Vaughan, J.M., Pai, V.J., Miller, B., Vieira de Souza, E., Donaldson, C.J., Saghatelian, A. Microprotein-Derived Secreted Peptide That Stimulates Cellular cAMP Production. (2026) Biochemistry. DOI: 10.1021/acs.biochem.5c00764

Świrski, M.I., Tierney, J.A.S., Albà, M.M., Andreev, D.E., Aspden, J.L., Atkins, J.F., Bassani-Sternberg, M., Berry, M.J., Biffo, S., Boris-Lawrie, K., Borodovsky, M., Brierley, I., Brook, M., Brunet, M.A., Bujnicki, J.M., Caliskan, N., Calviello, L., Carvunis, A.R., Cate, J.H.D., Cenik, C., Chang, K.Y., Chen, Y., Chothani, S., Choudhary, J.S., Clark, P.L., Clauwaert, J., Cooley, L., Dassi, E., Dean, K., Diaz, J.J., Dieterich, C., Dikstein, R., Dinman, J.D., Dmitriev, S.E., Dontsova, O.A., Dunham, C.M., Eswarappa, S.M., Farabaugh, P.J., Faridi, P., Fierro-Monti, I., Firth, A.E., Gatfield, D., Gebauer, F., Gelfand, M.S., Gray, N.K., Green, R., Hill, C.H., Hou, Y.M., Hübner, N., Ignatova, Z., Ivanov, P., Iwasaki, S., Johnson, R., Jomaa, A., Jovanovic, M., Jungreis, I., Kellis, M., Kieft, J.S., Kochetov, A.V., Koonin, E.V., Korostelev, A.A., Kufel, J., Kulakovskiy, I.V., Kurian, L., Lafontaine, D.L.J., Larsson, O., Loughran, G., Lukeš, J., Mariotti, M., Martens-Uzunova, E.S., Martinez, T.F., Matsumoto, A., McManus, J., Medenbach, J., Melnikov, S.V., Menschaert, G., Merchante, C., Mikl, M., Miller, W.A., Mühlemann, O., Namy, O., Nedialkova, D.D., Nosek, J., Orchard, S., Ozretić, P., Pertea, M., Pervouchine, D.D., Romão, L., Ron, D., Roucou, X., Rubtsova, M.P., Ruiz-Orera, J., Saghatelian, A., Salzberg, S.L., Seale, L.A., Seoighe, C., Sergiev, P.V., Shah, P., Shirokikh, N., Slavoff, S.A., Sonenberg, N., Stasevich, T.J., Szczesny, R.J., Tamm, T., Tchórzewski, M., Topisirovic, I., Tremblay, M.L., Tuller, T., Ulitsky, I., Valášek, L.S., Van Damme, P., Viero, G., Vizcaino, J.A., Vogel, C., Wallace, E.W.J., Weissman, J.S., Westhof, E., Whiffin, N., Wilson, D.N., Xie, Z., Yewdell, J.W., Yordanova, M.M., Yu, C.H., Yurchenko, V., Zagrovic, B., , Valen, E., Baranov, P.V. Translon: a single term for translated regions. (2025) Nature Methods. DOI: 10.1038/s41592-025-02810-3

Miller, B., de Souza, E.V., Pai, V.J., Kim, H., Vaughan, J.M., Lau, C.J., Diedrich, J.K., Saghatelian, A. ShortStop: a machine learning framework for microprotein discovery. (2025) BMC Methods. 2(1):16. DOI: 10.1186/s44330-025-00037-4

Pai, V.J., Shan, H., Donaldson, C.J., Vaughan, J.M., De Souza, E.V., O'Connor, C., Liem, M., Pinto, A.F.M., Diedrich, J., Saghatelian, A. CRISPR-Cas9 screening reveals microproteins regulating adipocyte proliferation and lipid metabolism. (2025) Proceedings of the National Academy of Sciences of the United States of America. 122(32):e2506534122. DOI: 10.1073/pnas.2506534122

Rocha, A.L., Schmedt, C., Perkins, G., Pinto, A., Diedrich, J.K., Shan, H., Plucińska, K., Vieira de Souza, E., Vaughan, J.M., Foster, M., Sampath, S.C., Sampath, S.C., Cohen, P., Ellisman, M.H., Saghatelian, A. Abnormal mitochondrial structure and function in brown adipose tissue of SLC35A4-MP knockout mice. (2025) Science Advances. 11(35):eads7381. DOI: 10.1126/sciadv.ads7381

Jayatissa, A., Jaunbocus, N., Erkalo, B., Jiang, K., Zheng, S.J., Su, H., Yan, L., Choi, J.Y., Vaughan, J., Bacchiocchi, A., Na, Z., Cao, X., Halaban, R., Saghatelian, A., Craft, J., Chen, Y.G., Slavoff, S.A. The ERVK3-1 Microprotein Interacts with the HUSH Complex. (2025) Biochemistry. DOI: 10.1021/acs.biochem.5c00023

Pai, V.J., Saghatelian, A. "Shunt-ing" down obesity with novel endogenous metabolites. (2025) Zellstoffwechsel. 37(3):564-565. DOI: 10.1016/j.cmet.2025.02.005

Agrawal, A., Saghatelian, A. Identification of microproteins with transactivation activity by polyalanine motif selection. (2025) RSC Chem Biol. DOI: 10.1039/d4cb00277f

Pai, V.J., Shan, H., Donaldson, C., Vaughan, J., O'Connor, C., Liem, M., Pinto, A., Diedrich, J., Saghatelian, A. CRISPR-Cas9 Screening Reveals Microproteins Regulating Adipocyte Proliferation and Lipid Metabolism. (2025) bioRxiv. DOI: 10.1101/2025.03.21.644636

Tan, D., Saghatelian, A. The measurement, regulation and biological activity of FAHFAs. (2025) Nature Chemical Biology. DOI: 10.1038/s41589-024-01827-7

de Souza, E.V., Dalberto, P.F., Miranda, A.C., Saghatelian, A., Pinto, A.M., Basso, L.A., Machado, P., Bizarro, C.V. Large-scale proteogenomics characterization of microproteins in Mycobacterium tuberculosis. (2024) Wissenschaftliche Berichte. 14(1):31186. DOI: 10.1038/s41598-024-82465-w

Pai, V.J., Lau, C.J., Garcia-Ruiz, A., Donaldson, C., Vaughan, J.M., Miller, B., De Souza, E.V., Pinto, A.M., Diedrich, J., Gavva, N.R., Yu, S., DeBoever, C., Horman, S.R., Saghatelian, A. Microprotein-encoding RNA regulation in cells treated with pro-inflammatory and pro-fibrotic stimuli. (2024) BMC Genomics. 25(1):1034. DOI: 10.1186/s12864-024-10948-1

Ertunc, M.E., Konduri, S., Ma, Z., Pinto, A.F.M., Donaldson, C.J., Momper, J., Siegel, D., Saghatelian, A. Acute inflammation upregulates FAHFAs in adipose tissue and in co-cultured adipocytes. (2024) Journal of Biological Chemistry.:107972 DOI: 10.1016/j.jbc.2024.107972

Chaix, A., Lin, T., Ramms, B., Cutler, R.G., Le, T., Lopez, C., Miu, P., Pinto, A.F.M., Saghatelian, A., Playford, M.P., Mehta, N.N., Mattson, M.P., Gordts, P., Witztum, J.L., Panda, S. Zeitlich begrenztes Füttern reduziert Atherosklerose bei LDLR-KO-Mäusen, nicht aber bei ApoE-Knockout-Mäusen. (2024) Arteriosklerose, Thrombose und vaskuläre Biologie. DOI: 10.1161/ATVBAHA.124.320998

Riecan, M., Domanska, V., Lupu, C., Patel, M., Vondrackova, M., Rossmeisl, M., Saghatelian, A., Lupu, F., Kuda, O. Tissue-specific sex-dependent difference in the metabolism of fatty acid esters of hydroxy fatty acids. (2024) Biochim Biophys Acta Mol Cell Biol Lipids.:159543 DOI: 10.1016/j.bbalip.2024.159543

