Dannielle Engle, PhD

Profesor adjunto

Laboratorio de Biología Reguladora

Helen McLoraine Silla de Desarrollo

Dannielle Engle
Instituto Salk de Estudios Biológicos - Publicaciones

Todas las publicaciones


Osorio-Vasquez, V., Zhu, J., Lumibao, J.C., Lande, K., Peck, K.L., Stamp, M.K., Okhovat, S.R., Song, H., Ogawa, S., Kubota, C., Pantazopoulou, V., Dai, Y., Rock, A., Bottomley, C., Thomas, E., Hsu, J., Morales, A.H., Fowler, A., McGriff, T., Evensen, K.G., Larsen, S., Abdulla, M., Greer, P., Gibson, J., Downes, M., Evans, R., Lowy, A.M., Whitcomb, D.C., Zou, J., Molinolo, A., Oh, T.G., White, R., Bellin, M., Tiriac, H., Engle, D.D. Chronic pancreatitis patient-derived organoids reveal new paths to precision therapeutics. (2025) bioRxiv. DOI: 10.1101/2024.10.30.620903

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Clausen, T.M., Weiss, R.J., Tremblay, J.R., Kellman, B.P., Coker, J., Dworkin, L.A., Rodriguez, J.P., Chang, I.M., Chen, T., Padala, V., Karlsson, R., Song, H., Peck, K.L., Ogawa, S., Sandoval, D.R., Joshi, H.J., Wang, G., Ferguson, L.P., Bhalerao, N., Moores, A., Reya, T., Sander, M., Caffrey, T.C., Grem, J.L., Aicher, A., Heeschen, C., Le, D., Lewis, N.E., Hollingsworth, M.A., Grandgenett, P.M., Bellis, S.L., Miller, R.L., Fuster, M.M., Dawson, D.W., Engle, D.D., Esko, J.D. Antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and suppresses pancreatic tumorigenesis. (2025) Journal of Clinical Investigation. DOI: 10.1172/JCI184172

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Pantazopoulou, V., Kubota, C.S., Ogawa, S., Gulay, K.C.M., Lin, X., Song, H., Weitz, J.R., Tiriac, H., Lowy, A.M., Engle, D.D. Experimental models of pancreas cancer: what has been the impact for precision medicine? (2025) Journal of Clinical Investigation. 135(16). DOI: 10.1172/JCI191945

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Dufresne, S., Kuna, R.S., Wong, K., Komarla, A., Rock, A., Rosada-Encarnación, J., Shen, C., Mondal, P., Parham, L.R., Layng, F.I., Peck, K.L., Fowler, A., Lowy, A.M., Engle, D., Tiriac, H., Shaw, R., Cosford, N., Metallo, C., Towers, C. Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer. (2025) bioRxiv. DOI: 10.1101/2025.05.29.656904

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Rosas, J.M., Campanale, J.P., Harwood, J.L., Li, L., Bae, R., Cheng, S., Tsou, J.M., Kaiser, K.M., Engle, D.D., Montell, D.J., Pitenis, A.A. Differential Effects of Confinement on the Dynamics of Normal and Tumor-Derived Pancreatic Ductal Organoids. (2024) ACS Appl Bio Mater. DOI: 10.1021/acsabm.4c01301

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Tremblay, J.R., Ortiz, J.A., Quijano, J.C., Zook, H.N., Erdem, N., LeBon, J.M., Li, W., Jou, K., Tsark, W., Mann, J.R., Kozlowski, M., Tirrell, D.A., Esni, F., Engle, D.D., Riggs, A.D., Ku, H.T. Rare, tightly-bound, multi-cellular clusters in the pancreatic ducts of adult mice function like progenitor cells and survive and proliferate after acinar cell injury. (2024) Stem Cells. DOI: 10.1093/stmcls/sxae005

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Lumibao, J.C., Okhovat, S.R., Peck, K.L., Lin, X., Lande, K., Yomtoubian, S., Ng, I., Tiriac, H., Lowy, A.M., Zou, J., Engle, D.D. The effect of extracellular matrix on the precision medicine utility of pancreatic cancer patient-derived organoids. (2023) JCI Insight. DOI: 10.1172/jci.insight.172419

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Liang, G., Oh, T.G., Hah, N., Tiriac, H., Shi, Y., Truitt, M.L., Antal, C.E., Atkins, A.R., Li, Y., Fraser, C., Ng, S., Pinto, A.F.M., Nelson, D.C., Estepa, G., Bashi, S., Banayo, E., Dai, Y., Liddle, C., Yu, R.T., Hunter, T., Engle, D.D., Han, H., Von Hoff, D.D., Downes, M., Evans, R.M. Inhibiting stromal Class I HDACs curbs pancreatic cancer progression. (2023) Nature Communications. 14(1):7791. DOI: 10.1038/s41467-023-42178-6

