Gatsby Charitable Foundation awards $4 million to Salk-UC San Diego consortium to study brain circuitry

March 22, 2010

Gatsby Charitable Foundation awards $4 million to Salk-UC San Diego consortium to study brain circuitry

March 22, 2010

LA JOLLA—A new consortium of four research teams from the Salk Institute for Biological Studies and the University of California, San Diego has been selected by the Gatsby Charitable Foundation, based in the United Kingdom, to receive a $4 million grant over five years to study neuronal circuits underlying higher brain function.

The teams headed by Salk researchers Edward M. Callaway, Ph.D., and John H. Reynolds, Ph.D., and UC San Diego professors Anirvan Ghosh, Ph.D., and Massimo Scanziani, Ph.D., look forward to formalizing a longstanding relationship developed through overlapping research interests and facilitated by geographical proximity.

“The grant from the Gatsby Charitable Foundation creates a tremendous opportunity to work closer together than ever before,” says Callaway, of the Salk Institute. “It allows us to capitalize on the unique strengths we have as a team.”

Higher brain functions, such as visual perception and attention, are the result of the coordinated activity of neurons in the cerebral cortex. But a lack of detailed knowledge of how different elements and cell types interact to give rise to sensations and thought has limited understanding of the neural mechanisms that underlie cortical functions.

The collaborating teams’ efforts will focus on developing and using genetic tools that will allow them to manipulate specific cell types in the brain to tease apart their contributions to higher order brain function.

“The human brain with its unrivaled complexity is biology’s last frontier,” says UC San Diego researcher Ghosh. “Thanks to the support of the Gatsby Foundation, we expect to greatly expand the understanding of brain circuitry. This will in turn allow us to explore the brain’s ability to adapt and rewire, as well as its remarkable capacity to learn and remember.”

Adds Callaway: “This collaborative study has the potential to provide us with exciting insight into how the brain makes us who we are.”

• Edward M. Callaway, Ph.D., a professor in the Systems Neurobiology Laboratories at the Salk Institute, studies the organization and function of neural circuits in the visual cortex to better understand how specific neural components contribute to the computations that give rise to visual perception and to elucidate the basic neural mechanisms that underlie cortical function.
• Anirvan Ghosh, Ph.D., a professor in UC San Diego’s Division of Biological Sciences and chair of the Division’s Neurobiology section, is interested in understanding the mechanisms that allow the developing brain to self-organize into functional circuits.
• John H. Reynolds, Ph.D., an associate professor in the Systems Neurobiology Laboratories at the Salk Institute seeks to understand the fundamental nature of the computations that are carried out by the neocortex, including the computations that enable us to attend to sensory stimuli, and to understand how and why these computations fail in brain disease.
• Massimo Scanziani, Ph.D., a professor in the UC San Diego Division of Biological Sciences’ section of Neurobiology and Howard Hughes Medical Institute investigator, studies the mechanisms by which elementary circuits operate in the brain. His work aims to reveal the function and logic by which basic building blocks of cortical architecture orchestrate cortical activity, which gives rise to all thought and sensation.

About the Gatsby Charitable Foundation
Established in 1967 by noted philanthropist Lord Sainsbury of Turville, the Gatsby Charitable Foundation is a London-based, endowed grant-making trust. Set up to provide funding for charitable causes, the Gatsby Charitable Foundation currently focuses on plant science, neuroscience, technical education, mental health in the criminal justice system, environmentally sustainable development and poverty alleviation in developing countries as well as the arts. Learn more at www.gatsby.org.uk.

关于萨尔克生物研究所
索尔克生物研究所是世界顶尖的基础研究机构之一，其国际知名的教职人员在一个独特、协作和富有创造性的环境中，深入探究生命科学的基本问题。索尔克科学家们致力于发现和指导未来几代研究人员，通过研究神经科学、遗传学、细胞和植物生物学以及相关学科，在癌症、衰老、阿尔茨海默氏症、糖尿病和传染病的认识方面做出了开创性的贡献。.

学院取得了许多成就，获得了包括诺贝尔奖和美国国家科学院院士在内的无数荣誉。该研究所由脊髓灰质炎疫苗先驱 Jonas Salk 博士于 1960 年创立，是一家独立的非营利组织和建筑地标。.

About UC San Diego

Founded in 1960, the University of California, San Diego is ranked the best value public university in California by Kiplinger’s Personal Finance magazine and the 7th best public university in the nation by U.S. News and World Report. Named the “hottest” institution to study science by Newsweek, UC San Diego is one of the nation’s most accomplished research universities, widely acknowledged for its local impact, national influence and global reach. Renowned for its collaborative, diverse and cross-disciplinary ethos that transcends traditional boundaries in science, arts and the humanities, the university attracts stellar faculty, students and staff. For more information, please visit www.ucsd.edu.