Profesor
Centro Waitt de Biofotónica Avanzada
Silla Françoise Gilot-Salk
Duff, M.K., Li, M.J., Nimmerjahn, A. Astrocyte Regulation of Spinal Circuit Function. (2026) J Neurochem. 170(2):e70366. DOI: 10.1111/jnc.70366
Barykina, N.V., Carey, E.M., Oliinyk, O.S., Mendonça-Gomes, J.M., de Oliveira, S., Nimmerjahn, A., Verkhusha, V.V. Plataforma de nanobodies sintéticos multicolores estabilizados contra antígenos para marcado intersecional e imagenología funcional. (2025) bioRxiv. DOI: 10.1101/2025.10.27.684934
Mi, X., Chen, A.B., Duarte, D., Carey, E., Taylor, C.R., Braaker, P.N., Bright, M., Almeida, R.G., Lim, J.X., Ruetten, V.M.S., Wang, Y., Wang, M., Zhang, W., Zheng, W., Reitman, M.E., Huang, Y., Wang, X., Li, L., Deng, H., Shi, S.H., Poskanzer, K.E., Lyons, D.A., Nimmerjahn, A., Ahrens, M.B., Yu, G. Plataforma de análisis de datos rápida, precisa y versátil para la cuantificación de señales moleculares espaciotemporales. (2025) Móvil. DOI: 10.1016/j.cell.2025.03.012
Barykina, N.V., Carey, E.M., Oliinyk, O.S., Nimmerjahn, A., Verkhusha, V.V. Destabilized near-infrared fluorescent nanobodies enable background-free targeting of GFP-based biosensors for imaging and manipulation. (2024) Nature Communications. 15(1):7788. DOI: 10.1038/s41467-024-51857-x
Su, Y., Xu, J., Zhu, Z., Chin, J., Xu, L., Yu, H., Nudell, V., Dash, B., Moya, E.A., Ye, L., Nimmerjahn, A., Sun, X. Brainstem Dbh neurons control allergen-induced airway hyperreactivity. (2024) Naturaleza. DOI: 10.1038/s41586-024-07608-5
Wu, Y., Temple, B.A., Sevilla, N., Zhang, J., Zhu, H., Zolotavin, P., Jin, Y., Duarte, D., Sanders, E., Azim, E., Nimmerjahn, A., Pfaff, S.L., Luan, L., Xie, C. Ultraflexible electrodes for recording neural activity in the mouse spinal cord during motor behavior. (2024) Cell Reports. 43(5):114199. DOI: 10.1016/j.celrep.2024.114199
Mi, X., Chen, A.B., Duarte, D., Carey, E., Taylor, C.R., Braaker, P.N., Bright, M., Almeida, R.G., Lim, J.X., Rutten, V.M., Zheng, W., Wang, M., Reitman, M.E., Wang, Y., Poskanzer, K.E., Lyons, D.A., Nimmerjahn, A., Ahrens, M.B., Yu, G. Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals. (2024) bioRxiv. DOI: 10.1101/2024.05.02.592259
Schafer, S.T., Mansour, A.A., Schlachetzki, J.C.M., Pena, M., Ghassemzadeh, S., Mitchell, L., Mar, A., Quang, D., Stumpf, S., Ortiz, I.S., Lana, A.J., Baek, C., Zaghal, R., Glass, C.K., Nimmerjahn, A., Gage, F.H. Un modelo de organoide neuroinmune in vivo para estudiar fenotipos de microglía humana. (2023) Móvil. 186(10):2111-2126.e20. DOI: 10.1016/j.cell.2023.04.022
Shekhtmeyster, P., Duarte, D., Carey, E.M., Ngo, A., Gao, G., Olmstead, J.A., Nelson, N.A., Nimmerjahn, A. Trans-segmental imaging in the spinal cord of behaving mice. (2023) Nature Biotechnology. DOI: 10.1038/s41587-023-01700-3
Shekhtmeyster, P., Carey, E.M., Duarte, D., Ngo, A., Gao, G., Nelson, N.A., Clark, C.L., Nimmerjahn, A. Multiplex translaminar imaging in the spinal cord of behaving mice. (2023) Nature Communications. 14(1):1427. DOI: 10.1038/s41467-023-36959-2
