Agnieszka Kendrick, PhD

助理教授

分子与细胞生物学实验室

Aga Kendrick
索尔克生物研究所 出版物

所有出版物


de la Gándara, , Kendrick, A.A. Capturing enzymes in motion. (2025) Elife. 14. DOI: 10.7554/eLife.108727

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Nguyen, K.H.V., Karasmanis, E.P., Kendrick, A.A., Reck-Peterson, S.L., Leschziner, A.E. Cryo-EM captures early intermediate steps in dynein activation by LIS1. (2025) 自然-通讯. 16(1):7054. DOI: 10.1038/s41467-025-62185-z

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Kendrick, A.A., Nguyen, K.H.V., Ma, W., Karasmanis, E.P., Amaro, R.E., Reck-Peterson, S.L., Leschziner, A.E. Multiple steps of dynein activation by Lis1 visualized by cryo-EM. (2025) 自然结构与分子生物学. DOI: 10.1038/s41594-025-01558-w

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Kendrick, A.A., Nguyen, K.H.V., Ma, W., Karasmanis, E.P., Amaro, R.E., Reck-Peterson, S.L., Leschziner, A.E. Cryo-EM visualizes multiple steps of dynein's activation pathway. (2024) bioRxiv. DOI: 10.1101/2024.09.28.615567

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Karasmanis, E.P., Reimer, J.M., Kendrick, A.A., Nguyen , K.H.V., Rodriguez, J.A., Truong, J.B., Lahiri, I., Reck-Peterson , S.L., Leschziner, A.E. Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge (2023) 自然结构与分子生物学. 30:1357-1364. DOI: 10.1038/s41594-023-01069-6

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Kendrick, A.A., Christensen, J.R. Bidirectional lysosome transport: a balancing act between ARL8 effectors. (2022) 自然-通讯. 13(1):5261. DOI: 10.1038/s41467-022-32965-y

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Christensen, J.R., Kendrick, A.A., Truong, J.B., Aguilar-Maldonado, A., Adani, V., Dzieciatkowska, M., Reck-Peterson, S.L. Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS-Hook-FHIP complexes. (2021) Elife. 10. DOI: 10.7554/eLife.74538

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Humphries, B.A., Hwang, P.Y., Kendrick, A.A., Kulkarni, R.P., Pozzar, R.A., San Martin, R. Overstretched and overlooked: solving challenges faced by early-career investigators after the pandemic. (2021) Trends in Cancer. 7(10):879-882. DOI: 10.1016/j.trecan.2021.07.005

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Kendrick, A.A., Dickey, A.M., Redwine, W.B., Tran, P.T., Vaites, L.P., Dzieciatkowska, M., Harper, J.W., Reck-Peterson, S.L. Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C. (2019) Journal of Cell Biology. 218(9):2982-3001. DOI: 10.1083/jcb.201812170

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Chi, Y.C., Rahkola, J.T., Kendrick, A.A., Holliday, M.J., Paukovich, N., Roberts, T.S., Janoff, E.N., Eisenmesser, E.Z. Streptococcus pneumoniae IgA1 protease: A metalloprotease that can catalyze in a split manner in vitro. (2017) Protein Science. 26(3):600-610. DOI: 10.1002/pro.3110

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Kendrick, A.A., Schafer, J., Dzieciatkowska, M., Nemkov, T., D'Alessandro, A., Neelakantan, D., Ford, H.L., Pearson, C.G., Weekes, C.D., Hansen, K.C., Eisenmesser, E.Z. CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming. (2017) Oncotarget. 8(4):6742-6762. DOI: 10.18632/oncotarget.14272

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Saeedi, B.J., Kao, D.J., Kitzenberg, D.A., Dobrinskikh, E., Schwisow, K.D., Masterson, J.C., Kendrick, A.A., Kelly, C.J., Bayless, A.J., Kominsky, D.J., Campbell, E.L., Kuhn, K.A., Furuta, G.T., Colgan, S.P., Glover, L.E. HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity. (2015) Molecular Biology of the Cell. 26(12):2252-62. DOI: 10.1091/mbc.E14-07-1194

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Kendrick, A.A., Holliday, M.J., Isern, N.G., Zhang, F., Camilloni, C., Huynh, C., Vendruscolo, M., Armstrong, G., Eisenmesser, E.Z. The dynamics of interleukin-8 and its interaction with human CXC receptor I peptide. (2014) Protein Science. 23(4):464-80. DOI: 10.1002/pro.2430

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Glover, L.E., Bowers, B.E., Saeedi, B., Ehrentraut, S.F., Campbell, E.L., Bayless, A.J., Dobrinskikh, E., Kendrick, A.A., Kelly, C.J., Burgess, A., Miller, L., Kominsky, D.J., Jedlicka, P., Colgan, S.P. Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis. (2013) 美国国家科学院院刊. 110(49):19820-5. DOI: 10.1073/pnas.1302840110

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Redzic, J.S., Kendrick, A.A., Bahmed, K., Dahl, K.D., Pearson, C.G., Robinson, W.A., Robinson, S.E., Graner, M.W., Eisenmesser, E.Z. Extracellular vesicles secreted from cancer cell lines stimulate secretion of MMP-9, IL-6, TGF-β1 and EMMPRIN. (2013) PLOS One. 8(8):e71225. DOI: 10.1371/journal.pone.0071225

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Kendrick, A.A., Choudhury, M., Rahman, S.M., McCurdy, C.E., Friederich, M., Van Hove, J.L., Watson, P.A., Birdsey, N., Bao, J., Gius, D., Sack, M.N., Jing, E., Kahn, C.R., Friedman, J.E., Jonscher, K.R. Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. (2011) Biochemical Journal. 433(3):505-14. DOI: 10.1042/BJ20100791

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教育

BS, Chemistry, University of Wroclaw
MS, Chemistry, University of Colorado, Denver
PhD, Structural Biology and Biochemistry, University of Colorado, Denver
Postdoctoral Fellow, Cellular and Molecular Medicine, University of California, San Diego


奖项与荣誉

  • Leading Edge Symposium Fellow, 2020
  • American Cancer Society Postdoctoral Fellowship, 2018
  • National Institutes of Health F32 Ruth L. Kirschstein Postdoctoral Fellowship, 2018
  • University of Colorado Graduate School Student Research Excellence Award, 2015
  • National Institutes of Health F31 Ruth L. Kirschstein Predoctoral Fellowship, 2013