Ye Zheng, doctor

Profesor

Centro NOMIS de Inmunobiología y Patogénesis Microbiana

Becky and Ralph S. O'Connor Chair

Instituto Salk de Estudios Biológicos - Publicaciones

Todas las publicaciones


Hu, X., Liu, Z., Li, Y., You, Y., Yue, K., Liang, Y., Loo, C.S., Yu, J., Leblanc, M., Wang, D., Li, H., Zheng, Y. REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis. (2026) Journal of Experimental Medicine. 223(2). DOI: 10.1084/jem.20241463

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Zheng, Y. Succinate undermines FOXP3 stability and disrupts T cell function. (2025) Naturaleza Inmunológica. DOI: 10.1038/s41590-025-02167-x


Strutzenberg, T.S., Mann, M.D., Li, X., Shin, H., Kelsey, J., Aiyer, S., Yu, J., Gray, G., Zhang, Z., Shan, Z., Zhou, B., Zheng, Y., Griffin, P.R., Lyumkis, D. La Interacción con el Nucleosoma Regula la Estructura y Dinámica del RORγt. (2025) bioRxiv. DOI: 10.1101/2025.03.10.642251

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Yang, Q., Liang, Y., Inoue-Hatanaka, T., Koh, Z., Ilkenhans, N., Suman, E., Yu, J., Zheng, Y. PPARδ restrains the suppression function of intra-tumoral Tregs by limiting CIITA-MHC II expression. (2024) bioRxiv. DOI: 10.1101/2024.12.16.628819

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Liu, Z., Lee, D.S., Liang, Y., Zheng, Y., Dixon, J.R. Foxp3 orchestrates reorganization of chromatin architecture to establish regulatory T cell identity. (2023) Nature Communications. 14(1):6943. DOI: 10.1038/s41467-023-42647-y

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Chen, D., Varanasi, S.K., Hara, T., Traina, K., Sun, M., McDonald, B., Farsakoglu, Y., Clanton, J., Xu, S., Garcia-Rivera, L., Mann, T.H., Du, V., Chung, H.K., Xu, Z., Tripple, V., Casillas, E., Ma, S., O'Connor, C., Yang, Q., Zheng, Y., Hunter, T., Lemke, G., Kaech, S.M. CTLA-4 blockade induces CD4 T cell IFNγ-driven microglial phagocytosis and anti-tumor function in glioblastoma. (2023) Inmunidad. DOI: 10.1016/j.immuni.2023.07.015

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Liu, Z., Lee, D.S., Liang, Y., Zheng, Y., Dixon, J.R. Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity. (2023) bioRxiv. DOI: 10.1101/2023.02.22.529589

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Ma, S., Yang, Q., Chen, N., Zheng, A., Abbasi, N., Wang, G., Patel, P.R., Cho, B.S., Yee, B.A., Zhang, L., Chu, H., Evans, S.M., Yeo, G.W., Zheng, Y., Huang, W.J.M. RNA binding protein DDX5 restricts RORγt T suppressor function to promote intestine inflammation. (2023) Avances en Ciencia. 9(5):eadd6165. DOI: 10.1126/sciadv.add6165

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Fu, T., Li, Y., Oh, T.G., Cayabyab, F., He, N., Tang, Q., Coulter, S., Truitt, M., Medina, P., He, M., Yu, R.T., Atkins, A., Zheng, Y., Liddle, C., Downes, M., Evans, R.M. FXR mediates ILC-intrinsic responses to intestinal inflammation. (2022) Actas de la Academia Nacional de Ciencias de los Estados Unidos de América. 119(51):e2213041119. DOI: 10.1073/pnas.2213041119

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Liu, Z., Hu, X., Liang, Y., Yu, J., Li, H., Shokhirev, M.N., Zheng, Y. Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche. [Pubmed] (2022) Naturaleza Inmunológica. DOI: 10.1038/s41590-022-01244-9