Ward, S., Riley, C., Carey, E.M., Nguyen, J., Esener, S., Nimmerjahn, A., Sirbuly, D.J. Electro-optical mechanically flexible coaxial microprobes for minimally invasive interfacing with intrinsic neural circuits. (2022) Nature Communications. 13(1):3286. DOI: 10.1038/s41467-022-30275-x
Oliinyk, O.S., Baloban, M., Clark, C.L., Carey, E., Pletnev, S., Nimmerjahn, A., Verkhusha, V.V. Single-domain near-infrared protein provides a scaffold for antigen-dependent fluorescent nanobodies. (2022) Nature Methods. DOI: 10.1038/s41592-022-01467-6
Nimmerjahn, A., Hirrlinger, J. Astrocyte regulation of neural circuit function and animal behavior. (2022) Glia. DOI: 10.1002/glia.24223
Hirrlinger, J., Nimmerjahn, A. A perspective on astrocyte regulation of neural circuit function and animal behavior. (2022) Glia. DOI: 10.1002/glia.24168
Abdelfattah, A.S., Ahuja, S., Akkin, T., Allu, S.R., Brake, J., Boas, D.A., Buckley, E.M., Campbell, R.E., Chen, A.I., Cheng, X., Čižmár, T., Costantini, I., De Vittorio, M., Devor, A., Doran, P.R., El Khatib, M., Emiliani, V., Fomin-Thunemann, N., Fainman, Y., Fernandez-Alfonso, T., Ferri, C.G.L., Gilad, A., Han, X., Harris, A., Hillman, E.M.C., Hochgeschwender, U., Holt, M.G., Ji, N., Kılıç, K., Lake, E.M.R., Li, L., Li, T., Mächler, P., Miller, E.W., Mesquita, R.C., Nadella, K.M.N.S., Nägerl, U.V., Nasu, Y., Nimmerjahn, A., Ondráčková, P., Pavone, F.S., Perez Campos, C., Peterka, D.S., Pisano, F., Pisanello, F., Puppo, F., Sabatini, B.L., Sadegh, S., Sakadzic, S., Shoham, S., Shroff, S.N., Silver, R.A., Sims, R.R., Smith, S.L., Srinivasan, V.J., Thunemann, M., Tian, L., Tian, L., Troxler, T., Valera, A., Vaziri, A., Vinogradov, S.A., Vitale, F., Wang, L.V., Uhlířová, H., Xu, C., Yang, C., Yang, M.H., Yellen, G., Yizhar, O., Zhao, Y. Neurophotonic tools for microscopic measurements and manipulation: status report. (2022) Neurophotonics. 9(Suppl 1):013001. DOI: 10.1117/1.NPh.9.S1.013001
Huang, Y., Happonen, K.E., Burrola, P.G., O'Connor, C., Hah, N., Huang, L., Nimmerjahn, A., Lemke, G. Microglia use TAM receptors to detect and engulf amyloid β plaques. (2021) Naturaleza Inmunológica. DOI: 10.1038/s41590-021-00913-5
Ceto, S., Sekiguchi, K.J., Takashima, Y., Nimmerjahn, A., Tuszynski, M.H. Neural Stem Cell Grafts Form Extensive Synaptic Networks that Integrate with Host Circuits after Spinal Cord Injury. (2020) Células Madre. DOI: 10.1016/j.stem.2020.07.007
Nimmerjahn, A. Monitoring neuronal health. (2020) Ciencia. 367(6477):510-511. DOI: 10.1126/science.aba4472
Patriarchi, T., Cho, J.R., Merten, K., Marley, A., Broussard, G.J., Liang, R., Williams, J., Nimmerjahn, A., von Zastrow, M., Gradinaru, V., Tian, L. Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators. (2019) Protocolos de la Naturaleza. 14(12):3471–3505. DOI: 10.1038/s41596-019-0239-2
Nelson, N.A., Wang, X., Cook, D., Carey, E.M., Nimmerjahn, A. Imaging spinal cord activity in behaving animals. (2019) Experimental Neurology. 230:112974. DOI: 10.1016/j.expneurol.2019.112974