Vieira de Souza, E., L Bookout, A., Barnes, C.A., Miller, B., Machado, P., Basso, L.A., Bizarro, C.V., Saghatelian, A. Rp3: Ribosome profiling-assisted proteogenomics improves coverage and confidence during microprotein discovery. (2024) Nature Communications. 15(1):6839. DOI: 10.1038/s41467-024-50301-4

Zlitni, S., Bowden, S., Sberro, H., Torres, M.D.T., Vaughan, J.M., Pinto, A.F.M., Pinto, Y., Fernandez, D., Röst, H., Saghatelian, A., de la Fuente-Nunez, C., Bhatt, A.S. Dual quorum-sensing control of purine biosynthesis drives pathogenic fitness of . (2024) bioRxiv. DOI: 10.1101/2024.08.13.607696

Kim, D.I., Park, S., Park, S., Ye, M., Chen, J.Y., Kang, S.J., Jhang, J., Hunker, A.C., Zweifel, L.S., Caron, K.M., Vaughan, J.M., Saghatelian, A., Palmiter, R.D., Han, S. Presynaptic sensor and silencer of peptidergic transmission reveal neuropeptides as primary transmitters in pontine fear circuit. (2024) Cell. DOI: 10.1016/j.cell.2024.06.035

Yan, S., Santoro, A., Niphakis, M.J., Pinto, A.M., Jacobs, C.L., Ahmad, R., Suciu, R.M., Fonslow, B.R., Herbst-Graham, R.A., Ngo, N., Henry, C.L., Herbst, D.M., Saghatelian, A., Kahn, B.B., Rosen, E.D. Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels. (2024) Nature Communications. 15(1):4605. DOI: 10.1038/s41467-024-48220-5

Rocha, A.L., Pai, V., Perkins, G., Chang, T., Ma, J., Chu, Q., Vaughan, J.M., Diedrich, J.K., Ellisman, M.H., Saghatelian, A. An inner mitochondrial membrane microprotein from the SLC35A4 upstream ORF regulates cellular metabolism. (2024) Journal of Molecular Biology.:168559 DOI: 10.1016/j.jmb.2024.168559

Noguchi, G.M., Castillo, V.C., Donaldson, C.J., Flisher, M.R., Momen, A.T., Saghatelian, A., Huising, M.O. Urocortin3 contributes to paracrine inhibition of islet alpha cells in mice. (2024) Journal of Endocrinology. DOI: 10.1530/JOE-24-0018

Köberlin, M.S., Fan, Y., Liu, C., Chung, M., Pinto, A.F.M., Jackson, P.K., Saghatelian, A., Meyer, T. A fast-acting lipid checkpoint in G1 prevents mitotic defects. (2024) Nature Communications. 15(1):2441. DOI: 10.1038/s41467-024-46696-9

Riecan, M., Domanska, V., Lupu, C., Patel, M., Vondrackova, M., Rossmeisl, M., Saghatelian, A., Lupu, F., Kuda, O. Tissue-specific sex difference in the metabolism of fatty acid esters of hydroxy fatty acids. (2023) bioRxiv. DOI: 10.1101/2023.11.15.567158

Xie, L., Bowman, M.E., Louie, G.V., Zhang, C., Ardejani, M.S., Huang, X., Chu, Q., Donaldson, C.J., Vaughan, J.M., Shan, H., Powers, E.T., Kelly, J.W., Lyumkis, D., Noel, J.P., Saghatelian, A. Biochemistry and Protein Interactions of the CYREN Microprotein. (2023) Biochemistry. DOI: 10.1021/acs.biochem.3c00397

de Souza, E.V., Bookout, A.L., Barnes, C.A., Miller, B., Machado, P., Basso, L.A., Bizarro, C.V., Saghatelian, A. The Integration of Proteogenomics and Ribosome Profiling Circumvents Key Limitations to Increase the Coverage and Confidence of Novel Microproteins. (2023) bioRxiv. DOI: 10.1101/2023.09.27.559809

Lazear, M.R., Remsberg, J.R., Jaeger, M.G., Rothamel, K., Her, H.L., DeMeester, K.E., Njomen, E., Hogg, S.J., Rahman, J., Whitby, L.R., Won, S.J., Schafroth, M.A., Ogasawara, D., Yokoyama, M., Lindsey, G.L., Li, H., Germain, J., Barbas, S., Vaughan, J., Hanigan, T.W., Vartabedian, V.F., Reinhardt, C.J., Dix, M.M., Koo, S.J., Heo, I., Teijaro, J.R., Simon, G.M., Ghosh, B., Abdel-Wahab, O., Ahn, K., Saghatelian, A., Melillo, B., Schreiber, S.L., Yeo, G.W., Cravatt, B.F. Proteomic discovery of chemical probes that perturb protein complexes in human cells. (2023) Molecular Cell. DOI: 10.1016/j.molcel.2023.03.026

Morgado-Palacin, L., Brown, J.A., Martinez, T.F., Garcia-Pedrero, J.M., Forouhar, F., Quinn, S.A., Reglero, C., Vaughan, J., Heydary, Y.H., Donaldson, C., Rodriguez-Perales, S., Allonca, E., Granda-Diaz, R., Fernandez, A.F., Fraga, M.F., Kim, A.L., Santos-Juanes, J., Owens, D.M., Rodrigo, J.P., Saghatelian, A., Ferrando, A.A. The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma. (2023) Nature Communications. 14(1):1328. DOI: 10.1038/s41467-023-36713-8

Martinez, T.F., Lyons-Abbott, S., Bookout, A.L., De Souza, E.V., Donaldson, C., Vaughan, J.M., Lau, C., Abramov, A., Baquero, A.F., Baquero, K., Friedrich, D., Huard, J., Davis, R., Kim, B., Koch, T., Mercer, A.J., Misquith, A., Murray, S.A., Perry, S., Pino, L.K., Sanford, C., Simon, A., Zhang, Y., Zipp, G., Bizarro, C.V., Shokhirev, M.N., Whittle, A.J., Searle, B.C., MacCoss, M.J., Saghatelian, A., Barnes, C.A. Profiling mouse brown and white adipocytes to identify metabolically relevant small ORFs and functional microproteins. (2023) Zellstoffwechsel. 35(1):166-183.e11. DOI: 10.1016/j.cmet.2022.12.004

Tan, D., Konduri, S., Erikci Ertunc, M., Zhang, P., Wang, J., Chang, T., Pinto, A.F.M., Rocha, A., Donaldson, C.J., Vaughan, J.M., Ludwig, R.G., Willey, E., Iyer, M., Gray, P.C., Maher, P., Allen, N.J., Zuchero, J.B., Dillin, A., Mori, M.A., Kohama, S.G., Siegel, D., Saghatelian, A. A class of anti-inflammatory lipids decrease with aging in the central nervous system. (2022) Nature Chemical Biology. DOI: 10.1038/s41589-022-01165-6

Miller, B., Kim, S.J., Mehta, H.H., Cao, K., Kumagai, H., Thumaty, N., Leelaprachakul, N., Jiao, H., Vaughan, J., Diedrich, J., Saghatelian, A., Arpawong, T.E., Crimmins, E.M., Ertekin-Taner, N., Tubi, M.A., Hare, E.T., Braskie, M.N., Décarie-Spain, L., Kanoski, S.E., Grodstein, F., Bennett, D.A., Zhao, L., Toga, A.W., Wan, J., Yen, K., Cohen, P. Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE. (2022) Molecular Psychiatry. DOI: 10.1038/s41380-022-01769-3

Russell, B.J., Brown, S.D., Siguenza, N., Mai, I., Saran, A.R., Lingaraju, A., Maissy, E.S., Dantas Machado, A.C., Pinto, A.F.M., Sanchez, C., Rossitto, L.A., Miyamoto, Y., Richter, R.A., Ho, S.B., Eckmann, L., Hasty, J., Gonzalez, D.J., Saghatelian, A., Knight, R., Zarrinpar, A. Intestinal transgene delivery with native E. coli chassis allows persistent physiological changes. (2022) Cell. DOI: 10.1016/j.cell.2022.06.050