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Choi, J., Oh, T.G., Jung, H., Park, K.Y., Shin, H., Jo, T., Kang, D.S., Chanda, D., Hong, S., Kim, J., Hwang, H., Ji, M., Jung, M., Takashihoji, Matsushima, A., Kim, P., Mun, J.Y., Paik, M.J., Cho, S.J., Lee, I.K., Whitcomb, D.C., Greer, P., Blobner, B., Goodarzi, M.O., Pandol, S.J., Rotter, J.I., Fan, W., Bapat, S.P., Zheng, Y., Liddle, C., Yu, R.T., Atkins, A.R., Downes, M., Yoshihara, E., Evans, R.M., Suh, J.M. Estrogen-Related Receptor γ maintains pancreatic acinar cell function and identity by regulating cellular metabolism. (2022) Gastroenterology. DOI: 10.1053/j.gastro.2022.04.013

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Bapat, S.P., Whitty, C., Mowery, C.T., Liang, Y., Yoo, A., Jiang, Z., Peters, M.C., Zhang, L.J., Vogel, I., Zhou, C., Nguyen, V.Q., Li, Z., Chang, C., Zhu, W.S., Hastie, A.T., He, H., Ren, X., Qiu, W., Gayer, S.G., Liu, C., Choi, E.J., Fassett, M., Cohen, J.N., Sturgill, J.L., Crotty Alexander, L.E., Suh, J.M., Liddle, C., Atkins, A.R., Yu, R.T., Downes, M., Liu, S., Nikolajczyk, B.S., Lee, I.K., Guttman-Yassky, E., Ansel, K.M., Woodruff, P.G., Fahy, J.V., Sheppard, D., Gallo, R.L., Ye, C.J., Evans, R.M., Zheng, Y., Marson, A. Obesity alters pathology and treatment response in inflammatory disease. (2022) Naturaleza. 604(7905):337-342. DOI: 10.1038/s41586-022-04536-0

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Qiu, Z., Zhao, L., Shen, J.Z., Liang, Z., Wu, Q., Yang, K., Min, L., Gimple, R.C., Yang, Q., Bhargava, S., Jin, C., Kim, C., Hinz, D., Dixit, D., Bernatchez, J.A., Prager, B.C., Zhang, G., Dong, Z., Lv, D., Wang, X., Kim, L.J.Y., Zhu, Z., Jones, K.A., Zheng, Y., Wang, X., Siqueira-Neto, J.L., Chavez, L., Fu, X.D., Spruck, C., Rich, J.N. Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells. (2021) Cancer Discovery. DOI: 10.1158/2159-8290.CD-20-1848

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Arnett, A., Moo, K.G., Flynn, K.J., Sundberg, T.B., Johannessen, L., Shamji, A.F., Gray, N.S., Decker, T., Zheng, Y., Gersuk, V.H., Rahman, Z.S., Levy, D.E., Marié, I.J., Linsley, P.S., Xavier, R.J., Khor, B. The CDK8 inhibitor DCA promotes a tolerogenic chemical immunophenotype in CD4 T cells via a novel CDK8-GATA3-FOXP3 pathway. (2021) Biología Molecular y Celular.:MCB0008521 DOI: 10.1128/MCB.00085-21

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Loo, C.S., Gatchalian, J., Liang, Y., Leblanc, M., Xie, M., Ho, J., Venkatraghavan, B., Hargreaves, D.C., Zheng, Y. A Genome-wide CRISPR Screen Reveals a Role for the Non-Canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function. (2020) Inmunidad. DOI: 10.1016/j.immuni.2020.06.011

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Hang, S., Paik, D., Yao, L., Kim, E., Jamma, T., Lu, J., Ha, S., Nelson, B.N., Kelly, S.P., Wu, L., Zheng, Y., Longman, R.S., Rastinejad, F., Devlin, A.S., Krout, M.R., Fischbach, M.A., Littman, D.R., Huh, J.R. Bile acid metabolites control T17 and T cell differentiation. (2019) Naturaleza. DOI: 10.1038/s41586-019-1785-z

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Bapat, S.P., Liang, Y., Zheng, Y. Characterization of Immune Cells from Adipose Tissue. (2019) Current Protocols in Immunology. 126(1):e86. DOI: 10.1002/cpim.86

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Chang, C., Loo, C.S., Zhao, X., Solt, L.A., Liang, Y., Bapat, S.P., Cho, H., Kamenecka, T.M., Leblanc, M., Atkins, A.R., Yu, R.T., Downes, M., Burris, T.P., Evans, R.M., Zheng, Y. The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease. (2019) Actas de la Academia Nacional de Ciencias de los Estados Unidos de América. 116(37):18528-18536. DOI: 10.1073/pnas.1907563116

