio- or enantioselectivity. (2002) Journal of the American Chemical Society. 124(42):12499-506.

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Paul, N., Joyce, G.F. A self-replicating ligase ribozyme. (2002) 美国国家科学院院刊. 99(20):12733-40. DOI: 10.1073/pnas.202471099

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Joyce, G.F. The antiquity of RNA-based evolution. (2002) 自然. 418(6894):214-21. DOI: 10.1038/418214a

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McGinness, K.E., Wright, M.C., Joyce, G.F. Continuous in vitro evolution of a ribozyme that catalyzes three successive nucleotidyl addition reactions. (2002) Chemistry & Biology. 9(5):585-96.

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McGinness, K.E., Joyce, G.F. RNA-catalyzed RNA ligation on an external RNA template. (2002) Chemistry & Biology. 9(3):297-307.

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McGinness, K.E., Joyce, G.F. Substitution of ribonucleotides in the T7 RNA polymerase promoter element. (2002) 生物化学杂志. 277(4):2987-91. DOI: 10.1074/jbc.M108820200

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2001

Rogers, J., Joyce, G.F. The effect of cytidine on the structure and function of an RNA ligase ribozyme. (2001) 核糖核酸. 7(3):395-404.

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Joyce, G.F. RNA cleavage by the 10-23 DNA enzyme. (2001) Meth. Enzymol. 341:503-17.


2000

Sheppard, T.L., Wong, C.H., Joyce, G.F. Nucleoglycoconjugates: design and synthesis of a new class of DNA-carbohydrate conjugates. (2000) Angewandte Chemie. 39(20):3660-3.


Dai, X., Joyce, G.F. In vitro evolution of a ribozyme that contains 5-bromouridine. (2000) Helv. Chim. Acta. 83(8):1701-10. DOI: 10.1002/1522-2675(20000809)83:8<1701::AID-HLCA1701

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Joyce, G.F. RNA structure. Ribozyme evolution at the crossroads. (2000) 科学. 289(5478):401-2.

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Sheppard, T.L., Ordoukhanian, P., Joyce, G.F. A DNA enzyme with N-glycosylase activity. (2000) 美国国家科学院院刊. 97(14):7802-7.

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Nowakowski, J., Shim, P.J., Stout, C.D., Joyce, G.F. Alternative conformations of a nucleic acid four-way junction. (2000) 分子生物学杂志. 300(1):93-102. DOI: 10.1006/jmbi.2000.3826

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Santoro, S.W., Joyce, G.F., Sakthivel, K., Gramatikova, S., Barbas CF 3rd RNA cleavage by a DNA enzyme with extended chemical functionality. (2000) Journal of the American Chemical Society. 122(11):2433-9.

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1999

Ordoukhanian, P., Joyce, G.F. A molecular description of the evolution of resistance. (1999) Chemistry & Biology. 6(12):881-9.

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Jaeger, L., Wright, M.C., Joyce, G.F. A complex ligase ribozyme evolved in vitro from a group I ribozyme domain. (1999) 美国国家科学院院刊. 96(26):14712-7.

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Rogers, J., Joyce, G.F. A ribozyme that lacks cytidine. (1999) 自然. 402(6759):323-5. DOI: 10.1038/46335

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Nowakowski, J., Shim, P.J., Joyce, G.F., Stout, C.D. Crystallization of the 10-23 DNA enzyme using a combinatorial screen of paired oligonucleotides. (1999) Acta Crystallogr. D Biol. Crystallogr. 55(Pt 11):1885-92.

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Joyce, G.F. The counterforce. (1999) 当前生物学。. 9(14):R500-1.


Bartlett, P.A., Joyce, G.F. Combinatorial chemistry: the search continues (1999) Current Opinion in Chemical Biology. 3(3):253-5.


Nowakowski, J., Shim, P.J., Prasad, G.S., Stout, C.D., Joyce, G.F. Crystal structure of an 82-nucleotide RNA-DNA complex formed by the 10-23 DNA enzyme. (1999) Nature Structural Biology. 6(2):151-6. DOI: 10.1038/5839

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1998

Santoro, S.W., Joyce, G.F. Mechanism and utility of an RNA-cleaving DNA enzyme. (1998) Biochemistry. 37(38):13330-42. DOI: 10.1021/bi9812221

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Joyce, G.F. Nucleic acid enzymes: playing with a fuller deck. (1998) 美国国家科学院院刊. 95(11):5845-7.


Joyce, G.F., Orgel, L.E. The origins of life--a status report. (1998) Am Biol Teach. 60(1):10-2.