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Antal, C.E., Oh, T.G., Aigner, S., Luo, E.C., Yee, B.A., Campos, T., Tiriac, H., Rothamel, K.L., Cheng, Z., Jiao, H., Wang, A., Hah, N., Lenkiewicz, E., Lumibao, J.C., Truitt, M.L., Estepa, G., Banayo, E., Bashi, S., Esparza, E., Munoz, R.M., Diedrich, J.K., Sodir, N.M., Mueller, J.R., Fraser, C.R., Borazanci, E., Propper, D., Von Hoff, D.D., Liddle, C., Yu, R.T., Atkins, A.R., Han, H., Lowy, A.M., Barrett, M.T., Engle, D.D., Evan, G.I., Yeo, G.W., Downes, M., Evans, R.M. A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer. (2023) Nature Communications. 14(1):5195. DOI: 10.1038/s41467-023-40798-6

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Lumibao, J.C., Tremblay, J.R., Hsu, J., Engle, D.D. Altered glycosylation in pancreatic cancer and beyond. (2022) Journal of Experimental Medicine. 219(6). DOI: 10.1084/jem.20211505

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Dasgupta, A., Shukla, S.K., Vernucci, E., King, R.J., Abrego, J., Mulder, S.E., Mullen, N.J., Graves, G., Buettner, K., Thakur, R., Murthy, D., Attri, K.S., Wang, D., Chaika, N.V., Pacheco, C.G., Rai, I., Engle, D.D., Grandgenett, P.M., Punsoni, M., Reames, B.N., Teoh-Fitzgerald, M., Oberley-Deegan, R., Yu, F., Klute, K.A., Hollingsworth, M.A., Zimmerman, M.C., Mehla, K., Sadoshima, J., Tuveson, D.A., Singh, P.K. SIRT1-NOX4 signaling axis regulates cancer cachexia. (2020) Journal of Experimental Medicine. 217(7). DOI: 10.1084/jem.20190745

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Ponz-Sarvise, M., Corbo, V., Tiriac, H., Engle, D.D., Frese, K.K., Oni, T.E., Hwang, C.I., Öhlund, D., Chio, I.I.C., Baker, L.A., Filippini, D., Wright, K., Bapiro, T.E., Huang, P.S., Smith, P.D., Yu, K.H., Jodrell, D.I., Park, Y., Tuveson, D.A. Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer. (2019) Clinical Cancer Research. DOI: 10.1158/1078-0432.CCR-19-1398

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Elyada, E., Bolisetty, M., Laise, P., Flynn, W.F., Courtois, E.T., Burkhart, R.A., Teinor, J.A., Belleau, P., Biffi, G., Lucito, M.S., Sivajothi, S., Armstrong, T.D., Engle, D.D., Yu, K.H., Hao, Y., Wolfgang, C.L., Park, Y., Preall, J., Jaffee, E.M., Califano, A., Robson, P., Tuveson, D.A. Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts. (2019) Cancer Discovery. 9(8):1102-1123. DOI: 10.1158/2159-8290.CD-19-0094

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Engle, D.D., Tiriac, H., Rivera, K.D., Pommier, A., Whalen, S., Oni, T.E., Alagesan, B., Lee, E.J., Yao, M.A., Lucito, M.S., Spielman, B., Da Silva, B., Schoepfer, C., Wright, K., Creighton, B., Afinowicz, L., Yu, K.H., Grützmann, R., Aust, D., Gimotty, P.A., Pollard, K.S., Hruban, R.H., Goggins, M.G., Pilarsky, C., Park, Y., Pappin, D.J., Hollingsworth, M.A., Tuveson, D.A. The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice. (2019) Ciencia. 364(6446):1156-1162. DOI: 10.1126/science.aaw3145

