Profesor
Centro NOMIS de Inmunobiología y Patogénesis Microbiana
Becky and Ralph S. O'Connor Chair
Hu, X., Liu, Z., Li, Y., You, Y., Yue, K., Liang, Y., Loo, C.S., Yu, J., Leblanc, M., Wang, D., Li, H., Zheng, Y. REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis. (2026) Journal of Experimental Medicine. 223(2). DOI: 10.1084/jem.20241463
Zheng, Y. Succinate undermines FOXP3 stability and disrupts T cell function. (2025) Naturaleza Inmunológica. DOI: 10.1038/s41590-025-02167-x
Strutzenberg, T.S., Mann, M.D., Li, X., Shin, H., Kelsey, J., Aiyer, S., Yu, J., Gray, G., Zhang, Z., Shan, Z., Zhou, B., Zheng, Y., Griffin, P.R., Lyumkis, D. La Interacción con el Nucleosoma Regula la Estructura y Dinámica del RORγt. (2025) bioRxiv. DOI: 10.1101/2025.03.10.642251
Yang, Q., Liang, Y., Inoue-Hatanaka, T., Koh, Z., Ilkenhans, N., Suman, E., Yu, J., Zheng, Y. PPARδ restrains the suppression function of intra-tumoral Tregs by limiting CIITA-MHC II expression. (2024) bioRxiv. DOI: 10.1101/2024.12.16.628819
Liu, Z., Lee, D.S., Liang, Y., Zheng, Y., Dixon, J.R. Foxp3 orchestrates reorganization of chromatin architecture to establish regulatory T cell identity. (2023) Nature Communications. 14(1):6943. DOI: 10.1038/s41467-023-42647-y
Chen, D., Varanasi, S.K., Hara, T., Traina, K., Sun, M., McDonald, B., Farsakoglu, Y., Clanton, J., Xu, S., Garcia-Rivera, L., Mann, T.H., Du, V., Chung, H.K., Xu, Z., Tripple, V., Casillas, E., Ma, S., O'Connor, C., Yang, Q., Zheng, Y., Hunter, T., Lemke, G., Kaech, S.M. CTLA-4 blockade induces CD4 T cell IFNγ-driven microglial phagocytosis and anti-tumor function in glioblastoma. (2023) Inmunidad. DOI: 10.1016/j.immuni.2023.07.015
Liu, Z., Lee, D.S., Liang, Y., Zheng, Y., Dixon, J.R. Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity. (2023) bioRxiv. DOI: 10.1101/2023.02.22.529589
Ma, S., Yang, Q., Chen, N., Zheng, A., Abbasi, N., Wang, G., Patel, P.R., Cho, B.S., Yee, B.A., Zhang, L., Chu, H., Evans, S.M., Yeo, G.W., Zheng, Y., Huang, W.J.M. RNA binding protein DDX5 restricts RORγt T suppressor function to promote intestine inflammation. (2023) Avances en Ciencia. 9(5):eadd6165. DOI: 10.1126/sciadv.add6165
Fu, T., Li, Y., Oh, T.G., Cayabyab, F., He, N., Tang, Q., Coulter, S., Truitt, M., Medina, P., He, M., Yu, R.T., Atkins, A., Zheng, Y., Liddle, C., Downes, M., Evans, R.M. FXR mediates ILC-intrinsic responses to intestinal inflammation. (2022) Actas de la Academia Nacional de Ciencias de los Estados Unidos de América. 119(51):e2213041119. DOI: 10.1073/pnas.2213041119
Liu, Z., Hu, X., Liang, Y., Yu, J., Li, H., Shokhirev, M.N., Zheng, Y. Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche. [Pubmed] (2022) Naturaleza Inmunológica. DOI: 10.1038/s41590-022-01244-9
Choi, J., Oh, T.G., Jung, H., Park, K.Y., Shin, H., Jo, T., Kang, D.S., Chanda, D., Hong, S., Kim, J., Hwang, H., Ji, M., Jung, M., Takashihoji, Matsushima, A., Kim, P., Mun, J.Y., Paik, M.J., Cho, S.J., Lee, I.K., Whitcomb, D.C., Greer, P., Blobner, B., Goodarzi, M.O., Pandol, S.J., Rotter, J.I., Fan, W., Bapat, S.P., Zheng, Y., Liddle, C., Yu, R.T., Atkins, A.R., Downes, M., Yoshihara, E., Evans, R.M., Suh, J.M. Estrogen-Related Receptor γ maintains pancreatic acinar cell function and identity by regulating cellular metabolism. (2022) Gastroenterology. DOI: 10.1053/j.gastro.2022.04.013