Faust, B., Billesbølle, C.B., Suomivuori, C.M., Singh, I., Zhang, K., Hoppe, N., Pinto, A.F.M., Diedrich, J.K., Muftuoglu, Y., Szkudlinski, M.W., Saghatelian, A., Dror, R.O., Cheng, Y., Manglik, A. Autoantibody mimicry of hormone action at the thyrotropin receptor. (2022) Natur. DOI: 10.1038/s41586-022-05159-1

Dantas Machado, A.C., Brown, S.D., Lingaraju, A., Sivaganesh, V., Martino, C., Chaix, A., Zhao, P., Pinto, A.F.M., Chang, M.W., Richter, R.A., Saghatelian, A., Saltiel, A.R., Knight, R., Panda, S., Zarrinpar, A. Ernährung und Fütterungsmuster modulieren die diurnal Dynamik des ilealen Mikrobioms und Transkriptoms. (2022) Cell Reports. 40(1):111008. DOI: 10.1016/j.celrep.2022.111008

Mudge, J.M., Ruiz-Orera, J., Prensner, J.R., Brunet, M.A., Calvet, F., Jungreis, I., Gonzalez, J.M., Magrane, M., Martinez, T.F., Schulz, J.F., Yang, Y.T., Albà, M.M., Aspden, J.L., Baranov, P.V., Bazzini, A.A., Bruford, E., Martin, M.J., Calviello, L., Carvunis, A.R., Chen, J., Couso, J.P., Deutsch, E.W., Flicek, P., Frankish, A., Gerstein, M., Hubner, N., Ingolia, N.T., Kellis, M., Menschaert, G., Moritz, R.L., Ohler, U., Roucou, X., Saghatelian, A., Weissman, J.S., van Heesch, S. Standardized annotation of translated open reading frames. (2022) Nature Biotechnology. DOI: 10.1038/s41587-022-01369-0

Patel, R., Santoro, A., Hofer, P., Tan, D., Oberer, M., Nelson, A.T., Konduri, S., Siegel, D., Zechner, R., Saghatelian, A., Kahn, B.B. ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids. (2022) Natur. DOI: 10.1038/s41586-022-04787-x

de Souza, E.V., Dalberto, P.F., Machado, V.P., Canedo Miranda, A., Saghatelian, A., Machado, P., Basso, L.A., Bizarro, C.V. µProteInS - a proteogenomics pipeline for finding novel bacterial microproteins encoded by small ORFs. (2022) Bioinformatics . DOI: 10.1093/bioinformatics/btac115

Sancar, G., Liu, S., Gasser, E., Alvarez, J.G., Moutos, C., Kim, K., van Zutphen, T., Wang, Y., Huddy, T.F., Ross, B., Dai, Y., Zepeda, D., Collins, B., Tilley, E., Kolar, M.J., Yu, R.T., Atkins, A.R., van Dijk, T.H., Saghatelian, A., Jonker, J.W., Downes, M., Evans, R.M. FGF1 and insulin control lipolysis by convergent pathways. (2022) Zellstoffwechsel. 34(1):171-183.e6. DOI: 10.1016/j.cmet.2021.12.004

Lewandowski, D., Foik, A.T., Smidak, R., Choi, E.H., Zhang, J., Hoang, T., Tworak, A., Suh, S., Leinonen, H., Dong, Z., Pinto, A.F., Tom, E., Luu, J.C., Lee, J.Y., Ma, X., Bieberich, E., Blackshaw, S., Saghatelian, A., Lyon, D.C., Skowronska-Krawczyk, D., Tabaka, M., Palczewski, K. Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision. (2022) JCI Insight. DOI: 10.1172/jci.insight.156301

Sander, C.L., Sears, A.E., Pinto, A.F.M., Choi, E.H., Kahremany, S., Gao, F., Salom, D., Jin, H., Pardon, E., Suh, S., Dong, Z., Steyaert, J., Saghatelian, A., Skowronska-Krawczyk, D., Kiser, P.D., Palczewski, K. Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition. (2021) Journal of Cell Biology. 220(8). DOI: 10.1083/jcb.202101063

Aryal, P., Syed, I., Lee, J., Patel, R., Nelson, A.T., Siegel, D., Saghatelian, A., Kahn, B.B. Distinct Biological Activities of Isomers from Different Families of Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs). (2021) Journal of Lipid Research.:100108 DOI: 10.1016/j.jlr.2021.100108

Koh, M., Ahmad, I., Ko, Y., Zhang, Y., Martinez, T.F., Diedrich, J.K., Chu, Q., Moresco, J.J., Erb, M.A., Saghatelian, A., Schultz, P.G., Bollong, M.J. A short ORF-encoded transcriptional regulator. (2021) Proceedings of the National Academy of Sciences of the United States of America. 118(4). DOI: 10.1073/pnas.2021943118

Dasyani, M., Gao, F., Xu, Q., Van Fossan, D., Zhang, E., F M Pinto, A., Saghatelian, A., Skowronska-Krawczyk, D., Chao, D.L. Elovl2 Is Required for Robust Visual Function in Zebrafish. (2020) Cells. 9(12). DOI: 10.3390/cells9122583

Becuwe, M., Bond, L.M., Pinto, A.F.M., Boland, S., Mejhert, N., Elliott, S.D., Cicconet, M., Graham, M.M., Liu, X.N., Ilkayeva, O., Saghatelian, A., Walther, T.C., Farese, R.V. FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis. (2020) Journal of Cell Biology. 219(10). DOI: 10.1083/jcb.202006111

Muthusamy, T., Cordes, T., Handzlik, M.K., You, L., Lim, E.W., Gengatharan, J., Pinto, A.F.M., Badur, M.G., Kolar, M.J., Wallace, M., Saghatelian, A., Metallo, C.M. Serine restriction alters sphingolipid diversity to constrain tumour growth. (2020) Natur. 586(7831):790-795. DOI: 10.1038/s41586-020-2609-x

Saghatelian, A. Networking in Circulation: Lipoproteins, PM20D1, and N-acyl Amino Acid Bioactivity. (2020) Cell Chemical Biology. 27(9):1112-1113. DOI: 10.1016/j.chembiol.2020.08.019

Chen, P.B., Black, A.S., Sobel, A.L., Zhao, Y., Mukherjee, P., Molparia, B., Moore, N.E., Aleman Muench, G.R., Wu, J., Chen, W., Pinto, A.F.M., Maryanoff, B.E., Saghatelian, A., Soroosh, P., Torkamani, A., Leman, L.J., Ghadiri, M.R. Directed remodeling of the mouse gut microbiome inhibits the development of atherosclerosis. (2020) Nature Biotechnology. DOI: 10.1038/s41587-020-0549-5

Charron, M.J., Williams, L., Seki, Y., Du, X.Q., Chaurasia, B., Saghatelian, A., Summers, S.A., Katz, E.B., Vuguin, P.M., Reznik, S.E. Antioxidant Effects of N-Acetylcysteine Prevent Programmed Metabolic Disease in Mice. (2020) Diabetes. DOI: 10.2337/db19-1129

Martinez, T.F., Vaughan, J., Saghatelian, A. Insights into GLP-1 Receptor Activation with a Nonpeptide Agonist. (2020) Biochemistry. DOI: 10.1021/acs.biochem.0c00180

Erikci Ertunc, M., Kok, B.P., Parsons, W.H., Wang, J.G., Tan, D., Donaldson, C.J., Pinto, A.F.M., Vaughan, J.M., Ngo, N., Lum, K.M., Henry, C.L., Coppola, A.R., Niphakis, M.J., Cravatt, B.F., Saez, E., Saghatelian, A. AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice. (2020) Journal of Biological Chemistry. DOI: 10.1074/jbc.RA119.012145

Chen, D., Chao, D.L., Rocha, L., Kolar, M., Nguyen Huu, V.A., Krawczyk, M., Dasyani, M., Wang, T., Jafari, M., Jabari, M., Ross, K.D., Saghatelian, A., Hamilton, B.A., Zhang, K., Skowronska-Krawczyk, D. The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina. (2020) Alternde Zelle.:e13100 DOI: 10.1111/acel.13100

