Goodluck, H.A., Kanoo, S., Kim, Y.C., Lopez, N., Oe, Y., Currais, A.J.M., Maher, P., Vallon, V. Glomerular hyperfiltration and enhanced sensitivity to kidney ischemia reperfusion with a blunted KIM-1 response in young male aging-accelerated SAMP8 mice. (2026) Am J Physiol Renal Physiol. DOI: 10.1152/ajprenal.00377.2025

Soriano-Castell, D., Goujon, M., Dar, N.J., Currais, A., Maher, P. Acid ceramidase modulates the lipid profile and exacerbates sensitivity to ferroptosis in senescent cells. (2025) Schaltfläche Rechts. DOI: 10.21203/rs.3.rs-8117957/v1

Maher, P., Soriano-Castell, D., Dar, N.J., Soriano, S., Currais, A. Ferroptosis-related stress during aging and its relevance to disease. (2025) Geroscience. DOI: 10.1007/s11357-025-01929-7

Dafre, A.L., Taguchi, T., Dayn, Y., Currais, A., Maher, P. Gender-Dependent Cognitive and Metabolic Benefits Due to Glyoxalase 1 (Glo1) Overexpression in Age-Accelerated SAMP8 Mice. (2025) Antioxidants (Basel). 14(8). DOI: 10.3390/antiox14080946

Currais, A., Sanchez, K., Soriano-Castell, D., Dar, N.J., Evensen, K.G., Soriano, S., Maher, P. Transcriptomic signatures of oxytosis/ferroptosis are enriched in Alzheimer's disease. (2025) BMC Biology. 23(1):132. DOI: 10.1186/s12915-025-02235-6

Schaller, E., Lamer, S., Schlosser, A., Stigloher, C., Maher, P., Decker, M. Affinity-Based Protein Profiling Reveals IDH2 as a Mitochondrial Target of Cannabinol in Receptor-Independent Neuroprotection. (2025) Chemistry.:e202501143 DOI: 10.1002/chem.202501143

Dar, N.J., Currais, A., Taguchi, T., Andrews, N., Maher, P. Cannabinol (CBN) alleviates age-related cognitive decline by improving synaptic and mitochondrial health. (2025) Redox Biol. 84:103692. DOI: 10.1016/j.redox.2025.103692

White, J.B., Sanchez, K.L., Currais, A., Soriano-Castell, D., Maher, P., Soriano, S. Ferroptosis and Charcot-Marie-Tooth Disease 1A: Emerging Evidence for a Pathogenic Association. (2025) Antioxidants (Basel). 14(3). DOI: 10.3390/antiox14030331

Sanchez, K.L., Kim, J., White, J.B., Tolan, A., Rajagopal, N.P., Anderson, D.W., Shin, A.N., Shin, S.D., Currais, A., Soriano-Castell, D., Maher, P., Soriano, S. Evidence of Oxytosis/Ferroptosis in Niemann-Pick Disease Type C. (2025) Int J Mol Sci. 26(7). DOI: 10.3390/ijms26072915

Schaller, E., Hofmann, J., Maher, P., Stigloher, C., Decker, M. Visualizing Intracellular Localization of Natural-Product-Based Chemical Probes Using Click-Correlative Light and Electron Microscopy. (2025) ACS Chemical Biology. DOI: 10.1021/acschembio.4c00849

Soares, P., Rahaman, M., Maher, P., Silverman, R.B. Protection against Amyloid-β Aggregation and Ferroptosis/Oxytosis Toxicity by Arylpyrazolones: Alzheimer's Disease Therapeutics. (2025) ACS Medicinal Chemistry Letters. 16(2):294-300. DOI: 10.1021/acsmedchemlett.4c00530

Dar, N.J., Soriano Castell, D., Bhat, S.A., Maher, P. Editorial: Oxytosis/ferroptosis: unraveling the mechanisms and its multifaceted role in neurodegenerative diseases. (2025) Frontiers in Molecular Neuroscience. 17:1547301. DOI: 10.3389/fnmol.2024.1547301

Oe, Y., Kim, Y.C., Kanoo, S., Goodluck, H.A., Lopez, N., Diedrich, J., Pinto, A.M., Evensen, K.G., Currais, A.J.M., Maher, P., Vallon, V. Western diet exacerbates a murine model of Balkan nephropathy. (2024) Am J Physiol Renal Physiol.

