Sanchez, K.K., McCarville, J.L., Stengel, S.J., Snyder, J.M., Williams, A.E., Ayres, J.S. Disease tolerance and infection pathogenesis age-related tradeoffs in mice. (2026) Natur. DOI: 10.1038/s41586-025-09923-x

Troha, K., Kambhampati, S., Insenga, A., Metallo, C.M., Ayres, J.S. Dietary methionine mitigates immune-mediated damage by enhancing renal clearance of cytokines. (2026) Zellstoffwechsel. DOI: 10.1016/j.cmet.2025.12.011

Gallant, R.M., Alam, S., Venkataraman, K., McKenna, B.S., Khairy, K., Ayres, J.S. Pre-infection cerebral cortex structure predicts murine sepsis outcome. (2025) PLOS One. 20(9):e0330947. DOI: 10.1371/journal.pone.0330947

Gallant, R.M., Sanchez, K.K., Joulia, E., Snyder, J.M., Metallo, C.M., Ayres, J.S. Fluoxetine promotes IL-10-dependent metabolic defenses to protect from sepsis-induced lethality. (2025) Science Advances. 11(7):eadu4034. DOI: 10.1126/sciadv.adu4034

Ayres, J.S. Host-encoded antivirulence defenses: host physiologies teach pathogens to play nice. (2024) Current Opinion in Immunology. 91:102472. DOI: 10.1016/j.coi.2024.102472

Gallant, R.M., Snyder, J.M., Ayres, J.S. Fluoxetine promotes immunometabolic defenses to mediate host-pathogen cooperation during sepsis. (2023) bioRxiv. DOI: 10.1101/2023.11.18.567681

Fu, T., Huan, T., Rahman, G., Zhi, H., Xu, Z., Oh, T.G., Guo, J., Coulter, S., Tripathi, A., Martino, C., McCarville, J.L., Zhu, Q., Cayabyab, F., Low, B., He, M., Xing, S., Vargas, F., Yu, R.T., Atkins, A., Liddle, C., Ayres, J., Raffatellu, M., Dorrestein, P.C., Downes, M., Knight, R., Evans, R.M. Paired microbiome and metabolome analyses associate bile acid changes with colorectal cancer progression. (2023) Cell Reports.:112997 DOI: 10.1016/j.celrep.2023.112997

Redford, S.E., Varanasi, S.K., Sanchez, K.K., Thorup, N.R., Ayres, J.S. CD4+ T cells regulate sickness-induced anorexia and fat wasting during a chronic parasitic infection. (2023) Cell Reports.:112814 DOI: 10.1016/j.celrep.2023.112814

Chen, G.Y., Thorup, N.R., Miller, A.J., Li, Y.C., Ayres, J.S. Cooperation between physiological defenses and immune resistance produces asymptomatic carriage of a lethal bacterial pathogen. (2023) Science Advances. 9(25):eadg8719. DOI: 10.1126/sciadv.adg8719

Ferrer, M., Anthony, T.G., Ayres, J.S., Biffi, G., Brown, J.C., Caan, B.J., Cespedes Feliciano, E.M., Coll, A.P., Dunne, R.F., Goncalves, M.D., Grethlein, J., Heymsfield, S.B., Hui, S., Jamal-Hanjani, M., Lam, J.M., Lewis, D.Y., McCandlish, D., Mustian, K.M., O'Rahilly, S., Perrimon, N., White, E.P., Janowitz, T. Cachexia: A systemic consequence of progressive, unresolved disease. (2023) Cell. 186(9):1824-1845. DOI: 10.1016/j.cell.2023.03.028

Sanchez, K.K., McCarville, J.L., Stengel, S.J., Snyder, J.M., Williams, A.E., Ayres, J.S. Preprint - Age-dependent roles of cardiac remodeling in sepsis defense and pathogenesis. (2023) bioRxiv. DOI: 10.1101/2023.03.14.532695

Chen, G.Y., Thorup, N.R., Miller, A.J., Li, Y.C., Ayres, J.S. Cooperation between physiological defenses and immune resistance produces asymptomatic carriage of a lethal bacterial pathogen. (2023) bioRxiv. DOI: 10.1101/2023.01.22.525099

Sanchez, K.K., Troha, K., Mu, A., Redford, S.E., McCarville, J.L., Insenga, A., Stengel, S., Lee, Y.M., Ayres, J.S. Chronic Leptin Deficiency Improves Tolerance of Physiological Damage and Host-Pathogen Cooperation during Yersinia pseudotuberculosis Infection. (2022) Infect Immun.:e0024222 DOI: 10.1128/iai.00242-22

McCarville, J.L., Ayres, J.S. Virulence triggered allergies: Pseudomonas gets the Las laugh. (2022) Immunity. 55(5):824-826. DOI: 10.1016/j.immuni.2022.04.011