Martinez, T.F., Chu, Q., Donaldson, C., Tan, D., Shokhirev, M.N., Saghatelian, A. Accurate annotation of human protein-coding small open reading frames. [Pubmed] (2019) Nature Chemical Biology.:458-468 DOI: 10.1038/s41589-019-0425-0

Chu, Q., Martinez, T.F., Novak, S.W., Donaldson, C.J., Tan, D., Vaughan, J.M., Chang, T., Diedrich, J.K., Andrade, L., Kim, A., Zhang, T., Manor, U., Saghatelian, A. Regulation of the ER stress response by a mitochondrial microprotein. (2019) Nature Communications. 10(1):4883. DOI: 10.1038/s41467-019-12816-z

Wang, H., Kolar, M.J., Chang, T., Rizo, J., Konduri, S., McNerlin, C., Saghatelian, A., Siegel, D. Stereochemistry of Linoleic Acid Esters of Hydroxy Linoleic Acids. (2019) Organic Letters. 21(19):8080-8084. DOI: 10.1021/acs.orglett.9b03054

Syed, I., Rubinde Celis, M.F., Mohan, J.F., Moraes-Vieira, P.M., Vijayakumar, A., Nelson, A.T., Siegel, D., Saghatelian, A., Mathis, D., Kahn, B.B. PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice. (2019) Journal of Clinical Investigation. 129. DOI: 10.1172/JCI122445

Chu, Q., Chang, T., Saghatelian, A. Substrate-Selective Enzyme Inhibitors. (2019) Trends in Pharmacological Sciences. DOI: 10.1016/j.tips.2019.07.009

Zhou, P., Santoro, A., Peroni, O.D., Nelson, A.T., Saghatelian, A., Siegel, D., Kahn, B.B. PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms. (2019) Journal of Clinical Investigation. 129(10):4138-4150. DOI: 10.1172/JCI127092

Tan, D., Ertunc, M.E., Konduri, S., Zhang, J., Pinto, A.M., Chu, Q., Kahn, B.B., Siegel, D., Saghatelian, A. Discovery of FAHFA-containing Triacylglycerols and Their Metabolic Regulation. (2019) Journal of the American Chemical Society. 141(22):8798-8806. DOI: 10.1021/jacs.9b00045

Kolar, M.J., Konduri, S., Chang, T., Wang, H., McNerlin, C., Ohlsson, L., Härröd, M., Siegel, D., Saghatelian, A. Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals. (2019) J. Biol. Chem. DOI: 10.1074/jbc.RA118.006956

Wang, H., Chang, T., Konduri, S., Huang, J., Saghatelian, A., Siegel, D. Synthesis of chemically edited derivatives of the endogenous regulator of inflammation 9-PAHSA. (2019) Journal of Antibiotics. DOI: 10.1038/s41429-019-0180-1

Chu, Q., Saghatelian, A. A Hidden ORF Reveals an Immune Protector. (2019) Biochemistry. DOI: 10.1021/acs.biochem.8b01317

Choi, S.H., Martinez, T.F., Kim, S., Donaldson, C., Shokhirev, M.N., Saghatelian, A., Jones, K.A. CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability. (2019) Genes & Development. 33(7-8):418-435. DOI: 10.1101/gad.322339.118

Garcia, D., Hellberg, K., Chaix, A., Wallace, M., Herzig, S., Badur, M.G., Lin, T., Shokhirev, M.N., Pinto, A.F.M., Ross, D.S., Saghatelian, A., Panda, S., Dow, L.E., Metallo, C.M., Shaw, R.J. Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD. (2019) Cell Reports. 26(1):192-208.e6. DOI: 10.1016/j.celrep.2018.12.036

Rathore, A., Martinez, T.F., Chu, Q., Saghatelian, A. Small, but mighty? Searching for human microproteins and their potential for understanding health and disease. (2018) Expert Review of Proteomics. 15(12):963-965. DOI: 10.1080/14789450.2018.1547194

Rathore, A., Chu, Q., Tan, D., Martinez, T.F., Donaldson, C.J., Diedrich, J.K., Yates, J.R., Saghatelian, A. MIEF1 Microprotein Regulates Mitochondrial Translation. (2018) Biochemistry. DOI: 10.1021/acs.biochem.8b00726

Syed, I., Lee, J., Peroni, O.D., Yore, M.M., Moraes-Vieira, P.M., Santoro, A., Wellenstein, K., Smith, U., McGraw, T.E., Saghatelian, A., Kahn, B.B. Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects. (2018) Zellstoffwechsel. DOI: 10.1016/j.cmet.2018.09.007

Zarrinpar, A., Chaix, A., Xu, Z.Z., Chang, M.W., Marotz, C.A., Saghatelian, A., Knight, R., Panda, S. Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism. (2018) Nature Communications. 9(1):2872. DOI: 10.1038/s41467-018-05336-9

Kolar, M.J., Nelson, A.T., Chang, T., Ertunc, M.E., Christy, M.P., Ohlsson, L., Härröd, M., Kahn, B.B., Siegel, D., Saghatelian, A. Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements. (2018) Analytical Chemistry. 90(8):5358-5365. DOI: 10.1021/acs.analchem.8b00503

Ma, J., Saghatelian, A., Shokhirev, M.N. The influence of transcript assembly on the proteogenomics discovery of microproteins. (2018) PLOS One. 13(3):e0194518. DOI: 10.1371/journal.pone.0194518

Sanz Muñoz, S., Li, H., Ruberu, K., Chu, Q., Saghatelian, A., Ooi, L., Garner, B. The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis. (2018) Journal of Biological Chemistry. DOI: 10.1074/jbc.RA117.001278

Syed, I., Lee, J., Moraes-Vieira, P.M., Donaldson, C.J., Sontheimer, A., Aryal, P., Wellenstein, K., Kolar, M.J., Nelson, A.T., Siegel, D., Mokrosinski, J., Farooqi, I.S., Zhao, J.J., Yore, M.M., Peroni, O.D., Saghatelian, A., Kahn, B.B. Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. (2018) Zellstoffwechsel. 27(2):419-427.e4. DOI: 10.1016/j.cmet.2018.01.001

Aebersold, R., Agar, J.N., Amster, I.J., Baker, M.S., Bertozzi, C.R., Boja, E.S., Costello, C.E., Cravatt, B.F., Fenselau, C., Garcia, B.A., Ge, Y., Gunawardena, J., Hendrickson, R.C., Hergenrother, P.J., Huber, C.G., Ivanov, A.R., Jensen, O.N., Jewett, M.C., Kelleher, N.L., Kiessling, L.L., Krogan, N.J., Larsen, M.R., Loo, J.A., Ogorzalek Loo, R.R., Lundberg, E., MacCoss, M.J., Mallick, P., Mootha, V.K., Mrksich, M., Muir, T.W., Patrie, S.M., Pesavento, J.J., Pitteri, S.J., Rodriguez, H., Saghatelian, A., Sandoval, W., Schlüter, H., Sechi, S., Slavoff, S.A., Smith, L.M., Snyder, M.P., Thomas, P.M., Uhlén, M., Van Eyk, J.E., Vidal, M., Walt, D.R., White, F.M., Williams, E.R., Wohlschlager, T., Wysocki, V.H., Yates, N.A., Young, N.L., Zhang, B. How many human proteoforms are there? (2018) Nature Chemical Biology. 14(3):206-214. DOI: 10.1038/nchembio.2576

Sulli, G., Rommel, A., Wang, X., Kolar, M.J., Puca, F., Saghatelian, A., Plikus, M.V., Verma, I.M., Panda, S. Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. (2018) Natur. 553(7688):351-355. DOI: 10.1038/nature25170