Currais, A., Raschke, W., Maher, P. CMS121, a Novel Drug Candidate for the Treatment of Alzheimer's Disease and Age-Related Dementia. (2024) J Alzheimers Dis. 101(s1):S179-S192. DOI: 10.3233/JAD-231062

Sanchez, K.L., Shin, S.D., Rajagopal, N.P., White, J.B., Currais, A., Soriano-Castell, D., Maher, P., Soriano, S. A Potential Role for the Amyloid Precursor Protein in the Regulation of Interferon Signaling, Cholesterol Homeostasis, and Tau Phosphorylation in Niemann-Pick Disease Type C. (2024) Genes (Basel). 15(8). DOI: 10.3390/genes15081066

Maher, P. The Flavonoid Fisetin Reduces Multiple Physiological Risk Factors for Dementia. (2024) Neurochem Int.:105805 DOI: 10.1016/j.neuint.2024.105805

Goujon, M., Liang, Z., Soriano-Castell, D., Currais, A., Maher, P. The Neuroprotective Flavonoids Sterubin and Fisetin Maintain Mitochondrial Health under Oxytotic/Ferroptotic Stress and Improve Bioenergetic Efficiency in HT22 Neuronal Cells. (2024) Antioxidants (Basel). 13(4). DOI: 10.3390/antiox13040460

Dafre, A.L., Zahid, S., Probst, J.J., Currais, A., Yu, J., Schubert, D., Maher, P. CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction. (2024) Aging. 16. DOI: 10.18632/aging.205673

Liang, Z., Candib, A., Soriano-Castell, D., Fischer, W., Finley, K., Maher, P. Fragment-based drug discovery and biological evaluation of novel cannabinol-based inhibitors of oxytosis/ferroptosis for neurological disorders. (2024) Redox Biol. 72:103138. DOI: 10.1016/j.redox.2024.103138

Tolan, A.J., Sanchez, K.L., Shin, S.D., White, J.B., Currais, A., Soriano-Castell, D., Wilson, C.G., Maher, P., Soriano, S. Differential Interferon Signaling Regulation and Oxidative Stress Responses in the Cerebral Cortex and Cerebellum Could Account for the Spatiotemporal Pattern of Neurodegeneration in Niemann-Pick Disease Type C. (2024) Genes (Basel). 15(1). DOI: 10.3390/genes15010101

Dos Santos, B., Bion, M.C., Goujon-Svrzic, M., Maher, P., Dafre, A.L. REAP+: A single preparation for rapid isolation of nuclei, cytoplasm, and mitochondria. (2023) Analytical Biochemistry.:115445 DOI: 10.1016/j.ab.2023.115445

Ates, G., Taguchi, T., Maher, P. CMS121 Partially Attenuates Disease Progression in Mouse Models of Huntington's Disease. (2023) Molecular Neurobiology. DOI: 10.1007/s12035-023-03711-2

Zahid, S., Dafre, A.L., Currais, A., Yu, J., Schubert, D., Maher, P. The Geroprotective Drug Candidate CMS121 Alleviates Diabetes, Liver Inflammation, and Renal Damage in db/db Leptin Receptor Deficient Mice. (2023) Int J Mol Sci. 24(7). DOI: 10.3390/ijms24076828

Pham, T.B., Boussaty, E.C., Currais, A., Maher, P., Schubert, D.R., Manor, U., Friedman, R.A. Attenuation of Age-Related Hearing Impairment in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice Treated with Fatty Acid Synthase Inhibitor CMS121. (2023) Journal of Molecular Neuroscience. DOI: 10.1007/s12031-023-02119-w

Liang, Z., Maher, P. Structural Requirements for the Neuroprotective and Anti-Inflammatory Activities of the Flavanone Sterubin. (2022) Antioxidants (Basel). 11(11). DOI: 10.3390/antiox11112197

Cabral, C., Carbone, C., Maher, P., Castelo-Branco, M. Editorial: Psychoactive natural products: Potential in the treatment of brain diseases and strategies to improve delivery. (2022) Front Pharmacol. 13:1032496. DOI: 10.3389/fphar.2022.1032496

Tan, D., Konduri, S., Erikci Ertunc, M., Zhang, P., Wang, J., Chang, T., Pinto, A.F.M., Rocha, A., Donaldson, C.J., Vaughan, J.M., Ludwig, R.G., Willey, E., Iyer, M., Gray, P.C., Maher, P., Allen, N.J., Zuchero, J.B., Dillin, A., Mori, M.A., Kohama, S.G., Siegel, D., Saghatelian, A. A class of anti-inflammatory lipids decrease with aging in the central nervous system. (2022) Nature Chemical Biology. DOI: 10.1038/s41589-022-01165-6