Patriarchi, T., Cho, J.R., Merten, K., Howe, M.W., Marley, A., Xiong, W.H., Folk, R.W., Broussard, G.J., Liang, R., Jang, M.J., Zhong, H., Dombeck, D., von Zastrow, M., Nimmerjahn, A., Gradinaru, V., Williams, J.T., Tian, L. Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors. (2018) Ciencia. DOI: 10.1126/science.aat4422
Tufail, Y., Cook, D., Fourgeaud, L., Powers, C.J., Merten, K., Clark, C.L., Hoffman, E., Ngo, A., Sekiguchi, K.J., O'Shea, C.C., Lemke, G., Nimmerjahn, A. Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia. (2017) Neurona. 93(3):574-586.e8. DOI: 10.1016/j.neuron.2016.12.021
Sekiguchi, K.J., Shekhtmeyster, P., Merten, K., Arena, A., Cook, D., Hoffman, E., Ngo, A., Nimmerjahn, A. Imaging large-scale cellular activity in spinal cord of freely behaving mice. (2016) Nature Communications. 7:11450. DOI: 10.1038/ncomms11450
Fourgeaud, L., Través, P.G., Tufail, Y., Leal-Bailey, H., Lew, E.D., Burrola, P.G., Callaway, P., Zagórska, A., Rothlin, C.V., Nimmerjahn, A., Lemke, G. TAM receptors regulate multiple features of microglial physiology. (2016) Naturaleza. 532(7598):240-244. DOI: 10.1038/nature17630
Nimmerjahn, A., Bergles, D.E. Large-scale recording of astrocyte activity. (2015) Current Opinion in Neurobiology. 32:95-106. DOI: 10.1016/j.conb.2015.01.015
Knowland, D., Arac, A., Sekiguchi, K.J., Hsu, M., Lutz, S.E., Perrino, J., Steinberg, G.K., Barres, B.A., Nimmerjahn, A., Agalliu, D. Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke. (2014) Neurona. 82(3):603-17. DOI: 10.1016/j.neuron.2014.03.003
Devor, A., Bandettini, P.A., Boas, D.A., Bower, J.M., Buxton, R.B., Cohen, L.B., Dale, A.M., Einevoll, G.T., Fox, P.T., Franceschini, M.A., Friston, K.J., Fujimoto, J.G., Geyer, M.A., Greenberg, J.H., Halgren, E., Hämäläinen, M.S., Helmchen, F., Hyman, B.T., Jasanoff, A., Jernigan, T.L., Judd, L.L., Kim, S.G., Kleinfeld, D., Kopell, N.J., Kutas, M., Kwong, K.K., Larkum, M.E., Lo, E.H., Magistretti, P.J., Mandeville, J.B., Masliah, E., Mitra, P.P., Mobley, W.C., Moskowitz, M.A., Nimmerjahn, A., Reynolds, J.H., Rosen, B.R., Salzberg, B.M., Schaffer, C.B., Silva, G.A., So, P.T., Spitzer, N.C., Tootell, R.B., Van Essen, D.C., Vanduffel, W., Vinogradov, S.A., Wald, L.L., Wang, L.V., Weber, B., Yodh, A.G. The challenge of connecting the dots in the B.R.A.I.N. (2013) Neurona. 80(2):270-4. DOI: 10.1016/j.neuron.2013.09.008
Nimmerjahn, A. Two-photon imaging of microglia in the mouse cortex in vivo. (2012) Protocolos de Cold Spring Harbor. 2012(5). DOI: 10.1101/pdb.prot069294
Nimmerjahn, A. Optical window preparation for two-photon imaging of microglia in mice. (2012) Protocolos de Cold Spring Harbor. 2012(5). DOI: 10.1101/pdb.prot069286
Nimmerjahn, A. Surgical implantation of a head plate in mice in preparation for in vivo two-photon imaging of microglia. (2012) Protocolos de Cold Spring Harbor. 2012(5). DOI: 10.1101/pdb.prot069278
Nimmerjahn, A., Helmchen, F. In vivo labeling of cortical astrocytes with sulforhodamine 101 (SR101). (2012) Protocolos de Cold Spring Harbor. 2012(3):326-34. DOI: 10.1101/pdb.prot068155
Kerr, J.N., Nimmerjahn, A. Functional imaging in freely moving animals. (2012) Current Opinion in Neurobiology. 22(1):45-53. DOI: 10.1016/j.conb.2011.12.002
