Dr. Sreekanth Chalasani

Profesor

Laboratorio de Neurobiología Molecular

Silla de la Fundación Jesse y Caryl Philips

Instituto Salk de Estudios Biológicos - Publicaciones

Todas las publicaciones


Walsh, C., Yoon, C.W., Anderson, M.S., Wei, F., Chalasani, S.H., Wang, Y. Introduction to Sonogenetics for Ultrasound Scientists, (2025) IEEE Transactions on Ultrasonics. DOI: 10.1109/TUSON.2025.3632859

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Haley, J.A., Chen, T., Aoi, M., Chalasani, S.H. Accept-reject decision-making revealed via a quantitative and ethological study of C. elegans foraging (2025) Elife. 13. DOI: 10.7554/eLife.103191

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Mackie, M., Le, V.V., Carstensen, H.R., Kushnir, N.R., Castro, D.L., Dimov, I.M., Quach, K.T., Cook, S.J., Hobert, O., Chalasani, S.H., Hong, R.L. Evolution of lateralized gustation in nematodes. (2025) Elife. 14. DOI: 10.7554/eLife.103796

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Haley, J.A., Chen, T., Aoi, M., Chalasani, S.H. Accept-reject decision-making revealed via a quantitative and ethological study of C. elegans foraging (2025) bioRxiv. DOI: 10.1101/2024.09.18.613674

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Shukla, S., Walsh, C., Bansal, S., Leugering, J., Uppal, A., Jaltare, V., Cauwenberghs, G., Chalasani, S.H., Jahed, Z. A Dynamic Spike Sorter for Multiscale Nanoelectrode Array Recordings (2025) Advanced materials interfaces. 12(14). DOI: 10.1002/admi.202500158

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Rusu, I., Cecere, Z.T., How, J.J., Quach, K.T., Yemini, E., Sharpee, T.O., Chalasani, S.H. A framework for analyzing C. elegans neural activity using multi-dimensional hyperbolic embedding (2025) bioRxiv. DOI: 10.1101/2021.04.09.439242

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Quach, K.T., Hughes, G.A., Chalasani, S.H. Interdependence between SEB-3 receptor and NLP-49 peptides shifts across predator-induced defensive behavioral modes in Caenorhabditis elegans (2025) Elife. 13. DOI: 10.7554/eLife.98262

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Shukla, S., Schwartz, J.L., Walsh, C., Wong, W.M., Patel, V., Hsieh, Y.P., Onwuasoanya, C., Chen, S., Offenhäusser, A., Cauwenberghs, G., Santoro, F., Muotri, A.R., Yeo, G.W., Chalasani, S.H., Jahed, Z. Supra- and sub-threshold intracellular-like recording of 2D and 3D neuronal networks using nanopillar electrode arrays. (2024) Microsyst Nanoeng. 10(1):184. DOI: 10.1038/s41378-024-00817-y

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Cowen, M.H., Haskell, D., Zoga, K., Reddy, K.C., Chalasani, S.H., Hart, M.P. Conserved autism-associated genes tune social feeding behavior in C. elegans. (2024) Nature Communications. 15(1):9301. DOI: 10.1038/s41467-024-53590-x

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Mackie, M., Le, V.V., Carstensen, H.R., Kushnir, N.R., Castro, D.L., Dimov, I.M., Quach, K.T., Cook, S.J., Hobert, O., Chalasani, S.H., Hong, R.L. Evolution of lateralized gustation in nematodes. (2024) bioRxiv. DOI: 10.1101/2024.08.31.610597

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Muirhead, C.S., Reddy, K.C., Guerra, S., Rieger, M., Hart, M.P., Srinivasan, J., Chalasani, S.H. Neurexin drives Caenorhabditis elegans avoidance behavior independently of its post-synaptic binding partner neuroligin. (2024) G3. 14(8). DOI: 10.1093/g3journal/jkae111

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Haghani, N.B., Lampe, R.H., Samuel, B.S., Chalasani, S.H., Matty, M.A. Identification and characterization of a skin microbiome on Caenorhabditis elegans suggests environmental microbes confer cuticle protection (2024) Microbiol Spectr.:e0016924 DOI: 10.1128/spectrum.00169-24

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Haley, J.A., Chalasani, S.H. C. elegans foraging as a model for understanding the neuronal basis of decision-making. (2024) Cellular and Molecular Life Sciences. 81(1):252. DOI: 10.1007/s00018-024-05223-1