Currais, A., Kepchia, D., Liang, Z., Maher, P. The Role of AMP-activated Protein Kinase (AMPK) in Oxytosis/Ferroptosis: Protector or Potentiator? (2022) Antioxid Redox Signal. DOI: 10.1089/ars.2022.0013

Liang, Z., Soriano-Castell, D., Kepchia, D., Duggan, B.M., Currais, A., Schubert, D., Maher, P. Cannabinol inhibits oxytosis/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors. (2022) Free Radical Biology & Medicine. DOI: 10.1016/j.freeradbiomed.2022.01.001

Kepchia, D., Huang, L., Currais, A., Liang, Z., Fischer, W., Maher, P. The Alzheimer's disease drug candidate J147 decreases blood plasma fatty acid levels via modulation of AMPK/ACC1 signaling in the liver. (2022) Biomed Pharmacother. 147:112648. DOI: 10.1016/j.biopha.2022.112648

Soriano-Castell, D., Liang, Z., Maher, P., Currais, A. Profiling the chemical nature of anti-oxytotic/ferroptotic compounds with phenotypic screening. (2021) Free Radical Biology & Medicine.:313-325 DOI: 10.1016/j.freeradbiomed.2021.11.003

Soriano-Castell, D., Currais, A., Maher, P. Defining a Pharmacological Inhibitor Fingerprint for Oxytosis/Ferroptosis. (2021) Free Radical Biology & Medicine. DOI: 10.1016/j.freeradbiomed.2021.05.023

Soriano-Castell, D., Liang, Z., Maher, P., Currais, A. The search for anti-oxytotic/ferroptotic compounds in the plant world. (2021) Br J Pharmacol. DOI: 10.1111/bph.15517

Kepchia, D., Currais, A., Dargusch, R., Finley, K., Schubert, D., Maher, P. Geroprotective effects of Alzheimer's disease drug candidates. (2021) Aging. 13. DOI: 10.18632/aging.202631

Maher, P. Preventing and Treating Neurological Disorders with the Flavonol Fisetin. (2021) Brain Plast. 6(2):155-166. DOI: 10.3233/BPL-200104

Maher, P. Investigations into the Role of Metabolism in the Inflammatory Response of BV2 Microglial Cells. (2021) Antioxidants (Basel). 10(1). DOI: 10.3390/antiox10010109

Maher, P., Currais, A., Schubert, D. Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases. (2020) Cell Chemical Biology. DOI: 10.1016/j.chembiol.2020.10.010

Maher, P. Modulation of the Neuroprotective and Anti-inflammatory Activities of the Flavonol Fisetin by the Transition Metals Iron and Copper. (2020) Antioxidants (Basel). 9(11). DOI: 10.3390/antiox9111113

Liang, Z., Currais, A., Soriano-Castell, D., Schubert, D., Maher, P. Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders. (2020) Pharmacol Ther.:107749 DOI: 10.1016/j.pharmthera.2020.107749

Huang, L., McClatchy, D.B., Maher, P., Liang, Z., Diedrich, J.K., Soriano-Castell, D., Goldberg, J., Shokhirev, M., Yates, J.R., Schubert, D., Currais, A. Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death. (2020) Cell Death & Disease. 11(10):828. DOI: 10.1038/s41419-020-03020-9

Gunesch, S., Soriano-Castell, D., Lamer, S., Schlosser, A., Maher, P., Decker, M. Development and Application of a Chemical Probe Based on a Neuroprotective Flavonoid Hybrid for Target Identification Using Activity-Based Protein Profiling. (2020) ACS Chem Neurosci. DOI: 10.1021/acschemneuro.0c00589

Ates, G., Goldberg, J., Currais, A., Maher, P. CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimer's disease. (2020) Redox Biology. 36:101648. DOI: 10.1016/j.redox.2020.101648

Goldberg, J., Currais, A., Ates, G., Huang, L., Shokhirev, M., Maher, P., Schubert, D. Targeting of intracellular Ca stores as a therapeutic strategy against age-related neurotoxicities. (2020) NPJ Aging and Mechanisms of Disease. 6:10. DOI: 10.1038/s41514-020-00048-1

Aguirre, C.A., Concetta Morale, M., Peng, Q., Sanchez-Alavez, M., Cintrón-Colón, R., Feng, K., Fazelpour, S., Maher, P., Conti, B. Two single nucleotide polymorphisms in IL13 and IL13RA1 from individuals with idiopathic Parkinson's disease increase cellular susceptibility to oxidative stress. (2020) Brain, Behavior, and Immunity. 88:920-924. DOI: 10.1016/j.bbi.2020.04.007

Goldberg, J., Currais, A., Ates, G., Huang, L., Shokhirev, M., Maher, P., Schubert, D. Targeting of intracellular Ca stores as a therapeutic strategy against age-related neurotoxicities. (2020) NPJ Aging and Mechanisms of Disease. 6(1):10. DOI: 10.1038/s41514-020-00048-1

Maher, P.A. Using Plants as a Source of Potential Therapeutics for the Treatment of Alzheimer's Disease. (2020) Yale J Biol Med. 93(2):365-373.