Tremblay, M., Stevens, B., Sierra, A., Wake, H., Bessis, A., Nimmerjahn, A. The role of microglia in the healthy brain. (2011) Diario de Neurociencia. 31(45):16064-9. DOI: 10.1523/JNEUROSCI.4158-11.2011
Ghosh, K.K., Burns, L.D., Cocker, E.D., Nimmerjahn, A., Ziv, Y., Gamal, A.E., Schnitzer, M.J. Miniaturized integration of a fluorescence microscope. (2011) Nature Methods. 8(10):871-8. DOI: 10.1038/nmeth.1694
Mukamel, E.A., Nimmerjahn, A., Schnitzer, M.J. Automated analysis of cellular signals from large-scale calcium imaging data. (2009) Neurona. 63(6):747-60. DOI: 10.1016/j.neuron.2009.08.009
Nimmerjahn, A., Mukamel, E.A., Schnitzer, M.J. Motor behavior activates Bergmann glial networks. (2009) Neurona. 62(3):400-12. DOI: 10.1016/j.neuron.2009.03.019
Nimmerjahn, A. Astrocytes going live: advances and challenges. (2009) Journal of Physiology. 587(Pt 8):1639-47. DOI: 10.1113/jphysiol.2008.167171
Flusberg, B.A., Nimmerjahn, A., Cocker, E.D., Mukamel, E.A., Barretto, R.P., Ko, T.H., Burns, L.D., Jung, J.C., Schnitzer, M.J. High-speed, miniaturized fluorescence microscopy in freely moving mice. (2008) Nature Methods. 5(11):935-8. DOI: 10.1038/nmeth.1256
Sullivan, M.R., Nimmerjahn, A., Sarkisov, D.V., Helmchen, F., Wang, S.S. In vivo calcium imaging of circuit activity in cerebellar cortex. (2005) Journal of Neurophysiology. 94(2):1636-44. DOI: 10.1152/jn.01013.2004
Nimmerjahn, A., Kirchhoff, F., Helmchen, F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. (2005) Ciencia. 308(5726):1314-8. DOI: 10.1126/science.1110647
Dittgen, T., Nimmerjahn, A., Komai, S., Licznerski, P., Waters, J., Margrie, T.W., Helmchen, F., Denk, W., Brecht, M., Osten, P. Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo. (2004) Actas de la Academia Nacional de Ciencias de los Estados Unidos de América. 101(52):18206-11. DOI: 10.1073/pnas.0407976101
Göbel, W., Kerr, J.N., Nimmerjahn, A., Helmchen, F. Miniaturized two-photon microscope based on a flexible coherent fiber bundle and a gradient-index lens objective. (2004) Opt Lett. 29(21):2521-3.
Nimmerjahn, A., Kirchhoff, F., Kerr, J.N., Helmchen, F. Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo. (2004) Nature Methods. 1(1):31-7. DOI: 10.1038/nmeth706
Göbel, W., Nimmerjahn, A., Helmchen, F. Distortion-free delivery of nanojoule femtosecond pulses from a Ti:sapphire laser through a hollow-core photonic crystal fiber. (2004) Optics Letters. 29(11):1285-7.
Kim, J., Dittgen, T., Nimmerjahn, A., Waters, J., Pawlak, V., Helmchen, F., Schlesinger, S., Seeburg, P.H., Osten, P. Sindbis vector SINrep(nsP2S726): a tool for rapid heterologous expression with attenuated cytotoxicity in neurons. (2004) Journal of Neuroscience Methods. 133(1-2):81-90.
MS, Física, Instituto Max Planck de Investigación Médica/Universidad de Heidelberg, Alemania
Doctorado en Física, Instituto Max Planck de Investigación Médica/Universidad de Heidelberg, Alemania
Investigador postdoctoral, Biología y Física Aplicada, Universidad de Stanford