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Owen, D.L., Mahmud, S.A., Sjaastad, L.E., Williams, J.B., Spanier, J.A., Simeonov, D.R., Ruscher, R., Huang, W., Proekt, I., Miller, C.N., Hekim, C., Jeschke, J.C., Aggarwal, P., Broeckel, U., LaRue, R.S., Henzler, C.M., Alegre, M.L., Anderson, M.S., August, A., Marson, A., Zheng, Y., Williams, C.B., Farrar, M.A. Thymic regulatory T cells arise via two distinct developmental programs. (2019) Naturaleza Inmunológica. DOI: 10.1038/s41590-018-0289-6

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Zhang, L.J., Chen, S.X., Guerrero-Juarez, C.F., Li, F., Tong, Y., Liang, Y., Liggins, M., Chen, X., Chen, H., Li, M., Hata, T., Zheng, Y., Plikus, M.V., Gallo, R.L. Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta. (2018) Inmunidad. DOI: 10.1016/j.immuni.2018.11.003

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Klann, J.E., Kim, S.H., Remedios, K.A., He, Z., Metz, P.J., Lopez, J., Tysl, T., Olvera, J.G., Ablack, J.N., Cantor, J.M., Boland, B.S., Yeo, G., Zheng, Y., Lu, L.F., Bui, J.D., Ginsberg, M.H., Petrich, B.G., Chang, J.T. Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance. (2018) Journal of Immunology. 200(12):4012-4023. DOI: 10.4049/jimmunol.1800112

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Cao, Q., Zhao, X., Bai, J., Gery, S., Sun, H., Lin, D.C., Chen, Q., Chen, Z., Mack, L., Yang, H., Deng, R., Shi, X., Chong, L.W., Cho, H., Xie, J., Li, Q.Z., Müschen, M., Atkins, A.R., Liddle, C., Yu, R.T., Alkan, S., Said, J.W., Zheng, Y., Downes, M., Evans, R.M., Koeffler, H.P. Circadian clock cryptochrome proteins regulate autoimmunity. (2017) Actas de la Academia Nacional de Ciencias de los Estados Unidos de América. 114(47):12548-12553. DOI: 10.1073/pnas.1619119114

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He, N., Fan, W., Henriquez, B., Yu, R.T., Atkins, A.R., Liddle, C., Zheng, Y., Downes, M., Evans, R.M. Metabolic control of regulatory T cell (Treg) survival and function by Lkb1. (2017) Proc. Natl. Acad. Sci. U.S.A. 114(47):12542-12547. DOI: 10.1073/pnas.1715363114

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Wang, J., He, N., Zhang, N., Quan, D., Zhang, S., Zhang, C., Yu, R.T., Atkins, A.R., Zhu, R., Yang, C., Cui, Y., Liddle, C., Downes, M., Xiao, H., Zheng, Y., Auwerx, J., Evans, R.M., Leng, Q. NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection. (2017) Nature Communications. 8(1):959. DOI: 10.1038/s41467-017-00931-8

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Zheng, Y. A Rogue Foxp3 Mutant Undermines Treg Cell Function. (2017) Inmunidad. 47(2):211-214. DOI: 10.1016/j.immuni.2017.07.024

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Klann, J.E., Remedios, K.A., Kim, S.H., Metz, P.J., Lopez, J., Mack, L.A., Zheng, Y., Ginsberg, M.H., Petrich, B.G., Chang, J.T. Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. (2017) Journal of Immunology. 198(12):4639-4651. DOI: 10.4049/jimmunol.1601165

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Chinen, T., Kannan, A.K., Levine, A.G., Fan, X., Klein, U., Zheng, Y., Gasteiger, G., Feng, Y., Fontenot, J.D., Rudensky, A.Y. An essential role for the IL-2 receptor in Treg cell function. (2016) Naturaleza Inmunológica. 17(11):1322-1333. DOI: 10.1038/ni.3540

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Liu, W.H., Kang, S.G., Huang, Z., Wu, C.J., Jin, H.Y., Maine, C.J., Liu, Y., Shepherd, J., Sabouri-Ghomi, M., Gonzalez-Martin, A., Xu, S., Hoffmann, A., Zheng, Y., Lu, L.F., Xiao, N., Fu, G., Xiao, C. A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells. (2016) Journal of Experimental Medicine. 213(9):1901-19. DOI: 10.1084/jem.20160204

