La Jolla, CA – With the help of genetically engineered mice whose livers turned into glowing light bulbs, researchers at the Salk Institute for Biological Studies have illuminated the underpinnings of an insidious and growing health concern – type II diabetes.
La Jolla, CA – Our brains are buzzing with electrical activity created by sodium and potassium ions moving in and out of neurons through specialized pores. To prevent the constant chatter from descending into chaos the activity of these ion channels has to be tightly regulated.
La Jolla, CA – Dr. Samuel L. Pfaff, a professor in the Molecular Neurobiology Laboratory at the Salk Institute for Biological Studies, has been awarded the prestigious Senator Jacob Javits Award in the Neurosciences for his pioneering work on the molecular pathways that shape the embryonic central nervous system. The award guarantees funding for up to seven years.
La Jolla, CA – The Salk Institute for Biological Studies today announced the appointment of Nobel laureate and distinguished professor Dr. 罗杰·吉耶曼 as Interim President. Guillemin officially takes office Oct. 1 and will remain in this capacity during the Institute’s ongoing search for a president.
加利福尼亚州拉霍亚——索尔克生物研究所的科学家们报告说，缺乏 PPARγ（一种调节脂肪储存的核受体）的小鼠乳腺会产生有毒的母乳，导致哺乳期的幼崽发炎和脱发。.
La Jolla, CA – Instead of immutable proprietary software, any species’ genetic information resembles open source code that is constantly tweaked and optimized to meet the users’ specific needs. But which parts of the code have withstood the test of time and which parts have undergone rapid evolutionary change has been difficult to assess.
La Jolla, CA – Salk scientist Marguerite Vogt, M.D., long regarded as one of science’s greatest unsung female researchers, died today. She was 94 years old.
La Jolla, CA – Every kid knows that moms have “eyes in the back of their heads.” We are adept at fixing our gaze on one object while independently directing attention to others. Salk Institute neurobiologists are beginning to tease apart the complex brain networks that enable humans and other higher mammals to achieve this feat.
La Jolla, CA – Researchers at the Salk Institute for Biological Studies have developed a novel strategy to expand the natural repertoire of 20 amino acids in mammalian cells, including neurons, and successfully inserted tailor-made amino acids into proteins in these cells. In a powerful demonstration of the method’s versatility, they then used unnatural amino acids to determine the operating mechanism of the “molecular gates” that regulate the movement of potassium ions in and out of nerve cells.
La Jolla, CA – Researchers at the Salk Institute for Biological Studies have developed a novel strategy to expand the natural repertoire of 20 amino acids in mammalian cells, including neurons, and successfully inserted tailor-made amino acids into proteins in these cells. In a powerful demonstration of the method’s versatility, they then used unnatural amino acids to determine the operating mechanism of the “molecular gates” that regulate the movement of potassium ions in and out of nerve cells.
La Jolla, CA – Subjecting mice to repeated emotional stress, the kind we experience in everyday life, may contribute to the accumulation of neurofibrillary tangles, one of the hallmarks of Alzheimer’s disease, report researchers at the Salk Institute for Biological Studies. While aging is still the greatest risk factor for Alzheimer’s disease, a number of studies have pointed to stress as a contributing factor.
La Jolla, CA – At the heart of most, if not all cancers, lie a handful of wayward stem cells that feed the ever growing tumor mass, but their scarcity make it difficult for scientists to study them. Now, times of plenty may lie ahead as a breast cancer cell line – established long ago – turned out to behave a lot like cancer stem cells.
La Jolla, CA – The Salk Institute for Biological Studies was awarded a $2.3 million share of the stem cell research facilities grants approved by the governing board of the California Institute for Regenerative Medicine (CIRM) on June 5.
La Jolla, CA – Salk scientist Dr. Tony Hunter is the recipient of the 2006 Pasarow Award in Cancer Research for his key discoveries of the chemical “switch” that turns healthy cells into cancer cells.
La Jolla, CA – Researchers at the Salk Institute for Biological Studies have overcome a long-standing problem in biology by equipping a protein with a small homing device, allowing it to slip behind the blood-brain barrier. Circumventing this barrier – specifically designed to keep substances out of the brain – is a crucial step for the delivery of drugs to the central nervous system (CNS).
La Jolla, CA – Like any new kid on the block that tries to fit in, newborn brain cells need to find their place within the existing network of neurons. The newcomers jump right into the fray and preferentially reach out to mature brain cells that are already well connected within the established circuitry, report scientists at the Salk Institute for Biological Studies in the online edition of 自然-神经科学.
La Jolla, CA – The Salk Institute for Biological Studies today announced the appointment of Dr. Marsha A. Chandler to the new position of Executive Vice President/Chief Operating Officer. The Salk Board of Trustees unanimously approved the appointment at its meeting in New York City on April 26.
La Jolla, CA – In studies going back to the 1930’s, mice and many other species subsisting on a severely calorie-restricted diet have consistently outlived their well-fed peers by as much as 40 percent. But just how a diet verging on the brink of starvation extends lifespan has remained elusive.
加利福尼亚州拉霍亚——索尔克研究所教授乌尔苏拉·贝尔吉（Ursula Bellugi）因其在语言生物学基础研究领域的开创性贡献，当选为美国国家科学院院士。国家科学院于今日在其于华盛顿特区召开的第144届年会期间公布了这一消息。当选国家科学院院士是对在原始研究领域取得杰出且持续成就的认可，被认为是授予美国科学家的最高荣誉之一。.
La Jolla, CA – Scientists at the Salk Institute for Biological Studies have identified an enzyme that pumps up a cell’s ability to maintain healthy muscle and restores normal muscle function in genetically engineered mice with weak muscles. The study, published online in 自然医学, is the first to explore the part this enzyme plays in a cascade of events triggered by exercise-induced hormones and other signals.