Mesci, P., Macia, A., Moore, S.M., Shiryaev, S.A., Pinto, A., Huang, C.T., Tejwani, L., Fernandes, I.R., Suarez, N.A., Kolar, M.J., Montefusco, S., Rosenberg, S.C., Herai, R.H., Cugola, F.R., Russo, F.B., Sheets, N., Saghatelian, A., Shresta, S., Momper, J.D., Siqueira-Neto, J.L., Corbett, K.D., Beltrão-Braga, P.C.B., Terskikh, A.V., Muotri, A.R. Blocking Zika virus vertical transmission. (2018) Wissenschaftliche Berichte. 8(1):1218. DOI: 10.1038/s41598-018-19526-4

Saison-Ridinger, M., DelGiorno, K.E., Zhang, T., Kraus, A., French, R., Jaquish, D., Tsui, C., Erikson, G., Spike, B.T., Shokhirev, M.N., Liddle, C., Yu, R.T., Downes, M., Evans, R.M., Saghatelian, A., Lowy, A.M., Wahl, G.M. Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. (2017) PLOS One. 12(12):e0189051. DOI: 10.1371/journal.pone.0189051

Saghatelian, A. Novel Biology and Druggable Targets via Chemoproteomics. (2017) Biochemistry. DOI: 10.1021/acs.biochem.7b01167

Vijayakumar, A., Aryal, P., Wen, J., Syed, I., Vazirani, R.P., Moraes-Vieira, P.M., Camporez, J.P., Gallop, M.R., Perry, R.J., Peroni, O.D., Shulman, G.I., Saghatelian, A., McGraw, T.E., Kahn, B.B. Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. (2017) Cell Reports. 21(4):1021-1035. DOI: 10.1016/j.celrep.2017.09.091

Arnoult, N., Correia, A., Ma, J., Merlo, A., Garcia-Gomez, S., Maric, M., Tognetti, M., Benner, C.W., Boulton, S.J., Saghatelian, A., Karlseder, J. Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN. (2017) Natur. 549(7673):548-552. DOI: 10.1038/nature24023

Chu, Q., Rathore, A., Diedrich, J.K., Donaldson, C.J., Yates, J.R., Saghatelian, A. Identification of Microprotein-Protein Interactions via APEX Tagging. (2017) Biochemistry. 56(26):3299-3306. DOI: 10.1021/acs.biochem.7b00265

Nelson, A.T., Kolar, M.J., Chu, Q., Syed, I., Kahn, B.B., Saghatelian, A., Siegel, D. Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation. (2017) Journal of the American Chemical Society. 139(13):4943-4947. DOI: 10.1021/jacs.7b01269

Krzeszinski, J.Y., Schwaid, A.G., Cheng, W.Y., Jin, Z., Gallegos, Z.R., Saghatelian, A., Wan, Y. Lipid Osteoclastokines Regulate Breast Cancer Bone Metastasis. (2017) Endocrinology. 158(3):477-489. DOI: 10.1210/en.2016-1570

Grünberg, J.R., Hoffmann, J.M., Hedjazifar, S., Nerstedt, A., Jenndahl, L., Elvin, J., Castellot, J., Wei, L., Movérare-Skrtic, S., Ohlsson, C., Holm, L.M., Bäckhed, F., Syed, I., Bosch, F., Saghatelian, A., Kahn, B.B., Hammarstedt, A., Smith, U. Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance. (2017) Wissenschaftliche Berichte. 7:43515. DOI: 10.1038/srep43515

Howell, J.J., Hellberg, K., Turner, M., Talbott, G., Kolar, M.J., Ross, D.S., Hoxhaj, G., Saghatelian, A., Shaw, R.J., Manning, B.D. Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex. (2017) Zellstoffwechsel. 25(2):463-471. DOI: 10.1016/j.cmet.2016.12.009

Oishi, Y., Spann, N.J., Link, V.M., Muse, E.D., Strid, T., Edillor, C., Kolar, M.J., Matsuzaka, T., Hayakawa, S., Tao, J., Kaikkonen, M.U., Carlin, A.F., Lam, M.T., Manabe, I., Shimano, H., Saghatelian, A., Glass, C.K. SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. (2017) Zellstoffwechsel. 25(2):412-427. DOI: 10.1016/j.cmet.2016.11.009

D'Lima, N.G., Ma, J., Winkler, L., Chu, Q., Loh, K.H., Corpuz, E.O., Budnik, B.A., Lykke-Andersen, J., Saghatelian, A., Slavoff, S.A. A human microprotein that interacts with the mRNA decapping complex. (2017) Nature Chemical Biology. 13(2):174-180. DOI: 10.1038/nchembio.2249

Chen, P., Zuo, H., Xiong, H., Kolar, M.J., Chu, Q., Saghatelian, A., Siegwart, D.J., Wan, Y. Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis. (2017) Proceedings of the National Academy of Sciences of the United States of America. 114(3):580-585. DOI: 10.1073/pnas.1614035114

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K.I., Clohessy, J.G., Pandolfi, P.P. mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide. (2017) Natur. 541(7636):228-232. DOI: 10.1038/nature21034

Saghatelian, A., Cravatt, B. Glucagon and Thyroid Hormone: A Championship Team. (2016) Cell. 167(3):604-605. DOI: 10.1016/j.cell.2016.10.008

Lee, J., Moraes-Vieira, P.M., Castoldi, A., Aryal, P., Yee, E.U., Vickers, C., Parnas, O., Donaldson, C.J., Saghatelian, A., Kahn, B.B. Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses. (2016) Journal of Biological Chemistry. 291(42):22207-22217. DOI: 10.1074/jbc.M115.703835

Svensson, R.U., Parker, S.J., Eichner, L.J., Kolar, M.J., Wallace, M., Brun, S.N., Lombardo, P.S., Van Nostrand, J.L., Hutchins, A., Vera, L., Gerken, L., Greenwood, J., Bhat, S., Harriman, G., Westlin, W.F., Harwood, H.J., Saghatelian, A., Kapeller, R., Metallo, C.M., Shaw, R.J. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. (2016) Nature Medicine. 22(10):1108-1119. DOI: 10.1038/nm.4181

Pirhaji, L., Milani, P., Leidl, M., Curran, T., Avila-Pacheco, J., Clish, C.B., White, F.M., Saghatelian, A., Fraenkel, E. Revealing disease-associated pathways by network integration of untargeted metabolomics. (2016) Nature Methods. 13(9):770-6. DOI: 10.1038/nmeth.3940

Kolar, M.J., Kamat, S.S., Parsons, W.H., Homan, E.A., Maher, T., Peroni, O.D., Syed, I., Fjeld, K., Molven, A., Kahn, B.B., Cravatt, B.F., Saghatelian, A. Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. (2016) Biochemistry. 55(33):4636-41. DOI: 10.1021/acs.biochem.6b00565

Chu, Q., Diedrich, J.K., Vaughan, J.M., Donaldson, C.J., Nunn, M.F., Lee, K.F., Saghatelian, A. HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective. (2016) Journal of the American Chemical Society. 138(30):9473-8. DOI: 10.1021/jacs.6b03463

Moraes-Vieira, P.M., Saghatelian, A., Kahn, B.B. GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects. (2016) Diabetes. 65(7):1808-15. DOI: 10.2337/db16-0221

Parsons, W.H., Kolar, M.J., Kamat, S.S., Cognetta, A.B., Hulce, J.J., Saez, E., Kahn, B.B., Saghatelian, A., Cravatt, B.F. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. (2016) Nature Chemical Biology. 12(5):367-372. DOI: 10.1038/nchembio.2051

Ma, J., Diedrich, J.K., Jungreis, I., Donaldson, C., Vaughan, J., Kellis, M., Yates, J.R., Saghatelian, A. Improved Identification and Analysis of Small Open Reading Frame Encoded Polypeptides. (2016) Analytical Chemistry. 88(7):3967-75. DOI: 10.1021/acs.analchem.6b00191

Zhang, T., Chen, S., Syed, I., Ståhlman, M., Kolar, M.J., Homan, E.A., Chu, Q., Smith, U., Borén, J., Kahn, B.B., Saghatelian, A. A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids. (2016) Nature Protocols. 11(4):747-63. DOI: 10.1038/nprot.2016.040