1997

Joyce, G.F. Evolutionary chemistry: getting there from here. (1997) 科学. 276(5319):1658-9.


Joyce, G.F., Still, W.C., Chapman, K.T. Combinatorial chemistry searching for a winning combination (1997) Current Opinion in Chemical Biology. 1(1):3-4.


Santoro, S.W., Joyce, G.F. A general purpose RNA-cleaving DNA enzyme. (1997) 美国国家科学院院刊. 94(9):4262-6.

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Hendrix, M., Priestley, E.S., Joyce, G.F., Wong, C.H. Direct observation of aminoglycoside-RNA interactions by surface plasmon resonance. (1997) Journal of the American Chemical Society. 119(16):3641-8.

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Bruick, R.K., Koppitz, M., Joyce, G.F., Orgel, L.E. A simple procedure for constructing 5'-amino-terminated oligodeoxynucleotides in aqueous solution. (1997) 核酸研究. 25(6):1309-10.

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1996

Tsang, J., Joyce, G.F. Specialization of the DNA-cleaving activity of a group I ribozyme through in vitro evolution. (1996) 分子生物学杂志. 262(1):31-42. DOI: 10.1006/jmbi.1996.0496

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Raillard, S.A., Joyce, G.F. Targeting sites within HIV-1 cDNA with a DNA-cleaving ribozyme. (1996) Biochemistry. 35(36):11693-701. DOI: 10.1021/bi960845g

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Joyce, G.F. Building the RNA world. Ribozymes. (1996) 当前生物学。. 6(8):965-7.

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Tsang, J., Joyce, G.F. In vitro evolution of randomized ribozymes. (1996) Meth. Enzymol. 267:410-26.


Bruick, R.K., Dawson, P.E., Kent, S.B., Usman, N., Joyce, G.F. Template-directed ligation of peptides to oligonucleotides. (1996) Chemistry & Biology. 3(1):49-56.

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1995

Breaker, R.R., Joyce, G.F. A DNA enzyme with Mg(2+)-dependent RNA phosphoesterase activity. (1995) Chemistry & Biology. 2(10):655-60.

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Breaker, R.R., Joyce, G.F. Self-incorporation of coenzymes by ribozymes. (1995) J. Mol. Evol. 40(6):551-8.

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Dai, X., De Mesmaeker, A., Joyce, G.F. Cleavage of an amide bond by a ribozyme. (1995) 科学. 267(5195):237-40.

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1994

Breaker, R.R., Joyce, G.F. A DNA enzyme that cleaves RNA. (1994) Chemistry & Biology. 1(4):223-9.

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Chakrabarti, A.C., Breaker, R.R., Joyce, G.F., Deamer, D.W. Production of RNA by a polymerase protein encapsulated within phospholipid vesicles. (1994) J. Mol. Evol. 39(6):555-9.

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Breaker, R.R., Banerji, A., Joyce, G.F. Continuous in vitro evolution of bacteriophage RNA polymerase promoters. (1994) Biochemistry. 33(39):11980-6.

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Breaker, R.R., Joyce, G.F. Inventing and improving ribozyme function: rational design versus iterative selection methods. (1994) Trends in Biotechnology. 12(7):268-75. DOI: 10.1016/0167-7799(94)90138-4

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Breaker, R.R., Joyce, G.F. Emergence of a replicating species from an in vitro RNA evolution reaction. (1994) 美国国家科学院院刊. 91(13):6093-7.

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Cadwell, R.C., Joyce, G.F. Mutagenic PCR. (1994) PCR Methods Appl. 3(6):S136-40.


Tsang, J., Joyce, G.F. Evolutionary optimization of the catalytic properties of a DNA-cleaving ribozyme. (1994) Biochemistry. 33(19):5966-73.

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Joyce, G.F. In vitro evolution of nucleic acids. (1994) Current Opinion in Structural Biology. 4:331-6.


1993

Lehman, N., Joyce, G.F. Evolution in vitro: analysis of a lineage of ribozymes. (1993) 当前生物学。. 3(11):723-34.

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Joyce, G.F. Evolution of catalytic function. (1993) Pure Appl. Chem. 65(6):1205-12.

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Joyce, G.F. Climbing Darwin's ladder. (1993) 当前生物学。. 3(10):703-4.


Lehman, N., Joyce, G.F. Evolution in vitro of an RNA enzyme with altered metal dependence. (1993) 自然. 361(6408):182-5. DOI: 10.1038/361182a0

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1992

Joyce, G.F. Directed molecular evolution. (1992) Sci. Am. 267(6):90-7.


