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Page Background Inside Salk A

ugust 2015

www.salk.edu

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Dear Friends,

STAR PERFORMERS ON STAGE OR SCREEN MAY RECEIVE THE

applause, but no complex production comes to fruition without an

extensive team of skilled individuals working behind the spotlight.

So it is with science.

While notable discoveries in Salk laboratories make headlines,

enabling these achievements is the provenance of our scientific

core facilities. We like to call them “idea factories” because they

provide the cutting-edge technology and expertise that allow our

scientists to perform the novel experiments they envision. In this

issue they’re getting a well-deserved turn in the spotlight.

Also receiving recognition are three Salk faculty members who have

been awarded chairs.

John Reynolds

is the inaugural holder of the

Fiona and Sanjay Jha Chair in Neuroscience.

Ursula Bellugi

will hold

another new chair, the Salk Founders’ Chair. And

Alan Saghatelian

has been named holder of the Dr. Frederik Paulsen Chair.

Discoveries at the Institute continue to pour forth at an impressive

pace.

Sam Pfaff

and his team have developed a technique that lets

researchers watch—for the first time—motor neuron activity in the

spinal cord.

Terrence Sejnowski

’s group has linked a particular

receptor in the mouse brain to aberrant behavior. Research with

cellular proteins in

Martin Hetzer

’s lab is revealing how age affects

organs in strikingly different ways. And

Björn Lillemeier

and his team

are uncovering ways to harness the immune system.

Other notable findings at the Institute are advancing our understand-

ing of cancer.

Geoff Wahl

’s lab identified a key molecular mechanism

underlying deadly behavior in some breast cancers. A group led by

Jan Karlseder

showed how disabling a chromosome’s telomeres could

aid chemotherapy.

Reuben Shaw

’s team, in collaboration with scientists

at Sanford Burnham Prebys Medical Discovery Institute, developed a

drug that blocks cancerous cells from obtaining nutrients. And novel

research in

Clodagh O’Shea

’s lab is paving the way for cancer-selective

viral therapies.

Critical to all these accomplishments are Salk’s loyal donors and

we take pleasure in honoring them in this issue in our annual Donor

Honor Roll. Much like the go-to experts in our core facilities, donors

are part of the team behind the scenes who make revolutionary

science possible.

This is my last message as President of the Salk Institute, as I will be

stepping down at the end of December. It has been my privilege to

work among such prodigious talent. Salk is in good shape and in good

hands, and the future looks bright indeed. I wish you all well.

William R. Brody, MD, PhD

President, Salk Institute

Irwin M. Jacobs Presidential Chair

www.salk.ed

Inside Salk 12 | 15

Exe

cutive Message

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William Brody

ON THE COVER

Salk’s 13 shared scientific facilities, or cores, enable discoveries and innovative breakthroughs to Salk labs.

The cores offer state-of-the-art technology and expertise on everything from stem cells to analyzing genomic data.

Where cures begin.

Salk Institute

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P H I L O S O P H Y

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In this issue:2015DonorHonorRoll