Wei, W., Schwaid, A.G., Wang, X., Wang, X., Chen, S., Chu, Q., Saghatelian, A., Wan, Y. Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects. (2016) Zellstoffwechsel. 23(3):479-91. DOI: 10.1016/j.cmet.2015.12.010

Saghatelian, A., Nomura, D.K., Weerapana, E. Editorial overview: Omics: The maturation of chemical biology. (2016) Current Opinion in Chemical Biology. 30:v-vi. DOI: 10.1016/j.cbpa.2015.12.005

Saghatelian, A., Couso, J.P. Discovery and characterization of smORF-encoded bioactive polypeptides. (2015) Nature Chemical Biology. 11(12):909-16. DOI: 10.1038/nchembio.1964

Denli, A.M., Narvaiza, I., Kerman, B.E., Pena, M., Benner, C., Marchetto, M.C., Diedrich, J.K., Aslanian, A., Ma, J., Moresco, J.J., Moore, L., Hunter, T., Saghatelian, A., Gage, F.H. Primate-specific ORF0 contributes to retrotransposon-mediated diversity. (2015) Cell. 163(3):583-93. DOI: 10.1016/j.cell.2015.09.025

Zhang, T., Barclay, L., Walensky, L.D., Saghatelian, A. Regulation of mitochondrial ceramide distribution by members of the BCL-2 family. (2015) Journal of Lipid Research. 56(8):1501-10. DOI: 10.1194/jlr.M058750

Zhang, T., Walensky, L.D., Saghatelian, A. A nonapoptotic role for BAX and BAK in eicosanoid metabolism. (2015) ACS Chemical Biology. 10(6):1398-403. DOI: 10.1021/acschembio.5b00168

Zamboni, N., Saghatelian, A., Patti, G.J. Defining the metabolome: size, flux, and regulation. (2015) Molecular Cell. 58(4):699-706. DOI: 10.1016/j.molcel.2015.04.021

Wu, J., Okamura, D., Li, M., Suzuki, K., Luo, C., Ma, L., He, Y., Li, Z., Benner, C., Tamura, I., Krause, M.N., Nery, J.R., Du, T., Zhang, Z., Hishida, T., Takahashi, Y., Aizawa, E., Kim, N.Y., Lajara, J., Guillen, P., Campistol, J.M., Esteban, C.R., Ross, P.J., Saghatelian, A., Ren, B., Ecker, J.R., Izpisua Belmonte, J.C. An alternative pluripotent state confers interspecies chimaeric competency. (2015) Natur. 521(7552):316-21. DOI: 10.1038/nature14413

Kim, K.J., Kim, Y.W., Kim, Y.G., Park, H.M., Jin, J.M., Hwan Kim, Y., Yang, Y.H., Kyu Lee, J., Chung, J., Lee, S.G., Saghatelian, A. Stable isotopic labeling-based quantitative targeted glycomics (i-QTaG). (2015) Biotechnol. Prog. 31(3):840-8. DOI: 10.1002/btpr.2078

Jin, Z., Du, Y., Schwaid, A.G., Asterholm, I.W., Scherer, P.E., Saghatelian, A., Wan, Y. Maternal adiponectin controls milk composition to prevent neonatal inflammation. (2015) Endocrinology. 156(4):1504-13. DOI: 10.1210/en.2014-1738

Chu, Q., Ma, J., Saghatelian, A. Identification and characterization of sORF-encoded polypeptides. (2015) Critical Reviews in Biochemistry and Molecular Biology. 50(2):134-41. DOI: 10.3109/10409238.2015.1016215

Prothiwa, M., Syed, I., Huising, M.O., van der Meulen, T., Donaldson, C.J., Trauger, S.A., Kahn, B.B., Saghatelian, A. Data-driven synthesis of proteolysis-resistant peptide hormones. (2014) Journal of the American Chemical Society. 136(51):17710-3. DOI: 10.1021/ja5065735

Nazarian, A., Lawlor, K., Yi, S.S., Philip, J., Ghosh, M., Yaneva, M., Villanueva, J., Saghatelian, A., Assel, M., Vickers, A.J., Eastham, J.A., Scher, H.I., Carver, B.S., Lilja, H., Tempst, P. Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer. (2014) Mol. Cell Proteomics. 13(11):3082-96. DOI: 10.1074/mcp.M114.038836

Yore, M.M., Syed, I., Moraes-Vieira, P.M., Zhang, T., Herman, M.A., Homan, E.A., Patel, R.T., Lee, J., Chen, S., Peroni, O.D., Dhaneshwar, A.S., Hammarstedt, A., Smith, U., McGraw, T.E., Saghatelian, A., Kahn, B.B. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. (2014) Cell. 159(2):318-32. DOI: 10.1016/j.cell.2014.09.035

Oliver, P.M., Crooks, J.A., Leidl, M., Yoon, E.J., Saghatelian, A., Weibel, D.B. Localization of anionic phospholipids in Escherichia coli cells. (2014) J. Bacteriol. 196(19):3386-98. DOI: 10.1128/JB.01877-14

Johnson, L.M., Barrick, S., Hager, M.V., McFedries, A., Homan, E.A., Rabaglia, M.E., Keller, M.P., Attie, A.D., Saghatelian, A., Bisello, A., Gellman, S.H. A potent α/β-peptide analogue of GLP-1 with prolonged action in vivo. (2014) Journal of the American Chemical Society. 136(37):12848-51. DOI: 10.1021/ja507168t

Maianti, J.P., McFedries, A., Foda, Z.H., Kleiner, R.E., Du, X.Q., Leissring, M.A., Tang, W.J., Charron, M.J., Seeliger, M.A., Saghatelian, A., Liu, D.R. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. (2014) Natur. 511(7507):94-8. DOI: 10.1038/nature13297

Chin, R.M., Fu, X., Pai, M.Y., Vergnes, L., Hwang, H., Deng, G., Diep, S., Lomenick, B., Meli, V.S., Monsalve, G.C., Hu, E., Whelan, S.A., Wang, J.X., Jung, G., Solis, G.M., Fazlollahi, F., Kaweeteerawat, C., Quach, A., Nili, M., Krall, A.S., Godwin, H.A., Chang, H.R., Faull, K.F., Guo, F., Jiang, M., Trauger, S.A., Saghatelian, A., Braas, D., Christofk, H.R., Clarke, C.F., Teitell, M.A., Petrascheck, M., Reue, K., Jung, M.E., Frand, A.R., Huang, J. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. (2014) Natur. 510(7505):397-401. DOI: 10.1038/nature13264

Slavoff, S.A., Heo, J., Budnik, B.A., Hanakahi, L.A., Saghatelian, A. A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining. (2014) Journal of Biological Chemistry. 289(16):10950-7. DOI: 10.1074/jbc.C113.533968

Ma, J., Ward, C.C., Jungreis, I., Slavoff, S.A., Schwaid, A.G., Neveu, J., Budnik, B.A., Kellis, M., Saghatelian, A. Discovery of human sORF-encoded polypeptides (SEPs) in cell lines and tissue. (2014) J. Proteome Res. 13(3):1757-65. DOI: 10.1021/pr401280w

Lone, A.M., Leidl, M., McFedries, A.K., Horner, J.W., Creemers, J., Saghatelian, A. Deletion of PREPl causes growth impairment and hypotonia in mice. (2014) PLOS One. 9(2):e89160. DOI: 10.1371/journal.pone.0089160

Pauli, A., Norris, M.L., Valen, E., Chew, G.L., Gagnon, J.A., Zimmerman, S., Mitchell, A., Ma, J., Dubrulle, J., Reyon, D., Tsai, S.Q., Joung, J.K., Saghatelian, A., Schier, A.F. Toddler: an embryonic signal that promotes cell movement via Apelin receptors. (2014) Wissenschaft. 343(6172):1248636. DOI: 10.1126/science.1248636

Schwaid, A.G., Shannon, D.A., Ma, J., Slavoff, S.A., Levin, J.Z., Weerapana, E., Saghatelian, A. Chemoproteomic discovery of cysteine-containing human short open reading frames. (2013) Journal of the American Chemical Society. 135(45):16750-3. DOI: 10.1021/ja406606j