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Hsiao, J., Deng, L.C., Moroz, L.L., Chalasani, S.H., Edsinger, E. Ocean to Tree: Leveraging Single-Molecule RNA-Seq to Repair Genome Gene Models and Improve Phylogenomic Analysis of Gene and Species Evolution. (2024) Métodos en Biología Molecular. 2757:461-490. DOI: 10.1007/978-1-0716-3642-8_19

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Cowen, M.H., Reddy, K.C., Chalasani, S.H., Hart, M.P. Conserved autism-associated genes tune social feeding behavior in C. elegans. (2023) bioRxiv. DOI: 10.1101/2023.12.05.570116

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Pribadi, A., Rieger, M.A., Rosales, K., Reddy, K.C., Chalasani, S.H. Dopamine signaling regulates predator-driven changes in Caenorhabditis elegans' egg laying behavior (2023) Elife. 12. DOI: 10.7554/eLife.83957

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Procko, C., Wong, W.M., Patel, J., Mousavi, S.A.R., Dabi, T., Duque, M., Baird, L., Chalasani, S.H., Chory, J. Mutational analysis of mechanosensitive ion channels in the carnivorous Venus flytrap plant. (2023) Biología Actual. DOI: 10.1016/j.cub.2023.06.048

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Pribadi, A.K., Chalasani, S.H. Fear conditioning in invertebrates. (2023) Front Behav Neurosci. 16:1008818. DOI: 10.3389/fnbeh.2022.1008818

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Magaram, U., Weiss, C., Vasan, A., Reddy, K.C., Friend, J., Chalasani, S.H. Two pathways are required for ultrasound-evoked behavioral changes in Caenorhabditis elegans. (2022) PLOS One. 17(5):e0267698. DOI: 10.1371/journal.pone.0267698

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Matty, M.A., Lau, H.E., Haley, J.A., Singh, A., Chakraborty, A., Kono, K., Reddy, K.C., Hansen, M., Chalasani, S.H. Intestine-to-neuronal signaling alters risk-taking behaviors in food-deprived Caenorhabditis elegans. (2022) PLOS Genetics. 18(5):e1010178. DOI: 10.1371/journal.pgen.1010178

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Mei, J., Vasan, A., Magaram, U., Takemura, K., Chalasani, S.H., Friend, J. Well-free agglomeration and on-demand three-dimensional cell cluster formation using guided surface acoustic waves through a couplant layer. (2022) Biomed Microdevices. 24(2):18. DOI: 10.1007/s10544-022-00617-z

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Vasan, A., Allein, F., Duque, M., Magaram, U., Boechler, N., Chalasani, S.H., Friend, J. Microscale concert hall acoustics to produce uniform ultrasound stimulation for targeted sonogenetics in hsTRPA1-transfected cells. (2022) Adv Nanobiomed Res. 2(5). DOI: 10.1002/anbr.202100135

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Quach, K.T., Chalasani, S.H. Flexible reprogramming of Pristionchus pacificus motivation for attacking Caenorhabditis elegans in predator-prey competition. (2022) Biología Actual. DOI: 10.1016/j.cub.2022.02.033

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Duque, M., Lee-Kubli, C.A., Tufail, Y., Magaram, U., Patel, J., Chakraborty, A., Mendoza Lopez, J., Edsinger, E., Vasan, A., Shiao, Weiss, C., Friends, J., Chalasani, S.H. Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels (2022) Nature Communications. 13. DOI: https://doi.org/10.1038/s41467-022-28205-y

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Vasan, A., Orosco, J., Magaram, U., Duque, M., Weiss, C., Tufail, Y., Chalasani, S.H., Friend, J. Ultrasound Mediated Cellular Deflection Results in Cellular Depolarization. (2021) Advanced Science .:e2101950 DOI: 10.1002/advs.202101950

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How, J.J., Navlakha, S., Chalasani, S.H. Neural network features distinguish chemosensory stimuli in Caenorhabditis elegans. (2021) PLOS Computational Biology. 17(11):e1009591. DOI: 10.1371/journal.pcbi.1009591

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Prakash, D., Ms, A., Radhika, B., Venkatesan, R., Chalasani, S.H., Singh, V. 1-Undecene from Pseudomonas aeruginosa is an olfactory signal for flight-or-fight response in Caenorhabditis elegans. (2021) EMBO Journal.:e106938 DOI: 10.15252/embj.2020106938