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Tiriac, H., Belleau, P.*, Engle, D.D.*, Plenker, D., Deschênes, A., Somerville, T.D.D., Froeling, F.E.M., Burkhart, R.A., Denroche, R.E., Jang, G.H., Miyabayashi, K., Young, C.M., Patel, H., Ma, M., LaComb, J.F., Palmaira, R.L.D., Javed, A.A., Huynh, J.C., Johnson, M., Arora, K., Robine, N., Shah, M., Sanghvi, R., Goetz, A.B., Lowder, C.Y., Martello, L., Driehuis, E., LeComte, N., Askan, G., Iacobuzio-Donahue, C.A., Clevers, H., Wood, L.D., Hruban, R.H., Thompson, E., Aguirre, A.J., Wolpin, B.M., Sasson, A., Kim, J., Wu, M., Bucobo, J.C., Allen, P., Sejpal, D.V., Nealon, W., Sullivan, J.D., Winter, J.M., Gimotty, P.A., Grem, J.L., DiMaio, D.J., Buscaglia, J.M., Grandgenett, P.M., Brody, J.R., Hollingsworth, M.A., O'Kane, G.M., Notta, F., Kim, E., Crawford, J.M., Devoe, C., Ocean, A., Wolfgang, C.L., Yu, K.H., Li, E., Vakoc, C.R., Hubert, B., Fischer, S.E., Wilson, J.M., Moffitt, R., Knox, J., Krasnitz, A., Gallinger, S., Tuveson, D.A. Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer. (2018) Cancer Discovery. 8(9):1112-1129. DOI: 10.1158/2159-8290.CD-18-0349

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Quaranta, V., Rainer, C., Nielsen, S.R., Raymant, M.L., Ahmed, M.S., Engle, D.D., Taylor, A., Murray, T., Campbell, F., Palmer, D.H., Tuveson, D.A., Mielgo, A., Schmid, M.C. Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer. (2018) Cancer Research. 78(15):4253-4269. DOI: 10.1158/0008-5472.CAN-17-3876

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Wolff, R.A.*, Wang-Gillam, A.*, Alvarez, H.*, Tiriac, H.*, Engle, D.*, Hou, S.*, Groff, A.F., San Lucas, A., Bernard, V., Allenson, K., Castillo, J., Kim, D., Mulu, F., Huang, J., Stephens, B., Wistuba, I.I., Katz, M., Varadhachary, G., Park, Y., Hicks, J., Chinnaiyan, A., Scampavia, L., Spicer, T., Gerhardinger, C., Maitra, A., Tuveson, D., Rinn, J., Lizee, G., Yee, C., Levine, A.J. Dynamic changes during the treatment of pancreatic cancer. (2018) Oncotarget. 9(19):14764-14790. DOI: 10.18632/oncotarget.24483

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Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A.S., Ponz-Sarvise, M., Corbo, V., Oni, T.E., Hearn, S.A., Lee, E.J., Chio, I.I., Hwang, C.I., Tiriac, H., Baker, L.A., Engle, D.D., Feig, C., Kultti, A., Egeblad, M., Fearon, D.T., Crawford, J.M., Clevers, H., Park, Y., Tuveson, D.A. Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. (2017) Journal of Experimental Medicine. 214(3):579-596. DOI: 10.1084/jem.20162024

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Ireland, L., Santos, A., Ahmed, M.S., Rainer, C., Nielsen, S.R., Quaranta, V., Weyer-Czernilofsky, U., Engle, D.D., Perez-Mancera, P.A., Coupland, S.E., Taktak, A., Bogenrieder, T., Tuveson, D.A., Campbell, F., Schmid, M.C., Mielgo, A. Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors. (2016) Cancer Research. 76(23):6851-6863. DOI: 10.1158/0008-5472.CAN-16-1201

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Nielsen, S.R., Quaranta, V., Linford, A., Emeagi, P., Rainer, C., Santos, A., Ireland, L., Sakai, T., Sakai, K., Kim, Y.S., Engle, D., Campbell, F., Palmer, D., Ko, J.H., Tuveson, D.A., Hirsch, E., Mielgo, A., Schmid, M.C. Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. (2016) Naturaleza y Biología Celular. 18(5):549-60. DOI: 10.1038/ncb3340

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Seifert, L., Werba, G., Tiwari, S., Giao Ly, N.N., Alothman, S., Alqunaibit, D., Avanzi, A., Barilla, R., Daley, D., Greco, S.H., Torres-Hernandez, A., Pergamo, M., Ochi, A., Zambirinis, C.P., Pansari, M., Rendon, M., Tippens, D., Hundeyin, M., Mani, V.R., Hajdu, C., Engle, D., Miller, G. The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. (2016) Naturaleza. 532(7598):245-9. DOI: 10.1038/nature17403

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Boj, S.F., Hwang, C.I., Baker, L.A., Engle, D.D., Tuveson, D.A., Clevers, H. Model organoids provide new research opportunities for ductal pancreatic cancer. (2016) Molecular & Cellular Oncology. 3(1):e1014757. DOI: 10.1080/23723556.2015.1014757