Bapat, S.P., Whitty, C., Mowery, C.T., Liang, Y., Yoo, A., Jiang, Z., Peters, M.C., Zhang, L.J., Vogel, I., Zhou, C., Nguyen, V.Q., Li, Z., Chang, C., Zhu, W.S., Hastie, A.T., He, H., Ren, X., Qiu, W., Gayer, S.G., Liu, C., Choi, E.J., Fassett, M., Cohen, J.N., Sturgill, J.L., Crotty Alexander, L.E., Suh, J.M., Liddle, C., Atkins, A.R., Yu, R.T., Downes, M., Liu, S., Nikolajczyk, B.S., Lee, I.K., Guttman-Yassky, E., Ansel, K.M., Woodruff, P.G., Fahy, J.V., Sheppard, D., Gallo, R.L., Ye, C.J., Evans, R.M., Zheng, Y., Marson, A. Obesity alters pathology and treatment response in inflammatory disease. (2022) Naturaleza. 604(7905):337-342. DOI: 10.1038/s41586-022-04536-0
Qiu, Z., Zhao, L., Shen, J.Z., Liang, Z., Wu, Q., Yang, K., Min, L., Gimple, R.C., Yang, Q., Bhargava, S., Jin, C., Kim, C., Hinz, D., Dixit, D., Bernatchez, J.A., Prager, B.C., Zhang, G., Dong, Z., Lv, D., Wang, X., Kim, L.J.Y., Zhu, Z., Jones, K.A., Zheng, Y., Wang, X., Siqueira-Neto, J.L., Chavez, L., Fu, X.D., Spruck, C., Rich, J.N. Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells. (2021) Cancer Discovery. DOI: 10.1158/2159-8290.CD-20-1848
Arnett, A., Moo, K.G., Flynn, K.J., Sundberg, T.B., Johannessen, L., Shamji, A.F., Gray, N.S., Decker, T., Zheng, Y., Gersuk, V.H., Rahman, Z.S., Levy, D.E., Marié, I.J., Linsley, P.S., Xavier, R.J., Khor, B. The CDK8 inhibitor DCA promotes a tolerogenic chemical immunophenotype in CD4 T cells via a novel CDK8-GATA3-FOXP3 pathway. (2021) Biología Molecular y Celular.:MCB0008521 DOI: 10.1128/MCB.00085-21
Loo, C.S., Gatchalian, J., Liang, Y., Leblanc, M., Xie, M., Ho, J., Venkatraghavan, B., Hargreaves, D.C., Zheng, Y. A Genome-wide CRISPR Screen Reveals a Role for the Non-Canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function. (2020) Inmunidad. DOI: 10.1016/j.immuni.2020.06.011
Hang, S., Paik, D., Yao, L., Kim, E., Jamma, T., Lu, J., Ha, S., Nelson, B.N., Kelly, S.P., Wu, L., Zheng, Y., Longman, R.S., Rastinejad, F., Devlin, A.S., Krout, M.R., Fischbach, M.A., Littman, D.R., Huh, J.R. Bile acid metabolites control T17 and T cell differentiation. (2019) Naturaleza. DOI: 10.1038/s41586-019-1785-z
Bapat, S.P., Liang, Y., Zheng, Y. Characterization of Immune Cells from Adipose Tissue. (2019) Current Protocols in Immunology. 126(1):e86. DOI: 10.1002/cpim.86
Chang, C., Loo, C.S., Zhao, X., Solt, L.A., Liang, Y., Bapat, S.P., Cho, H., Kamenecka, T.M., Leblanc, M., Atkins, A.R., Yu, R.T., Downes, M., Burris, T.P., Evans, R.M., Zheng, Y. The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease. (2019) Actas de la Academia Nacional de Ciencias de los Estados Unidos de América. 116(37):18528-18536. DOI: 10.1073/pnas.1907563116