Hofmann, J., Fayez, S., Scheiner, M., Hoffmann, M., Oerter, S., Appelt-Menzel, A., Maher, P., Maurice, T., Bringmann, G., Decker, M. Sterubin: Enantioresolution and Configurational Stability, Enantiomeric Purity in Nature, and Neuroprotective Activity in Vitro and in Vivo. (2020) Chemistry. 26(32):7299-7308. DOI: 10.1002/chem.202001264

Maher, P., Fischer, W., Liang, Z., Soriano-Castell, D., Pinto, A.F.M., Rebman, J., Currais, A. The Value of Herbarium Collections to the Discovery of Novel Treatments for Alzheimer's Disease, a Case Made With the Genus . (2020) Front Pharmacol. 11:208. DOI: 10.3389/fphar.2020.00208

Gunesch, S., Hoffmann, M., Kiermeier, C., Fischer, W., Pinto, A.F.M., Maurice, T., Maher, P., Decker, M. 7-O-Esters of taxifolin with pronounced and overadditive effects in neuroprotection, anti-neuroinflammation, and amelioration of short-term memory impairment in vivo. (2020) Redox Biol. 29:101378. DOI: 10.1016/j.redox.2019.101378

Dafre, A.L., Schmitz, A.E., Maher, P. Rapid and persistent loss of TXNIP in HT22 neuronal cells under carbonyl and hyperosmotic stress. (2019) Neurochemistry International.:104585 DOI: 10.1016/j.neuint.2019.104585

Leclercq, K., Liefferinge, J.V., Albertini, G., Neveux, M., Dardenne, S., Mairet-Coello, G., Vandenplas, C., Deprez, T., Chong, S.A., Foerch, P., Bentea, E., Sato, H., Maher, P., Massie, A., Smolders, I., Kaminski, R.M. Anticonvulsant and antiepileptogenic effects of system inactivation in chronic epilepsy models. (2019) Epilepsia. 60(7):1412-1423. DOI: 10.1111/epi.16055

Maher, P. The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases. (2019) International Journal of Molecular Sciences. 20(12). DOI: 10.3390/ijms20123056

Schubert, D., Kepchia, D., Liang, Z., Dargusch, R., Goldberg, J., Maher, P. Efficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer's Disease. (2019) Molecular Neurobiology. 56(11):7719-7730. DOI: 10.1007/s12035-019-1637-8

Dafre, A.L., Schmitz, A.E., Maher, P. Hyperosmotic Stress Initiates AMPK-Independent Autophagy and AMPK- and Autophagy-Independent Depletion of Thioredoxin 1 and Glyoxalase 2 in HT22 Nerve Cells. (2019) Oxid Med Cell Longev. 2019:2715810. DOI: 10.1155/2019/2715810

Fischer, W., Currais, A., Liang, Z., Pinto, A., Maher, P. Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa. (2019) Redox Biol. 21:101089. DOI: 10.1016/j.redox.2018.101089

Schubert, D., Currais, A., Goldberg, J., Finley, K., Petrascheck, M., Maher, P. Geroneuroprotectors: Effective Geroprotectors for the Brain. (2018) Trends in Pharmacological Sciences. 39(12):1004-1007. DOI: 10.1016/j.tips.2018.09.008

Lewerenz, J., Ates, G., Methner, A., Conrad, M., Maher, P. Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System. (2018) Frontiers in Neuroscience. 12:214. DOI: 10.3389/fnins.2018.00214

Maher, P., Conti, B. Deciphering the pathways that protect from IL-13-mediated potentiation of oxidative stress-induced dopaminergic nerve cell death. (2018) Cytokine. 103:114-120. DOI: 10.1016/j.cyto.2017.09.018

Schramm, S., Huang, G., Gunesch, S., Lang, F., Roa, J., Högger, P., Sabaté, R., Maher, P., Decker, M. Regioselective synthesis of 7-O-esters of the flavonolignan silibinin and SARs lead to compounds with overadditive neuroprotective effects. (2018) Eur J Med Chem. 146:93-107. DOI: 10.1016/j.ejmech.2018.01.036