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Zambirinis, C.P., Levie, E., Nguy, S., Avanzi, A., Barilla, R., Xu, Y., Seifert, L., Daley, D., Greco, S.H., Deutsch, M., Jonnadula, S., Torres-Hernandez, A., Tippens, D., Pushalkar, S., Eisenthal, A., Saxena, D., Ahn, J., Hajdu, C., Engle, D.D., Tuveson, D., Miller, G. TLR9 ligation in pancreatic stellate cells promotes tumorigenesis. (2015) J. Exp. Med. 212(12):2077-94. DOI: 10.1084/jem.20142162

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Roy, I., McAllister, D.M., Gorse, E., Dixon, K., Piper, C.T., Zimmerman, N.P., Getschman, A.E., Tsai, S., Engle, D.D., Evans, D.B., Volkman, B.F., Kalyanaraman, B., Dwinell, M.B. Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling. (2015) Cancer Research. 75(17):3529-42. DOI: 10.1158/0008-5472.CAN-14-2645

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Boj, S.F.*, Hwang, C.I.*, Baker, L.A.*, Chio, I.I.*, Engle, D.D.*, Corbo, V.*, Jager, M.*, Ponz-Sarvise, M., Tiriac, H., Spector, M.S., Gracanin, A., Oni, T., Yu, K.H., van Boxtel, R., Huch, M., Rivera, K.D., Wilson, J.P., Feigin, M.E., Öhlund, D., Handly-Santana, A., Ardito-Abraham, C.M., Ludwig, M., Elyada, E., Alagesan, B., Biffi, G., Yordanov, G.N., Delcuze, B., Creighton, B., Wright, K., Park, Y., Morsink, F.H., Molenaar, I.Q., Borel Rinkes, I.H., Cuppen, E., Hao, Y., Jin, Y., Nijman, I.J., Iacobuzio-Donahue, C., Leach, S.D., Pappin, D.J., Hammell, M., Klimstra, D.S., Basturk, O., Hruban, R.H., Offerhaus, G.J., Vries, R.G., Clevers, H., Tuveson, D.A. Organoid models of human and mouse ductal pancreatic cancer. (2015) Móvil. 160(1-2):324-38. DOI: 10.1016/j.cell.2014.12.021

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Naguib, A., Bencze, G., Engle, D.D., Chio, I.I., Herzka, T., Watrud, K., Bencze, S., Tuveson, D.A., Pappin, D.J., Trotman, L.C. p53 mutations change phosphatidylinositol acyl chain composition. (2015) Cell Reports. 10(1):8-19. DOI: 10.1016/j.celrep.2014.12.010

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Sherman, M.H., Yu, R.T., Engle, D.D., Ding, N., Atkins, A.R., Tiriac, H., Collisson, E.A., Connor, F., Van Dyke, T., Kozlov, S., Martin, P., Tseng, T.W., Dawson, D.W., Donahue, T.R., Masamune, A., Shimosegawa, T., Apte, M.V., Wilson, J.S., Ng, B., Lau, S.L., Gunton, J.E., Wahl, G.M., Hunter, T., Drebin, J.A., O'Dwyer, P.J., Liddle, C., Tuveson, D.A., Downes, M., Evans, R.M. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. (2014) Móvil. 159(1):80-93. DOI: 10.1016/j.cell.2014.08.007

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Spike, B.T.*, Engle, D.D.*, Lin, J.C., Cheung, S.K., La, J., Wahl, G.M. A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. (2012) Cell Stem Cell. 10(2):183-97. DOI: 10.1016/j.stem.2011.12.018

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Wang, Y.V., Leblanc, M., Fox, N., Mao, J.H., Tinkum, K.L., Krummel, K., Engle, D., Piwnica-Worms, D., Piwnica-Worms, H., Balmain, A., Kaushansky, K., Wahl, G.M. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. (2011) Genes & Development. 25(13):1426-38. DOI: 10.1101/gad.2024411

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Educación

BA, Ciencias Biológicas y Estudios Asiáticos, Universidad Northwestern
Doctorado en Ciencias Biológicas, Universidad de California, San Diego


Afiliaciones


Premios y distinciones

  • Prebys Research Hero, 2024
  • Premio de desarrollo profesional Lustgarten Foundation-AACR para la investigación sobre el cáncer de páncreas en honor a Ruth Bader Ginsburg, 2021
  • Premio para Nuevos Investigadores del Programa de Investigación sobre Enfermedades Relacionadas con el Tabaco, 2020
  • Premio NIH NCI K99/R00 de Transición Profesional, 2016 - 2018
  • Programa de Investigación sobre Cáncer de Mama de California, Beca, 2009 - 2011
  • Beca del