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Quach, K.T., Chalasani, S.H. Intraguild predation between Pristionchus pacificus and Caenorhabditis elegans: a complex interaction with the potential for aggressive behaviour. (2020) Journal of Neurogenetics.:1-16 DOI: 10.1080/01677063.2020.1833004

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Matty, M.A., Chalasani, S.H. Microbial Mind Control. (2020) Cell Host & Microbe. 28(2):147-149. DOI: 10.1016/j.chom.2020.07.016

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Liu, Z., Kariya, M.J., Chute, C.D., Pribadi, A.K., Leinwand, S.G., Tong, A., Curran, K.P., Bose, N., Schroeder, F.C., Srinivasan, J., Chalasani, S.H. Predator-secreted sulfolipids induce defensive responses in C. elegans. (2018) Nature Communications. 9(1):1128. DOI: 10.1038/s41467-018-03333-6

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Hale, L.A., Lee, E.S., Pantazis, A.K., Chronis, N., Chalasani, S.H. Altered Sensory Code Drives Juvenile-to-Adult Behavioral Maturation in Caenorhabditis elegans. (2017) eNeuro. 3(6). DOI: 10.1523/ENEURO.0175-16.2016

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Leinwand, S.G., Yang, C.J., Bazopoulou, D., Chronis, N., Srinivasan, J., Chalasani, S.H. Circuit mechanisms encoding odors and driving aging-associated behavioral declines in Caenorhabditis elegans. (2015) Elife. 4:e10181. DOI: 10.7554/eLife.10181

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Ibsen, S., Tong, A., Schutt, C., Esener, S., Chalasani, S.H. Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans. (2015) Nature Communications. 6:8264. DOI: 10.1038/ncomms9264

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Calhoun, A.J., Tong, A., Pokala, N., Fitzpatrick, J.A., Sharpee, T.O., Chalasani, S.H. Neural Mechanisms for Evaluating Environmental Variability in Caenorhabditis elegans. (2015) Neuron. 86(2):428-41. DOI: 10.1016/j.neuron.2015.03.026

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Erickstad, M., Hale, L.A., Chalasani, S.H., Groisman, A. A microfluidic system for studying the behavior of zebrafish larvae under acute hypoxia. (2015) Lab on a Chip. 15(3):857-66. DOI: 10.1039/c4lc00717d

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Calhoun, A.J., Chalasani, S.H., Sharpee, T.O. Maximally informative foraging by Caenorhabditis elegans. (2014) Elife. 3. DOI: 10.7554/eLife.04220

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Lau, H.E., Chalasani, S.H. Divergent and convergent roles for insulin-like peptides in the worm, fly and mammalian nervous systems. (2014) Invertebrate Neuroscience. 14(2):71-8. DOI: 10.1007/s10158-013-0166-9

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Sharpee, T.O., Calhoun, A.J., Chalasani, S.H. Information theory of adaptation in neurons, behavior, and mood. (2014) Current Opinion in Neurobiology. 25:47-53. DOI: 10.1016/j.conb.2013.11.007

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Leinwand, S.G., Chalasani, S.H. From genes to circuits and behaviors: Neuropeptides expand the coding potential of the nervous system. (2014) Worm. 3:e27730. DOI: 10.4161/worm.27730

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Joens, M.S., Huynh, C., Kasuboski, J.M., Ferranti, D., Sigal, Y.J., Zeitvogel, F., Obst, M., Burkhardt, C.J., Curran, K.P., Chalasani, S.H., Stern, L.A., Goetze, B., Fitzpatrick, J.A. Helium Ion Microscopy (HIM) for the imaging of biological samples at sub-nanometer resolution. (2013) Scientific Reports. 3:3514. DOI: 10.1038/srep03514

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Leinwand, S.G., Chalasani, S.H. Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans. (2013) Nature Neuroscience. 16(10):1461-7. DOI: 10.1038/nn.3511

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Curran, K.P., Chalasani, S.H. Serotonin circuits and anxiety: what can invertebrates teach us? (2012) Invertebrate Neuroscience. 12(2):81-92. DOI: 10.1007/s10158-012-0140-y

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Leinwand, S.G., Chalasani, S.H. Olfactory networks: from sensation to perception. (2011) Current Opinion in Genetics & Development. 21(6):806-11. DOI: 10.1016/j.gde.2011.07.006