Maher, P. Potentiation of glutathione loss and nerve cell death by the transition metals iron and copper: Implications for age-related neurodegenerative diseases. (2018) Free Radical Biology & Medicine. 115:92-104. DOI: 10.1016/j.freeradbiomed.2017.11.015

Goldberg, J., Currais, A., Prior, M., Fischer, W., Chiruta, C., Ratliff, E., Daugherty, D., Dargusch, R., Finley, K., Esparza-Moltó, P.B., Cuezva, J.M., Maher, P., Petrascheck, M., Schubert, D. The mitochondrial ATP synthase is a shared drug target for aging and dementia. (2018) Alternde Zelle. 17(2). DOI: 10.1111/acel.12715

Maher, P. Protective effects of fisetin and other berry flavonoids in Parkinson's disease. (2017) Food & Function. 8(9):3033-3042. DOI: 10.1039/c7fo00809k

Daugherty, D., Goldberg, J., Fischer, W., Dargusch, R., Maher, P., Schubert, D. A novel Alzheimer's disease drug candidate targeting inflammation and fatty acid metabolism. (2017) Alzheimers Res Ther. 9(1):50. DOI: 10.1186/s13195-017-0277-3

Dafre, A.L., Schmitz, A.E., Maher, P. Methylglyoxal-induced AMPK activation leads to autophagic degradation of thioredoxin 1 and glyoxalase 2 in HT22 nerve cells. (2017) Free Radical Biology & Medicine. 108:270-279. DOI: 10.1016/j.freeradbiomed.2017.03.028

Currais, A., Farrokhi, C., Dargusch, R., Armando, A., Quehenberger, O., Schubert, D., Maher, P. Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse. (2017) J. Gerontol. A Biol. Sci. Med. Sci. 73(3):299-307. DOI: 10.1093/gerona/glx104

Maher, P., van Leyen, K., Dey, P.N., Honrath, B., Dolga, A., Methner, A. The role of Ca(2+) in cell death caused by oxidative glutamate toxicity and ferroptosis. (2017) Cell Calcium. 70:47-55. DOI: 10.1016/j.ceca.2017.05.007

Schmitz, A.E., de Souza, L.F., Dos Santos, B., Maher, P., Lopes, F.M., Londero, G.F., Klamt, F., Dafre, A.L. Methylglyoxal-Induced Protection Response and Toxicity: Role of Glutathione Reductase and Thioredoxin Systems. (2017) Neurotoxicity Research. 32(3):340-350. DOI: 10.1007/s12640-017-9738-5

Mori, S., Sugama, S., Nguyen, W., Michel, T., Sanna, M.G., Sanchez-Alavez, M., Cintron-Colon, R., Moroncini, G., Kakinuma, Y., Maher, P., Conti, B. Lack of interleukin-13 receptor α1 delays the loss of dopaminergic neurons during chronic stress. (2017) Journal of Neuroinflammation. 14(1):88. DOI: 10.1186/s12974-017-0862-1

Merckx, E., Albertini, G., Paterka, M., Jensen, C., Albrecht, P., Dietrich, M., Van Liefferinge, J., Bentea, E., Verbruggen, L., Demuyser, T., Deneyer, L., Lewerenz, J., van Loo, G., De Keyser, J., Sato, H., Maher, P., Methner, A., Massie, A. Absence of system xc(-) on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis. (2017) Journal of Neuroinflammation. 14(1):9. DOI: 10.1186/s12974-016-0787-0

Currais, A., Fischer, W., Maher, P., Schubert, D. Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain. (2017) FASEB Journal. 31(1):5-10. DOI: 10.1096/fj.201601184

Currais, A., Quehenberger, O., M Armando, A., Daugherty, D., Maher, P., Schubert, D. Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. (2016) NPJ Aging and Mechanisms of Disease. 2:16012. DOI: 10.1038/npjamd.2016.12

Mori, S., Maher, P., Conti, B. Neuroimmunology of the Interleukins 13 and 4. (2016) Brain Sci. 6(2). DOI: 10.3390/brainsci6020018

Currais, A., Farrokhi, C., Dargusch, R., Goujon-Svrzic, M., Maher, P. Dietary glycemic index modulates the behavioral and biochemical abnormalities associated with autism spectrum disorder. (2016) Molecular Psychiatry. 21(3):426-36. DOI: 10.1038/mp.2015.64

McClatchy, D.B., Savas, J.N., Martínez-Bartolomé, S., Park, S.K., Maher, P., Powell, S.B., Yates, J.R. Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex. (2016) Molecular Psychiatry. 21(2):205-15. DOI: 10.1038/mp.2015.41