Owen, D.L., Mahmud, S.A., Sjaastad, L.E., Williams, J.B., Spanier, J.A., Simeonov, D.R., Ruscher, R., Huang, W., Proekt, I., Miller, C.N., Hekim, C., Jeschke, J.C., Aggarwal, P., Broeckel, U., LaRue, R.S., Henzler, C.M., Alegre, M.L., Anderson, M.S., August, A., Marson, A., Zheng, Y., Williams, C.B., Farrar, M.A. Thymic regulatory T cells arise via two distinct developmental programs. (2019) Naturaleza Inmunológica. DOI: 10.1038/s41590-018-0289-6
Zhang, L.J., Chen, S.X., Guerrero-Juarez, C.F., Li, F., Tong, Y., Liang, Y., Liggins, M., Chen, X., Chen, H., Li, M., Hata, T., Zheng, Y., Plikus, M.V., Gallo, R.L. Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta. (2018) Inmunidad. DOI: 10.1016/j.immuni.2018.11.003
Klann, J.E., Kim, S.H., Remedios, K.A., He, Z., Metz, P.J., Lopez, J., Tysl, T., Olvera, J.G., Ablack, J.N., Cantor, J.M., Boland, B.S., Yeo, G., Zheng, Y., Lu, L.F., Bui, J.D., Ginsberg, M.H., Petrich, B.G., Chang, J.T. Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance. (2018) Journal of Immunology. 200(12):4012-4023. DOI: 10.4049/jimmunol.1800112
Cao, Q., Zhao, X., Bai, J., Gery, S., Sun, H., Lin, D.C., Chen, Q., Chen, Z., Mack, L., Yang, H., Deng, R., Shi, X., Chong, L.W., Cho, H., Xie, J., Li, Q.Z., Müschen, M., Atkins, A.R., Liddle, C., Yu, R.T., Alkan, S., Said, J.W., Zheng, Y., Downes, M., Evans, R.M., Koeffler, H.P. Circadian clock cryptochrome proteins regulate autoimmunity. (2017) Actas de la Academia Nacional de Ciencias de los Estados Unidos de América. 114(47):12548-12553. DOI: 10.1073/pnas.1619119114
He, N., Fan, W., Henriquez, B., Yu, R.T., Atkins, A.R., Liddle, C., Zheng, Y., Downes, M., Evans, R.M. Metabolic control of regulatory T cell (Treg) survival and function by Lkb1. (2017) Proc. Natl. Acad. Sci. U.S.A. 114(47):12542-12547. DOI: 10.1073/pnas.1715363114
Wang, J., He, N., Zhang, N., Quan, D., Zhang, S., Zhang, C., Yu, R.T., Atkins, A.R., Zhu, R., Yang, C., Cui, Y., Liddle, C., Downes, M., Xiao, H., Zheng, Y., Auwerx, J., Evans, R.M., Leng, Q. NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection. (2017) Nature Communications. 8(1):959. DOI: 10.1038/s41467-017-00931-8
Zheng, Y. A Rogue Foxp3 Mutant Undermines Treg Cell Function. (2017) Inmunidad. 47(2):211-214. DOI: 10.1016/j.immuni.2017.07.024
Klann, J.E., Remedios, K.A., Kim, S.H., Metz, P.J., Lopez, J., Mack, L.A., Zheng, Y., Ginsberg, M.H., Petrich, B.G., Chang, J.T. Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. (2017) Journal of Immunology. 198(12):4639-4651. DOI: 10.4049/jimmunol.1601165
Chinen, T., Kannan, A.K., Levine, A.G., Fan, X., Klein, U., Zheng, Y., Gasteiger, G., Feng, Y., Fontenot, J.D., Rudensky, A.Y. An essential role for the IL-2 receptor in Treg cell function. (2016) Naturaleza Inmunológica. 17(11):1322-1333. DOI: 10.1038/ni.3540
Liu, W.H., Kang, S.G., Huang, Z., Wu, C.J., Jin, H.Y., Maine, C.J., Liu, Y., Shepherd, J., Sabouri-Ghomi, M., Gonzalez-Martin, A., Xu, S., Hoffmann, A., Zheng, Y., Lu, L.F., Xiao, N., Fu, G., Xiao, C. A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells. (2016) Journal of Experimental Medicine. 213(9):1901-19. DOI: 10.1084/jem.20160204