Cadwell, R.C., Joyce, G.F. Randomization of genes by PCR mutagenesis. (1992) PCR Methods Appl. 2(1):28-33.

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Beaudry, A.A., Joyce, G.F. Directed evolution of an RNA enzyme. (1992) 科学. 257(5070):635-41.

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1991

Joyce, G.F. RNA today. Molecular Evolution of Introns and Other RNA Elements: a Keystone Symposium, Taos, NM, USA, February 2-8, 1991. (1991) New Biol. 3(6):565-9.

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Joyce, G.F. The rise and fall of the RNA world. (1991) New Biol. 3(4):399-407.

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1990

Beaudry, A.A., Joyce, G.F. Minimum secondary structure requirements for catalytic activity of a self-splicing group I intron. (1990) Biochemistry. 29(27):6534-9.

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Robertson, D.L., Joyce, G.F. Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA. (1990) 自然. 344(6265):467-8. DOI: 10.1038/344467a0

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1989

Joyce, G.F. Amplification, mutation and selection of catalytic RNA. (1989) Gene. 82(1):83-7.

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Joyce, G.F., van der Horst, G., Inoue, T. Catalytic activity is retained in the Tetrahymena group I intron despite removal of the large extension of element P5. (1989) 核酸研究. 17(19):7879-89.

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Joyce, G.F. RNA evolution and the origins of life. (1989) 自然. 338(6212):217-24. DOI: 10.1038/338217a0

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Joyce, G.F., Inoue, T. A novel technique for the rapid preparation of mutant RNAs. (1989) 核酸研究. 17(2):711-22.

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1988

Joyce, G.F., Orgel, L.E. Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C,A) templates. (1988) 分子生物学杂志. 202(3):677-81.

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1987

Joyce, G.F., Inoue, T. Structure of the catalytic core of the Tetrahymena ribozyme as indicated by reactive abbreviated forms of the molecule. (1987) 核酸研究. 15(23):9825-40.

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Joyce, G.F., Schwartz, A.W., Miller, S.L., Orgel, L.E. The case for an ancestral genetic system involving simple analogues of the nucleotides. (1987) 美国国家科学院院刊. 84(13):4398-402.

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Joyce, G.F. Nonenzymatic template-directed synthesis of informational macromolecules. (1987) 冷泉港定量生物学研讨会。. 52:41-51.


1984

Joyce, G.F. Non-enzymatic template-directed synthesis of RNA copolymers. (1984) Orig. Life. 14(1-4):613-20.

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Inoue, T., Joyce, G.F., Grzeskowiak, K., Orgel, L.E., Brown, J.M., Reese, C.B. Template-directed synthesis on the pentanucleotide CpCpGpCpC. (1984) 分子生物学杂志. 178(3):669-76.

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Joyce, G.F., Visser, G.M., van Boeckel, C.A., van Boom, J.H., Orgel, L.E., van Westrenen, J. Chiral selection in poly(C)-directed synthesis of oligo(G). (1984) 自然. 310(5978):602-4.

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Joyce, G.F., Inoue, T., Orgel, L.E. Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C, U) templates. (1984) 分子生物学杂志. 176(2):279-306.

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Joyce, G.F., Tschirgi, R.D. Automata simulation of the selection process. (1984) BioSystems. 17(1):65-72.

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1983

Joyce, G.F. The instability of the autogen. (1983) J. Mol. Evol. 19(2):192-4.

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教育

BA, Biological Sciences, The University of Chicago
PhD, Neurosciences / Chemistry, University of California, San Diego
MD, Medicine, University of California, San Diego


奖项与荣誉

  • Honorary Member (Royal Irish Academy), 2025
  • Royal Swedish Academy of Sciences Foreign Member, 2019
  • American Association for the Advancement of Science Fellow, 2017
  • Harvard Origins Prize, Harvard University, 2016
  • National Academy of Medicine Member, 2014
  • American Academy of Arts and Sciences Member, 2012
  • US National Academy of Sciences Award for Early Earth and Life Sciences (Stanley Miller Medal), 2010
  • Göttingen Academy of Science, Dannie Heineman Prize, 2009
  • International Society for the Study of the Origin of Life HC Urey Award, 2005
  • National Academy of Sciences Member, 2001
  • Hans Sigrist Prize, University of Bern, Switzerland, 1997
  • Herbert W. Dickerman Award, State of New York Department of Health, 1997
  • Pfizer Award in Enzyme Chemistry, Biological Chemistry Division, American Chemical Society, 1995
  • National Academy of Sciences Award in Molecular Biology, 1994