Lewerenz, J., Maher, P. Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence? (2015) Frontiers in Neuroscience. 9:469. DOI: 10.3389/fnins.2015.00469

Dafre, A.L., Goldberg, J., Wang, T., Spiegel, D.A., Maher, P. Methylglyoxal, the foe and friend of glyoxalase and Trx/TrxR systems in HT22 nerve cells. (2015) Free Radical Biology & Medicine. 89:8-19. DOI: 10.1016/j.freeradbiomed.2015.07.005

Currais, A., Goldberg, J., Farrokhi, C., Chang, M., Prior, M., Dargusch, R., Daugherty, D., Armando, A., Quehenberger, O., Maher, P., Schubert, D. A comprehensive multiomics approach toward understanding the relationship between aging and dementia. (2015) Aging. 7(11):937-55. DOI: 10.18632/aging.100838

Krasieva, T.B., Ehren, J., O'Sullivan, T., Tromberg, B.J., Maher, P. Cell and brain tissue imaging of the flavonoid fisetin using label-free two-photon microscopy. (2015) Neurochem. Int. 89:243-8. DOI: 10.1016/j.neuint.2015.08.003

Maher, P. How fisetin reduces the impact of age and disease on CNS function. (2015) Frontiers in Bioscience. 7:58-82.

Maher, P., Kontoghiorghes, G.J. Characterization of the neuroprotective potential of derivatives of the iron chelating drug deferiprone. (2015) Neurochemical Research. 40(3):609-20. DOI: 10.1007/s11064-014-1508-7

Currais, A., Chiruta, C., Goujon-Svrzic, M., Costa, G., Santos, T., Batista, M.T., Paiva, J., do Céu Madureira, M., Maher, P. Screening and identification of neuroprotective compounds relevant to Alzheimer׳s disease from medicinal plants of S. Tomé e Príncipe. (2014) Journal of Ethnopharmacology. 155(1):830-40. DOI: 10.1016/j.jep.2014.06.046

Prior, M., Chiruta, C., Currais, A., Goldberg, J., Ramsey, J., Dargusch, R., Maher, P.A., Schubert, D. Back to the future with phenotypic screening. (2014) ACS Chem Neurosci. 5(7):503-13. DOI: 10.1021/cn500051h

Currais, A., Prior, M., Dargusch, R., Armando, A., Ehren, J., Schubert, D., Quehenberger, O., Maher, P. Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. (2014) Alternde Zelle. 13(2):379-90. DOI: 10.1111/acel.12185

Maher, P. Proteasome Assay in Cell Lysates. (2014) Bio Protocol. 4(2).

Currais, A., Maher, P. Functional consequences of age-dependent changes in glutathione status in the brain. (2013) Antioxid. Redox Signal. 19(8):813-22. DOI: 10.1089/ars.2012.4996

Valera, E., Dargusch, R., Maher, P.A., Schubert, D. Modulation of 5-lipoxygenase in proteotoxicity and Alzheimer's disease. (2013) Journal of Neuroscience. 33(25):10512-25. DOI: 10.1523/JNEUROSCI.5183-12.2013

Ehren, J.L., Maher, P. Concurrent regulation of the transcription factors Nrf2 and ATF4 mediates the enhancement of glutathione levels by the flavonoid fisetin. (2013) Biochem. Pharmacol. 85(12):1816-26. DOI: 10.1016/j.bcp.2013.04.010

Currais, A., Prior, M., Lo, D., Jolivalt, C., Schubert, D., Maher, P. Diabetes exacerbates amyloid and neurovascular pathology in aging-accelerated mice. (2012) Alternde Zelle. 11(6):1017-26. DOI: 10.1111/acel.12002

Schubert, D., Maher, P. An alternative approach to drug discovery for Alzheimer's disease dementia. (2012) Future Medicinal Chemistry. 4(13):1681-8. DOI: 10.4155/fmc.12.109

Maher, P. Methylglyoxal, advanced glycation end products and autism: is there a connection? (2012) Medical Hypotheses. 78(4):548-52. DOI: 10.1016/j.mehy.2012.01.032

Chiruta, C., Schubert, D., Dargusch, R., Maher, P. Chemical modification of the multitarget neuroprotective compound fisetin. (2012) Journal of Medicinal Chemistry. 55(1):378-89. DOI: 10.1021/jm2012563

Chen, Q., Prior, M., Dargusch, R., Roberts, A., Riek, R., Eichmann, C., Chiruta, C., Akaishi, T., Abe, K., Maher, P., Schubert, D. A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. (2011) PLOS One. 6(12):e27865. DOI: 10.1371/journal.pone.0027865