López-Sagaseta, J., Dulberger, C.L., McFedries, A., Cushman, M., Saghatelian, A., Adams, E.J. MAIT recognition of a stimulatory bacterial antigen bound to MR1. (2013) Journal of Immunology. 191(10):5268-77. DOI: 10.4049/jimmunol.1301958

Liu, S., Brown, J.D., Stanya, K.J., Homan, E., Leidl, M., Inouye, K., Bhargava, P., Gangl, M.R., Dai, L., Hatano, B., Hotamisligil, G.S., Saghatelian, A., Plutzky, J., Lee, C.H. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. (2013) Natur. 502(7472):550-4. DOI: 10.1038/nature12710

Zhang, T., Saghatelian, A. Emerging roles of lipids in BCL-2 family-regulated apoptosis. (2013) Biochimica et Biophysica Acta. 1831(10):1542-54. DOI: 10.1016/j.bbalip.2013.03.001

Kim, Y.G., Lone, A.M., Saghatelian, A. Analysis of the proteolysis of bioactive peptides using a peptidomics approach. (2013) Nature Protocols. 8(9):1730-42. DOI: 10.1038/nprot.2013.104

Tatematsu, S., Francis, S.A., Natarajan, P., Rader, D.J., Saghatelian, A., Brown, J.D., Michel, T., Plutzky, J. Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. (2013) Arterioscler. Thromb. Vasc. Biol. 33(8):1788-94. DOI: 10.1161/ATVBAHA.113.301300

Mitchell, A.J., Lone, A.M., Tinoco, A.D., Saghatelian, A. Proteolysis controls endogenous substance P levels. (2013) PLOS One. 8(7):e68638. DOI: 10.1371/journal.pone.0068638

Miraldi, E.R., Sharfi, H., Friedline, R.H., Johnson, H., Zhang, T., Lau, K.S., Ko, H.J., Curran, T.G., Haigis, K.M., Yaffe, M.B., Bonneau, R., Lauffenburger, D.A., Kahn, B.B., Kim, J.K., Neel, B.G., Saghatelian, A., White, F.M. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. (2013) Integr Biol (Camb). 5(7):940-63. DOI: 10.1039/c3ib40013a

McFedries, A., Schwaid, A., Saghatelian, A. Methods for the elucidation of protein-small molecule interactions. (2013) Chemistry & Biology. 20(5):667-73. DOI: 10.1016/j.chembiol.2013.04.008

López-Sagaseta, J., Dulberger, C.L., Crooks, J.E., Parks, C.D., Luoma, A.M., McFedries, A., Van Rhijn, I., Saghatelian, A., Adams, E.J. The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins. (2013) Proceedings of the National Academy of Sciences of the United States of America. 110(19):E1771-8. DOI: 10.1073/pnas.1222678110

Lone, A.M., Kim, Y.G., Saghatelian, A. Peptidomics methods for the identification of peptidase-substrate interactions. (2013) Current Opinion in Chemical Biology. 17(1):83-9. DOI: 10.1016/j.cbpa.2012.10.038

Cezairliyan, B., Vinayavekhin, N., Grenfell-Lee, D., Yuen, G.J., Saghatelian, A., Ausubel, F.M. Identification of Pseudomonas aeruginosa phenazines that kill Caenorhabditis elegans. (2013) PLOS pathogens. 9(1):e1003101. DOI: 10.1371/journal.ppat.1003101

Slavoff, S.A., Mitchell, A.J., Schwaid, A.G., Cabili, M.N., Ma, J., Levin, J.Z., Karger, A.D., Budnik, B.A., Rinn, J.L., Saghatelian, A. Peptidomic discovery of short open reading frame-encoded peptides in human cells. (2013) Nature Chemical Biology. 9(1):59-64. DOI: 10.1038/nchembio.1120

Slavoff, S.A., Saghatelian, A. Discovering ligand-receptor interactions. (2012) Nature Biotechnology. 30(10):959-61. DOI: 10.1038/nbt.2373

Du, Y., Yang, M., Wei, W., Huynh, H.D., Herz, J., Saghatelian, A., Wan, Y. Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates. (2012) Nature Communications. 3:1008. DOI: 10.1038/ncomms2011

Du, Y., Yang, M., Lee, S., Behrendt, C.L., Hooper, L.V., Saghatelian, A., Wan, Y. Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity. (2012) Genes & Development. 26(12):1306-11. DOI: 10.1101/gad.191031.112

Kim, Y.G., Lone, A.M., Nolte, W.M., Saghatelian, A. Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(22):8523-7. DOI: 10.1073/pnas.1203195109

Tinoco, A.D., Thomas, H.R., Incarvito, C.D., Saghatelian, A., Valentine, A.M. Cytotoxicity of a Ti(IV) compound is independent of serum proteins. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(13):5016-21. DOI: 10.1073/pnas.1119303109

Guzman-Rojas, L., Rangel, R., Salameh, A., Edwards, J.K., Dondossola, E., Kim, Y.G., Saghatelian, A., Giordano, R.J., Kolonin, M.G., Staquicini, F.I., Koivunen, E., Sidman, R.L., Arap, W., Pasqualini, R. Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(5):1637-42. DOI: 10.1073/pnas.1120790109

Kim, Y.G., Saghatelian, A. Functional analysis of protein targets by metabolomic approaches. (2012) Top Curr Chem. 324:137-62. DOI: 10.1007/128_2011_284

Vinayavekhin, N., Saghatelian, A. Discovery of a protein-metabolite interaction between unsaturated fatty acids and the nuclear receptor Nur77 using a metabolomics approach. (2011) Journal of the American Chemical Society. 133(43):17168-71. DOI: 10.1021/ja208199h

Tinoco, A.D., Saghatelian, A. Investigating endogenous peptides and peptidases using peptidomics. (2011) Biochemistry. 50(35):7447-61. DOI: 10.1021/bi200417k

Lone, A.M., Bachovchin, D.A., Westwood, D.B., Speers, A.E., Spicer, T.P., Fernandez-Vega, V., Chase, P., Hodder, P.S., Rosen, H., Cravatt, B.F., Saghatelian, A. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. (2011) Journal of the American Chemical Society. 133(30):11665-74. DOI: 10.1021/ja2036095

Brown, J.D., Oligino, E., Rader, D.J., Saghatelian, A., Plutzky, J. VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses. (2011) PLOS One. 6(7):e21209. DOI: 10.1371/journal.pone.0021209

Homan, E.A., Kim, Y.G., Cardia, J.P., Saghatelian, A. Monoalkylglycerol ether lipids promote adipogenesis. (2011) Journal of the American Chemical Society. 133(14):5178-81. DOI: 10.1021/ja111173c

Kim, Y.G., Lou, A.C., Saghatelian, A. A metabolomics strategy for detecting protein-metabolite interactions to identify natural nuclear receptor ligands. (2011) Mol Biosyst. 7(4):1046-9. DOI: 10.1039/c0mb00324g

Tinoco, A.D., Kim, Y.G., Tagore, D.M., Wiwczar, J., Lane, W.S., Danial, N.N., Saghatelian, A. A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones. (2011) Biochemistry. 50(12):2213-22. DOI: 10.1021/bi2000033

Scharf, L., Li, N.S., Hawk, A.J., Garzón, D., Zhang, T., Fox, L.M., Kazen, A.R., Shah, S., Haddadian, E.J., Gumperz, J.E., Saghatelian, A., Faraldo-Gómez, J.D., Meredith, S.C., Piccirilli, J.A., Adams, E.J. The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation. (2010) Immunity. 33(6):853-62. DOI: 10.1016/j.immuni.2010.11.026

Lone, A.M., Nolte, W.M., Tinoco, A.D., Saghatelian, A. Peptidomics of the prolyl peptidases. (2010) AAPS J. 12(4):483-91. DOI: 10.1208/s12248-010-9208-y

Vinayavekhin, N., Saghatelian, A. Untargeted metabolomics. (2010) Current Protocols in Molecular Biology. Chapter 30:Unit 30.1.1-24. DOI: 10.1002/0471142727.mb3001s90