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Bapat, S.P., Myoung Suh, J., Fang, S., Liu, S., Zhang, Y., Cheng, A., Zhou, C., Liang, Y., LeBlanc, M., Liddle, C., Atkins, A.R., Yu, R.T., Downes, M., Evans, R.M., Zheng, Y. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. (2015) Naturaleza. 528(7580):137-41. DOI: 10.1038/nature16151

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Hernandez, J.B., Chang, C., LeBlanc, M., Grimm, D., Le Lay, J., Kaestner, K.H., Zheng, Y., Montminy, M. The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation. (2015) Nature Communications. 6:7216. DOI: 10.1038/ncomms8216

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Li, X., Zheng, Y. Regulatory T cell identity: formation and maintenance. (2015) Trends in Immunology. 36(6):344-53. DOI: 10.1016/j.it.2015.04.006

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Li, X., Liang, Y., LeBlanc, M., Benner, C., Zheng, Y. Function of a Foxp3 cis-element in protecting regulatory T cell identity. (2014) Móvil. 158(4):734-48. DOI: 10.1016/j.cell.2014.07.030

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Zheng, Y. ChIP-on-chip for FoxP3. (2011) Métodos en Biología Molecular. 707:71-82. DOI: 10.1007/978-1-61737-979-6_6

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Zheng, Y., Josefowicz, S., Chaudhry, A., Peng, X.P., Forbush, K., Rudensky, A.Y. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. (2010) Naturaleza. 463(7282):808-12. DOI: 10.1038/nature08750

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Zheng, Y., Chaudhry, A., Kas, A., deRoos, P., Kim, J.M., Chu, T.T., Corcoran, L., Treuting, P., Klein, U., Rudensky, A.Y. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. (2009) Naturaleza. 458(7236):351-6. DOI: 10.1038/nature07674

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Wang, J., Wang, X., Hussain, S., Zheng, Y., Sanjabi, S., Ouaaz, F., Beg, A.A. Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells. (2007) Journal of Immunology. 178(11):6777-88.

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Zheng, Y., Rudensky, A.Y. Foxp3 in control of the regulatory T cell lineage. (2007) Naturaleza Inmunológica. 8(5):457-62. DOI: 10.1038/ni1455

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Zheng, Y., Josefowicz, S.Z., Kas, A., Chu, T.T., Gavin, M.A., Rudensky, A.Y. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. (2007) Naturaleza. 445(7130):936-40. DOI: 10.1038/nature05563

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Hsieh, C.S., Zheng, Y., Liang, Y., Fontenot, J.D., Rudensky, A.Y. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. (2006) Naturaleza Inmunológica. 7(4):401-10. DOI: 10.1038/ni1318

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Prendes, M., Zheng, Y., Beg, A.A. Regulation of developing B cell survival by RelA-containing NF-kappa B complexes. (2003) Journal of Immunology. 171(8):3963-9.

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Qu, J., Li, X., Novitch, B.G., Zheng, Y., Kohn, M., Xie, J.M., Kozinn, S., Bronson, R., Beg, A.A., Minden, A. PAK4 kinase is essential for embryonic viability and for proper neuronal development. (2003) Biología Molecular y Celular. 23(20):7122-33.

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Tao, X., Xu, Y., Zheng, Y., Beg, A.A., Tong, L. An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2. (2002) Biochemical and Biophysical Research Communications. 299(2):216-21. DOI: 10.1016/s0006-291x(02)02581-0

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Ouaaz, F., Arron, J., Zheng, Y., Choi, Y., Beg, A.A. Dendritic cell development and survival require distinct NF-kappaB subunits. (2002) Inmunidad. 16(2):257-70.

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Educación

BS, Biochemistry and Molecular Biology, Peking University, Beijing, China
PhD, Columbia University
Postdoctoral Fellow, University of Washington
Memorial Sloan-Kettering Cancer Center Research Scholar
Cancer Research Institute Postdoctoral Fellowship


Afiliaciones


Premios y distinciones

  • Rita Allen Foundation Scholar Award, 2010-2015