La Jolla, CA – The Salk Institute for Biological Studies was awarded a $2.3 million share of the stem cell research facilities grants approved by the governing board of the California Institute for Regenerative Medicine (CIRM) on June 5.
La Jolla, CA – Salk scientist Dr. Tony Hunter is the recipient of the 2006 Pasarow Award in Cancer Research for his key discoveries of the chemical “switch” that turns healthy cells into cancer cells.
La Jolla, CA – Researchers at the Salk Institute for Biological Studies have overcome a long-standing problem in biology by equipping a protein with a small homing device, allowing it to slip behind the blood-brain barrier. Circumventing this barrier – specifically designed to keep substances out of the brain – is a crucial step for the delivery of drugs to the central nervous system (CNS).
La Jolla, CA – Like any new kid on the block that tries to fit in, newborn brain cells need to find their place within the existing network of neurons. The newcomers jump right into the fray and preferentially reach out to mature brain cells that are already well connected within the established circuitry, report scientists at the Salk Institute for Biological Studies in the online edition of 自然-神经科学.
La Jolla, CA – The Salk Institute for Biological Studies today announced the appointment of Dr. Marsha A. Chandler to the new position of Executive Vice President/Chief Operating Officer. The Salk Board of Trustees unanimously approved the appointment at its meeting in New York City on April 26.
La Jolla, CA – In studies going back to the 1930’s, mice and many other species subsisting on a severely calorie-restricted diet have consistently outlived their well-fed peers by as much as 40 percent. But just how a diet verging on the brink of starvation extends lifespan has remained elusive.
加利福尼亚州拉霍亚——索尔克研究所教授乌尔苏拉·贝尔吉（Ursula Bellugi）因其在语言生物学基础研究领域的开创性贡献，当选为美国国家科学院院士。国家科学院于今日在其于华盛顿特区召开的第144届年会期间公布了这一消息。当选国家科学院院士是对在原始研究领域取得杰出且持续成就的认可，被认为是授予美国科学家的最高荣誉之一。.
La Jolla, CA – Scientists at the Salk Institute for Biological Studies have identified an enzyme that pumps up a cell’s ability to maintain healthy muscle and restores normal muscle function in genetically engineered mice with weak muscles. The study, published online in 自然医学, is the first to explore the part this enzyme plays in a cascade of events triggered by exercise-induced hormones and other signals.
拉霍亚，加利福尼亚州 罗纳德·M·埃文斯, 索尔克研究所基因表达实验室的Ph.D.，教授，霍华德·休斯医学研究所研究员，荣获2007年美国医学最高奖——奥尔巴尼医学院医学和生物医学研究奖。.
La Jolla, CA – Cilia, tiny hair-like structures that propel mucus out of airways, have to agree on the direction of the fluid flow to get things moving. Researchers at the Salk Institute for Biological Studies discovered a novel two-step mechanism that ensures that all cilia beat in unison.
加州拉霍亚——科学家们已经识别出三种不同的信号，它们表明叶绿体受损。叶绿体是植物细胞的光合作用工厂，赋予植物绿色，但人们对其信号如何传递给细胞核知之甚少。索尔克生物研究所的科学家们在解释叶绿体如何让细胞核得知周边发生问题时，以及如何据此调整核基因表达方面取得了重大进展。.
La Jolla, CA – “Green” means “go,” but what does “red” mean? Just about everybody says “stop” since we all have learned to imbue certain colors with meaning (or we would be road kill by now). Long thought to be limited to higher levels of information processing, researchers at the Salk Institute for Biological Studies successfully traced this type of associative learning to early stages of the visual processing pathway.
拉霍亚，加州——杰克神奇的豆子或许能长出直入云霄的豆茎，但普通植物的生长高度却有限。一个多世纪以来，科学家们一直在努力探究是植物的哪个部分驱动并限制了生长：是茎的外部蜡质层？是内含叶绿体的内层？还是输送养分和水分的维管系统？这个答案可能对现代农业有重大意义，因为现代农业渴望能有“现 代魔法豆”出现。.
La Jolla, CA – Although the Galápagos finches were to play a pivotal role in the inception of Darwin’s theory of evolution through natural selection, he had no inkling of their significance when he collected them during his voyage on the HMS Beagle.
La Jolla, CA – Knocking out the gene for a peptide associated with insulin secretion protects mice against the harmful effects of a high-fat diet, report researchers at the Salk Institute for Biological Studies. Their findings, detailed in the Proceedings of the National Academy of Sciences, suggest that urocortin 3, a new peptide recently discovered in the insulin secreting cells of the pancreas, plays a role in the increased production of insulin in response to high caloric intake in animals.
La Jolla, CA – The ability to hit a baseball or play a piano well is part practice and part innate talent. One side of the equation required for skilled performances has its roots in the architecture of the brain genetically determined before birth, say scientists at the Salk Institute for Biological Studies. Practice takes no explaining, just persistence.
La Jolla, CA – Form does follow function, as far as visual cortex neurons tasked with perceiving action are concerned. Far from being the static nerve cells researchers believed them to be, capable of performing only a single function, scientists at the Salk Institute for Biological Studies found these neurons rapidly shift back and forth between two ways of collecting information about moving objects.
La Jolla, CA – Researchers have long said they won't be able to understand the brain until they can put together a "wiring diagram" – a map of how billions of neurons are interconnected. Now, researchers at the Salk Institute for Biological Studies have jumped what many believe to be a major hurdle to preparing that chart: identifying all of the connections to a single neuron.
La Jolla, CA – Every time a cell repairs or replicates its DNA, the resulting single strand is wrapped up by a dedicated protein complex. In eukaryotes or organisms whose cells have a nucleus, this job is handled by a tripartite complex called replication protein A (RPA). Researchers at the Salk Institute for Biological Studies have now unearthed a novel RPA-like complex that specifically homes in on the short single-stranded DNA “tail” end of yeast chromosomes.
La Jolla, CA – Wielding a palette of chromosome paints, scientists at the Salk Institute for Biological Studies have taken a step closer to understanding the relationship between aging and cancer by visualizing chromosomes of cells from patients with a heritable premature aging disease known as Werner Syndrome.