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Chalasani, S.H., Kato, S., Albrecht, D.R., Nakagawa, T., Abbott, L.F., Bargmann, C.I. Neuropeptide feedback modifies odor-evoked dynamics in Caenorhabditis elegans olfactory neurons. (2010) Nature Neuroscience. 13(5):615-21. DOI: 10.1038/nn.2526

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Tian, L., Hires, S.A., Mao, T., Huber, D., Chiappe, M.E., Chalasani, S.H., Petreanu, L., Akerboom, J., McKinney, S.A., Schreiter, E.R., Bargmann, C.I., Jayaraman, V., Svoboda, K., Looger, L.L. Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. (2009) Nature Methods. 6(12):875-81. DOI: 10.1038/nmeth.1398

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Macosko, E.Z., Pokala, N., Feinberg, E.H., Chalasani, S.H., Butcher, R.A., Clardy, J., Bargmann, C.I. A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans. (2009) Naturaleza. 458(7242):1171-5. DOI: 10.1038/nature07886

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Tsunozaki, M., Chalasani, S.H., Bargmann, C.I. A behavioral switch: cGMP and PKC signaling in olfactory neurons reverses odor preference in C. elegans. (2008) Neuron. 59(6):959-71. DOI: 10.1016/j.neuron.2008.07.038

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Chalasani, S.H., Chronis, N., Tsunozaki, M., Gray, J.M., Ramot, D., Goodman, M.B., Bargmann, C.I. Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans. (2007) Naturaleza. 450(7166):63-70. DOI: 10.1038/nature06292

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Chalasani, S.H., Feinberg, E.H., Hilliard, M.A. Global 'worming'. (2007) Biología del Genoma. 8(9):314. DOI: 10.1186/gb-2007-8-9-314


Chalasani, S.H., Sabol, A., Xu, H., Gyda, M.A., Rasband, K., Granato, M., Chien, C.B., Raper, J.A. Stromal cell-derived factor-1 antagonizes slit/robo signaling in vivo. (2007) Journal of Neuroscience. 27(5):973-80. DOI: 10.1523/JNEUROSCI.4132-06.2007

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Kreibich, T.A., Chalasani, S.H., Raper, J.A. The neurotransmitter glutamate reduces axonal responsiveness to multiple repellents through the activation of metabotropic glutamate receptor 1. (2004) Journal of Neuroscience. 24(32):7085-95. DOI: 10.1523/JNEUROSCI.0349-04.2004

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Vatamaniuk, O.K., Mari, S., Lang, A., Chalasani, S., Demkiv, L.O., Rea, P.A. Phytochelatin synthase, a dipeptidyltransferase that undergoes multisite acylation with gamma-glutamylcysteine during catalysis: stoichiometric and site-directed mutagenic analysis of arabidopsis thal (2004) Revista de Química Biológica. 279(21):22449-60. DOI: 10.1074/jbc.M313142200

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Chalasani, S.H., Baribaud, F., Coughlan, C.M., Sunshine, M.J., Lee, V.M., Doms, R.W., Littman, D.R., Raper, J.A. The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells. (2003) Journal of Neuroscience. 23(11):4601-12. DOI: https://doi.org/10.1523/JNEUROSCI.23-11-04601.2003

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Chalasani, S.H., Sabelko, K.A., Sunshine, M.J., Littman, D.R., Raper, J.A. A chemokine, SDF-1, reduces the effectiveness of multiple axonal repellents and is required for normal axon pathfinding. (2003) Journal of Neuroscience. 23(4):1360-71. DOI: https://doi.org/10.1523/JNEUROSCI.23-04-01360.2003

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Educación

BS, Genetics, Zoology, and Chemistry, Osmania University, India
ADV DIP, Computer Science, National Institute of Information Technology
PhD, Biology, University of Pennsylvania
Postdoctoral Fellow, Rockefeller University (lab moved from UCSF)


Afiliaciones


Premios y distinciones

  • National Postdoctoral Association (NPA) Gallagher Mentor Award, 2021
  • National Institutes of Health Brain Initiative Awardee, 2016
  • Glenn Award for Research in Biological Mechanisms of Aging, 2015
  • W.M. Keck Foundation Award, 2013
  • Rita Allen Foundation Scholar, 2012
  • The March of Dimes Basil O’connor Award, 2010
  • Searle Scholar, 2010