Maher, P., Dargusch, R., Ehren, J.L., Okada, S., Sharma, K., Schubert, D. Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. (2011) PLOS One. 6(6):e21226. DOI: 10.1371/journal.pone.0021226

Lapchak, P.A., Schubert, D.R., Maher, P.A. De-Risking of Stilbazulenyl Nitrone (STAZN), a Lipophilic Nitrone to Treat Stroke Using a Unique Panel of In Vitro Assays. (2011) Transl Stroke Res. 2(2):209-17. DOI: 10.1007/s12975-011-0071-7

Maher, P., Dargusch, R., Bodai, L., Gerard, P.E., Purcell, J.M., Marsh, J.L. ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. (2011) Human Molecular Genetics. 20(2):261-70. DOI: 10.1093/hmg/ddq460

Lapchak, P.A., Schubert, D.R., Maher, P.A. Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke. (2011) J. Neurochem. 116(1):122-31. DOI: 10.1111/j.1471-4159.2010.07090.x

Maher, P., Akaishi, T., Schubert, D., Abe, K. A pyrazole derivative of curcumin enhances memory. (2010) Neurobiology of Aging. 31(4):706-9. DOI: 10.1016/j.neurobiolaging.2008.05.020

Maher, P. Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin. (2009) Genes & Nutrition. 4(4):297-307. DOI: 10.1007/s12263-009-0142-5

Lewerenz, J., Albrecht, P., Tien, M.L., Henke, N., Karumbayaram, S., Kornblum, H.I., Wiedau-Pazos, M., Schubert, D., Maher, P., Methner, A. Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro. (2009) J. Neurochem. 111(2):332-43. DOI: 10.1111/j.1471-4159.2009.06347.x

Herrera, F., Chen, Q., Fischer, W.H., Maher, P., Schubert, D.R. Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down's syndrome. (2009) Cell Death and Differentiation. 16(6):910-20. DOI: 10.1038/cdd.2009.24

Maher, P.A., Schubert, D.R. Metabolic links between diabetes and Alzheimer's disease. (2009) Expert Rev Neurother. 9(5):617-30. DOI: 10.1586/ern.09.18

Schubert, D., Herrera, F., Cumming, R., Read, J., Low, W., Maher, P., Fischer, W.H. Neural cells secrete a unique repertoire of proteins. (2009) J. Neurochem. 109(2):427-35. DOI: 10.1111/j.1471-4159.2009.05968.x

Lewerenz, J., Maher, P. Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression. (2009) Journal of Biological Chemistry. 284(2):1106-15. DOI: 10.1074/jbc.M807325200

Maher, P., Lewerenz, J., Lozano, C., Torres, J.L. A novel approach to enhancing cellular glutathione levels. (2008) J. Neurochem. 107(3):690-700. DOI: 10.1111/j.1471-4159.2008.05620.x

Maher, P. The flavonoid fisetin promotes nerve cell survival from trophic factor withdrawal by enhancement of proteasome activity. (2008) Arch. Biochem. Biophys. 476(2):139-44. DOI: 10.1016/j.abb.2008.03.023

Maher, P. Proteasome inhibitors prevent oxidative stress-induced nerve cell death by a novel mechanism. (2008) Biochem. Pharmacol. 75(10):1994-2006. DOI: 10.1016/j.bcp.2008.02.008

Liu, Y., Dargusch, R., Maher, P., Schubert, D. A broadly neuroprotective derivative of curcumin. (2008) J. Neurochem. 105(4):1336-45. DOI: 10.1111/j.1471-4159.2008.05236.x

Maher, P., Hanneken, A. Flavonoids protect retinal ganglion cells from ischemia in vitro. (2008) Experimental Eye Research. 86(2):366-74. DOI: 10.1016/j.exer.2007.11.009

Burdo, J., Schubert, D., Maher, P. Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons. (2008) Brain Research. 1189:12-22. DOI: 10.1016/j.brainres.2007.10.077

Lapchak, P.A., Maher, P., Schubert, D., Zivin, J.A. Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes. (2007) Neuroscience. 150(3):585-91. DOI: 10.1016/j.neuroscience.2007.09.033

Maher, P., Salgado, K.F., Zivin, J.A., Lapchak, P.A. A novel approach to screening for new neuroprotective compounds for the treatment of stroke. (2007) Brain Research. 1173:117-25. DOI: 10.1016/j.brainres.2007.07.061

Maher, P. Redox control of neural function: background, mechanisms, and significance. (2006) Antioxid. Redox Signal. 8(11-12):1941-70. DOI: 10.1089/ars.2006.8.1941