Tinoco, A.D., Tagore, D.M., Saghatelian, A. Expanding the dipeptidyl peptidase 4-regulated peptidome via an optimized peptidomics platform. (2010) Journal of the American Chemical Society. 132(11):3819-30. DOI: 10.1021/ja909524e

Vinayavekhin, N., Homan, E.A., Saghatelian, A. Exploring disease through metabolomics. (2010) ACS Chemical Biology. 5(1):91-103. DOI: 10.1021/cb900271r

Nolte, W.M., Tagore, D.M., Lane, W.S., Saghatelian, A. Peptidomics of prolyl endopeptidase in the central nervous system. (2009) Biochemistry. 48(50):11971-81. DOI: 10.1021/bi901637c

MacBeath, G., Saghatelian, A. The promise and challenge of '-omic' approaches. (2009) Current Opinion in Chemical Biology. 13(5-6):501-2. DOI: 10.1016/j.cbpa.2009.10.008

Vinayavekhin, N., Saghatelian, A. Regulation of alkyl-dihydrothiazole-carboxylates (ATCs) by iron and the pyochelin gene cluster in Pseudomonas aeruginosa. (2009) ACS Chemical Biology. 4(8):617-23. DOI: 10.1021/cb900075n

Rodgers, M.A., Saghatelian, A., Yang, P.L. Identification of an overabundant cholesterol precursor in hepatitis B virus replicating cells by untargeted lipid metabolite profiling. (2009) Journal of the American Chemical Society. 131(14):5030-1. DOI: 10.1021/ja809949r

Tagore, D.M., Nolte, W.M., Neveu, J.M., Rangel, R., Guzman-Rojas, L., Pasqualini, R., Arap, W., Lane, W.S., Saghatelian, A. Peptidase substrates via global peptide profiling. (2009) Nature Chemical Biology. 5(1):23-5. DOI: 10.1038/nchembio.126

Tagore, R., Thomas, H.R., Homan, E.A., Munawar, A., Saghatelian, A. A global metabolite profiling approach to identify protein-metabolite interactions. (2008) Journal of the American Chemical Society. 130(43):14111-3. DOI: 10.1021/ja806463c

Voelcker, N.H., Guckian, K.M., Saghatelian, A., Ghadiri, M.R. Sequence-addressable DNA logic. (2008) Small. 4(4):427-31. DOI: 10.1002/smll.200700113

Chamero, P., Marton, T.F., Logan, D.W., Flanagan, K., Cruz, J.R., Saghatelian, A., Cravatt, B.F., Stowers, L. Identification of protein pheromones that promote aggressive behaviour. (2007) Natur. 450(7171):899-902. DOI: 10.1038/nature05997

Everley, P.A., Gartner, C.A., Haas, W., Saghatelian, A., Elias, J.E., Cravatt, B.F., Zetter, B.R., Gygi, S.P. Assessing enzyme activities using stable isotope labeling and mass spectrometry. (2007) Mol. Cell Proteomics. 6(10):1771-7. DOI: 10.1074/mcp.M700057-MCP200

Wan, Y., Saghatelian, A., Chong, L.W., Zhang, C.L., Cravatt, B.F., Evans, R.M. Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk. (2007) Genes & Development. 21(15):1895-908. DOI: 10.1101/gad.1567207

Ostash, B., Saghatelian, A., Walker, S. A streamlined metabolic pathway for the biosynthesis of moenomycin A. (2007) Chemistry & Biology. 14(3):257-67. DOI: 10.1016/j.chembiol.2007.01.008

Chiang, K.P., Niessen, S., Saghatelian, A., Cravatt, B.F. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. (2006) Chemistry & Biology. 13(10):1041-50. DOI: 10.1016/j.chembiol.2006.08.008

Saghatelian, A., McKinney, M.K., Bandell, M., Patapoutian, A., Cravatt, B.F. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. (2006) Biochemistry. 45(30):9007-15. DOI: 10.1021/bi0608008

Leung, D., Saghatelian, A., Simon, G.M., Cravatt, B.F. Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids. (2006) Biochemistry. 45(15):4720-6. DOI: 10.1021/bi060163l

Evans, M.J., Saghatelian, A., Sorensen, E.J., Cravatt, B.F. Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. (2005) Nature Biotechnology. 23(10):1303-7. DOI: 10.1038/nbt1149

Saghatelian, A., Cravatt, B.F. Assignment of protein function in the postgenomic era. (2005) Nature Chemical Biology. 1(3):130-42. DOI: 10.1038/nchembio0805-130

Saghatelian, A., Cravatt, B.F. Discovery metabolite profiling--forging functional connections between the proteome and metabolome. (2005) Life Sciences. 77(14):1759-66. DOI: 10.1016/j.lfs.2005.05.019

Go, E.P., Apon, J.V., Luo, G., Saghatelian, A., Daniels, R.H., Sahi, V., Dubrow, R., Cravatt, B.F., Vertes, A., Siuzdak, G. Desorption/ionization on silicon nanowires. (2005) Analytical Chemistry. 77(6):1641-6. DOI: 10.1021/ac048460o

Saghatelian, A., Cravatt, B.F. Global strategies to integrate the proteome and metabolome. (2005) Current Opinion in Chemical Biology. 9(1):62-8. DOI: 10.1016/j.cbpa.2004.12.004

Saghatelian, A., Trauger, S.A., Want, E.J., Hawkins, E.G., Siuzdak, G., Cravatt, B.F. Assignment of endogenous substrates to enzymes by global metabolite profiling. (2004) Biochemistry. 43(45):14332-9. DOI: 10.1021/bi0480335

Lichtman, A.H., Leung, D., Shelton, C.C., Saghatelian, A., Hardouin, C., Boger, D.L., Cravatt, B.F. Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. (2004) J. Pharmacol. Exp. Ther. 311(2):441-8. DOI: 10.1124/jpet.104.069401

Cravatt, B.F., Saghatelian, A., Hawkins, E.G., Clement, A.B., Bracey, M.H., Lichtman, A.H. Functional disassociation of the central and peripheral fatty acid amide signaling systems. (2004) Proceedings of the National Academy of Sciences of the United States of America. 101(29):10821-6. DOI: 10.1073/pnas.0401292101

Saghatelian, A., Jessani, N., Joseph, A., Humphrey, M., Cravatt, B.F. Activity-based probes for the proteomic profiling of metalloproteases. (2004) Proceedings of the National Academy of Sciences of the United States of America. 101(27):10000-5. DOI: 10.1073/pnas.0402784101

Sánchez-Quesada, J., Saghatelian, A., Cheley, S., Bayley, H., Ghadiri, M.R. Single DNA rotaxanes of a transmembrane pore protein. (2004) Angew. Chem. Int. Ed. Engl. 43(23):3063-7. DOI: 10.1002/anie.200453907

Saghatelian, A., Völcker, N.H., Guckian, K.M., Lin, V.S., Ghadiri, M.R. DNA-based photonic logic gates: AND, NAND, and INHIBIT. (2003) Journal of the American Chemical Society. 125(2):346-7. DOI: 10.1021/ja029009m

Saghatelian, A., Guckian, K.M., Thayer, D.A., Ghadiri, M.R. DNA detection and signal amplification via an engineered allosteric enzyme. (2003) Journal of the American Chemical Society. 125(2):344-5. DOI: 10.1021/ja027885u

Merlic, C.A., Aldrich, C.C., Albaneze-Walker, J., Saghatelian, A., Mammen, J. Total synthesis of the calphostins: application of fischer carbene complexes and thermodynamic control of atropisomers. (2001) Journal of Organic Chemistry. 66(4):1297-309.

Saghatelian, A., Yokobayashi, Y., Soltani, K., Ghadiri, M.R. A chiroselective peptide replicator. (2001) Natur. 409(6822):797-801. DOI: 10.1038/35057238

Merlic, C.A., Aldrich, C.C., Albaneze-Walker, J., Saghatelian, A. Carbene Complexes in the Synthesis of Complex Natural Products: Total Synthesis of the Calphostins. (2000) Journal of the American Chemical Society. 122(13):3224-3225.