Bapat, S.P., Myoung Suh, J., Fang, S., Liu, S., Zhang, Y., Cheng, A., Zhou, C., Liang, Y., LeBlanc, M., Liddle, C., Atkins, A.R., Yu, R.T., Downes, M., Evans, R.M., Zheng, Y. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. (2015) Naturaleza. 528(7580):137-41. DOI: 10.1038/nature16151
Hernandez, J.B., Chang, C., LeBlanc, M., Grimm, D., Le Lay, J., Kaestner, K.H., Zheng, Y., Montminy, M. The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation. (2015) Nature Communications. 6:7216. DOI: 10.1038/ncomms8216
Li, X., Zheng, Y. Regulatory T cell identity: formation and maintenance. (2015) Trends in Immunology. 36(6):344-53. DOI: 10.1016/j.it.2015.04.006
Li, X., Liang, Y., LeBlanc, M., Benner, C., Zheng, Y. Function of a Foxp3 cis-element in protecting regulatory T cell identity. (2014) Móvil. 158(4):734-48. DOI: 10.1016/j.cell.2014.07.030
Zheng, Y. ChIP-on-chip for FoxP3. (2011) Métodos en Biología Molecular. 707:71-82. DOI: 10.1007/978-1-61737-979-6_6
Zheng, Y., Josefowicz, S., Chaudhry, A., Peng, X.P., Forbush, K., Rudensky, A.Y. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. (2010) Naturaleza. 463(7282):808-12. DOI: 10.1038/nature08750
Zheng, Y., Chaudhry, A., Kas, A., deRoos, P., Kim, J.M., Chu, T.T., Corcoran, L., Treuting, P., Klein, U., Rudensky, A.Y. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. (2009) Naturaleza. 458(7236):351-6. DOI: 10.1038/nature07674
Wang, J., Wang, X., Hussain, S., Zheng, Y., Sanjabi, S., Ouaaz, F., Beg, A.A. Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells. (2007) Journal of Immunology. 178(11):6777-88.
Zheng, Y., Rudensky, A.Y. Foxp3 in control of the regulatory T cell lineage. (2007) Naturaleza Inmunológica. 8(5):457-62. DOI: 10.1038/ni1455
Zheng, Y., Josefowicz, S.Z., Kas, A., Chu, T.T., Gavin, M.A., Rudensky, A.Y. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. (2007) Naturaleza. 445(7130):936-40. DOI: 10.1038/nature05563
Hsieh, C.S., Zheng, Y., Liang, Y., Fontenot, J.D., Rudensky, A.Y. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. (2006) Naturaleza Inmunológica. 7(4):401-10. DOI: 10.1038/ni1318
Prendes, M., Zheng, Y., Beg, A.A. Regulation of developing B cell survival by RelA-containing NF-kappa B complexes. (2003) Journal of Immunology. 171(8):3963-9.
Qu, J., Li, X., Novitch, B.G., Zheng, Y., Kohn, M., Xie, J.M., Kozinn, S., Bronson, R., Beg, A.A., Minden, A. PAK4 kinase is essential for embryonic viability and for proper neuronal development. (2003) Biología Molecular y Celular. 23(20):7122-33.
Tao, X., Xu, Y., Zheng, Y., Beg, A.A., Tong, L. An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2. (2002) Biochemical and Biophysical Research Communications. 299(2):216-21. DOI: 10.1016/s0006-291x(02)02581-0
Ouaaz, F., Arron, J., Zheng, Y., Choi, Y., Beg, A.A. Dendritic cell development and survival require distinct NF-kappaB subunits. (2002) Inmunidad. 16(2):257-70.
BS, Biochemistry and Molecular Biology, Peking University, Beijing, China
PhD, Columbia University
Postdoctoral Fellow, University of Washington
Memorial Sloan-Kettering Cancer Center Research Scholar
Cancer Research Institute Postdoctoral Fellowship