Romero, A.R., Mu, A., Ayres, J.S. Adipose triglyceride lipase mediates lipolysis and lipid mobilization in response to iron-mediated negative energy balance. (2022) iScience. 25(3):103941. DOI: 10.1016/j.isci.2022.103941

Troha, K., Ayres, J.S. Cooperative defenses during enteropathogenic infection. (2021) Current Opinion in Microbiology. 65:123-130. DOI: 10.1016/j.mib.2021.11.003

Lee, Y.M., Mu, A., Wallace, M., Gengatharan, J.M., Furst, A.J., Bode, L., Metallo, C.M., Ayres, J.S. Microbiota control of maternal behavior regulates early postnatal growth of offspring. (2021) Science Advances. 7(5). DOI: 10.1126/sciadv.abe6563

Chen, G.Y., Ayres, J.S. Beyond tug-of-war: Iron metabolism in cooperative host-microbe interactions. (2020) PLOS pathogens. 16(8):e1008698. DOI: 10.1371/journal.ppat.1008698

Ayres, J.S. A metabolic handbook for the COVID-19 pandemic. (2020) Nat Metab. 2(7):572-585. DOI: 10.1038/s42255-020-0237-2

Ayres, J.S. Surviving COVID-19: A disease tolerance perspective. (2020) Science Advances. 6(18):eabc1518. DOI: 10.1126/sciadv.abc1518

Ayres, J.S. The Biology of Physiological Health. (2020) Cell. 181(2):250-269. DOI: 10.1016/j.cell.2020.03.036

McCarville, J.L., Chen, G.Y., Cuevas, V.D., Troha, K., Ayres, J.S. Microbiota Metabolites in Health and Disease. (2020) Annual Review of Immunology. 38:147-170. DOI: 10.1146/annurev-immunol-071219-125715

Troha, K., Ayres, J.S. Metabolic Adaptations to Infections at the Organismal Level. (2020) Trends in Immunology. DOI: 10.1016/j.it.2019.12.001

Ayres, J.S. Immunometabolism of infections. (2019) Nature Reviews Immunology. DOI: 10.1038/s41577-019-0266-9

McCarville, J.L., Ayres, J.S. Host-Pathogen Relationship Advice: Fat Protects against a Broken Heart. (2019) Zellstoffwechsel. 30(3):409-411. DOI: 10.1016/j.cmet.2019.08.007

Wallace, M., Green, C.R., Roberts, L.S., Lee, Y.M., McCarville, J.L., Sanchez-Gurmaches, J., Meurs, N., Gengatharan, J.M., Hover, J.D., Phillips, S.A., Ciaraldi, T.P., Guertin, D.A., Cabrales, P., Ayres, J.S., Nomura, D.K., Loomba, R., Metallo, C.M. Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. (2018) Nature Chemical Biology. 14(11):1021-1031. DOI: 10.1038/s41589-018-0132-2

Sanchez, K.K., Chen, G.Y., Schieber, A.M.P., Redford, S.E., Shokhirev, M.N., Leblanc, M., Lee, Y.M., Ayres, J.S. Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen. (2018) Cell. 175(1):146-158. DOI: 10.1016/j.cell.2018.07.016

Chen, G.Y., Ayres, J.S. When the Gut Gets Tough, the Enterocytes Get Going. (2018) Immunity. 48(5):837-839. DOI: 10.1016/j.immuni.2018.04.036

McCarville, J.L., Ayres, J.S. Disease tolerance: concept and mechanisms. (2018) Current Opinion in Immunology. 50:88-93. DOI: 10.1016/j.coi.2017.12.003

Lee, Y.M., Ayres, J.S. Decoding the intestinal epithelium cell by cell. (2018) Nature Immunology. 19(1):7-9. DOI: 10.1038/s41590-017-0011-0

Rao, S., Ayres, J.S. Resistance and tolerance defenses in cancer: Lessons from infectious diseases. (2017) Seminars in Immunology. 32:54-61. DOI: 10.1016/j.smim.2017.08.004

Rauch, I., Deets, K.A., Ji, D.X., von Moltke, J., Tenthorey, J.L., Lee, A.Y., Philip, N.H., Ayres, J.S., Brodsky, I.E., Gronert, K., Vance, R.E. NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. (2017) Immunity. 46(4):649-659. DOI: 10.1016/j.immuni.2017.03.016

Rao, S., Schieber, A.M., O'Connor, C.P., Leblanc, M., Michel, D., Ayres, J.S. Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and Transmission. (2017) Cell. 168(3):503-516.e12. DOI: 10.1016/j.cell.2017.01.006