Maher, P., Akaishi, T., Abe, K. Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory. (2006) Proceedings of the National Academy of Sciences of the United States of America. 103(44):16568-73. DOI: 10.1073/pnas.0607822103

Maher, P. A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives. (2006) Free Radic. Res. 40(10):1105-11. DOI: 10.1080/10715760600672509

Maher, P., Hanneken, A. Flavonoids protect retinal ganglion cells from oxidative stress-induced death. (2005) Investigative Ophthalmology & Visual Science. 46(12):4796-803. DOI: 10.1167/iovs.05-0397

Maher, P. The effects of stress and aging on glutathione metabolism. (2005) Ageing Research Reviews. 4(2):288-314. DOI: 10.1016/j.arr.2005.02.005

Conti, B., Sugama, S., Lucero, J., Winsky-Sommerer, R., Wirz, S.A., Maher, P., Andrews, Z., Barr, A.M., Morale, M.C., Paneda, C., Pemberton, J., Gaidarova, S., Behrens, M.M., Beal, F., Sanna, P.P., Horvath, T., Bartfai, T. Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity. (2005) Journal of Neurochemistry. 93(2):493-501. DOI: 10.1111/j.1471-4159.2005.03052.x

Maher, P., Hanneken, A. The molecular basis of oxidative stress-induced cell death in an immortalized retinal ganglion cell line. (2005) Investigative Ophthalmology & Visual Science. 46(2):749-57. DOI: 10.1167/iovs.04-0883

Soucek, T., Cumming, R., Dargusch, R., Maher, P., Schubert, D. The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide. (2003) Neuron. 39(1):43-56. DOI: 10.1016/s0896-6273(03)00367-2

Tan, S., Schubert, D., Maher, P. Oxytosis: A novel form of programmed cell death. (2001) Current Topics in Medicinal Chemistry. 1(6):497-506.

Chen, Q., Yoshida, H., Schubert, D., Maher, P., Mallory, M., Masliah, E. Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation. (2001) Am. J. Pathol. 159(5):1597-602. DOI: 10.1016/S0002-9440(10)63005-2

Tan, S., Somia, N., Maher, P., Schubert, D. Regulation of antioxidant metabolism by translation initiation factor 2alpha. (2001) Journal of Cell Biology. 152(5):997-1006.

Maher, P., Schubert, D. Signaling by reactive oxygen species in the nervous system. (2000) Cellular and Molecular Life Sciences. 57(8-9):1287-305.

Sagara, Y., Dargusch, R., Chambers, D., Davis, J., Schubert, D., Maher, P. Cellular mechanisms of resistance to chronic oxidative stress. (1998) Free Radical Biology & Medicine. 24(9):1375-89.

Tan, S., Sagara, Y., Liu, Y., Maher, P., Schubert, D. The regulation of reactive oxygen species production during programmed cell death. (1998) Journal of Cell Biology. 141(6):1423-32.

Li, Y., Maher, P., Schubert, D. Phosphatidylcholine-specific phospholipase C regulates glutamate-induced nerve cell death. (1998) Proceedings of the National Academy of Sciences of the United States of America. 95(13):7748-53. DOI: 10.1073/pnas.95.13.7748

Sagara, Y., Tan, S., Maher, P., Schubert, D. Mechanisms of resistance to oxidative stress in Alzheimer's disease. (1998) Biofactors. 8(1-2):45-50.

Li, Y., Maher, P., Schubert, D. Requirement for cGMP in nerve cell death caused by glutathione depletion. (1997) Journal of Cell Biology. 139(5):1317-24.

Tan, S., Maher, P., Schubert, D. The role of protein phosphorylation in beta amyloid toxicity. (1997) Brain Research. 765(1):159-63.

Li, Y., Maher, P., Schubert, D. A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion. (1997) Neuron. 19(2):453-63.

Davis, J.B., Maher, P. Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line. (1994) Brain Research. 652(1):169-73. DOI: 10.1016/0006-8993(94)90334-4

Schubert, D., Kimura, H., Maher, P. Growth factors and vitamin E modify neuronal glutamate toxicity. (1992) Proceedings of the National Academy of Sciences of the United States of America. 89(17):8264-7.

Sagbo, I.J., Soriano-Castell, D., Rebman, J., Maher, P. Neuroprotective and anti-inflammatory activity of Wyethia species: therapeutic potential for neurodegenerative diseases. (n.d.) Front Pharmacol. 16:1740121. DOI: 10.3389/fphar.2025.1740121