Ayres, J.S. Microbes Dress for Success: Tolerance or Resistance? (2017) Trends in Microbiology. 25(1):1-3. DOI: 10.1016/j.tim.2016.11.006

Schieber, A.M., Ayres, J.S. Thermoregulation as a disease tolerance defense strategy. (2016) Pathog Dis. 74(9). DOI: 10.1093/femspd/ftw106

Ayres, J.S. Disease Tolerance Trick or Treat: Give Your Brain Something Good to Eat. (2016) Cell. 166(6):1368-70. DOI: 10.1016/j.cell.2016.08.034

Ayres, J.S. Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism. (2016) Cell. 165(6):1323-1331. DOI: 10.1016/j.cell.2016.05.049

Shen, R., Wang, B., Giribaldi, M.G., Ayres, J., Thomas, J.B., Montminy, M. Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(23):E3307-14. DOI: 10.1073/pnas.1606106113

Schieber, A.M., Lee, Y.M., Chang, M.W., Leblanc, M., Collins, B., Downes, M., Evans, R.M., Ayres, J.S. Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling. (2015) Wissenschaft. 350(6260):558-63. DOI: 10.1126/science.aac6468

Ayres, J.S. Inflammasome-microbiota interplay in host physiologies. (2013) Zelle Wirt & Mikrobe. 14(5):491-7. DOI: 10.1016/j.chom.2013.10.013

Manzanillo, P.S., Ayres, J.S., Watson, R.O., Collins, A.C., Souza, G., Rae, C.S., Schneider, D.S., Nakamura, K., Shiloh, M.U., Cox, J.S. The ubiquitin ligase parkin mediates resistance to intracellular pathogens. (2013) Natur. 501(7468):512-6. DOI: 10.1038/nature12566

von Moltke, J., Ayres, J.S., Kofoed, E.M., Chavarría-Smith, J., Vance, R.E. Recognition of bacteria by inflammasomes. (2013) Annual Review of Immunology. 31:73-106. DOI: 10.1146/annurev-immunol-032712-095944

Ayres, J.S., Trinidad, N.J., Vance, R.E. Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota. (2012) Nature Medicine. 18(5):799-806. DOI: 10.1038/nm.2729

Ayres, J.S., Vance, R.E. Cellular teamwork in antibacterial innate immunity. (2012) Nature Immunology. 13(2):115-7. DOI: 10.1038/ni.2212

Stone, E.F., Fulton, B.O., Ayres, J.S., Pham, L.N., Ziauddin, J., Shirasu-Hiza, M.M. The circadian clock protein timeless regulates phagocytosis of bacteria in Drosophila. (2012) PLOS pathogens. 8(1):e1002445. DOI: 10.1371/journal.ppat.1002445

Ayres, J.S., Schneider, D.S. Tolerance of infections. (2012) Annual Review of Immunology. 30:271-94. DOI: 10.1146/annurev-immunol-020711-075030

Ayres, J.S., Schneider, D.S. The role of anorexia in resistance and tolerance to infections in Drosophila. (2009) PLOS Biology. 7(7):e1000150. DOI: 10.1371/journal.pbio.1000150

Ayres, J.S., Schneider, D.S. A signaling protease required for melanization in Drosophila affects resistance and tolerance of infections. (2008) PLOS Biology. 6(12):2764-73. DOI: 10.1371/journal.pbio.0060305

Schneider, D.S., Ayres, J.S. Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases. (2008) Nature Reviews. Immunology. 8(11):889-95. DOI: 10.1038/nri2432

Gordon, M.D., Ayres, J.S., Schneider, D.S., Nusse, R. Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin. (2008) PLOS pathogens. 4(7):e1000111. DOI: 10.1371/journal.ppat.1000111

Ayres, J.S., Freitag, N., Schneider, D.S. Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection. (2008) Genetics. 178(3):1807-15. DOI: 10.1534/genetics.107.083782

Shirasu-Hiza, M.M., Dionne, M.S., Pham, L.N., Ayres, J.S., Schneider, D.S. Interactions between circadian rhythm and immunity in Drosophila melanogaster. (2007) Current Biology. 17(10):R353-5. DOI: 10.1016/j.cub.2007.03.049

Schneider, D.S., Ayres, J.S., Brandt, S.M., Costa, A., Dionne, M.S., Gordon, M.D., Mabery, E.M., Moule, M.G., Pham, L.N., Shirasu-Hiza, M.M. Drosophila eiger mutants are sensitive to extracellular pathogens. (2007) PLOS pathogens. 3(3):e41. DOI: 10.1371/journal.ppat.0030041

Ayres, J.S., Schneider, D.S. Genomic dissection of microbial pathogenesis in cultured Drosophila cells. (2006) Trends in Microbiology. 14(3):101-4. DOI: 10.1016/j.tim.2006.01.008